Skip to main content

Articles

Page 2 of 50

  1. Increasing studies have shown that circRNA is closely related to the carcinogenesis and development of many cancers. However, biological functions and the underlying molecular mechanism of circRNAs in triple-n...

    Authors: Xiaying Zheng, Mengge Huang, Lei Xing, Rui Yang, Xiaosong Wang, Rong Jiang, Luyu Zhang and Junxia Chen

    Citation: Molecular Cancer 2020 19:73

    Content type: Research

    Published on:

  2. Epigenetic alterations are involved in various aspects of colorectal carcinogenesis. N6-methyladenosine (m6A) modifications of RNAs are emerging as a new layer of epigenetic regulation. As the most abundant chemi...

    Authors: Chaoqin Shen, Baoqin Xuan, Tingting Yan, Yanru Ma, Pingping Xu, Xianglong Tian, Xinyu Zhang, Yingying Cao, Dan Ma, Xiaoqiang Zhu, Youwei Zhang, Jing-Yuan Fang, Haoyan Chen and Jie Hong

    Citation: Molecular Cancer 2020 19:72

    Content type: Research

    Published on:

  3. Colon cancer (CC) is a common malignant cancer. Recently, circFNDC3B was found to exert biological function in multiple cancers. However, it was unclear whether the potential protein encoded by circFNDC3B is i...

    Authors: Zihao Pan, Jianye Cai, Jiatong Lin, Huinian Zhou, Jingwen Peng, Jinliang Liang, Long Xia, Qi Yin, Baojia Zou, Jun Zheng, Liang Qiao and Lei Zhang

    Citation: Molecular Cancer 2020 19:71

    Content type: Research

    Published on:

  4. Non coding RNAs (ncRNAs) have emerged as regulators of human carcinogenesis by affecting the expression of key tumor suppressor genes and oncogenes. They are divided into short and long ncRNAs, according to th...

    Authors: Martina Ghetti, Ivan Vannini, Clelia Tiziana Storlazzi, Giovanni Martinelli and Giorgia Simonetti

    Citation: Molecular Cancer 2020 19:69

    Content type: Review

    Published on:

  5. Tumor repopulation is a major cause of radiotherapy failure. Previous investigations highlighted that dying tumor cells played vital roles in tumor repopulation through promoting proliferation of the residual ...

    Authors: Ming-jie Jiang, Yi-yun Chen, Juan-juan Dai, Dian-na Gu, Zhu Mei, Fu-rao Liu, Qian Huang and Ling Tian

    Citation: Molecular Cancer 2020 19:68

    Content type: Research

    Published on:

  6. Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to exp...

    Authors: Gehao Liang, Yun Ling, Maryam Mehrpour, Phei Er Saw, Zihao Liu, Weige Tan, Zhenluan Tian, Wenjing Zhong, Wanyi Lin, Qing Luo, Qun Lin, Qiufang Li, You Zhou, Ahmed Hamai, Patrice Codogno, Jun Li…

    Citation: Molecular Cancer 2020 19:65

    Content type: Research

    Published on:

  7. Empowered by recent advances of sequencing techniques, transcriptome-wide studies have characterized over 150 different types of post-transcriptional chemical modifications of RNA, ranging from methylations of...

    Authors: Xiao Yang, Ming Liu, Mengmeng Li, Sen Zhang, Hong Hiju, Jing Sun, Zhihai Mao, Minhua Zheng and Bo Feng

    Citation: Molecular Cancer 2020 19:64

    Content type: Review

    Published on:

  8. As the most frequently diagnosed non-skin cancer in men and a leading cause of cancer-related death, understanding the molecular mechanisms that drive treatment resistance in prostate cancer poses a significan...

    Authors: Maureen Labbé, Christianne Hoey, Jessica Ray, Vincent Potiron, Stéphane Supiot, Stanley K. Liu and Delphine Fradin

    Citation: Molecular Cancer 2020 19:63

    Content type: Review

    Published on:

  9. Gastric cancer is the fourth most common malignancy and the third leading cause of cancer-related deaths worldwide. Advanced gastric cancer patients can notably benefit from chemotherapy including adriamycin, ...

