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  1. Content type: Review

    Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion, metastasis and drug-resistance. ...

    Authors: Ladan Mashouri, Hassan Yousefi, Amir Reza Aref, Ali mohammad Ahadi, Fatemeh Molaei and Suresh K. Alahari

    Citation: Molecular Cancer 2019 18:75

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  2. Content type: Letter to the Editor

    tRNA-derived small RNA (tsRNA) is a novel regulatory small non-coding RNA and participates in diverse physiological and pathological processes. However, the presence of tsRNAs in exosome and their diagnostic p...

    Authors: Lei Zhu, Jiao Li, Youling Gong, Qingbin Wu, Shuangyan Tan, Dan Sun, Xiaomin Xu, Yuanli Zuo, Yun Zhao, Yu-Quan Wei, Xia-Wei Wei and Yong Peng

    Citation: Molecular Cancer 2019 18:74

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  3. Content type: Research

    As a subclass of noncoding RNAs, circular RNAs (circRNAs) have been demonstrated to play a critical role in regulating gene expression in eukaryotes. Recent studies have revealed the pivotal functions of circR...

    Authors: Yizheng Wu, Ziang Xie, Junxin Chen, Jiaxin Chen, Weiyu Ni, Yan Ma, Kangmao Huang, Gangliang Wang, Jiying Wang, Jianjun Ma, Shuying Shen and Shunwu Fan

    Citation: Molecular Cancer 2019 18:73

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  4. Content type: Research

    Cisplatin (CDDP) treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). A better understanding of the mechanisms of CDDP resistance can greatly improve ther...

    Authors: Xiaoxu Huang, Zheng Li, Qiang Zhang, Weizhi Wang, Bowen Li, Lu Wang, Zhipeng Xu, Ailiang Zeng, Xing Zhang, Xuan Zhang, Zhongyuan He, Qiang Li, Guangli Sun, Sen Wang, Qing Li, Linjun Wang…

    Citation: Molecular Cancer 2019 18:71

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  5. Content type: Review

    In the last decades, the role of the microenvironment in tumor progression and therapeutic outcome has gained increasing attention. Cancer-associated fibroblasts (CAFs) have emerged as key players among stroma...

    Authors: Micol Eleonora Fiori, Simone Di Franco, Lidia Villanova, Paola Bianca, Giorgio Stassi and Ruggero De Maria

    Citation: Molecular Cancer 2019 18:70

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  6. Content type: Research

    Although the tumor stroma in solid tumors like gastric cancer (GC) plays a crucial role in chemo-resistance, specific targets to inhibit the interaction between the stromal and cancer cells have not yet been u...

    Authors: In-Hye Ham, Hye Jeong Oh, Hyejin Jin, Cheong A Bae, Sang-Min Jeon, Kyeong Sook Choi, Sang-Yong Son, Sang-Uk Han, Rolf A. Brekken, Dakeun Lee and Hoon Hur

    Citation: Molecular Cancer 2019 18:68

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  7. Content type: Review

    Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endotheli...

    Authors: Jana Plava, Marina Cihova, Monika Burikova, Miroslava Matuskova, Lucia Kucerova and Svetlana Miklikova

    Citation: Molecular Cancer 2019 18:67

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  8. Content type: Review

    The intestinal epithelial lining is one of the most rapidly renewing cell populations in the body. As a result, the gut has been an attractive model to resolve key mechanisms in epithelial homeostasis. In part...

    Authors: Maartje van der Heijden and Louis Vermeulen

    Citation: Molecular Cancer 2019 18:66

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  9. Content type: Research

    Tumor-associated macrophages (TAMs) are major components of tumor microenvironment that frequently associated with tumor metastasis in human cancers. Circulating tumor cell (CTC), originating from primary tumo...

    Authors: Chen Wei, Chaogang Yang, Shuyi Wang, Dongdong Shi, Chunxiao Zhang, Xiaobin Lin, Qing Liu, Rongzhang Dou and Bin Xiong

    Citation: Molecular Cancer 2019 18:64

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  10. Content type: Review

    The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. T...

    Authors: Barbora Peltanova, Martina Raudenska and Michal Masarik

    Citation: Molecular Cancer 2019 18:63

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  11. Content type: Review

    Gastric cancer (GC) is one of the leading causes of cancer-related death in both men and women due to delayed diagnosis and high metastatic frequency. Extracellular vesicles (EVs) are membrane-bound nanovesicl...

    Authors: Tingting Huang, Chunli Song, Lei Zheng, Ligang Xia, Yang Li and Yiwen Zhou

    Citation: Molecular Cancer 2019 18:62

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  12. Content type: Research

    Myeloid-derived suppressor cells (MDSCs) participate in tumor-elicited immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby influencing the effectiveness of cancer immunothera...

