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  1. Research

    The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness

    The Ghrelin-system is a complex, pleiotropic family composed of several peptides, including native-ghrelin and its In1-ghrelin splicing variant, and receptors (GHSR 1a/b), which are dysregulated in various end...

    Daniel Hormaechea-Agulla, Manuel D. Gahete, Juan M. Jiménez-Vacas, Enrique Gómez-Gómez, Alejandro Ibáñez-Costa, Fernando L-López, Esther Rivero-Cortés, André Sarmento-Cabral, José Valero-Rosa, Julia Carrasco-Valiente, Rafael Sánchez-Sánchez, Rosa Ortega-Salas, María M. Moreno, Natia Tsomaia, Steve M. Swanson, Michael D. Culler…

    Molecular Cancer 2017 16:146

    Published on: 29 August 2017

  2. Review

    Role of exosomal proteins in cancer diagnosis

    Exosomes are emerging as a new type of cancer biomarkers. Exosome is a bilayered nano-sized vesicle secreted by various living cells in all body fluids. Based on the expanding albeit incomplete knowledge of th...

    Weihua Li, Chuanyun Li, Tong Zhou, Xiuhong Liu, Xiaoni Liu, Xiuhui Li and Dexi Chen

    Molecular Cancer 2017 16:145

    Published on: 29 August 2017

  3. Review

    Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts

    The present review aimed to assess the role of exosomal miRNAs in cancer-associated fibroblasts (CAFs), normal fibroblasts (NFs), and cancer cells. The roles of exosomal miRNAs and miRNA dysregulation in CAF f...

    Fengming Yang, Zhiqiang Ning, Ling Ma, Weitao Liu, Chuchu Shao, Yongqian Shu and Hua Shen

    Molecular Cancer 2017 16:148

    Published on: 29 August 2017

  4. Research

    Phospholipid Phosphatase 4 promotes proliferation and tumorigenesis, and activates Ca2+-permeable Cationic Channel in lung carcinoma cells

    Phospholipid phosphatase 4 (PPAPDC1A or PLPP4) has been demonstrated to be involved in the malignant process of many cancers. The purpose of this study was to investigate the clinical significance and biologic...

    Xin Zhang, Lan Zhang, Bihua Lin, Xingxing Chai, Ronggang Li, Yuehua Liao, Xinghui Deng, Qiongru Liu, Wenli Yang, Yubo Cai, Wei Zhou, Zhichao Lin, Wenhai Huang, Meigong Zhong, Fangyong Lei, Jinhua Wu…

    Molecular Cancer 2017 16:147

    Published on: 29 August 2017

  5. Research

    Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1

    To overcome the hostile hypoxic microenvironment of solid tumors, tumor cells secrete a large number of non-coding RNA-containing exosomes that facilitate tumor development and metastasis. However, the precise...

    Mei Xue, Wei Chen, An Xiang, Ruiqi Wang, He Chen, Jingjing Pan, Huan Pang, Hongli An, Xiang Wang, Huilian Hou and Xu Li

    Molecular Cancer 2017 16:143

    Published on: 25 August 2017

  6. Research

    Long noncoding RNA ZEB1-AS1 epigenetically regulates the expressions of ZEB1 and downstream molecules in prostate cancer

    Emerging studies show that long noncoding RNAs (lncRNAs) play important roles in carcinogenesis and cancer progression. The lncRNA ZEB1 antisense 1 (ZEB1-AS1) derives from the promoter region of ZEB1 and we st...

    Wenjing Su, Miao Xu, Xueqin Chen, Ni Chen, Jing Gong, Ling Nie, Ling Li, Xinglan Li, Mengni Zhang and Qiao Zhou

    Molecular Cancer 2017 16:142

    Published on: 23 August 2017

  7. Research

    MicroRNA-218 functions as a tumor suppressor in lung cancer by targeting IL-6/STAT3 and negatively correlates with poor prognosis

    Aberrant expression of microRNAs in different human cancer types has been widely reported. MiR-218 acts as a tumor suppressor in diverse human cancer types impacting regulation of multiple genes in oncogenic p...