    Authors: Ling Wei, Jujie Sun, Nasha Zhang, Yan Zheng, Xingwu Wang, Liyan Lv, Jiandong Liu, Yeyang Xu, Yue Shen and Ming Yang

    Citation: Molecular Cancer 2020 19:62

    Content type: Review

    Published on:

  10. Non-coding RNAs are now recognized as fundamental components of the cellular processes. Non-coding RNAs are composed of different classes, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Their...

    Authors: Francesca Crudele, Nicoletta Bianchi, Eva Reali, Marco Galasso, Chiara Agnoletto and Stefano Volinia

    Citation: Molecular Cancer 2020 19:61

    Content type: Review

    Published on:

  11. Metastasis causes the vast majority of colorectal carcinoma (CRC)-related deaths. However, little is known about the specific traits and underlying mechanisms of metastasis-initiating cells in primary CRC. And...

    Authors: Kai Han, Feng-Wei Wang, Chen-Hui Cao, Han Ling, Jie-Wei Chen, Ri-Xin Chen, Zi-Hao Feng, Jie Luo, Xiao-Han Jin, Jin-Ling Duan, Shu-Man Li, Ning-Fang Ma, Jing-Ping Yun, Xin-Yuan Guan, Zhi-Zhong Pan, Ping Lan…

    Citation: Molecular Cancer 2020 19:60

    Content type: Research

    Published on:

  12. Following the publication of article [1], the authors found that the images of Transwell Matrigel invasion (Fig. 7d) are incorrect.

    Authors: Liang-qi Cao, Xue-wei Yang, Yu-bin Chen, Da-wei Zhang, Xiao-Feng Jiang and Ping Xue

    Citation: Molecular Cancer 2020 19:59

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:148

  13. Circular RNAs (circRNAs), one type of non-coding RNA, were initially misinterpreted as nonfunctional products of pre-mRNA mis-splicing. Currently, circRNAs have been proven to manipulate the functions of diver...

    Authors: Chaochu Cui, Jianbo Yang, Xiao Li, Dongling Liu, Liwu Fu and Xianwei Wang

    Citation: Molecular Cancer 2020 19:58

    Content type: Review

    Published on:

  14. Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approache...

    Authors: Ajaz A. Bhat, Salma N. Younes, Syed Shadab Raza, Lubna Zarif, Sabah Nisar, Ikhlak Ahmed, Rashid Mir, Sachin Kumar, Surender K. Sharawat, Sheema Hashem, Imadeldin Elfaki, Michal Kulinski, Shilpa Kuttikrishnan, Kirti S. Prabhu, Abdul Q. Khan, Santosh K. Yadav…

    Citation: Molecular Cancer 2020 19:57

    Content type: Review

    Published on:

  15. Aberrant expression of circular RNAs contributes to the initiation and progression of cancers, but the underlying mechanism remains elusive.

    Authors: Mengmeng Jie, Yaran Wu, Mengyuan Gao, Xinzhe Li, Cheng Liu, Qin Ouyang, Qingyun Tang, Changyu Shan, Yangfan Lv, Kebin Zhang, Qian Dai, Yang Chen, Shuo Zeng, Chenglin Li, Liting Wang, Fengtian He…

    Citation: Molecular Cancer 2020 19:56

    Content type: Research

    Published on:

  16. Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various mechanisms. Over the last decade...

    Authors: Kaisheng Liu, Lin Gao, Xiaoshi Ma, Juan-Juan Huang, Juan Chen, Leli Zeng, Charles R. Ashby Jr., Chang Zou and Zhe-Sheng Chen

    Citation: Molecular Cancer 2020 19:54

    Content type: Review

    Published on:

  17. The epigenetic regulation of immune response has been demonstrated in recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m6A) modification in tumor microenvironment (TME) cell infiltration re...

