Skip to main content

Articles

Page 53 of 66

  1. CD95 is a death receptor controlling not only apoptotic pathways but also activating mechanisms promoting tumor growth. During the acquisition of chemoresistance to oxaliplatin there is a progressive loss of C...

    Authors: Elisabet Ametller, Susana García-Recio, Domizziana Costamagna, Cristina Mayordomo, Patricia Fernández-Nogueira, Neus Carbó, Eva María Pastor-Arroyo, Pedro Gascón and Vanessa Almendro
    Citation: Molecular Cancer 2010 9:161
    Content type: Research Published on:

  2. Glioblastomas are characterized by rapid cell growth, aggressive CNS infiltration, and are resistant to all known anticancer regimens. Recent studies indicate that fibrates and statins possess anticancer poten...

    Authors: Justyna Drukala, Katarzyna Urbanska, Anna Wilk, Maja Grabacka, Ewa Wybieralska, Luis Del Valle, Zbigniew Madeja and Krzysztof Reiss
    Citation: Molecular Cancer 2010 9:159
    Content type: Research Published on:

  3. The polycomb group (PcG) protein BMI1 is an important regulator of development. Additionally, aberrant expression of BMI1 has been linked to cancer stem cell phenotype and oncogenesis. In particular, its overe...

    Authors: Ajay K Yadav, Anagh A Sahasrabuddhe, Manjari Dimri, Prashant V Bommi, Rachana Sainger and Goberdhan P Dimri
    Citation: Molecular Cancer 2010 9:158
    Content type: Research Published on:

  4. Although several anti-angiogenic therapies have been approved in the treatment of cancer, the survival benefits of such therapies are relatively modest. Discovering new molecules and/or better understating sig...

    Authors: Rodrigue Romon, Eric Adriaenssens, Chann Lagadec, Emmanuelle Germain, Hubert Hondermarck and Xuefen Le Bourhis
    Citation: Molecular Cancer 2010 9:157
    Content type: Research Published on:

  5. Ca2+ is a ubiquitous messenger that has been shown to be responsible for controlling numerous cellular processes including cell growth and cell death. Whereas the involvement of IP3-induced Ca2+ signalling (IICS)...

    Authors: Cécilia Szatkowski, Jan B Parys, Halima Ouadid-Ahidouch and Fabrice Matifat
    Citation: Molecular Cancer 2010 9:156
    Content type: Research Published on:

  6. Epstein-Barr virus (EBV)-encoded LMP1 protein is commonly expressed in nasopharyngeal carcinoma (NPC). LMP1 is a prime candidate for driving tumourigenesis given its ability to activate multiple signalling pat...

    Authors: Angela KF Lo, Christopher W Dawson, Kwok W Lo, Yanxing Yu and Lawrence S Young
    Citation: Molecular Cancer 2010 9:155
    Content type: Research Published on:

  7. Formation of tumour cell aggregation/emboli prolongs the survival of circulating tumour cells in the circulation, enhances their physical trapping in the micro-vasculature and thus increases metastatic spread ...

    Authors: Qicheng Zhao, Monica Barclay, John Hilkens, Xiuli Guo, Hannah Barrow, Jonathan M Rhodes and Lu-Gang Yu
    Citation: Molecular Cancer 2010 9:154
    Content type: Research Published on:

  8. Centrosome aberrations can cause genomic instability and correlate with malignant progression in common human malignancies such as breast and prostate cancer. Deregulation of cyclin/cyclin-dependent kinase 2 (...

    Authors: Nina Korzeniewski, Sarah Wheeler, Payel Chatterjee, Anette Duensing and Stefan Duensing
    Citation: Molecular Cancer 2010 9:153
    Content type: Research Published on:

  9. Selection of early stage non-small cell lung cancer patients with a high risk of recurrence is warranted in order to select patients who will benefit from adjuvant treatment strategies. We evaluated the progno...

