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  1. Very few proteins encoded by the presumed non-coding RNA transcripts have been identified. Their cellular functions remain largely unknown. This study identifies the tumor-suppressor function of a novel microp...

    Authors: Min Kang, Bo Tang, Jixi Li, Ziyan Zhou, Kang Liu, Rensheng Wang, Ziyan Jiang, Fangfang Bi, David Patrick, Dongin Kim, Anirban K. Mitra and Yang Yang-Hartwich

    Citation: Molecular Cancer 2020 19:143

    Content type: Research

    Published on:

  2. Triple negative breast cancer (TNBC) remains the most challenging breast cancer subtype so far. Specific therapeutic approaches have rarely achieved clinical improvements in treatment of TNBC patients and effe...

    Authors: Jie Li, Maoguang Ma, Xuesong Yang, Maolei Zhang, Jingyan Luo, Huangkai Zhou, Nunu Huang, Feizhe Xiao, Bingquan Lai, Weiming Lv and Nu Zhang

    Citation: Molecular Cancer 2020 19:142

    Content type: Research

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  3. Immunotherapy (IO) has revolutionized the therapy landscape of non-small cell lung cancer (NSCLC), significantly prolonging the overall survival (OS) of advanced stage patients. Over the recent years IO therap...

    Authors: Lena Horvath, Bernard Thienpont, Liyun Zhao, Dominik Wolf and Andreas Pircher

    Citation: Molecular Cancer 2020 19:141

    Content type: Review

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  4. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Dawei Rong, Chen Lu, Betty Zhang, Kai Fu, Shuli Zhao, Weiwei Tang and Hongyong Cao

    Citation: Molecular Cancer 2020 19:140

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:25

  5. Human T cell leukemia virus type 1 (HTLV-1)-associated adult T cell leukemia (ATL) has a very poor prognosis with a median survival of 8 months and a 4-year overall survival of 11% for acute ATL. Present treat...

    Authors: Chien-Hung Yeh, Marcia Bellon, Fang Wang, Hong Zhang, Liwu Fu and Christophe Nicot

    Citation: Molecular Cancer 2020 19:139

    Content type: Research

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  6. Inactivation of the tumor suppressor p53 is critical for pathogenesis of glioma, in particular glioblastoma multiforme (GBM). MDM2, the main negative regulator of p53, binds to and forms a stable complex with ...

    Authors: Jiacheng Lou, Yuchao Hao, Kefeng Lin, Yizhu Lyu, Meiwei Chen, Han Wang, Deyu Zou, Xuewen Jiang, Renchun Wang, Di Jin, Eric W.-F. Lam, Shujuan Shao, Quentin Liu, Jinsong Yan, Xiang Wang, Puxiang Chen…

    Citation: Molecular Cancer 2020 19:138

    Content type: Research

    Published on:

  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jiajie Hou, He Zhang, Jun Liu, Zhenjun Zhao, Jianye Wang, Zhike Lu, Bian Hu, Jiankui Zhou, Zhicong Zhao, Mingxuan Feng, Haiyan Zhang, Bin Shen, Xingxu Huang, Beicheng Sun, Mark J. Smyth, Chuan He…

    Citation: Molecular Cancer 2020 19:137

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:163

  8. The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor immunity by generating type I interferons. In recent decades, we have witnessed that producing dsDNA upon various stimuli...

    Authors: Yang Wang, Jingwen Luo, Aqu Alu, Xuejiao Han, Yuquan Wei and Xiawei Wei

    Citation: Molecular Cancer 2020 19:136

    Content type: Review

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  9. Cisplatin is a first-line drug for the treatment of human non-small cell lung cancer (NSCLC); however, the majority of patients will develop drug resistance after treatment. In order to overcome cisplatin resi...

    Authors: Wenjing Wang, Mengyue Zhao, Lijuan Cui, Yong Ren, Jingyuan Zhang, Junli Chen, Lina Jia, Jiayu Zhang, Jingyu Yang, Guoliang Chen, Charles R. Ashby Jr, Chunfu Wu, Zhe-Sheng Chen and Lihui Wang

    Citation: Molecular Cancer 2020 19:134

    Content type: Research

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  10. Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its downstream effector, stimulator of int...