    Authors: Bo Zhang, Qiong Wu, Ben Li, Defeng Wang, Lei Wang and You Lang Zhou

    Citation: Molecular Cancer 2020 19:53

    Content type: Research

    Published on:

  18. Hepatic metastasis develops in ~ 50% of uveal melanoma (UM) patients with no effective treatments. Although GNAQ/GNA11 mutations are believed to confer pathogenesis of UM, the underlying mechanism of liver met...

    Authors: Bei Jin, Ping Zhang, Hailin Zou, Huijing Ye, Yun Wang, Jing Zhang, Huasheng Yang and Jingxuan Pan

    Citation: Molecular Cancer 2020 19:52

    Content type: Research

    Published on:

  19. Long noncoding RNAs (lncRNAs) are emerging as critical regulatory elements and play fundamental roles in the biology of various cancers. However, we are still lack of knowledge about their expression patterns ...

    Authors: Juan Xu, Tingting Shao, Mingxu Song, Yunjin Xie, Jialiang Zhou, Jiaqi Yin, Na Ding, Haozhe Zou, Yongsheng Li and Jiwei Zhang

    Citation: Molecular Cancer 2020 19:51

    Content type: Research

    Published on:

  20. Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing evidence has shown that reprogrammed metabolism may play a critical role in the carcinogenesis, progression, treatmen...

    Authors: Cheng Qin, Gang Yang, Jinshou Yang, Bo Ren, Huanyu Wang, Guangyu Chen, Fangyu Zhao, Lei You, Weibin Wang and Yupei Zhao

    Citation: Molecular Cancer 2020 19:50

    Content type: Review

    Published on:

  21. Pancreatic cancer is a highly lethal disease with a poor prognosis, and existing therapies offer only limited effectiveness. Mutation gene sequencing has shown several gene associations that may account for it...

    Authors: Heng Zhu, Miaoyan Wei, Jin Xu, Jie Hua, Chen Liang, Qingcai Meng, Yiyin Zhang, Jiang Liu, Bo Zhang, Xianjun Yu and Si Shi

    Citation: Molecular Cancer 2020 19:49

    Content type: Review

    Published on:

  22. As the standard treatments for cancer, chemotherapy and radiotherapy have been widely applied to clinical practice worldwide. However, the resistance to cancer therapies is a major challenge in clinics and sci...

    Authors: Xinyi Zhang, Kai Xie, Honghua Zhou, Yuwei Wu, Chan Li, Yating Liu, Zhaoya Liu, Qian Xu, Shuang Liu, Desheng Xiao and Yongguang Tao

    Citation: Molecular Cancer 2020 19:47

    Content type: Review

    Published on:

  23. N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulation in eukaryotic cells. However, understanding of m6A in colorectal cancer (CRC) is very limited. We designed this study to investigate the...

    Authors: Xiao Yang, Sen Zhang, Changyu He, Pei Xue, Luyang Zhang, Zirui He, Lu Zang, Bo Feng, Jing Sun and Minhua Zheng

    Citation: Molecular Cancer 2020 19:46

    Content type: Research

    Published on:

  24. Circular RNA (circRNA) has been proven to play a significant role in multiple types of cancer. However, the expression and role of circRNAs in epithelial ovarian cancer (EOC) remains elusive.

    Authors: Xiaoling Gan, Hongtao Zhu, Xingwei Jiang, Samuel C. Obiegbusi, Min Yong, Xingtao Long and Jianguo Hu

    Citation: Molecular Cancer 2020 19:45

    Content type: Research

    Published on:

  25. Ferroptosis is a novel mode of non-apoptotic cell death induced by build-up of toxic lipid peroxides (lipid-ROS) in an iron dependent manner. Cancer-associated fibroblasts (CAFs) support tumor progression and ...

    Authors: Haiyang Zhang, Ting Deng, Rui Liu, Tao Ning, Haiou Yang, Dongying Liu, Qiumo Zhang, Dan Lin, Shaohua Ge, Ming Bai, Xinyi Wang, Le Zhang, Hongli Li, Yuchong Yang, Zhi Ji, Hailong Wang…

    Citation: Molecular Cancer 2020 19:43

    Content type: Research

    Published on:

  26. The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested the involvement of CCL2 and tumor associated macropha...

