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  1. TRAIL is considered as a promising anti-cancer agent, because of its ability to induce apoptosis in cancer but not in most normal cells. However, growing evidence exist that many cancer cells are resistant to ...

    Authors: Alena Vaculova, Vitaliy Kaminskyy, Elham Jalalvand, Olga Surova and Boris Zhivotovsky
    Citation: Molecular Cancer 2010 9:87
    Content type: Research Published on:

  2. Most prostate cancer (PCa)-related deaths are due to metastasis, which is mediated in part by chemokine receptor and corresponding ligand interaction. We have previously shown that PCa tissue and cell lines ex...

    Authors: Christelle P. El Haibi, Praveen K. Sharma, Rajesh Singh, Paul R. Johnson, Jill Suttles, Shailesh Singh and James W. Lillard Jr
    Citation: Molecular Cancer 2010 9:85
    Content type: Research Published on:

  3. RGD-motif acts as a specific integrins-ligand and regulates a variety of cell-functions via extracellular action affecting cell-adhesion properties. However, increasing evidence identifies additional RGDS-func...

    Authors: Maria Simona Aguzzi, Paola Fortugno, Claudia Giampietri, Gianluca Ragone, Maurizio C. Capogrossi and Antonio Facchiano
    Citation: Molecular Cancer 2010 9:84
    Content type: Research Published on:

  4. Neuroblastoma is a paediatric cancer of the sympathetic nervous system. The single most important genetic indicator of poor clinical outcome is amplification of the MYCN transcription factor. One of many down-str...

    Authors: Niamh H. Foley, Isabella M. Bray, Amanda Tivnan, Kenneth Bryan, Derek M. Murphy, Patrick G. Buckley, Jacqueline Ryan, Anne O'Meara, Maureen O'Sullivan and Raymond L. Stallings
    Citation: Molecular Cancer 2010 9:83
    Content type: Research Published on:

  5. Our previous studies showed that the expression of the monocyte-chemoattractant protein (MCP)-1, a chemokine, which triggers the infiltration and activation of cells of the monocyte-macrophage lineage, is abro...

    Authors: Katrin Hacke, Bladimiro Rincon-Orozco, Gilles Buchwalter, Simone Y. Siehler, Bohdan Wasylyk, Lisa Wiesmüller and Frank Rösl
    Citation: Molecular Cancer 2010 9:82
    Content type: Research Published on:

  6. Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with poor prognosis due to resistance to conventional chemotherapy and limited efficacy of radiotherapy. There is an urgent need ...

    Authors: Fenglian Ren, Hong Wu, Yunlong Lei, Haiyuan Zhang, Rui Liu, Yong Zhao, Xiancheng Chen, Dequan Zeng, Aiping Tong, Lijuan Chen, Yuquan Wei and Canhua Huang
    Citation: Molecular Cancer 2010 9:81
    Content type: Research Published on:

  7. Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors with a dismal prognosis and no effective conservative therapeutic strategies. Although it is demonstrated that histone deacetylases (...

    Authors: Susanne Schüler, Petra Fritsche, Sandra Diersch, Alexander Arlt, Roland M. Schmid, Dieter Saur and Günter Schneider
    Citation: Molecular Cancer 2010 9:80
    Content type: Research Published on:

  8. Because some of heat shock protein 90's (HSP90) clients are key cell cycle regulators, HSP90 inhibition can affect the cell cycle. Recently, celastrol is identified both as a novel inhibitor of HSP90 and as a ...

    Authors: Bin Peng, Limin Xu, Fanfan Cao, Tingxuan Wei, Chunxin Yang, Georges Uzan and Denghai Zhang
    Citation: Molecular Cancer 2010 9:79
    Content type: Research Published on:

  9. The aim of the present study was to analyze the expression of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathologic features, inc...

    Authors: Luxia Tu, Zhen Liu, Xiufang He, Ying He, Huiling Yang, Qingping Jiang, Siming Xie, Guanghui Xiao, Xin Li, Kaitai Yao and Weiyi Fang
    Citation: Molecular Cancer 2010 9:78
    Content type: Research Published on:

  10. Survivin is a dual functioning protein. It inhibits the apoptosis of cancer cells by inhibiting caspases, and also promotes cancer cell growth by stabilizing microtubules during mitosis. Since the molecular ch...

    Authors: Chun Hei Antonio Cheung, Huang-Hui Chen, Li-Ting Cheng, Kevin W. Lyu, Jagat R. Kanwar and Jang-Yang Chang
    Citation: Molecular Cancer 2010 9:77
    Content type: Research Published on:

  11. Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes.

