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  1. Dynamic N6-methyladenosine (m6A) RNA modification generated and erased by N6-methyltransferases and demethylases regulates gene expression, alternative splicing and cell fate. Ocular melanoma, comprising uveal me...

    Authors: Ruobing Jia, Peiwei Chai, Shanzheng Wang, Baofa Sun, Yangfan Xu, Ying Yang, Shengfang Ge, Renbing Jia, Yun-Gui Yang and Xianqun Fan
    Citation: Molecular Cancer 2019 18:161
    Content type: Research Published on:

  2. Uveal melanoma (UM) is the most common primary intraocular tumor. Hepatic metastasis is the major and direct death-related reason in UM patients. Given that cancer stem-like cells (CSCs) are roots of metastasi...

    Authors: Jingfeng Zhou, Shenglan Liu, Yun Wang, Wei Dai, Hailin Zou, Shubo Wang, Jing Zhang and Jingxuan Pan
    Citation: Molecular Cancer 2019 18:159
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2021 20:47

  3. Circular RNAs (circRNAs), a subclass of non-coding RNAs, play essential roles in tumorigenesis and aggressiveness. Our previous study has identified that circAGO2 drives gastric cancer progression through activat...

    Authors: Feng Yang, Anpei Hu, Dan Li, Jianqun Wang, Yanhua Guo, Yang Liu, Hongjun Li, Yajun Chen, Xiaojing Wang, Kai Huang, Liduan Zheng and Qiangsong Tong
    Citation: Molecular Cancer 2019 18:158
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2023 22:155

  4. Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy ...

    Authors: Xinming Jing, Fengming Yang, Chuchu Shao, Ke Wei, Mengyan Xie, Hua Shen and Yongqian Shu
    Citation: Molecular Cancer 2019 18:157
    Content type: Review Published on:

  5. Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable proo...

    Authors: Qiushi Lin, Xuesong Chen, Fanzheng Meng, Kosuke Ogawa, Min Li, Ruipeng Song, Shugeng Zhang, Ziran Zhang, Xianglu Kong, Qinggang Xu, Fuliang He, Xuewei Bai, Bei Sun, Mien-Chie Hung, Lianxin Liu, Jack Wands…
    Citation: Molecular Cancer 2019 18:156
    Content type: Research Published on:

  6. The emergence of immune checkpoint inhibitors (ICIs), mainly including anti-programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) and anti-cytotoxic T lymphocyte-associated antigen-4 (CTL...

    Authors: Shuang Qin, Linping Xu, Ming Yi, Shengnan Yu, Kongming Wu and Suxia Luo
    Citation: Molecular Cancer 2019 18:155
    Content type: Review Published on:

  7. Proteasome inhibitors, immunomodulatory agents and monoclonal antibodies have dramatically changed the natural history of multiple myeloma (MM). However, most patients eventually suffer a relapse and succumb t...

    Authors: Quande Lin, Juanjuan Zhao, Yongping Song and Delong Liu
    Citation: Molecular Cancer 2019 18:154
    Content type: Review Published on:

  8. Molecular targeted therapy for cancer has been a research hotspot for decades. AXL is a member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 (GAS6). The Gas6/AXL signalling p...

    Authors: Chenjing Zhu, Yuquan Wei and Xiawei Wei
    Citation: Molecular Cancer 2019 18:153
    Content type: Review Published on:

  9. The aberrant appearance of DNA in the cytoplasm triggers the activation of cGAS-cGAMP-STING signaling and induces the production of type I interferons, which play critical roles in activating both innate and a...

    Authors: Yuanyuan Zhu, Xiang An, Xiao Zhang, Yu Qiao, Tongsen Zheng and Xiaobo Li
    Citation: Molecular Cancer 2019 18:152
    Content type: Review Published on:

  10. Circular RNA (circRNA) is a type of circular endogenous RNA produced by special selective splicing and participates in progression of diverse diseases. However, the role of circRNA in clear cell renal cell car...

    Authors: Dingwei Xue, Huan Wang, Yuanlei Chen, Danyang Shen, Jieyang Lu, Mingchao Wang, Abudureheman Zebibula, Liwei Xu, Haiyang Wu, Gonghui Li and Liqun Xia
    Citation: Molecular Cancer 2019 18:151
    Content type: Research Published on:

  11. CircMYO10 is a circular RNA generated by back-splicing of gene MYO10 and is upregulated in osteosarcoma cell lines, but its functional role in osteosarcoma is still unknown. This study aimed to clarify the mec...

