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  1. Content type: Research

    Circular RNAs (circRNAs) have been considered to mediate occurrence and development of human cancers, generally acting as microRNA (miRNA) sponges to regulate downstream genes expression. However, the aberrant...

    Authors: Wei Dong, Junming Bi, Hongwei Liu, Dong Yan, Qingqing He, Qianghua Zhou, Qiong Wang, Ruihui Xie, Yinjie Su, Meihua Yang, Tianxin Lin and Jian Huang

    Citation: Molecular Cancer 2019 18:95

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  2. Content type: Research

    Mediator complex subunit 12 (MED12) is an essential hub for transcriptional regulation, in which mutations and overexpression were reported to be associated with several kinds of malignancies. Nevertheless, th...

    Authors: Meng Xu, Fang Wang, Guibo Li, Xiaokun Wang, Xiaona Fang, Haoxuan Jin, Zhen Chen, Jianye Zhang and Liwu Fu

    Citation: Molecular Cancer 2019 18:93

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  3. Content type: Letter to the Editor

    The receptor for hyaluronic acid-mediated motility (RHAMM) is upregulated in various cancers. We previously screened genes upregulated in human hepatocellular carcinomas for their metastatic function in a mous...

    Authors: Soyoung Choi, Dunrui Wang, Xiang Chen, Laura H. Tang, Akanksha Verma, Zhengming Chen, Bu Jung Kim, Leigh Selesner, Kenneth Robzyk, George Zhang, Sharon Pang, Teng Han, Chang S. Chan, Thomas J. Fahey III, Olivier Elemento and Yi-Chieh Nancy Du

    Citation: Molecular Cancer 2019 18:92

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  4. Content type: Research

    Cancer associated fibroblasts (CAFs) are key stroma cells that play dominant roles in tumor progression. However, the CAFs-derived molecular determinants that regulate colorectal cancer (CRC) metastasis and ch...

    Authors: J. L. Hu, W. Wang, X. L. Lan, Z. C. Zeng, Y. S. Liang, Y. R. Yan, F. Y. Song, F. F. Wang, X. H. Zhu, W. J. Liao, W. T. Liao, Y. Q. Ding and L. Liang

    Citation: Molecular Cancer 2019 18:91

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  5. Content type: Review

    Circular RNAs (circRNAs) are a class of RNA molecules with closed loops and high stability. CircRNAs are abundantly expressed in eukaryotic organisms and exhibit both location- and step-specificity. In recent ...

    Authors: Min Su, Yuhang Xiao, Junliang Ma, Yanyan Tang, Bo Tian, Yuqin Zhang, Xu Li, Zhining Wu, Desong Yang, Yong Zhou, Hui Wang, Qianjin Liao and Wenxiang Wang

    Citation: Molecular Cancer 2019 18:90

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  6. Content type: Research

    The biology function of antisense intronic long noncoding RNA (Ai-lncRNA) is still unknown. Meanwhile, cancer patients with paclitaxel resistance have limited therapeutic options in the clinic. However, the po...

    Authors: Shouping Xu, Peiyuan Wang, Jian Zhang, Hao Wu, Shiyao Sui, Jinfeng Zhang, Qin Wang, Kun Qiao, Weiwei Yang, Hongbiao Xu and Da Pang

    Citation: Molecular Cancer 2019 18:89

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  7. Content type: Research

    Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are two important cellular components in the tumor microenvironment, which may modify the cancer phenotype and affect patient survival. How...

    Authors: Lisha Ai, Shidai Mu, Chunyan Sun, Fengjuan Fan, Han Yan, You Qin, Guohui Cui, Yadan Wang, Tao Guo, Heng Mei, Huafang Wang and Yu Hu

    Citation: Molecular Cancer 2019 18:88

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  8. Content type: Research

    Long noncoding RNAs (lncRNAs) have emerged as critical players in cancer progression, but their functions in colorectal cancer (CRC) metastasis have not been systematically clarified.

    Authors: Yingmin Wu, Xiangling Yang, Zhuojia Chen, Lin Tian, Guanmin Jiang, Feng Chen, Jiexin Li, Panpan An, Linlin Lu, Nan Luo, Jun Du, Hong Shan, Huanliang Liu and Hongsheng Wang

    Citation: Molecular Cancer 2019 18:87

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  9. Content type: Research

    Clear cell renal cell carcinoma (CCRCC) is characterized by a highly metastatic potential. The stromal communication between stem cells and cancer cells critically influences metastatic dissemination of cancer...