    Authors: Juyan Zheng, Junluan Mo, Tao Zhu, Wei Zhuo, Yueneng Yi, Shuo Hu, Jiye Yin, Wei Zhang, Honghao Zhou and Zhaoqian Liu

    Citation: Molecular Cancer 2020 19:133

    Content type: Review

    Published on:

  11. At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracell...

    Authors: Abakundana Nsenga Ariston Gabriel, Fang Wang, Qinlian Jiao, Umwali Yvette, Xuemei Yang, Samed Ahmed Al-Ameri, Lutao Du, Yun-shan Wang and Chuanxin Wang

    Citation: Molecular Cancer 2020 19:132

    Content type: Review

    Published on:

  12. Controlling metastasis is essential for improving the prognosis of patients with gastric cancer (GC). Here, we aimed to identify a molecule required for GC metastasis and to investigate its potential utility a...

    Authors: Mitsuro Kanda, Dai Shimizu, Koichi Sawaki, Shunsuke Nakamura, Shinichi Umeda, Takashi Miwa, Haruyoshi Tanaka, Chie Tanaka, Masamichi Hayashi, Yohei Iguchi, Suguru Yamada, Masahisa Katsuno and Yasuhiro Kodera

    Citation: Molecular Cancer 2020 19:131

    Content type: Research

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  13. Pancreatic cancer is one of the most lethal human cancers. N6-methyladenosine (m6A), a common eukaryotic mRNA modification, plays critical roles in both physiological and pathological processes. However, its role...

    Authors: Min Wang, Jun Liu, Yan Zhao, Ruizhi He, Xiaodong Xu, Xingjun Guo, Xu Li, Simiao Xu, Ji Miao, Jianpin Guo, Hang Zhang, Jun Gong, Feng Zhu, Rui Tian, Chengjian Shi, Feng Peng…

    Citation: Molecular Cancer 2020 19:130

    Content type: Research

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  14. Heat shock transcription factor1 (HSF1) was overexpressed to promote glutaminolysis and activate mTOR in colorectal cancer (CRC). Here, we investigated the mechanism for cancer-specific overexpression of HSF1.

    Authors: Ping Song, Lifeng Feng, Jiaqiu Li, Dongjun Dai, Liyuan Zhu, Chaoqun Wang, Jingyi Li, Ling Li, Qiyin Zhou, Rongkai Shi, Xian Wang and Hongchuan Jin

    Citation: Molecular Cancer 2020 19:129

    Content type: Research

    Published on:

  15. Deregulated circular RNAs (circRNAs) are associated with the development of cancer and therapy resistance. However, functional research of circRNAs mostly focus on potential miRNA or protein binding and more p...

    Authors: Xiaolong Xu, Jingwei Zhang, Yihao Tian, Yang Gao, Xin Dong, Wenbo Chen, Xiaoning Yuan, Weinan Yin, Jinjing Xu, Ke Chen, Chunjiang He and Lei Wei

    Citation: Molecular Cancer 2020 19:128

    Content type: Research

    Published on:

  16. CircRNAs are a novel class of RNA molecules with a unique closed continuous loop structure. CircRNAs are abundant in eukaryotic cells, have unique stability and tissue specificity, and can play a biological re...

    Authors: Tianwei Xu, Mengwei Wang, Lihua Jiang, Li Ma, Li Wan, Qinnan Chen, Chenchen Wei and Zhaoxia Wang

    Citation: Molecular Cancer 2020 19:127

    Content type: Review

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  17. This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1186/s12943-015-0389-y

    Authors: Paola Bendinelli, Paola Maroni, Emanuela Matteucci and Maria Alfonsina Desiderio

    Citation: Molecular Cancer 2020 19:126

    Content type: Retraction Note

    Published on:

    The original article was published in Molecular Cancer 2015 14:112

  18. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jing Zhang, Lidan Hou, Rui Liang, Xiaoyu Chen, Rui Zhang, Wei Chen and Jinshui Zhu

    Citation: Molecular Cancer 2020 19:125

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:80

  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Hongwei Liu, Junming Bi, Wei Dong, Meihua Yang, Juanyi Shi, Ning Jiang, Tianxin Lin and Jian Huang

    Citation: Molecular Cancer 2020 19:124

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2018 17:161

  20. N6-methyladenosine (m6A) modification is an emerging layer of epigenetic regulation which is widely implicated in the tumorigenicity of hepatocellular carcinoma (HCC), offering a novel perspective for investigati...