    Authors: Yu Zheng, Xinyu Tian, Tingting Wang, Xueli Xia, Fenghua Cao, Jie Tian, Ping Xu, Jie Ma, Huaxi Xu and Shengjun Wang

    Citation: Molecular Cancer 2019 18:61

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  13. Content type: Review

    Therapy resistance can arise within tumor cells because of genetic or phenotypic changes (intrinsic resistance), or it can be the result of an interaction with the tumor microenvironment (extrinsic resistance)...

    Authors: Teresa Bernadette Steinbichler, József Dudás, Sergej Skvortsov, Ute Ganswindt, Herbert Riechelmann and Ira-Ida Skvortsova

    Citation: Molecular Cancer 2019 18:58

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  14. Content type: Review

    Hypoxic tumor microenvironment is a common feature of solid tumors and is associated with aggressiveness and poor patient outcomes. A continuous interference between cancer cells and stromal cells within the h...

    Authors: Wanrong Meng, Yaying Hao, Chuanshi He, Ling Li and Guiquan Zhu

    Citation: Molecular Cancer 2019 18:57

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  15. Content type: Review

    CircRNAs, as new members of long noncoding RNAs, have been the focus of recent investigation. CircRNAs feature a closed continuous loop structure without 5′-3′ polarity or a poly A tail. Many studies have repo...

    Authors: Hetian Bai, Kexin Lei, Fei Huang, Zhou Jiang and Xikun Zhou

    Citation: Molecular Cancer 2019 18:56

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  16. Content type: Review

    The tumor microenvironment represents a complex network, in which tumor cells not only communicate with each other but also with stromal and immune cells. Current research has demonstrated the vital role of th...

    Authors: Selma Maacha, Ajaz A. Bhat, Lizandra Jimenez, Afsheen Raza, Mohammad Haris, Shahab Uddin and Jean-Charles Grivel

    Citation: Molecular Cancer 2019 18:55

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  17. Content type: Research

    MicroRNAs (miRs) are involved in lymphoma progression by regulating tumor cell interaction with microenvironment. MiR155 is overexpressed in diffuse large B-cell lymphoma (DLBCL) and its biological effect on t...

    Authors: Zhong Zheng, Rui Sun, Hui-Jin Zhao, Di Fu, Hui-Juan Zhong, Xiang-Qin Weng, Bin Qu, Yan Zhao, Li Wang and Wei-Li Zhao

    Citation: Molecular Cancer 2019 18:54

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  18. Content type: Review

    Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intra...

    Authors: Kathleen M. McAndrews and Raghu Kalluri

    Citation: Molecular Cancer 2019 18:52

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  19. Content type: Review

    The tumor microenvironment is a complex and dynamic cellular community comprising the tumor epithelium and various tumor-supporting cells such as immune cells, fibroblasts, immunosuppressive cells, adipose cel...

    Authors: Hong Sheng Cheng, Jeannie Xue Ting Lee, Walter Wahli and Nguan Soon Tan

    Citation: Molecular Cancer 2019 18:51

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  20. Content type: Review

    Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) ...

    Authors: Xiaojie Bian, Yu-Tian Xiao, Tianqi Wu, Mengfei Yao, Leilei Du, Shancheng Ren and Jianhua Wang

    Citation: Molecular Cancer 2019 18:50

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  21. Content type: Review

    Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a p...

    Authors: Nancy T. Chee, Ines Lohse and Shaun P. Brothers

    Citation: Molecular Cancer 2019 18:49

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  22. Content type: Review

    Among all the deadly cancers, pancreatic cancer ranks seventh in mortality. The absence of any grave symptoms coupled with the unavailability of early prognostic and diagnostic markers make the disease incurab...

    Authors: Manendra Babu Lankadasari, Pramiti Mukhopadhyay, Sabira Mohammed and Kuzhuvelil B. Harikumar

    Citation: Molecular Cancer 2019 18:48

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  23. Content type: Research

    It has been well established that circular RNAs (circRNAs) play an important regulatory role during tumor progression. Recent studies have indicated that even though circRNAs generally regulate gene expression...

    Authors: Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu and Jingting Jiang

    Citation: Molecular Cancer 2019 18:47

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  24. Content type: Research

    N6-methyladenosine (m6A) modification is the most pervasive modification in mRNA, and has been considered as a new layer of epigenetic regulation on mRNA processing, stability and translation. Despite its func...

    Authors: Yi Niu, Ziyou Lin, Arabella Wan, Honglei Chen, Heng Liang, Lei Sun, Yuan Wang, Xi Li, Xiao-feng Xiong, Bo Wei, Xiaobin Wu and Guohui Wan

    Citation: Molecular Cancer 2019 18:46

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  25. Content type: Research

    Circular RNAs (circRNAs) are a novel type of noncoding RNAs and play important roles in tumorigenesis, including gastric cancer (GC). However, the functions of most circRNAs remain poorly understood. In our st...