    Authors: Lu Wang, Guang Yang, Danfeng Zhao, Jiaqi Wang, Yang Bai, Qiang Peng, Hongzhi Wang, Ruizhe Fang, Guang Chen, Zhichao Wang, Keliang Wang, Guangbin Li, Yinhui Yang, Ziqi Wang, Pengyu Guo, Li Peng…

    Citation: Molecular Cancer 2019 18:86

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  10. Content type: Research

    Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic interventions. Development of a new class of anticancer agents t...

    Authors: Ke Xu, Dongkyoo Park, Andrew T. Magis, Jun Zhang, Wei Zhou, Gabriel L. Sica, Suresh S. Ramalingam, Walter J. Curran and Xingming Deng

    Citation: Molecular Cancer 2019 18:85

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  11. Content type: Research

    Long noncoding RNAs (lncRNAs), defined as the transcripts longer than 200 nt without protein-coding capacity, have been found to be aberrantly expressed in diverse human diseases including cancer. A reciprocal...

    Authors: Xuefei Wang, Jianling Yang, Guijie Guo, Riyue Feng, Ke Chen, Yuan Liao, Lianfeng Zhang, Liping Sun, Shile Huang and Ji-Long Chen

    Citation: Molecular Cancer 2019 18:84

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  12. Content type: Review

    The proliferation and metastasis ability of tumors are mediate by the "mutual dialogue" between cells in the tumor microenvironment (TME). Extracellular vesicles (EVs), mainly exosomes and microvesicles, play ...

    Authors: Changqing Xie, Ning Ji, Zhangui Tang, Jing Li and Qianming Chen

    Citation: Molecular Cancer 2019 18:83

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  13. Content type: Research

    Gallbladder cancer is the most common biliary tract malignancy and not sensitive to chemotherapy. Autophagy is an important factor prolonging the survival of cancer cells under chemotherapeutic stress. We aime...

    Authors: Qiang Cai, Shouhua Wang, Longyang Jin, Mingzhe Weng, Di Zhou, Jiandong Wang, Zhaohui Tang and Zhiwei Quan

    Citation: Molecular Cancer 2019 18:82

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  14. Content type: Research

    The aberrant expression of long noncoding RNAs (lncRNAs) has recently emerged as key molecules in human cancers; however, whether lncRNAs are implicated in the progression of clear cell renal cell carcinoma (c...

    Authors: Wei Zhai, Rujian Zhu, Junjie Ma, Dongkui Gong, Haimin Zhang, Jin Zhang, Yonghui Chen, Yiran Huang, Junhua Zheng and Wei Xue

    Citation: Molecular Cancer 2019 18:81

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  15. Content type: Research

    Accumulating evidence shows that, the dysregulation of circular RNAs (circRNAs) is associated with the progression of multiple malignancies. But, the underlying mechanisms by which has_circ_0032627 (circDLST) ...

    Authors: Jing Zhang, Lidan Hou, Rui Liang, Xiaoyu Chen, Rui Zhang, Wei Chen and Jinshui Zhu

    Citation: Molecular Cancer 2019 18:80

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  16. Content type: Research

    Emerging evidence indicates that tumor cells release a large amount of exosomes loaded with cargos during tumorigenesis. Exosome secretion is a multi-step process regulated by certain related molecules. Long n...

    Authors: Liang Yang, Xueqiang Peng, Yan Li, Xiaodong Zhang, Yingbo Ma, Chunli Wu, Qing Fan, Shibo Wei, Hangyu Li and Jingang Liu

    Citation: Molecular Cancer 2019 18:78

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  17. Content type: Review

    Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to substrate proteins, modulates many important biological processes, including tumorigenesis. The process of protein ne...

    Authors: Lisha Zhou, Yanyu Jiang, Qin Luo, Lihui Li and Lijun Jia

    Citation: Molecular Cancer 2019 18:77

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  18. Content type: Letter to the Editor

    Cervical cancer screening through detection and treatment of high-grade cervical intraepithelial neoplasia (CIN) is most successful in cancer prevention. However, the accuracy of the current cervical cancer sc...

    Authors: Mengyue Zheng, Ling Hou, Yu Ma, Lanyun Zhou, Fenfen Wang, Bei Cheng, Wei Wang, Bingjian Lu, Pengyuan Liu, Weiguo Lu and Yan Lu

    Citation: Molecular Cancer 2019 18:76

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  19. Content type: Review

    Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion, metastasis and drug-resistance. ...

    Authors: Ladan Mashouri, Hassan Yousefi, Amir Reza Aref, Ali mohammad Ahadi, Fatemeh Molaei and Suresh K. Alahari

    Citation: Molecular Cancer 2019 18:75

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  20. Content type: Letter to the Editor

    tRNA-derived small RNA (tsRNA) is a novel regulatory small non-coding RNA and participates in diverse physiological and pathological processes. However, the presence of tsRNAs in exosome and their diagnostic p...