    Authors: Hui Yang, Qiannan Zhang, Miao Xu, Lei Wang, Xuewei Chen, Yongquan Feng, Yongning Li, Xin Zhang, Wenming Cui and Xudong Jia

    Citation: Molecular Cancer 2020 19:41

    Content type: Research

    Published on:

  27. The importance of mRNA methylation erased by ALKBH5 in mRNA biogenesis, decay, and translation control is an emerging research focus. Ectopically activated YAP is associated with the development of many human ...

    Authors: Dan Jin, Jiwei Guo, Yan Wu, Lijuan Yang, Xiaohong Wang, Jing Du, Juanjuan Dai, Weiwei Chen, Kaikai Gong, Shuang Miao, Xuelin Li and Hongliang Sun

    Citation: Molecular Cancer 2020 19:40

    Content type: Research

    Published on:

  28. Ferroptosis, a novel form of regulated cell death, is different from other types of cell death in morphology, genetics and biochemistry. Increasing evidence indicates that ferroptosis has significant implicati...

    Authors: Yuqing Wu, Siwei Zhang, Xiaoxiao Gong, Samantha Tam, Desheng Xiao, Shuang Liu and Yongguang Tao

    Citation: Molecular Cancer 2020 19:39

    Content type: Review

    Published on:

  29. Despite their small numbers, cancer stem cells play a central role in driving cancer cell growth, chemotherapeutic resistance, and distal metastasis. Previous studies mainly focused on how DNA or histone modif...

    Authors: Weicheng Liang, Zexiao Lin, Cong Du, Dongbo Qiu and Qi Zhang

    Citation: Molecular Cancer 2020 19:38

    Content type: Review

    Published on:

  30. Differential expression of mucins has been associated with several cancers including colorectal cancer (CRC). In normal physiological conditions, secretory mucin MUC5AC is not expressed in the colonic mucosa, ...

    Authors: Ramesh Pothuraju, Satyanarayana Rachagani, Shiv Ram Krishn, Sanjib Chaudhary, Rama Krishna Nimmakayala, Jawed A. Siddiqui, Koelina Ganguly, Imayavaramban Lakshmanan, Jesse L. Cox, Kavita Mallya, Sukhwinder Kaur and Surinder K. Batra

    Citation: Molecular Cancer 2020 19:37

    Content type: Research

    Published on:

  31. Literature reports that mature microRNA (miRNA) can be methylated at adenosine, guanosine and cytosine. However, the molecular mechanisms involved in cytosine methylation of miRNAs have not yet been fully eluc...

    Authors: Mathilde Cheray, Amandine Etcheverry, Camille Jacques, Romain Pacaud, Gwenola Bougras-Cartron, Marc Aubry, Florent Denoual, Pierre Peterlongo, Arulraj Nadaradjane, Joséphine Briand, Farida Akcha, Dominique Heymann, François M. Vallette, Jean Mosser, Benjamin Ory and Pierre-François Cartron

    Citation: Molecular Cancer 2020 19:36

    Content type: Research

    Published on:

  32. The activation of NF-κB signaling pathway is regarded as the dominant process that correlates with tumorigenesis. Recently, increasing evidence shows that long noncoding RNAs (lncRNAs) play crucial roles in su...

    Authors: Xiaofan Ren, Changhao Chen, Yuming Luo, Mingyang Liu, Yuting Li, Shangyou Zheng, Huilin Ye, Zhiqiang Fu, Min Li, Zhihua Li and Rufu Chen

    Citation: Molecular Cancer 2020 19:35

    Content type: Research

    Published on:

  33. CircRNAs are a class of single-stranded RNA molecules with a covalently closed loop structure and have been characterized by high stability, abundance, conservation, and display tissue/developmental stage-spec...