    Authors: Junxin Chen, Gang Liu, Yizheng Wu, Jianjun Ma, Hongfei Wu, Ziang Xie, Shuai Chen, Yute Yang, Shengyu Wang, Panyang Shen, Yifan Fang, Shunwu Fan, Shuying Shen and Xiangqian Fang
    Citation: Molecular Cancer 2019 18:150
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:75

  12. In the published article [1], an error was noticed in Fig. 6B. The western blot results were reversed between the overexpression group and the knockdown group of circ-AKT3. The corrected and updated Fig. 6 is ...

    Authors: Xin Xia, Xixi Li, Fanying Li, Xujia Wu, Maolei Zhang, Huangkai Zhou, Nunu Huang, Xuesong Yang, Feizhe Xiao, Dawei Liu, Lixuan Yang and Nu Zhang
    Citation: Molecular Cancer 2019 18:149
    Content type: Correction Published on:

    The original article was published in Molecular Cancer 2019 18:131

  13. As an important means of communication, exosomes play an important role in the development of hepatocellular carcinoma (HCC).

    Authors: Liang-qi Cao, Xue-wei Yang, Yu-bin Chen, Da-wei Zhang, Xiao-Feng Jiang and Ping Xue
    Citation: Molecular Cancer 2019 18:148
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:59

  14. Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the second most lethal human cancer. A portion of patients with advanced HCC can significantly benefit from treatments with sora...

    Authors: Ling Wei, Xingwu Wang, Liyan Lv, Jibing Liu, Huaixin Xing, Yemei Song, Mengyu Xie, Tianshui Lei, Nasha Zhang and Ming Yang
    Citation: Molecular Cancer 2019 18:147
    Content type: Review Published on:

  15. Programmed death ligand 1 (PD-L1), a type I transmembrane protein, binds to its receptor PD-1 to suppress the activation of T cells, thereby maintaining immunological homeostasis. In contrast, tumor cells high...

    Authors: Feiting Xie, Mengxue Xu, Jian Lu, Lingxiang Mao and Shengjun Wang
    Citation: Molecular Cancer 2019 18:146
    Content type: Review Published on:

  16. Circular RNAs (circRNAs) have recently been identified as potential functional modulators of the cellular physiology processes. The study aims to uncover the potential clinical value and driving molecular mech...

    Authors: Shouhua Wang, Yongjie Zhang, Qiang Cai, Mingzhe Ma, Long Yang Jin, Mingzhe Weng, Di Zhou, Zhaohui Tang, Jian Dong Wang and Zhiwei Quan
    Citation: Molecular Cancer 2019 18:145
    Content type: Research Published on:

  17. Emerging evidence has shown that circular RNAs (circRNAs) play essential roles in cancer biology and are potential biomarkers and targets for cancer therapy. However, the expression and function of circRNAs in...

    Authors: Lei Zhang, Qing Zhou, Qiongzi Qiu, Ling Hou, Mengting Wu, Jia Li, Xufan Li, Bingjian Lu, Xiaodong Cheng, Pengyuan Liu, Weiguo Lu and Yan Lu
    Citation: Molecular Cancer 2019 18:144
    Content type: Research Published on:

  18. YAP activation is crucial for cancer development including colorectal cancer (CRC). Nevertheless, it remains unclear whether N6-Methyladenosine (m6A) modified transcripts of long noncoding RNAs (lncRNAs) can regu...

    Authors: Wen Ni, Su Yao, Yunxia Zhou, Yuanyuan Liu, Piao Huang, Aijun Zhou, Jingwen Liu, Liheng Che and Jianming Li
    Citation: Molecular Cancer 2019 18:143
    Content type: Research Published on:

  19. As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing, and translation. Recently, the regulatory rol...

    Authors: Ben Yue, Chenlong Song, Linxi Yang, Ran Cui, Xingwang Cheng, Zizhen Zhang and Gang Zhao
    Citation: Molecular Cancer 2019 18:142
    Content type: Research Published on:

  20. PVT1 has emerged as an oncogene in many tumor types. However, its role in Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) is unknown. The aim of this study was to assess the role of PVT1 in BE/EAC...

    Authors: Yan Xu, Yuan Li, Jiankang Jin, Guangchun Han, Chengcao Sun, Melissa Pool Pizzi, Longfei Huo, Ailing Scott, Ying Wang, Lang Ma, Jeffrey H. Lee, Manoop S. Bhutani, Brian Weston, Christopher Vellano, Liuqing Yang, Chunru Lin…
    Citation: Molecular Cancer 2019 18:141
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2021 20:56

  21. Life of patients with uveal melanoma (UM) is largely threatened by liver metastasis. Little is known about the drivers of liver organotropic metastasis in UM. The elevated activity of transcription of oncogene...