    Authors: Yunhao Chen, Yanchun Zhao, Junru Chen, Chuanhui Peng, Yanpeng Zhang, Rongliang Tong, Qiyang Cheng, Beng Yang, Xiaode Feng, Yuejie Lu, Haiyang Xie, Lin Zhou, Jian Wu and Shusen Zheng

    Citation: Molecular Cancer 2020 19:123

    Content type: Research

    Published on:

  21. Super-enhancers (SEs) play a crucial role in cancer, which is often associate with activated oncogenes. However, little is known about how SEs facilitate tumour suppression. Individuals with Down syndrome exhi...

    Authors: Rong Deng, Jun-Hao Huang, Yan Wang, Li-Huan Zhou, Zi-Feng Wang, Bing-Xin Hu, Yu-Hong Chen, Dong Yang, Jia Mai, Zhi-Ling Li, Hai-Liang Zhang, Yun Huang, Xiao-Dan Peng, Gong-Kan Feng, Xiao-Feng Zhu and Jun Tang

    Citation: Molecular Cancer 2020 19:122

    Content type: Research

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  22. The tumor microenvironment is highly complex, and immune escape is currently considered an important hallmark of cancer, largely contributing to tumor progression and metastasis. Named for their capability of ...

    Authors: Song-Yang Wu, Tong Fu, Yi-Zhou Jiang and Zhi-Ming Shao

    Citation: Molecular Cancer 2020 19:120

    Content type: Review

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  23. Pancreatic cancer is one of the most lethal malignancies and has an extremely poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major challenge. The long noncoding RNA PVT1 ...

    Authors: Cefan Zhou, Changhua Yi, Yongxiang Yi, Wenying Qin, Yanan Yan, Xueying Dong, Xuewen Zhang, Yuan Huang, Rui Zhang, Jie Wei, Declan William Ali, Marek Michalak, Xing-Zhen Chen and Jingfeng Tang

    Citation: Molecular Cancer 2020 19:118

    Content type: Research

    Published on:

  24. Colorectal cancer (CRC) is the leading cause of cancer-related death worldwide. Exosome shave emerged as crucial regulators of intercellular communication and that abundant Circular RNAs (circRNAs) are enriche...

    Authors: Anquan Shang, Chenzheng Gu, Weiwei Wang, Xuan Wang, Junjun Sun, Bingjie Zeng, Chen Chen, Wenjing Chang, Yili Ping, Ping Ji, Junlu Wu, Wenqiang Quan, Yiwen Yao, Yongxin Zhou, Zujun Sun and Dong Li

    Citation: Molecular Cancer 2020 19:117

    Content type: Research

    Published on:

  25. Regulatory T cells (Tregs) characterized by the expression of the master transcription factor forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective immunosurveillance of tu...

    Authors: Chunxiao Li, Ping Jiang, Shuhua Wei, Xiaofei Xu and Junjie Wang

    Citation: Molecular Cancer 2020 19:116

    Content type: Review

    Published on:

  26. Long non-coding RNAs (lncRNAs) have been identified as important epigenetic regulators that play critical roles in human cancers. However, the regulatory functions of lncRNAs in tumorigenesis remains to be elu...

    Authors: Xiaoyu He, Peiwei Chai, Fang Li, Leilei Zhang, Chuandi Zhou, Xiaoling Yuan, Yongyun Li, Jie Yang, Yingxiu Luo, Shengfang Ge, He Zhang, Renbing Jia and Xianqun Fan

    Citation: Molecular Cancer 2020 19:115

    Content type: Research

    Published on:

  27. BATF2, also known as SARI, has been implicated in tumor progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive.