    Authors: Jikui Sun, Banban Li, Chang Shu, Quanfeng Ma and Jinhuan Wang

    Citation: Molecular Cancer 2020 19:34

    Content type: Review

    Published on:

  34. Circular RNAs (circRNAs), a new type of noncoding RNA (ncRNA), have been identified as significant gene expression regulators and are involved in cancer progression. However, the roles of circRNAs in nasophary...

    Authors: Xiaohong Hong, Na Liu, Yelin Liang, Qingmei He, Xiaojing Yang, Yuan Lei, Panpan Zhang, Yin Zhao, Shiwei He, Yaqin Wang, Junyan Li, Qian Li, Jun Ma and Yingqin Li

    Citation: Molecular Cancer 2020 19:33

    Content type: Research

    Published on:

  35. Pancreatic ductal adenocarcinoma (PDAC) is an incurable cancer resistant to traditional treatments, although a limited number of early-stage patients can undergo radical resection. Immunotherapies for the trea...

    Authors: Jia-qiao Fan, Meng-Fei Wang, Hai-Long Chen, Dong Shang, Jugal K. Das and Jianxun Song

    Citation: Molecular Cancer 2020 19:32

    Content type: Review

    Published on:

  36. Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed loops through backsplicing. Recent methodologies have enabled in-depth characterization of circRNAs for identification an...

    Authors: Ming Lei, Guantao Zheng, Qianqian Ning, Junnian Zheng and Dong Dong

    Citation: Molecular Cancer 2020 19:30

    Content type: Review

    Published on:

  37. Brain metastasis (BM) predominantly occurs in triple-negative (TN) and epidermal growth factor 2 (HER2)-positive breast cancer (BC) patients, and currently, there is an unmet need for the treatment of these pa...

    Authors: Ranjana K. Kanchan, Jawed A. Siddiqui, Sidharth Mahapatra, Surinder K. Batra and Mohd W. Nasser

    Citation: Molecular Cancer 2020 19:29

    Content type: Review

    Published on:

  38. After publication of the article [1], authors found out that Fig. 1 was inadvertently replaced.

    Authors: Daixi Ren, Yuze Hua, Boyao Yu, Xin Ye, Ziheng He, Chunwei Li, Jie Wang, Yongzhen Mo, Xiaoxu Wei, Yunhua Chen, Yujuan Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Ming Zhou, Xiaoling Li…

    Citation: Molecular Cancer 2020 19:31

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2020 19:19

  39. Accumulating evidence shows that long noncoding RNAs (lncRNAs) are important regulator molecules involved in diverse biological processes. Acquired drug resistance is a major challenge in the clinical treatmen...

    Authors: Chenfei Lu, Yutian Wei, Xiefeng Wang, Zhuoran Zhang, Jianxing Yin, Wentao Li, Lijiu Chen, Xiao Lyu, Zhumei Shi, Wei Yan and Yongping You

    Citation: Molecular Cancer 2020 19:28

    Content type: Research

    Published on:

  40. Although trastuzumab provides significant clinical benefit for HER2-positive breast cancers, responses are limited by the emergence of resistance. Recent evidence suggests that long noncoding RNAs (lncRNAs) pl...

    Authors: Mingli Han, Yuanting Gu, Pengwei Lu, Jingyi Li, Hui Cao, Xiangke Li, Xueke Qian, Chao Yu, Yunqing Yang, Xue Yang, Na Han, Dongwei Dou, Jianguo Hu and Huaying Dong

    Citation: Molecular Cancer 2020 19:26

    Content type: Research

    Published on:

  41. After the publication of this work [1], the authors noticed that the affiliations were incorrectly provided. Updated affiliation section is provided in this paper.

    Authors: Li Liu, Jing Wang, Guifeng Sun, Qiong Wu, Ji Ma, Xin Zhang, Nan Huang, Zhixuan Bian, Song Gu, Min Xu, Minzhi Yin, Fenyong Sun and Qiuhui Pan

    Citation: Molecular Cancer 2020 19:24

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:188

Annual Journal Metrics