    Authors: Lixian Ding, Yuying Zhao, Shuwei Dang, Yue Wang, Xinglong Li, Xiaotong Yu, Zhongsheng Li, Jiufeng Wei, Ming Liu and Guodong Li

    Citation: Molecular Cancer 2019 18:45

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  26. Content type: Review

    Circular RNAs are abundant endogenous non-coding RNA with no 5′ cap and 3′ polyadenylation tail that modify liner mRNAs and have no terminal structures. Our knowledge of the biogenesis of circular RNAs has bee...

    Authors: Yang Guo, Jiechao Yang, Qiang Huang, Chiyao Hsueh, Juan Zheng, Chunping Wu, Hui Chen and Liang Zhou

    Citation: Molecular Cancer 2019 18:44

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  27. Content type: Research

    Oxaliplatin resistance is a major challenge for treatment of advanced colorectal cancer (CRC). Both acquisition of epithelial-mesenchymal transition (EMT) and suppressed drug accumulation in cancer cells contr...

    Authors: Tong Liu, Xin Zhang, Lutao Du, Yunshan Wang, Xiaoming Liu, Hui Tian, Lili Wang, Peilong Li, Yinghui Zhao, Weili Duan, Yujiao Xie, Zhaowei Sun and Chuanxin Wang

    Citation: Molecular Cancer 2019 18:43

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  28. Content type: Research

    Triple-negative breast cancer (TNBC) is a poor prognostic breast cancer with the highest mutations and limited therapeutic choices. Cytokine networking between cancer cells and the tumor microenvironment (TME)...

    Authors: Yueh-Shan Weng, Hong-Yu Tseng, Yen-An Chen, Pei-Chun Shen, Aushia Tanzih Al Haq, Li-Mei Chen, Yi-Chung Tung and Hsin-Ling Hsu

    Citation: Molecular Cancer 2019 18:42

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  29. Content type: Review

    Exosomes are nanosized extracellular vesicles that can be released by almost all types of cells. Initially considered as the garbage bins acting to discard unwanted products of cells, exosomes are now recogniz...

    Authors: Min Fu, Jianmei Gu, Pengcheng Jiang, Hui Qian, Wenrong Xu and Xu Zhang

    Citation: Molecular Cancer 2019 18:41

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  30. Content type: Research

    Metastasis is the main cause of lung cancer mortality. Bone marrow-derived mesenchymal stem cells (BMSCs) are a component of the cancer microenvironment and contribute to cancer progression. Intratumoral hypox...

    Authors: Xina Zhang, Buqing Sai, Fan Wang, Lujuan Wang, Yuhui Wang, Leliang Zheng, Guiyuan Li, Jingqun Tang and Juanjuan Xiang

    Citation: Molecular Cancer 2019 18:40

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  31. Content type: Review

    A pre-metastatic niche is a microenvironment prepared for the colonization of circulating tumor cells in specific organs. Exosomes are extracellular vesicles with a variety of biological functions. Exosomes pl...

    Authors: Yaxin Guo, Xiang Ji, Jinbo Liu, Dandan Fan, Quanbo Zhou, Chen Chen, Weiwei Wang, Guixian Wang, Haijiang Wang, Weitang Yuan, Zhenyu Ji and Zhenqiang Sun

    Citation: Molecular Cancer 2019 18:39

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  32. Content type: Research

    Long intergenic noncoding RNA p21 (lincRNA-p21) is considered a target of wild-type p53, but little is known about its regulation by mutant p53 and its functions during the progression of head and neck squamou...

    Authors: Shufang Jin, Xi Yang, Jiayi Li, Wenyi Yang, Hailong Ma and Zhiyuan Zhang

    Citation: Molecular Cancer 2019 18:38

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  33. Content type: Review

    Extracellular vesicles (EVs) membranes enclose nanosized vesicles with a size range of 30–150 nm and are plentiful in our body in both physiological and pathological conditions. Exosomes, a type of EV, are imp...

    Authors: Yan Xie, Wei Dang, Siwei Zhang, Wenxing Yue, Li Yang, Xingyu Zhai, Qijia Yan and Jianhong Lu

    Citation: Molecular Cancer 2019 18:37

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  34. Content type: Review

    Peripheral circulating free DNA (cfDNA) is DNA that is detected in plasma or serum fluid with a cell-free status. For cancer patients, cfDNA not only originates from apoptotic cells but also from necrotic tumo...

    Authors: Lei Zhang, Yiyi Liang, Shifu Li, Fanyuan Zeng, Yongan Meng, Ziwei Chen, Shuang Liu, Yongguang Tao and Fenglei Yu

    Citation: Molecular Cancer 2019 18:36

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  35. Content type: Letter to Editor

    Circular RNA (circRNA) is a group of RNA families generated by RNA circularization, which was discovered ubiquitously across different cancers. However, the internal structure of circRNA is difficult to determ...