    Authors: Gry Kalstad Lønne, Louise Cornmark, Iris Omanovic Zahirovic, Göran Landberg, Karin Jirström and Christer Larsson
    Citation: Molecular Cancer 2010 9:76
    Content type: Research Published on:

  13. The goal of this study was to understand gene expression signatures of hepatocellular carcinoma (HCC) recurrence in subjects with hepatitis C virus (HCV) infection. Recurrence-free survival (RFS) following cur...

    Authors: Masato Tsuchiya, Joel S. Parker, Hiroshi Kono, Masanori Matsuda, Hideki Fujii and Ivan Rusyn
    Citation: Molecular Cancer 2010 9:74
    Content type: Research Published on:

  14. Tumor necrosis factor alpha (TNFα) has been used to treat certain tumors in clinic trials. However, the curative effect of TNFα has been undermined by the induced-NF-κB activation in many types of tumor. Masli...

    Authors: Chenghai Li, Zhengfeng Yang, Chunyan Zhai, Wenwei Qiu, Dali Li, Zhengfang Yi, Lei Wang, Jie Tang, Min Qian, Jian Luo and Mingyao Liu
    Citation: Molecular Cancer 2010 9:73
    Content type: Research Published on:

  15. PCBP1 (or alpha CP1 or hnRNP E1), a member of the PCBP family, is widely expressed in many human tissues and involved in regulation of transcription, transportation process, and function of RNA molecules. Howe...

    Authors: Tong Zhang, Xian-Hong Huang, Lan Dong, Deqing Hu, Changhui Ge, Yi-Qun Zhan, Wang-Xiang Xu, Miao Yu, Wei Li, Xiaohui Wang, Liujun Tang, Chang-Yan Li and Xiao-Ming Yang
    Citation: Molecular Cancer 2010 9:72
    Content type: Research Published on:

  16. Autotaxin (ATX) is an extracellular lysophospholipase D that generates lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC). Both ATX and LPA have been shown to be involved in many cancers. However, ...

    Authors: Jian-Min Wu, Yan Xu, Nicholas J. Skill, Hongmiao Sheng, Zhenwen Zhao, Menggang Yu, Romil Saxena and Mary A. Maluccio
    Citation: Molecular Cancer 2010 9:71
    Content type: Research Published on:

  17. Global hypomethylation and genomic instability are cardinal features of cancers. Recently, we established a method for the detection of DNA methylation levels at sites close to endogenous DNA double strand bre...

    Authors: Narisorn Kongruttanachok, Chutipa Phuangphairoj, Araya Thongnak, Wanpen Ponyeam, Prakasit Rattanatanyong, Wichai Pornthanakasem and Apiwat Mutirangura
    Citation: Molecular Cancer 2010 9:70
    Content type: Research Published on:

  18. The endothelin system is implicated in the pathogenesis of melanoma. We evaluated the effects of bosentan - a dual endothelin receptor antagonist - in patients receiving first-line dacarbazine therapy for stag...

    Authors: Richard F. Kefford, Philip R. Clingan, Benjamin Brady, Andrea Ballmer, Adele Morganti and Peter Hersey
    Citation: Molecular Cancer 2010 9:69
    Content type: Research Published on:

  19. Breast cancer is the most frequent cancer in women and consists of a heterogeneous collection of diseases with distinct histopathological, genetic and epigenetic characteristics. In this study, we aimed to ide...

    Authors: Emelyne Dejeux, Jo Anders Rønneberg, Hiroko Solvang, Ida Bukholm, Stephanie Geisler, Turid Aas, Ivo G. Gut, Anne-Lise Børresen-Dale, Per Eystein Lønning, Vessela N. Kristensen and Jörg Tost
    Citation: Molecular Cancer 2010 9:68
    Content type: Research Published on:

  20. Cells are constantly exposed to stresses from cellular metabolites as well as environmental genotoxins. DNA damage caused by these genotoxins can be efficiently fixed by DNA repair in cooperation with cell cyc...

    Authors: Lu Han, Zhishang Hu, Yuheng Liu, Xiangyuan Wang, Kevin M. Hopkins, Howard B. Lieberman and Haiying Hang
    Citation: Molecular Cancer 2010 9:67
    Content type: Research Published on:

  21. High-resolution magic angle spinning (HRMAS) NMR spectroscopy allows detailed metabolic analysis of whole biopsy samples for investigating tumour biology and tumour classification. Accurate biochemical assignm...