    Authors: Jing Zhang, Shenglan Liu, Qianyun Ye and Jingxuan Pan
    Citation: Molecular Cancer 2019 18:140
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2021 20:135

  22. Immunotherapy has been incorporated into the first- and second-line treatment strategies for non-small cell lung cancer (NSCLC), profoundly ushering in a new treatment landscape. However, both adaptive signali...

    Authors: Anqi Lin, Ting Wei, Hui Meng, Peng Luo and Jian Zhang
    Citation: Molecular Cancer 2019 18:139
    Content type: Review Published on:

  23. Cancer has become a major health issue worldwide, contributing to a high mortality rate. Tumor metastasis is attributed to the death of most patients. Epithelial-to-mesenchymal transition (EMT) plays a vital r...

    Authors: Bing-Qing Shang, Min-Le Li, Hao-yu Quan, Ping-Fu Hou, Zhong-Wei Li, Su-Fang Chu, Jun-Nian Zheng and Jin Bai
    Citation: Molecular Cancer 2019 18:138
    Content type: Review Published on:

  24. The methylation of N6 adenosine (m6A) plays a critical role in diverse biological processes. However, knowledge regarding the reconstitution of m6A across cancer types is still lacking. Here, we systematically an...

    Authors: Yongsheng Li, Jun Xiao, Jing Bai, Yi Tian, Yinwei Qu, Xiang Chen, Qi Wang, Xinhui Li, Yunpeng Zhang and Juan Xu
    Citation: Molecular Cancer 2019 18:137
    Content type: Letter to the Editor Published on:

  26. Emerging studies suggest that long non-coding RNAs (lncRNAs) play crucial roles in colorectal cancer (CRC). Here, we report a lncRNA, SATB2-AS1, which is specifically expressed in colorectal tissue and is sign...

    Authors: Mu Xu, Xueni Xu, Bei Pan, Xiaoxiang Chen, Kang Lin, Kaixuan Zeng, Xiangxiang Liu, Tao Xu, Li Sun, Jian Qin, Bangshun He, Yuqin Pan, Huiling Sun and Shukui Wang
    Citation: Molecular Cancer 2019 18:135
    Content type: Research Published on:

  27. Emerging evidences demonstrate that circular RNAs (circRNAs) are abnormally expressed in tumors and could serve as prognostic markers for cancers. However, the expression patterns and clinical implications of ...

    Authors: Chengdi Wang, Shuangyan Tan, Wen-Rong Liu, Qian Lei, Wenliang Qiao, Yangping Wu, Xiaoqi Liu, Wei Cheng, Yu-Quan Wei, Yong Peng and Weimin Li
    Citation: Molecular Cancer 2019 18:134
    Content type: Letter to the Editor Published on:

  28. Circular RNAs (circRNAs) represent a subclass of regulatory RNAs that have been shown to have significant regulatory roles in cancer progression. However, the biological functions of circRNAs in bladder cancer...

    Authors: Junming Bi, Hongwei Liu, Wei Dong, Weibin Xie, Qingqing He, Zijian Cai, Jian Huang and Tianxin Lin
    Citation: Molecular Cancer 2019 18:133
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:148

  29. Surgical resection is an important avenue for cancer treatment, which, in most cases, can effectively alleviate the patient symptoms. However, accumulating evidence has documented that surgical resection poten...

    Authors: Zhiwei Chen, Peidong Zhang, Ya Xu, Jiahui Yan, Zixuan Liu, Wayne Bond Lau, Bonnie Lau, Ying Li, Xia Zhao, Yuquan Wei and Shengtao Zhou
    Citation: Molecular Cancer 2019 18:132
    Content type: Review Published on:

  30. The RTK/PI3K/AKT pathway plays key roles in the development and progression of many cancers, including GBM. As a regulatory molecule and a potential drug target, the oncogenic role of AKT has been substantiall...

    Authors: Xin Xia, Xixi Li, Fanying Li, Xujia Wu, Maolei Zhang, Huangkai Zhou, Nunu Huang, Xuesong Yang, Feizhe Xiao, Dawei Liu, Lixuan Yang and Nu Zhang
    Citation: Molecular Cancer 2019 18:131
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2022 21:124

    The Correction to this article has been published in Molecular Cancer 2019 18:149

  31. Incidence of hepatocellular carcinoma (HCC) is on the rise due to the prevalence of chronic hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues the mortality rate of HCC rem...