    Authors: Jian-Wei Xie, Xiao-Bo Huang, Qi-Yue Chen, Yu-Bin Ma, Ya-Jun Zhao, Li-Chao Liu, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Chang-Ming Huang and Ping Li

    Citation: Molecular Cancer 2020 19:114

    Content type: Research

    Published on:

  28. Circular RNAs (circRNAs) play important regulatory roles in the development of various cancers. However, biological functions and the underlying molecular mechanism of circRNAs in gastric cancer (GC) remain ob...

    Authors: Mengyan Xie, Tao Yu, Xinming Jing, Ling Ma, Yu Fan, Fengming Yang, Pei Ma, Huning Jiang, Xi Wu, Yongqian Shu and Tongpeng Xu

    Citation: Molecular Cancer 2020 19:112

    Content type: Research

    Published on:

  29. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Wei-Luo Cai, Wen-Ding Huang, Bo Li, Tian-Rui Chen, Zhen-Xi Li, Cheng-Long Zhao, Heng-Yu Li, Yan-Mei Wu, Wang-Jun Yan and Jian-Ru Xiao

    Citation: Molecular Cancer 2020 19:111

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2018 17:9

  30. Natural killer (NK) cells play a critical role in the innate antitumor immune response. Recently, NK cell dysfunction has been verified in various malignant tumors, including hepatocellular carcinoma (HCC). Ho...

    Authors: Peng-Fei Zhang, Chao Gao, Xiao-Yong Huang, Jia-Cheng Lu, Xiao-Jun Guo, Guo-Ming Shi, Jia-Bin Cai and Ai-Wu Ke

    Citation: Molecular Cancer 2020 19:110

    Content type: Research

    Published on:

  31. We previously reported an inverse relationship between B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) and Raf kinase inhibitory protein (RKIP), which is associated with the prognosis ...

    Authors: Yaqing Li, Zhenfeng Tian, Ying Tan, Guoda Lian, Shangxiang Chen, Shaojie Chen, Jiajia Li, Xuanna Li, Kaihong Huang and Yinting Chen

    Citation: Molecular Cancer 2020 19:109

    Content type: Research

    Published on:

  32. Emerging evidence has revealed significant roles for small nucleolar RNAs (snoRNAs) in tumorigenesis. However, the genetic and pharmacogenomic landscape of snoRNAs has not been characterized. Using the genotyp...

    Authors: Yaoming Liu, Hang Ruan, Shengli Li, Youqiong Ye, Wei Hong, Jing Gong, Zhao Zhang, Ying Jing, Xiulan Zhang, Lixia Diao and Leng Han

    Citation: Molecular Cancer 2020 19:108

    Content type: Letter to the Editor

    Published on:

  33. Colorectal cancer (CRC) is one of the leading causes of tumor-related death worldwide, and its main cause of death is distant metastasis. Methyltransferase-like 14(METTL14), a major RNA N6-adenosine methyltran...

    Authors: Xiaoxiang Chen, Mu Xu, Xueni Xu, Kaixuan Zeng, Xiangxiang Liu, Bei Pan, Chenmeng Li, Li Sun, Jian Qin, Tao Xu, Bangshun He, Yuqin Pan, Huilin Sun and Shukui Wang

    Citation: Molecular Cancer 2020 19:106

    Content type: Research

    Published on:

  34. N6-methyladenosine (m6A), the most abundant modification in eukaryotic cells, regulates RNA transcription, processing, splicing, degradation, and translation. Circular RNA (circRNA) is a class of covalently close...

    Authors: Lele Zhang, Chaofeng Hou, Chen Chen, Yaxin Guo, Weitang Yuan, Detao Yin, Jinbo Liu and Zhenqiang Sun

    Citation: Molecular Cancer 2020 19:105

    Content type: Review

    Published on:

  35. Since the breakthrough discoveries of DNA and histone modifications, the field of RNA modifications has gained increasing interest in the scientific community. The discovery of N6-methyladenosine (m6A), a pred...

    Authors: Zijian Zhou, Jiancheng Lv, Hao Yu, Jie Han, Xiao Yang, Dexiang Feng, Qikai Wu, Baorui Yuan, Qiang Lu and Haiwei Yang

    Citation: Molecular Cancer 2020 19:104

    Content type: Review

    Published on:

  36. Circular RNAs (circRNAs), a novel type of noncoding RNA (ncRNA), are covalently linked circular configurations that form via a loop structure. Accumulating evidence indicates that circRNAs are potential biomar...