    Authors: Alan J. Wright, Greg A. Fellows, John R. Griffiths, M. Wilson, B. Anthony Bell and Franklyn A. Howe
    Citation: Molecular Cancer 2010 9:66
    Content type: Research Published on:

  22. Functional loss of the tumor suppressor Smad4 is involved in pancreatic and colorectal carcinogenesis and has been associated with the acquisition of invasiveness. We have previously demonstrated that the hete...

    Authors: Dirk Zboralski, Bettina Warscheid, Susanne Klein-Scory, M. Bassel Malas, Heiko Becker, Miriam Böckmann, Helmut E Meyer, Wolff Schmiegel, Patricia Simon-Assmann and Irmgard Schwarte-Waldhoff
    Citation: Molecular Cancer 2010 9:65
    Content type: Research Published on:

  23. Many cancerous cells accumulate β-catenin in the nucleus. We examined the role of epidermal growth factor receptor (EGFR) signaling in the accumulation of β-catenin in the nuclei of oral cancer cells.

    Authors: Chien-Hsing Lee, Hsing-Wen Hung, Pei-Hsin Hung and Yi-Shing Shieh
    Citation: Molecular Cancer 2010 9:64
    Content type: Research Published on:

  24. Both mutational inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene and activation of the KRAS oncogene are implicated in the pathogenesis of colorectal cancer. Mice harboring a germline Ap...

    Authors: Mandayam O. Nandan, Amr M. Ghaleb, Beth B. McConnell, Nilesh V. Patel, Sylvie Robine and Vincent W. Yang
    Citation: Molecular Cancer 2010 9:63
    Content type: Research Published on:

  25. MFSD2A (major facilitator superfamily domain containing 2) gene maps on chromosome 1p34 within a linkage disequilibrium block containing genetic elements associated with progression of lung cancer.

    Authors: Monica Spinola, Felicia S. Falvella, Francesca Colombo, James P. Sullivan, David S. Shames, Luc Girard, Paola Spessotto, John D. Minna and Tommaso A. Dragani
    Citation: Molecular Cancer 2010 9:62
    Content type: Research Published on:

  26. Our understanding of the mechanism regulating pancreatic cancer metastatic phenotype is limited. We analyzed the role of RHOA and PRKCZ in the motility attitude of two subclones of the pancreatic adenocarcinom...

    Authors: Marco Della Peruta, Cinzia Giagulli, Carlo Laudanna, Aldo Scarpa and Claudio Sorio
    Citation: Molecular Cancer 2010 9:61
    Content type: Research Published on:

  27. Epithelial Protein Lost in Neoplasm α is a novel cytoskeleton-associated tumor suppressor whose expression inversely correlates with cell growth, motility, invasion and cancer mortality. Here we show that Epli...

    Authors: Laura Leitner, Dmitry Shaposhnikov, Arnaud Descot, Reinhard Hoffmann and Guido Posern
    Citation: Molecular Cancer 2010 9:60
    Content type: Short communication Published on:

  28. Although an increasing number of histone demethylases have been identified and biochemically characterized, their biological functions largely remain uncharacterized, particularly in the context of human disea...

    Authors: Shinya Hayami, Masanori Yoshimatsu, Abhimanyu Veerakumarasivam, Motoko Unoki, Yukiko Iwai, Tatsuhiko Tsunoda, Helen I. Field, John D Kelly, David E. Neal, Hiroki Yamaue, Bruce A. J. Ponder, Yusuke Nakamura and Ryuji Hamamoto
    Citation: Molecular Cancer 2010 9:59
    Content type: Research Published on:

  29. To understand the role of two interacting proteins LIMD1 and pRB in development of head and neck squamous cell carcinoma (HNSCC), alterations of these genes were analyzed in 25 dysplastic head and neck lesions...

    Authors: Susmita Ghosh, Amlan Ghosh, Guru P Maiti, Nupur Mukherjee, Sankhadeep Dutta, Anup Roy, Susanta Roychoudhury and Chinmay K Panda
    Citation: Molecular Cancer 2010 9:58
    Content type: Research Published on:

  30. The mammalian target of rapamycin (mTOR), which exists in two functionally distinct complexes, mTORC1 and mTORC2 plays an important role in tumor growth. Whereas the role of mTORC1 has been well characterized ...

    Authors: Didier Roulin, Yannick Cerantola, Anne Dormond-Meuwly, Nicolas Demartines and Olivier Dormond
    Citation: Molecular Cancer 2010 9:57
    Content type: Short communication Published on:

  31. We have previously shown that nuclear factor (NF)-κ B activation of mouse Lewis lung carcinoma (LLC) specifically promotes the induction of malignant pleural effusions (MPE) by these cells. In the present studies...