    Yan Yang, Lili Ding, Qun Hu, Jia Xia, Junjie Sun, Xudong Wang, Hua Xiong, Deepak Gurbani, Lianbo Li, Yan Liu and Aiguo Liu

    Molecular Cancer 2017 16:141

    Published on: 22 August 2017

  8. Research

    Role of MEK partner-1 in cancer stemness through MEK/ERK pathway in cancerous neural stem cells, expressing EGFRviii

    Glioma stem cells (GSCs) are a major cause of the frequent relapse observed in glioma, due to their high drug resistance and their differentiation potential. Therefore, understanding the molecular mechanisms g...

    Soo-Jung Kwon, Ok-Seon Kwon, Keun-Tae Kim, Young-Hyun Go, Si-in Yu, Byeong-ha Lee, Hiroyuki Miyoshi, Eunsel Oh, Seung-Ju Cho and Hyuk-Jin Cha

    Molecular Cancer 2017 16:140

    Published on: 22 August 2017

  9. Research

    miR-140-5p suppresses the proliferation, migration and invasion of gastric cancer by regulating YES1

    The aberrant expression of microRNA-140-5p (miR-140-5p) has been described in gastric cancer (GC). However, the role of miR-140-5p in GC remains unclear. In this study, the prognostic relevance of miR-140-5p i...

    Zheng Fang, Shuai Yin, Ruochuan Sun, Shangxin Zhang, Min Fu, Youliang Wu, Tao Zhang, Junaid Khaliq and Yongxiang Li

    Molecular Cancer 2017 16:139

    Published on: 17 August 2017

  10. Review

    Neutrophils in cancer: prognostic role and therapeutic strategies

    Expression of high levels of immune cells including neutrophils has been associated with detrimental outcome in several solid tumors and new strategies to decrease their presence and activity are currently und...

    Alberto Ocana, Cristina Nieto-Jiménez, Atanasio Pandiella and Arnoud J Templeton

    Molecular Cancer 2017 16:137

    Published on: 15 August 2017

  11. Research

    STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4

    Several of the thousands of human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in hepatocellular carcinoma (HCC) remains poorly understood.

    Hui Wang, Xisong Huo, Xin-Rong Yang, Jia He, Lijun Cheng, Na Wang, Xuan Deng, Haojie Jin, Ning Wang, Cun Wang, Fangyu Zhao, Jingyuan Fang, Ming Yao, Jia Fan and Wenxin Qin

    Molecular Cancer 2017 16:136

    Published on: 14 August 2017

  12. Research

    Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis

    RAB GTPases are important in the regulation of membrane trafficking and cell movement. Recently, exocytic RABs have received increasing attention in cancer research. However, the functional roles of exocytic R...

    Yu-Chan Chang, Chia-Yi Su, Ming-Huang Chen, Wei-Shone Chen, Chi-Long Chen and Michael Hsiao

    Molecular Cancer 2017 16:135

    Published on: 7 August 2017

  13. Review

    Nano-based delivery of RNAi in cancer therapy

    RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention. In the development of RNAi-based therapies, nanoparticle...

    Yong Xin, Min Huang, Wen Wen Guo, Qian Huang, Long zhen Zhang and Guan Jiang

    Molecular Cancer 2017 16:134

    Published on: 28 July 2017

  14. Research

    MEG2 is regulated by miR-181a-5p and functions as a tumour suppressor gene to suppress the proliferation and migration of gastric cancer cells

    Protein-tyrosine phosphatase MEG2 (MEG2) is a classic tyrosine-specific protein tyrosine phosphatase (PTP). It has been reported that MEG2 participates in the carcinogenesis of the breast and liver. However, f...

    Zhijian Liu, Feng Sun, Yeting Hong, Yanqing Liu, Min Fen, Kai Yin, Xiaolong Ge, Feng Wang, Xi Chen and Wenxian Guan

    Molecular Cancer 2017 16:133

    Published on: 26 July 2017

  15. Research

    Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p

    Although gemcitabine-based chemotherapy has been established as a core multimodal therapy for non-small cell lung cancer (NSCLC) treatment, its clinical efficacy remains limited by the development of acquired ...