    Authors: Jianfa Li, Chenchen Huang, Yifan Zou, Jing Ye, Jing Yu and Yaoting Gui

    Citation: Molecular Cancer 2020 19:103

    Content type: Research

    Published on:

  37. Extracellular vesicles (EVs), a class of heterogeneous membrane vesicles, are generally divided into exosomes and microvesicles on basis of their origination from the endosomal membrane or the plasma membrane,...

    Authors: Wei Hu, Cong Liu, Zhuo-Yue Bi, Qun Zhou, Han Zhang, Lin-Lin Li, Jian Zhang, Wei Zhu, Yang-Yi-Yan Song, Feng Zhang, Hui-Min Yang, Yong-Yi Bi, Qi-Qiang He, Gong-Jun Tan, Cheng-Cao Sun and De-Jia Li

    Citation: Molecular Cancer 2020 19:102

    Content type: Review

    Published on:

  38. Lung cancer has high morbidity and mortality worldwide with non-small cell lung cancer (NSCLC) accounting for 85% of the cases. Therapies for lung cancer have relatively poor outcomes and further improvements ...

    Authors: Nan Zhang, Aruo Nan, Lijian Chen, Xin Li, Yangyang Jia, Miaoyun Qiu, Xin Dai, Hanyu Zhou, Jialu Zhu, Han Zhang and Yiguo Jiang

    Citation: Molecular Cancer 2020 19:101

    Content type: Research

    Published on:

  39. Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor of the head and neck. LSCC patients have seriously impaired vocal, respiratory, and swallowing functions with poor prognosis. Circular RNA (...

    Authors: Yongyan Wu, Yuliang Zhang, Xiwang Zheng, Fengsheng Dai, Yan Lu, Li Dai, Min Niu, Huina Guo, Wenqi Li, Xuting Xue, Yunfeng Bo, Yujia Guo, Jiangbo Qin, Yixiao Qin, Hongliang Liu, Yu Zhang…

    Citation: Molecular Cancer 2020 19:99

    Content type: Research

    Published on:

  40. Anti-angiogenic therapy represents a promising strategy for non-small-cell lung cancer (NSCLC) but its application in lung squamous cell carcinoma (SQC) is limited due to the high-risk adverse effects. Accumul...

    Authors: Jiarong Chen, Aibin Liu, Zhihui Wang, Bin Wang, Xingxing Chai, Wenjie Lu, Ting Cao, Ronggang Li, Minyan Wu, Zhuming Lu, Wenguang Pang, Lin Xiao, Xiangmeng Chen, Yan Zheng, Qiong Chen, Jincheng Zeng…

    Citation: Molecular Cancer 2020 19:98

    Content type: Research

    Published on:

  41. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xianfan Ding, Dong-Rong Yang, Liqun Xia, Bide Chen, Shicheng Yu, Yuanjie Niu, Mingchao Wang, Gonghui Li and Chawnshang Chang

    Citation: Molecular Cancer 2020 19:97

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2015 14:16

  42. Gastric cancer is a deadly disease and remains the third leading cause of cancer-related death worldwide. The 5-year overall survival rate of patients with early-stage localized gastric cancer is more than 60%...

    Authors: Li Yuan, Zhi-Yuan Xu, Shan-Ming Ruan, Shaowei Mo, Jiang-Jiang Qin and Xiang-Dong Cheng

    Citation: Molecular Cancer 2020 19:96

    Content type: Review

    Published on:

  43. Increasing evidence supports the role of small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs) as master gene regulators at the epigenetic modification level. However, the underlying mechanism of t...

    Authors: Huizhe Wu, Wenyan Qin, Senxu Lu, Xiufang Wang, Jing Zhang, Tong Sun, Xiaoyun Hu, Yalun Li, Qiuchen Chen, Yuanhe Wang, Haishan Zhao, Haiyan Piao, Rui Zhang and Minjie Wei

    Citation: Molecular Cancer 2020 19:95

    Content type: Research

    Published on:

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