    Authors: Ioannis Psallidas, Sophia P Karabela, Charalampos Moschos, Taylor P Sherrill, Androniki Kollintza, Sophia Magkouta, Panagiota Theodoropoulou, Charis Roussos, Timothy S Blackwell, Ioannis Kalomenidis and Georgios T Stathopoulos
    Citation: Molecular Cancer 2010 9:56
    Content type: Research Published on:

  32. Wnt-11 is a secreted protein that modulates cell growth, differentiation and morphogenesis during development. We previously reported that Wnt-11 expression is elevated in hormone-independent prostate cancer a...

    Authors: Pinar Uysal-Onganer, Yoshiaki Kawano, Mercedes Caro, Marjorie M Walker, Soraya Diez, R Siobhan Darrington, Jonathan Waxman and Robert M Kypta
    Citation: Molecular Cancer 2010 9:55
    Content type: Research Published on:

  34. Medulloblastoma is amongst the most common malignant brain tumors in childhood, arising from neoplastic transformation of granule neuron precursors (GNPs) of the cerebellum via deregulation of pathways involved i...

    Authors: Mirella Tanori, Melissa Santone, Mariateresa Mancuso, Emanuela Pasquali, Simona Leonardi, Vincenzo Di Majo, Simonetta Rebessi, Anna Saran and Simonetta Pazzaglia
    Citation: Molecular Cancer 2010 9:53
    Content type: Research Published on:

  35. CD40 and its ligand (CD40L) play a critical role in co-ordinating immune responses. CD40 is also expressed in lymphoid malignancies and a number of carcinomas. In carcinoma cells the physiological outcome of C...

    Authors: Taha Elmetwali, Peter F Searle, Iain McNeish, Lawrence S Young and Daniel H Palmer
    Citation: Molecular Cancer 2010 9:52
    Content type: Research Published on:

  36. There are several high throughput approaches to identify methylated genes in cancer. We utilized one such recently developed approach, MIRA (methylated-CpG island recovery assay) combined with CpG island array...

    Authors: Victoria K Hill, Luke B Hesson, Temuujin Dansranjavin, Ashraf Dallol, Ivan Bieche, Sophie Vacher, Stella Tommasi, Timothy Dobbins, Dean Gentle, David Euhus, Cheryl Lewis, Reinhard Dammann, Robyn L Ward, John Minna, Eammon R Maher, Gerd P Pfeifer…
    Citation: Molecular Cancer 2010 9:51
    Content type: Research Published on:

  37. BRCA2 gene expression is tightly regulated during the cell cycle in human breast cells. The expression of BRCA2 gene is silenced at the G0/G1 phase of cell growth and is de-silenced at the S/G2 phase. While st...

    Authors: Smita Misra, Shvetank Sharma, Anupriya Agarwal, Sheetal V Khedkar, Manish K Tripathi, Mukul K Mittal and Gautam Chaudhuri
    Citation: Molecular Cancer 2010 9:50
    Content type: Research Published on:

  38. Uterine sarcomas are very rare malignancies with no approved chemotherapy protocols. Histone deacetylase (HDAC) inhibitors belong to the most promising groups of compounds for molecular targeting therapy. Here...

    Authors: Andelko Hrzenjak, Farid Moinfar, Marie-Luise Kremser, Bettina Strohmeier, Edgar Petru, Kurt Zatloukal and Helmut Denk
    Citation: Molecular Cancer 2010 9:49
    Content type: Research Published on:

  39. Podoplanin expression is attracting interest as a marker for cancer diagnosis and prognosis. We therefore investigated the expression pattern and clinical significance of podoplanin during the development and ...

    Authors: Juan P Rodrigo, Dario García-Carracedo, María V González, Gonzalo Mancebo, Manuel F Fresno and Juana García-Pedrero
    Citation: Molecular Cancer 2010 9:48
    Content type: Research Published on:

  40. Sulforaphane (SFN), an isothiocyanate phytochemical present predominantly in cruciferous vegetables such as brussels sprout and broccoli, is considered a promising chemo-preventive agent against cancer. In-vit...

    Authors: Christopher S Bryant, Sanjeev Kumar, Sreedhar Chamala, Jay Shah, Jagannath Pal, Mahdi Haider, Shelly Seward, Aamer M Qazi, Robert Morris, Assaad Semaan, Masood A Shammas, Christopher Steffes, Ravindra B Potti, Madhu Prasad, Donald W Weaver and Ramesh B Batchu
    Citation: Molecular Cancer 2010 9:47
    Content type: Research Published on:

  41. Clinical efficacy of chemotherapy in colorectal cancer is subjected to broad inter-individual variations leading to the inability to predict outcome and toxicity. The topoisomerase I inhibitor irinotecan (CPT-...