    Authors: Chen Lu, Dawei Rong, Betty Zhang, Wubin Zheng, Xuehao Wang, Ziyi Chen and Weiwei Tang
    Citation: Molecular Cancer 2019 18:130
    Content type: Review Published on:

  32. Following publication of the original article [1], authors reported Pro. Gang Zhao has to be considered as another corresponding author, according to his important contribution.

    Authors: Chao-Jie Wang, Chun-Chao Zhu, Jia Xu, Ming Wang, Wen-Yi Zhao, Qiang Liu, Gang Zhao and Zi-Zhen Zhang
    Citation: Molecular Cancer 2019 18:129
    Content type: Correction Published on:

    The original article was published in Molecular Cancer 2019 18:115

  33. Genetic instability of tumor cells often leads to the occurrence of a large number of mutations, and expression of non-synonymous mutations can produce tumor-specific antigens called neoantigens. Neoantigens a...

    Authors: Miao Peng, Yongzhen Mo, Yian Wang, Pan Wu, Yijie Zhang, Fang Xiong, Can Guo, Xu Wu, Yong Li, Xiaoling Li, Guiyuan Li, Wei Xiong and Zhaoyang Zeng
    Citation: Molecular Cancer 2019 18:128
    Content type: Review Published on:

  34. N6-methyladenosine (m6A) methylation, a well-known modification with new epigenetic functions, has been reported to participate in the tumorigenesis of hepatocellular carcinoma (HCC), providing novel insights ...

    Authors: Yunhao Chen, Chuanhui Peng, Junru Chen, Diyu Chen, Beng Yang, Bin He, Wendi Hu, Yanpeng Zhang, Hua Liu, Longfei Dai, Haiyang Xie, Lin Zhou, Jian Wu and Shusen Zheng
    Citation: Molecular Cancer 2019 18:127
    Content type: Research Published on:

  35. Mounting evidences indicate that circular RNAs (circRNAs) play vital roles in the development and progression of various cancers. However, the detail functions and underlying mechanisms of circRNAs in gastric ...

    Authors: Zhonglin Zhu, Zeyin Rong, Zai Luo, Zhilong Yu, Jing Zhang, Zhengjun Qiu and Chen Huang
    Citation: Molecular Cancer 2019 18:126
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:67

  37. Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic gro...

    Authors: Wenlong Feng, Dylan C. Dean, Francis J. Hornicek, Huirong Shi and Zhenfeng Duan
    Citation: Molecular Cancer 2019 18:124
    Content type: Review Published on:

  38. Piwi interacting RNAs (piRNAs) constitute novel small non-coding RNA molecules of approximately 24–31 nucleotides in length that often bind to members of the piwi protein family to play regulatory roles. Recen...

    Authors: Yongmei Liu, Mei Dou, Xuxia Song, Yanhan Dong, Si Liu, Haoran Liu, Jiaping Tao, Wenjing Li, Xunhua Yin and Wenhua Xu
    Citation: Molecular Cancer 2019 18:123
    Content type: Review Published on:

  39. After publication of the article [1], the author reported that this article contained some errors.

    Authors: Zhuo-yuan Lin, Guo Chen, Yan-qiong Zhang, Hui-chan He, Yu-xiang Liang, Jian-heng Ye, Ying-ke Liang, Ru-jun Mo, Jian-ming Lu, Yang-jia Zhuo, Yu Zheng, Fu-neng Jiang, Zhao-dong Han, Shu-lin Wu, Wei-de Zhong and Chin-Lee Wu
    Citation: Molecular Cancer 2019 18:122
    Content type: Correction Published on:

    The original article was published in Molecular Cancer 2017 16:48

  40. After publication of the article [1], the author reported that this article contained error. In Funding section, the funding number provided 2016YFC0105100 should have been 2016YFC0105106.

    Authors: Liyuan Fan, Qiang Cao, Jia Liu, Junpeng Zhang and Baosheng Li
    Citation: Molecular Cancer 2019 18:121
    Content type: Correction Published on:

    The original article was published in Molecular Cancer 2019 18:16

  41. Bone metastasis (BM) has long been recognized as a major threat to the quality of life of hepatocellular cancer (HCC) patients. While LncRNA34a (Lnc34a) has been shown to regulate colon cancer stem cell asymme...