    Authors: Anne-Marie C Dingemans, Vivian van den Boogaart, Bettine A Vosse, Robert-Jan van Suylen, Arjan W Griffioen and Victor L Thijssen
    Citation: Molecular Cancer 2010 9:152
    Content type: Research Published on:

  10. NK- and T-cells are closely related lymphocytes, originating from the same early progenitor cells during hematopoiesis. In these differentiation processes deregulation of developmental genes may contribute to ...

    Authors: Stefan Nagel, Letizia Venturini, Victor E Marquez, Corinna Meyer, Maren Kaufmann, Michaela Scherr, Roderick AF MacLeod and Hans G Drexler
    Citation: Molecular Cancer 2010 9:151
    Content type: Research Published on:

  11. The HER4 intracellular domain (4ICD) is a potent estrogen receptor (ERα) coactivator with activities in breast cancer and the developing mammary gland that appear to overlap with progesterone receptor (PgR). I...

    Authors: Jerzy Rokicki, Partha M Das, Jennifer M Giltnane, Olivia Wansbury, David L Rimm, Beatrice A Howard and Frank E Jones
    Citation: Molecular Cancer 2010 9:150
    Content type: Short communication Published on:

  12. Pancreatic intraepithelial neoplasias (PanINs) are precursors of malignant pancreatic cancer, an ideal stage for early cancer detection. We applied quantitative proteomics to identify aberrantly elevated prote...

    Authors: Ru Chen, Sheng Pan, Xiaobo Duan, Brad H Nelson, Rob A Sahota, Sarah de Rham, Richard A Kozarek, Martin McIntosh and Teresa A Brentnall
    Citation: Molecular Cancer 2010 9:149
    Content type: Research Published on:

  13. Prostate-derived Ets factor (PDEF) is expressed in tissues of high epithelial content including prostate, although its precise function has not been fully established. Conventional therapies produce a high rat...

    Authors: Thomas R Johnson, Sweaty Koul, Binod Kumar, Lakshmipathi Khandrika, Sarah Venezia, Paul D Maroni, Randall B Meacham and Hari K Koul
    Citation: Molecular Cancer 2010 9:148
    Content type: Research Published on:

    The Retraction Note to this article has been published in Molecular Cancer 2021 20:109

  14. Cisplatin and its derivatives are commonly used anti-cancer drugs. However, cisplatin has clinical limitations including serious side effects and frequent emergence of intrinsic or acquired resistance. Thus, t...

    Authors: Veronika Kvardova, Roman Hrstka, Dawid Walerych, Petr Muller, Eva Matoulkova, Veronika Hruskova, Dagmar Stelclova, Petr Sova and Borivoj Vojtesek
    Citation: Molecular Cancer 2010 9:147
    Content type: Research Published on:

  15. Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related deaths worldwide. It is often diagnosed at an advanced stage, and hence typically has a poor prognosis. To identify distinct molecula...

    Authors: Dilek Colak, Muhammad A Chishti, Al-Bandary Al-Bakheet, Ahmed Al-Qahtani, Mohamed M Shoukri, Malcolm H Goyns, Pinar T Ozand, John Quackenbush, Ben H Park and Namik Kaya
    Citation: Molecular Cancer 2010 9:146
    Content type: Research Published on:

  16. Drug resistance is the outcome of multiple-gene interactions in cancer cells under stress of anticancer agents. MDR1 overexpression is most commonly detected in drug-resistant cancers and accompanied with other g...

    Authors: Yong-Yu Liu, Vineet Gupta, Gauri A Patwardhan, Kaustubh Bhinge, Yunfeng Zhao, Jianxiong Bao, Harihara Mehendale, Myles C Cabot, Yu-Teh Li and S Michal Jazwinski
    Citation: Molecular Cancer 2010 9:145
    Content type: Research Published on:

  18. Lymphotropism in oral squamous cell carcinoma (OSCC) is one of the most important prognostic factors of 5-year survival. In an effort to identify genes that may be responsible for the initiation of OSCC lympho...