    Authors: Caroline Raynal, Jean-Marc Pascussi, Géraldine Leguelinel, Cyril Breuker, Jovana Kantar, Benjamin Lallemant, Sylvain Poujol, Caroline Bonnans, Dominique Joubert, Frédéric Hollande, Serge Lumbroso, Jean-Paul Brouillet and Alexandre Evrard
    Citation: Molecular Cancer 2010 9:46
    Content type: Research Published on:

  42. The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been li...

    Authors: Muy-Teck Teh, Emilios Gemenetzidis, Tracy Chaplin, Bryan D Young and Michael P Philpott
    Citation: Molecular Cancer 2010 9:45
    Content type: Research Published on:

  43. Genetic as well as epigenetic alterations are a hallmark of both epithelial and haematological malignancies. High throughput screens are required to identify epigenetic markers that can be useful for diagnosti...

    Authors: Thomas Dunwell, Luke Hesson, Tibor A Rauch, Lihui Wang, Richard E Clark, Ashraf Dallol, Dean Gentle, Daniel Catchpoole, Eamonn R Maher, Gerd P Pfeifer and Farida Latif
    Citation: Molecular Cancer 2010 9:44
    Content type: Research Published on:

  44. Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin (PG) synthase, has been implicated in tumor metastasis. Interaction of COX-2 with its specific EP receptors on the surface of cancer cells has bee...

    Authors: Ju-Fang Liu, Yi-Chin Fong, Chih-Shiang Chang, Chun-Yin Huang, Hsien-Te Chen, Wei-Hung Yang, Chin-Jung Hsu, Long-Bin Jeng, Chih-Yi Chen and Chih-Hsin Tang
    Citation: Molecular Cancer 2010 9:43
    Content type: Research Published on:

  45. Aurora B kinase is an important mitotic kinase involved in chromosome segregation and cytokinesis. It is overexpressed in many cancers and thus may be an important molecular target for chemotherapy. AZD1152 is...

    Authors: Christopher P Gully, Fanmao Zhang, Jian Chen, James A Yeung, Guermarie Velazquez-Torres, Edward Wang, Sai-Ching Jim Yeung and Mong-Hong Lee
    Citation: Molecular Cancer 2010 9:42
    Content type: Research Published on:

  46. Expression levels of the cell surface glycoprotein, CD7, and the serine protease, elastase 2 (ELA2), in the leukemic cells of patients with chronic myeloid leukemia (CML) have been associated with clinical out...

    Authors: Sally L Rogers, Yun Zhao, Xiaoyan Jiang, Connie J Eaves, Dixie L Mager and Arefeh Rouhi
    Citation: Molecular Cancer 2010 9:41
    Content type: Research Published on:

  47. The BMI1 oncogene is overexpressed in several human malignancies including gastric cancer. In addition to BMI1, mammalian cells also express Mel-18, which is closely related to BMI1. We have reported that Mel-18 ...

    Authors: Xiao-Wei Zhang, Ya-Ping Sheng, Qian Li, Wei Qin, You-Wei Lu, Yu-Fan Cheng, Bing-Ya Liu, Feng-Chun Zhang, Jin Li, Goberdhan P Dimri and Wei-Jian Guo
    Citation: Molecular Cancer 2010 9:40
    Content type: Research Published on:

  48. An increasing number of studies support the presence of stem-like cells in human malignancies. These cells are primarily responsible for tumor initiation and thus considered as a potential target to eradicate ...

    Authors: Kouichi Tabu, Taichi Kimura, Ken Sasai, Lei Wang, Norihisa Bizen, Hiroshi Nishihara, Tetsuya Taga and Shinya Tanaka
    Citation: Molecular Cancer 2010 9:39
    Content type: Research Published on:

  49. The cyclin-dependent kinase (CDK) and mitogen-activated protein kinase (MAPK) mediated phosphorylation of glucocorticoid receptor (GR) exerts opposite effects on GR transcriptional activity and affects other p...

    Authors: James T Lynch, Ramkumar Rajendran, Georgia Xenaki, Ilhem Berrou, Constantinos Demonacos and Marija Krstic-Demonacos
    Citation: Molecular Cancer 2010 9:38
    Content type: Research Published on:
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Molecular Cancer

ISSN: 1476-4598