    Authors: Jing Feng, Ke Chen, Xin Dong, Xiaolong Xu, Yuxuan Jin, Xinyang Zhang, Wenbo Chen, Yujing Han, Lin Shao, Yang Gao and Chunjiang He

    Citation: Molecular Cancer 2019 18:35

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  36. Content type: Letter to the Editor

    In lung cancer, antiangiogenic strategies targeting tumor-derived endothelial cells (TECs) afford a survival advantage, but the characteristics of TECs have not been comprehensively elucidated. Herein, high-pu...

    Authors: Huiqin Zhuo, Yan Zhao, Xiao Cheng, Mao Xu, Lin Wang, Lingyun Lin, Zhi Lyu, Xuehui Hong and Jianchun Cai

    Citation: Molecular Cancer 2019 18:34

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  37. Content type: Research

    The long non-coding RNA PVT1 (lncRNA PVT1) has been reported to act as an oncogenic regulator of several cancers. However, its expression and function in gallbladder cancer (GBC) remain largely unknown.

    Authors: Jianan Chen, Yan Yu, Hua Li, Qiuyue Hu, Xiaolong Chen, Yuting He, Chen Xue, Fang Ren, Zhigang Ren, Juan Li, Liwen Liu, Zhenfeng Duan, Guangying Cui and Ranran Sun

    Citation: Molecular Cancer 2019 18:33

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  38. Content type: Research

    Long noncoding RNAs (lncRNAs) have been indicated to play critical roles in cancer development and progression. LncRNA HOXD cluster antisense RNA1 (HOXD-AS1) has recently been found to be dysregulated in sever...

    Authors: Min-Hui Yang, Li Zhao, Lan Wang, Wen Ou-Yang, Sha-Sha Hu, Wen-Lu Li, Mei-Ling Ai, Yi-Qing Wang, Yue Han, Ting-Ting Li, Yan-Qing Ding and Shuang Wang

    Citation: Molecular Cancer 2019 18:31

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  39. Content type: Letter to the Editor

    Ectopic Viral Integration site 1 (EVI1) upregulation is implicated in 10–25% of pediatric acute myeloid leukemia (AML) and has an inferior outcome with current chemotherapy regimens. Here we report that EVI1 u...

    Authors: Nupur Mittal, Liping Li, Yue Sheng, Chao Hu, Fuxing Li, Tongyu Zhu, Xiaohong Qiao and Zhijian Qian

    Citation: Molecular Cancer 2019 18:30

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  40. Content type: Review

    The immune system plays important roles in tumor development. According to the immune-editing theory, immune escape is the key to tumor survival, and exploring the mechanisms of tumor immune escape can provide...

    Authors: Shixin Duan, Weihua Guo, Zuxing Xu, Yunbo He, Chuting Liang, Yongzhen Mo, Yian Wang, Fang Xiong, Can Guo, Yong Li, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong and Fuyan Wang

    Citation: Molecular Cancer 2019 18:29

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  41. Content type: Research

    Hepatocellular carcinoma (HCC) is the most common malignant liver tumor with poor clinical outcomes. Increasing amount of long non-coding RNAs (lncRNAs) have been revealed to be implicated in the carcinogenesi...

    Authors: Yufeng Wang, Liu Yang, Tianxiang Chen, Xin Liu, Yang Guo, Qiaojuan Zhu, Xiangmin Tong, Wei Yang, Qiuran Xu, Dongsheng Huang and Kangsheng Tu

    Citation: Molecular Cancer 2019 18:28

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  42. Content type: Research

    Circular RNA (circRNA) represents a broad and diverse endogenous RNAs that can regulate gene expression in cancer. However, the regulation and function of bladder cancer (BC) circRNAs remain largely unknown.

    Authors: Hongwei Su, Tao Tao, Zhao Yang, Xing Kang, Xu Zhang, Danyue Kang, Song Wu and Chong Li

    Citation: Molecular Cancer 2019 18:27

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  43. Content type: Review

    Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one of the most important intracellular pathways, which can be considered as a master regulator for cancer. Enormous e...

    Authors: Jing Yang, Ji Nie, Xuelei Ma, Yuquan Wei, Yong Peng and Xiawei Wei

    Citation: Molecular Cancer 2019 18:26

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  44. Content type: Research

    Circular RNAs (circRNAs) are a class of non-coding RNAs with a loop structure, but its functions remain largely unknown. Growing evidence has revealed that circRNAs play a striking role as functional RNAs in t...

    Authors: Dawei Rong, Chen Lu, Betty Zhang, Kai Fu, Shuli Zhao, Weiwei Tang and Hongyong Cao

    Citation: Molecular Cancer 2019 18:25

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