    Authors: Lei Zhu, Jiao Li, Youling Gong, Qingbin Wu, Shuangyan Tan, Dan Sun, Xiaomin Xu, Yuanli Zuo, Yun Zhao, Yu-Quan Wei, Xia-Wei Wei and Yong Peng

    Citation: Molecular Cancer 2019 18:74

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  21. Content type: Research

    As a subclass of noncoding RNAs, circular RNAs (circRNAs) have been demonstrated to play a critical role in regulating gene expression in eukaryotes. Recent studies have revealed the pivotal functions of circR...

    Authors: Yizheng Wu, Ziang Xie, Junxin Chen, Jiaxin Chen, Weiyu Ni, Yan Ma, Kangmao Huang, Gangliang Wang, Jiying Wang, Jianjun Ma, Shuying Shen and Shunwu Fan

    Citation: Molecular Cancer 2019 18:73

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  22. Content type: Correction

    Following publication of the original article [1], the authors reported an error in affiliation 5.

    Authors: Yu-Shui Ma, Tao Huang, Xiao-Ming Zhong, Hong-Wei Zhang, Xian-Ling Cong, Hong Xu, Gai-Xia Lu, Fei Yu, Shao-Bo Xue, Zhong-Wei Lv and Da Fu

    Citation: Molecular Cancer 2019 18:72

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    The original article was published in Molecular Cancer 2018 17:139

  23. Content type: Research

    Cisplatin (CDDP) treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). A better understanding of the mechanisms of CDDP resistance can greatly improve ther...

    Authors: Xiaoxu Huang, Zheng Li, Qiang Zhang, Weizhi Wang, Bowen Li, Lu Wang, Zhipeng Xu, Ailiang Zeng, Xing Zhang, Xuan Zhang, Zhongyuan He, Qiang Li, Guangli Sun, Sen Wang, Qing Li, Linjun Wang…

    Citation: Molecular Cancer 2019 18:71

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  24. Content type: Review

    In the last decades, the role of the microenvironment in tumor progression and therapeutic outcome has gained increasing attention. Cancer-associated fibroblasts (CAFs) have emerged as key players among stroma...

    Authors: Micol Eleonora Fiori, Simone Di Franco, Lidia Villanova, Paola Bianca, Giorgio Stassi and Ruggero De Maria

    Citation: Molecular Cancer 2019 18:70

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  25. Content type: Research

    Although the tumor stroma in solid tumors like gastric cancer (GC) plays a crucial role in chemo-resistance, specific targets to inhibit the interaction between the stromal and cancer cells have not yet been u...

    Authors: In-Hye Ham, Hye Jeong Oh, Hyejin Jin, Cheong A Bae, Sang-Min Jeon, Kyeong Sook Choi, Sang-Yong Son, Sang-Uk Han, Rolf A. Brekken, Dakeun Lee and Hoon Hur

    Citation: Molecular Cancer 2019 18:68

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  26. Content type: Review

    Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endotheli...

    Authors: Jana Plava, Marina Cihova, Monika Burikova, Miroslava Matuskova, Lucia Kucerova and Svetlana Miklikova

    Citation: Molecular Cancer 2019 18:67

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  27. Content type: Review

    The intestinal epithelial lining is one of the most rapidly renewing cell populations in the body. As a result, the gut has been an attractive model to resolve key mechanisms in epithelial homeostasis. In part...

    Authors: Maartje van der Heijden and Louis Vermeulen

    Citation: Molecular Cancer 2019 18:66

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  28. Content type: Research

    Tumor-associated macrophages (TAMs) are major components of tumor microenvironment that frequently associated with tumor metastasis in human cancers. Circulating tumor cell (CTC), originating from primary tumo...

    Authors: Chen Wei, Chaogang Yang, Shuyi Wang, Dongdong Shi, Chunxiao Zhang, Xiaobin Lin, Qing Liu, Rongzhang Dou and Bin Xiong

    Citation: Molecular Cancer 2019 18:64

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  29. Content type: Review

    The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. T...

    Authors: Barbora Peltanova, Martina Raudenska and Michal Masarik

    Citation: Molecular Cancer 2019 18:63

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  30. Content type: Review

    Gastric cancer (GC) is one of the leading causes of cancer-related death in both men and women due to delayed diagnosis and high metastatic frequency. Extracellular vesicles (EVs) are membrane-bound nanovesicl...

    Authors: Tingting Huang, Chunli Song, Lei Zheng, Ligang Xia, Yang Li and Yiwen Zhou

    Citation: Molecular Cancer 2019 18:62

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  31. Content type: Research

    Myeloid-derived suppressor cells (MDSCs) participate in tumor-elicited immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby influencing the effectiveness of cancer immunothera...