    Authors: Chang Xu, Yan Liu, Pei Wang, Wenhong Fan, Tessa C Rue, Melissa P Upton, John R Houck, Pawadee Lohavanichbutr, David R Doody, Neal D Futran, Lue Ping Zhao, Stephen M Schwartz, Chu Chen and Eduardo Méndez
    Citation: Molecular Cancer 2010 9:143
    Content type: Research Published on:

  19. Prostate cancer shows an extremely slow progression, appearing in its metastatic, hormone refractory phenotype mostly in elderly men. The chemopreventive targeting of this tumor could accordingly delay its mal...

    Authors: Roberto Benelli, Stefano Monteghirfo, Roberta Venè, Francesca Tosetti and Nicoletta Ferrari
    Citation: Molecular Cancer 2010 9:142
    Content type: Research Published on:

  20. Solid tumors are often poorly vascularized, with cells that can be 100 μm away from blood vessels. These distant cells get less oxygen and nutrients and are exposed to lower doses of chemotherapeutic agents. A...

    Authors: Sylvine Cottin, Karim Ghani, Pedro Otavio de Campos-Lima and Manuel Caruso
    Citation: Molecular Cancer 2010 9:141
    Content type: Research Published on:

  21. Although the incidence of melanoma in the U.S. is rising faster than any other cancer, the FDA-approved chemotherapies lack efficacy for advanced disease, which results in poor overall survival. Lysophosphatid...

    Authors: Molly K Altman, Vashisht Gopal, Wei Jia, Shuangxing Yu, Hassan Hall, Gordon B Mills, A Cary McGinnis, Michael G Bartlett, Guowei Jiang, Damian Madan, Glenn D Prestwich, Yong Xu, Michael A Davies and Mandi M Murph
    Citation: Molecular Cancer 2010 9:140
    Content type: Research Published on:

  22. Cetuximab, an antibody targeting the epidermal growth factor receptor (EGFR), increases survival in patients with advanced EGFR-positive non-small cell lung cancer when administrated in combination with chemot...

    Authors: Yi-Fan Hsu, Daniel Ajona, Leticia Corrales, Jose M Lopez-Picazo, Alfonso Gurpide, Luis M Montuenga and Ruben Pio
    Citation: Molecular Cancer 2010 9:139
    Content type: Research Published on:

  23. New, more effective strategies are needed to treat highly aggressive neuroblastoma. Our laboratory has previously shown that full-length Secreted Protein Acidic and Rich in Cysteine (SPARC) and a SPARC peptide...

    Authors: Alexandre Chlenski, Lisa J Guerrero, Radhika Peddinti, Jared A Spitz, Payton T Leonhardt, Qiwei Yang, Yufeng Tian, Helen R Salwen and Susan L Cohn
    Citation: Molecular Cancer 2010 9:138
    Content type: Research Published on:

  24. Sharing the common neuroectodermal origin, melanoma and neuroblastoma are tumors widely diffused among adult and children, respectively. Clinical prognosis of aggressive neuroectodermal cancers remains dismal,...

    Authors: Marina Pisano, Gabriella Pagnan, Maria Antonietta Dettori, Sara Cossu, Irene Caffa, Ilaria Sassu, Laura Emionite, Davide Fabbri, Michele Cilli, Fabio Pastorino, Giuseppe Palmieri, Giovanna Delogu, Mirco Ponzoni and Carla Rozzo
    Citation: Molecular Cancer 2010 9:137
    Content type: Research Published on:

  25. In a variety of cancers, altered patterns of microRNA (miRNA) expression are reported and may affect the cell cycle and cell survival. Recent studies suggest that the expression level of miRNAs that act as tum...

    Authors: Akio Iio, Yoshihito Nakagawa, Ichiro Hirata, Tomoki Naoe and Yukihiro Akao
    Citation: Molecular Cancer 2010 9:136
    Content type: Short communication Published on:

  28. Glioblastoma (GBM) is the most common and malignant primary intracranial human neoplasm. GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hyp...