    Feng Wei, Chengyuan Ma, Tong Zhou, Xuechao Dong, Qinghua Luo, Li Geng, Lijuan Ding, Yandong Zhang, Li Zhang, Nan Li, Yang Li and Yan Liu

    Molecular Cancer 2017 16:132

    Published on: 25 July 2017

  16. Research

    Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer

    Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated mortality worldwide with an overall five-year survival rate less than 7%. Accumulating evidence has revealed the cancer ...

    Ke Chen, Weikun Qian, Zhengdong Jiang, Liang Cheng, Jie Li, Liankang Sun, Cancan Zhou, Luping Gao, Meng Lei, Bin Yan, Junyu Cao, Wanxing Duan and Qingyong Ma

    Molecular Cancer 2017 16:131

    Published on: 24 July 2017

  17. Review

    Role of long non-coding RNAs in glucose metabolism in cancer

    Long-noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides and do not code for proteins. However, this class of RNAs plays pivotal regulatory roles. The mechanism of their ac...

    Chunmei Fan, Yanyan Tang, Jinpeng Wang, Fang Xiong, Can Guo, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Fang Wei, Liting Yang, Yi He, Ming Zhou, Xiaoling Li, Guiyuan Li, Wei Xiong and Zhaoyang Zeng

    Molecular Cancer 2017 16:130

    Published on: 24 July 2017

  18. Research

    The noncoding RNA HOXD-AS1 is a critical regulator of the metastasis and apoptosis phenotype in human hepatocellular carcinoma

    Despite accumulating evidence that long noncoding RNAs (lncRNAs) are associated with cancer development in multiple types of cancer, the biological roles of many lncRNAs in human hepatocellular carcinoma (HCC)...

    Shan Lu, Jiansheng Zhou, Yimin Sun, Nan Li, Mingyong Miao, Binghua Jiao and Huan Chen

    Molecular Cancer 2017 16:125

    Published on: 19 July 2017

  19. Research

    The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia

    Long non-coding RNAs (lncRNAs) play a variety of cellular roles, including regulation of transcription and translation, leading to alterations in gene expression. Some lncRNAs modulate the expression of chromo...

    Thilini R. Fernando, Jorge R. Contreras, Matteo Zampini, Norma I. Rodriguez-Malave, Michael O. Alberti, Jaime Anguiano, Tiffany M. Tran, Jayanth K. Palanichamy, Jasmine Gajeton, Nolan M. Ung, Cody J. Aros, Ella V. Waters, David Casero, Giuseppe Basso, Martina Pigazzi and Dinesh S. Rao

    Molecular Cancer 2017 16:126

    Published on: 19 July 2017

  20. Review

    WW domain-binding protein 2: an adaptor protein closely linked to the development of breast cancer

    The WW domain is composed of 38 to 40 semi-conserved amino acids shared with structural, regulatory, and signaling proteins. WW domain-binding protein 2 (WBP2), as a binding partner of WW domain protein, inter...

    Shuai Chen, Han Wang, Yu-Fan Huang, Ming-Li Li, Jiang-Hong Cheng, Peng Hu, Chuan-Hui Lu, Ya Zhang, Na Liu, Chi-Meng Tzeng and Zhi-Ming Zhang

    Molecular Cancer 2017 16:128

    Published on: 19 July 2017

  21. Research

    EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer

    Epidermal growth factor receptor (EGFR), a well-known oncogenic driver, contributes to the initiation and progression of a wide range of cancer types. Aberrant lipid metabolism including highly produced monoun...

    Jiqin Zhang, Fei Song, Xiaojing Zhao, Hua Jiang, Xiuqi Wu, Biao Wang, Min Zhou, Mi Tian, Bizhi Shi, Huamao Wang, Yuanhui Jia, Hai Wang, Xiaorong Pan and Zonghai Li

    Molecular Cancer 2017 16:127

    Published on: 19 July 2017

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