    Authors: Yu Zheng, Xinyu Tian, Tingting Wang, Xueli Xia, Fenghua Cao, Jie Tian, Ping Xu, Jie Ma, Huaxi Xu and Shengjun Wang

    Citation: Molecular Cancer 2019 18:61

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  32. Content type: Review

    Therapy resistance can arise within tumor cells because of genetic or phenotypic changes (intrinsic resistance), or it can be the result of an interaction with the tumor microenvironment (extrinsic resistance)...

    Authors: Teresa Bernadette Steinbichler, József Dudás, Sergej Skvortsov, Ute Ganswindt, Herbert Riechelmann and Ira-Ida Skvortsova

    Citation: Molecular Cancer 2019 18:58

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  33. Content type: Review

    Hypoxic tumor microenvironment is a common feature of solid tumors and is associated with aggressiveness and poor patient outcomes. A continuous interference between cancer cells and stromal cells within the h...

    Authors: Wanrong Meng, Yaying Hao, Chuanshi He, Ling Li and Guiquan Zhu

    Citation: Molecular Cancer 2019 18:57

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  34. Content type: Review

    CircRNAs, as new members of long noncoding RNAs, have been the focus of recent investigation. CircRNAs feature a closed continuous loop structure without 5′-3′ polarity or a poly A tail. Many studies have repo...

    Authors: Hetian Bai, Kexin Lei, Fei Huang, Zhou Jiang and Xikun Zhou

    Citation: Molecular Cancer 2019 18:56

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  35. Content type: Review

    The tumor microenvironment represents a complex network, in which tumor cells not only communicate with each other but also with stromal and immune cells. Current research has demonstrated the vital role of th...

    Authors: Selma Maacha, Ajaz A. Bhat, Lizandra Jimenez, Afsheen Raza, Mohammad Haris, Shahab Uddin and Jean-Charles Grivel

    Citation: Molecular Cancer 2019 18:55

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  36. Content type: Research

    MicroRNAs (miRs) are involved in lymphoma progression by regulating tumor cell interaction with microenvironment. MiR155 is overexpressed in diffuse large B-cell lymphoma (DLBCL) and its biological effect on t...

    Authors: Zhong Zheng, Rui Sun, Hui-Jin Zhao, Di Fu, Hui-Juan Zhong, Xiang-Qin Weng, Bin Qu, Yan Zhao, Li Wang and Wei-Li Zhao

    Citation: Molecular Cancer 2019 18:54

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  37. Content type: Review

    Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intra...

    Authors: Kathleen M. McAndrews and Raghu Kalluri

    Citation: Molecular Cancer 2019 18:52

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  38. Content type: Review

    The tumor microenvironment is a complex and dynamic cellular community comprising the tumor epithelium and various tumor-supporting cells such as immune cells, fibroblasts, immunosuppressive cells, adipose cel...

    Authors: Hong Sheng Cheng, Jeannie Xue Ting Lee, Walter Wahli and Nguan Soon Tan

    Citation: Molecular Cancer 2019 18:51

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  39. Content type: Review

    Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) ...

    Authors: Xiaojie Bian, Yu-Tian Xiao, Tianqi Wu, Mengfei Yao, Leilei Du, Shancheng Ren and Jianhua Wang

    Citation: Molecular Cancer 2019 18:50

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  40. Content type: Review

    Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a p...

    Authors: Nancy T. Chee, Ines Lohse and Shaun P. Brothers

    Citation: Molecular Cancer 2019 18:49

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  41. Content type: Review

    Among all the deadly cancers, pancreatic cancer ranks seventh in mortality. The absence of any grave symptoms coupled with the unavailability of early prognostic and diagnostic markers make the disease incurab...

    Authors: Manendra Babu Lankadasari, Pramiti Mukhopadhyay, Sabira Mohammed and Kuzhuvelil B. Harikumar

    Citation: Molecular Cancer 2019 18:48

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  42. Content type: Research

    It has been well established that circular RNAs (circRNAs) play an important regulatory role during tumor progression. Recent studies have indicated that even though circRNAs generally regulate gene expression...

    Authors: Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu and Jingting Jiang

    Citation: Molecular Cancer 2019 18:47

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  43. Content type: Research

    Circular RNAs (circRNAs) are a novel type of noncoding RNAs and play important roles in tumorigenesis, including gastric cancer (GC). However, the functions of most circRNAs remain poorly understood. In our st...

    Authors: Lixian Ding, Yuying Zhao, Shuwei Dang, Yue Wang, Xinglong Li, Xiaotong Yu, Zhongsheng Li, Jiufeng Wei, Ming Liu and Guodong Li

    Citation: Molecular Cancer 2019 18:45

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