    Authors: Olga Méndez, Jiri Zavadil, Mine Esencay, Yevgeniy Lukyanov, Daniel Santovasi, Shu-Chi Wang, Elizabeth W Newcomb and David Zagzag
    Citation: Molecular Cancer 2010 9:133
    Content type: Research Published on:

  29. Telomerase is activated in oncogenesis, which confers an immortal phenotype to cancer cells. The AAA + ATPase Reptin is required for telomerase biogenesis by maintaining telomerase RNA (hTER) stability and is ...

    Authors: Wenjuan Li, Jiping Zeng, Qiao Li, Li Zhao, Tiantian Liu, Magnus Björkholm, Jihui Jia and Dawei Xu
    Citation: Molecular Cancer 2010 9:132
    Content type: Research Published on:

  30. A maximum entropy approach is proposed to predict the cytotoxic effects of a panel of colchicine derivatives in several human cancer cell lines. Data was obtained from cytotoxicity assays performed with 21 dru...

    Authors: Chih-Yuan Tseng, Jonathan Y Mane, Philip Winter, Lorelei Johnson, Torin Huzil, Elzbieta Izbicka, Richard F Luduena and Jack A Tuszynski
    Citation: Molecular Cancer 2010 9:131
    Content type: Research Published on:

  31. Lung cancer is one of the most prevalent neoplasias in developed countries. Advances in patient survival have been limited and the identification of prognostic molecules is needed. Resistance to treatment is s...

    Authors: Marta Irigoyen, María J Pajares, Jackeline Agorreta, Mariano Ponz-Sarvisé, Elisabeth Salvo, María D Lozano, Ruben Pío, Ignacio Gil-Bazo and Ana Rouzaut
    Citation: Molecular Cancer 2010 9:130
    Content type: Research Published on:

  32. Human mesenchymal stromal cells (MSC) hold a promise for future cell-based therapies due to their immunomodulatory properties and/or secretory activity. Nevertheless non-neoplastic tumor compartment could also...

    Authors: Lucia Kucerova, Miroslava Matuskova, Kristina Hlubinova, Veronika Altanerova and Cestmir Altaner
    Citation: Molecular Cancer 2010 9:129
    Content type: Research Published on:

  33. VHZ is a VH1-like (member Z) dual specific protein phosphatase encoded by DUSP23 gene. Some of the dual specific protein phosphatases (DSPs) play an important role in cell cycle control and have shown to be as...

    Authors: Jing Ping Tang, Cheng Peow Tan, Jie Li, Md Monowarul Siddique, Ke Guo, Siew Wee Chan, Jung Eun Park, Wan Ngee Tay, Zhi Yuan Huang, Wen Cai Li, Jian Chen and Qi Zeng
    Citation: Molecular Cancer 2010 9:128
    Content type: Short communication Published on:

  34. Inactivation of the Fanconi anemia (FA) pathway through defects in one of 13 FA genes occurs at low frequency in various solid cancer entities among the general population. As FA pathway inactivation confers a...

    Authors: Andreas Palagyi, Kornelia Neveling, Ursula Plinninger, Andreas Ziesch, Bianca-Sabrina Targosz, Gerald U Denk, Stephanie Ochs, Antonia Rizzani, Daniel Meier, Wolfgang E Thasler, Helmut Hanenberg, Enrico N De Toni, Florian Bassermann, Claus Schäfer, Burkhard Göke, Detlev Schindler…
    Citation: Molecular Cancer 2010 9:127
    Content type: Research Published on:

  35. Our previous study showed that, in basal cell carcinoma cells, arecoline reduces levels of the tumor cell survival factor interleukin-6 (IL-6), increases levels of tumor suppressor factor p53, and elicits cell...

    Authors: Hsiao-Ling Cheng, Shu-Jem Su, Li-Wen Huang, Bau-Shan Hsieh, Yu-Chen Hu, Thu-Ching Hung and Kee-Lung Chang
    Citation: Molecular Cancer 2010 9:126
    Content type: Research Published on:

  36. Genome-wide DNA hypomethylation plays a role in genomic instability and carcinogenesis. LINE-1 (L1 retrotransposon) constitutes a substantial portion of the human genome, and LINE-1 methylation correlates with...