    Authors: Li Zhang, Hao Niu, Jie Ma, Bao-Ying Yuan, Yu-Han Chen, Yuan Zhuang, Gen-Wen Chen, Zhao-Chong Zeng and Zuo-Lin Xiang
    Citation: Molecular Cancer 2019 18:120
    Content type: Research Published on:

  42. Increasing evidence has revealed a close relationship between non-coding RNAs and cancer progression. Circular RNAs (circRNAs), a recently identified new member of non-coding RNAs, are demonstrated to particip...

    Authors: Liyan Wang, Haiyan Long, Qinghua Zheng, Xiaotong Bo, Xuhua Xiao and Bin Li
    Citation: Molecular Cancer 2019 18:119
    Content type: Research Published on:

  43. The Editor-in-Chief has retracted this article [1] because Figure 6b overlaps with Figure 8 of [2] and Figure 4a overlaps with Figure 2b of [3]

    Authors: Wenqiao Zang, Yuanyuan Wang, Tao Wang, Yuwen Du, Xiaonan Chen, Min Li and Guoqiang Zhao
    Citation: Molecular Cancer 2019 18:118
    Content type: Retraction Note Published on:

    The original article was published in Molecular Cancer 2015 14:37

  44. After the publication of this work [1], a spelling error was found: the ID of the circRNA, termed circYAP1, in the original publication was misspelled as “has_circ_0002320”.

    Authors: Hui Liu, Yuan Liu, Zhaolian Bian, Jing Zhang, Rui Zhang, Xiaoyu Chen, Yanxia Huang, Yang Wang and Jinshui Zhu
    Citation: Molecular Cancer 2019 18:117
    Content type: Correction Published on:

    The original article was published in Molecular Cancer 2018 17:151

  45. Exosomes have emerged as critical mediators of intercellular communication, both locally and systemically, by regulating a diverse range of biological processes between cells. Circular RNA (circRNA) is a novel...

    Authors: Yangxia Wang, Jinbo Liu, Junfen Ma, Ting Sun, Quanbo Zhou, Weiwei Wang, Guixian Wang, Pingjun Wu, Haijiang Wang, Li Jiang, Weitang Yuan, Zhenqiang Sun and Liang Ming
    Citation: Molecular Cancer 2019 18:116
    Content type: Review Published on:

  46. UCA1 is a long non-coding RNA which was found overexpressed in various human cancers including gastric cancer (GC). It is identified that UCA1 promotes GC cells proliferation, migration and invasion, however, ...

    Authors: Chao-Jie Wang, Chun-Chao Zhu, Jia Xu, Ming Wang, Wen-Yi Zhao, Qiang Liu, Gang Zhao and Zi-Zhen Zhang
    Citation: Molecular Cancer 2019 18:115
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2021 20:120

    The Correction to this article has been published in Molecular Cancer 2019 18:129

  48. Virtually all patients with metastatic prostate cancer (PCa) will relapse and develop lethal castration-resistant prostate cancer (CRPC). Long noncoding RNAs (lncRNAs) are emerging as critical regulatory eleme...

    Authors: Huy Q. Ta, Hilary Whitworth, Yi Yin, Mark Conaway, Henry F. Frierson Jr, Moray J. Campbell, Ganesh V. Raj and Daniel Gioeli
    Citation: Molecular Cancer 2019 18:113
    Content type: Research Published on:

  49. Colorectal carcinoma (CRC) is one of the most common malignant tumors, and its main cause of death is tumor metastasis. RNA N6-methyladenosine (m6A) is an emerging regulatory mechanism for gene expression and met...

    Authors: Ting Li, Pei-Shan Hu, Zhixiang Zuo, Jin-Fei Lin, Xingyang Li, Qi-Nian Wu, Zhan-Hong Chen, Zhao-Lei Zeng, Feng Wang, Jian Zheng, Demeng Chen, Bo Li, Tie-Bang Kang, Dan Xie, Dongxin Lin, Huai-Qiang Ju…
    Citation: Molecular Cancer 2019 18:112
    Content type: Research Published on:

  50. METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder ...

    Authors: Jie Han, Jing-zi Wang, Xiao Yang, Hao Yu, Rui Zhou, Hong-Cheng Lu, Wen-Bo Yuan, Jian-chen Lu, Zi-jian Zhou, Qiang Lu, Ji-Fu Wei and Haiwei Yang
    Citation: Molecular Cancer 2019 18:110
    Content type: Research Published on:
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Molecular Cancer

ISSN: 1476-4598