    Authors: Yoshifumi Baba, Curtis Huttenhower, Katsuhiko Nosho, Noriko Tanaka, Kaori Shima, Aditi Hazra, Eva S Schernhammer, David J Hunter, Edward L Giovannucci, Charles S Fuchs and Shuji Ogino
    Citation: Molecular Cancer 2010 9:125
    Content type: Research Published on:

  37. Androgen signaling plays a critical role in the development of prostate cancer and its progression. However, androgen-independent prostate cancer cells emerge after hormone ablation therapy, resulting in signi...

    Authors: Young-Rang Kim, Kyung-Jin Oh, Ra-Young Park, Nguyen Thi Xuan, Taek-Won Kang, Dong-Deuk Kwon, Chan Choi, Min Soo Kim, Kwang Il Nam, Kyu Youn Ahn and Chaeyong Jung
    Citation: Molecular Cancer 2010 9:124
    Content type: Research Published on:

  38. Fludarabine, is one of the most active single agents in the treatment of chronic lymphocytic leukemia (CLL). Over time, however, virtually all CLL patients become fludarabine-refractory. To elucidate whether m...

    Authors: Manuela Ferracin, Barbara Zagatti, Lara Rizzotto, Francesco Cavazzini, Angelo Veronese, Maria Ciccone, Elena Saccenti, Laura Lupini, Andrea Grilli, Cristiano De Angeli, Massimo Negrini and Antonio Cuneo
    Citation: Molecular Cancer 2010 9:123
    Content type: Research Published on:

  39. Transforming Growth Factor β (TGF-β) plays an important role in tumor invasion and metastasis. We set out to investigate the possible clinical utility of TGF-β antagonists in a human metastatic basal-like brea...

    Authors: Vidya Ganapathy, Rongrong Ge, Alison Grazioli, Wen Xie, Whitney Banach-Petrosky, Yibin Kang, Scott Lonning, John McPherson, Jonathan M Yingling, Swati Biswas, Gregory R Mundy and Michael Reiss
    Citation: Molecular Cancer 2010 9:122
    Content type: Research Published on:

  40. Gastric cancer is the second leading cause of cancer mortality in the world. The receptor tyrosine kinase MET is constitutively activated in many gastric cancers and its expression is strictly required for sur...

    Authors: Simona Corso, Elena Ghiso, Virna Cepero, J Rafael Sierra, Cristina Migliore, Andrea Bertotti, Livio Trusolino, Paolo M Comoglio and Silvia Giordano
    Citation: Molecular Cancer 2010 9:121
    Content type: Research Published on:

  41. The t(9;22)(q34;q11), generating the Philadelphia (Ph) chromosome, is found in more than 90% of patients with chronic myeloid leukemia (CML). As a result of the translocation, the 3' portion of the ABL1 oncogene ...

    Authors: Francesco Albano, Luisa Anelli, Antonella Zagaria, Nicoletta Coccaro, Paola Casieri, Antonella Russo Rossi, Laura Vicari, Vincenzo Liso, Mariano Rocchi and Giorgina Specchia
    Citation: Molecular Cancer 2010 9:120
    Content type: Research Published on:

  42. Nuclear pore complexes are massive multiprotein channels responsible for traffic between the nucleus and cytoplasm, and are composed of approximately 30 proteins, termed nucleoporins (Nup). Our recent studies ...

    Authors: Chieko Hashizume, Hiroshi Nakano, Kimihisa Yoshida and Richard W Wong
    Citation: Molecular Cancer 2010 9:119
    Content type: Short communication Published on:

  43. MUC16 is a cell surface mucin expressed at high levels by epithelial ovarian tumors. Following proteolytic cleavage, cell surface MUC16 (csMUC16) is shed in the extracellular milieu and is detected in the seru...

    Authors: Jennifer A Belisle, Sachi Horibata, Gubbels AA Jennifer, Sarah Petrie, Arvinder Kapur, Sabine André, Hans-Joachim Gabius, Claudine Rancourt, Joseph Connor, James C Paulson and Manish S Patankar
    Citation: Molecular Cancer 2010 9:118
    Content type: Research Published on:

  44. Nuclear factor-κB (NF-κB) is constitutively activated in many cancers and plays a key role in promoting cell proliferation, survival, and invasion. Our understanding of NF-κB signaling in thyroid cancer, howev...

    Authors: Kevin T Bauerle, Rebecca E Schweppe and Bryan R Haugen
    Citation: Molecular Cancer 2010 9:117
    Content type: Research Published on:

  45. p27Kip1 (p27) is an important negative regulator of the cell cycle and a putative tumor suppressor. The finding that a spontaneous germline frameshift mutation in Cdkn1b (encoding p27) causes the MENX multiple en...

    Authors: Sara Molatore, Eva Kiermaier, Christian B Jung, Misu Lee, Elke Pulz, Heinz Höfler, Michael J Atkinson and Natalia S Pellegata
    Citation: Molecular Cancer 2010 9:116
    Content type: Research Published on:

  46. Chronic lymphocytic leukemia (CLL) cells are often affected by genomic aberrations targeting key regulatory genes. Although fludarabine is the standard first line therapy to treat CLL, only few data are availa...

    Authors: Etienne Moussay, Valérie Palissot, Laurent Vallar, Hélène A Poirel, Thomas Wenner, Victoria El Khoury, Nasséra Aouali, Kris Van Moer, Bernadette Leners, François Bernardin, Arnaud Muller, Pascale Cornillet-Lefebvre, Alain Delmer, Caroline Duhem, Fernand Ries, Eric van Dyck…
    Citation: Molecular Cancer 2010 9:115
    Content type: Research Published on:

  47. Chemotherapeutic drugs like Adriamycin (ADR) induces apoptosis or senescence in cancer cells but these cells often develop resistance and generate responses of short duration or complete failure. The methylxan...

    Authors: Alejandro Bravo-Cuellar, Pablo C Ortiz-Lazareno, Jose M Lerma-Diaz, Jorge R Dominguez-Rodriguez, Luis F Jave-Suarez, Adriana Aguilar-Lemarroy, Susana del Toro-Arreola, Ruth de Celis-Carrillo, Jose E Sahagun-Flores, Javier E Garcia de Alba-Garcia and Georgina Hernandez-Flores
    Citation: Molecular Cancer 2010 9:114
    Content type: Research Published on:

  48. A recent genome-wide association study (GWAS) has identified a single nucleotide polymorphism (SNP) rs11249433 in the 1p11.2 region as a novel genetic risk factor for breast cancer, and this association was st...

    Authors: Yi-Ping Fu, Hege Edvardsen, Alpana Kaushiva, Juan P Arhancet, Tiffany M Howe, Indu Kohaar, Patricia Porter-Gill, Anushi Shah, Hege Landmark-Høyvik, Sophie D Fosså, Stefan Ambs, Bjørn Naume, Anne-Lise Børresen-Dale, Vessela N Kristensen and Ludmila Prokunina-Olsson
    Citation: Molecular Cancer 2010 9:113
    Content type: Research Published on:

  49. Chronic myelogenous leukemia (CML) is characterized by the chimeric tyrosine kinase Bcr-Abl. Bcr-Abl-T315I is the notorious point mutation that causes resistance to imatinib and the second generation tyrosine ...

    Authors: Zhongzheng Lu, Yanli Jin, Chun Chen, Juan Li, Qi Cao and Jingxuan Pan
    Citation: Molecular Cancer 2010 9:112
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2021 20:172

Submit manuscript

Annual Journal Metrics

  • 2022 Citation Impact
    37.3 - 2-year Impact Factor
    33.1 - 5-year Impact Factor
    5.740 - SNIP (Source Normalized Impact per Paper)
    8.703 - SJR (SCImago Journal Rank)

    2023 Speed
    5 days submission to first editorial decision for all manuscripts (Median)
    91 days submission to accept (Median)

    2023 Usage 
    3,569,666 downloads
    2,070 Altmetric mentions 

Follow

Molecular Cancer

ISSN: 1476-4598