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  1. The IκB kinase (IKK) complex, comprising the two enzymes IKKα and IKKβ, is the main activator of the inflammatory transcription factor NF-κB, which is constitutively active in many cancers. While several conne...

    Authors: Bernhard Moser, Bernhard Hochreiter, José Basílio, Viola Gleitsmann, Anja Panhuber, Alan Pardo-Garcia, Bastian Hoesel, Manuel Salzmann, Ulrike Resch, Mamoona Noreen and Johannes A. Schmid

    Citation: Molecular Cancer 2021 20:16

    Content type: Research

    Published on:

  2. Currently, there is no strong evidence of the well-established biomarkers for immune checkpoint inhibitors (ICIs) in nasopharyngeal carcinoma (NPC). Here, we aimed to reveal the heterogeneity of tumour microen...

    Authors: Yu-Pei Chen, Jia-Wei Lv, Yan-Ping Mao, Xiao-Min Li, Jun-Yan Li, Ya-Qin Wang, Cheng Xu, Ying-Qin Li, Qing-Mei He, Xiao-Jing Yang, Yuan Lei, Jia-Yi Shen, Ling-Long Tang, Lei Chen, Guan-Qun Zhou, Wen-Fei Li…

    Citation: Molecular Cancer 2021 20:14

    Content type: Letter

    Published on:

  3. Cancer is a leading cause of death worldwide, particularly because of its high mortality rate in patients who are diagnosed at late stages. Conventional biomarkers originating from blood are widely used for ca...

    Authors: Sumeng Wang, Ke Zhang, Shanyue Tan, Junyi Xin, Qianyu Yuan, Huanhuan Xu, Xian Xu, Qi Liang, David C. Christiani, Meilin Wang, Lingxiang Liu and Mulong Du

    Citation: Molecular Cancer 2021 20:13

    Content type: Review

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  4. Resistances to immunotherapies remains a major hurdle towards a cure for melanoma in numerous patients. An increase in the mesenchymal phenotype and a loss of differentiation have been clearly associated with ...

    Authors: Yann Cheli, Meri K. Tulic, Najla El Hachem, Nicolas Nottet, Arnaud Jacquel, Maeva Gesson, Thomas Strub, Karine Bille, Alexandra Picard-Gauci, Henri Montaudié, Guillaume E. Beranger, Thierry Passeron, Pierre Close, Corine Bertolotto and Robert Ballotti

    Citation: Molecular Cancer 2021 20:12

    Content type: Letter to the Editor

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    The Correction to this article has been published in Molecular Cancer 2021 20:21

  5. Emerging evidence has revealed that the removal of N-linked glycosylation could enhance PD-L1 detection. However, whether PD-L1 antibodies against different epitopes of PD-L1 antigens responding to deglycosyla...

    Authors: Jie Mei, Junying Xu, Xuejing Yang, Dingyi Gu, Weijian Zhou, Huiyu Wang and Chaoying Liu

    Citation: Molecular Cancer 2021 20:11

    Content type: Letter to the Editor

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  6. FOLFOX is a combinational regimen of folinic acid (FnA, FOL), fluorouracil (5-Fu, F) and oxaliplatin (OxP, OX), and has been long considered as the standard treatment of colorectal cancer (CRC) and hepatocellular...

    Authors: Jianfeng Guo, Zhuo Yu, Dandan Sun, Yifang Zou, Yun Liu and Leaf Huang

    Citation: Molecular Cancer 2021 20:10

    Content type: Research

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  7. MicroRNAs (miRNAs) show considerable promise as therapeutic agents to improve tumor treatment, as they have been revealed as crucial modulators in tumor progression. However, our understanding of their roles i...

    Authors: Shan Xing, Zhi Tian, Wenying Zheng, Wenjuan Yang, Nan Du, Yixue Gu, Jiang Yin, Hao Liu, Xiaoting Jia, Donglan Huang, Wanli Liu and Min Deng

    Citation: Molecular Cancer 2021 20:9

    Content type: Research

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  8. Acute myeloid leukemia (AML) is still incurable due to its heterogeneity and complexity of tumor microenvironment. It is imperative therefore to understand the molecular pathogenesis of AML and identify leukem...

    Authors: Yu-Jun Dai, Si-Yuan He, Fang Hu, Xue-Ping Li, Jian-Ming Zhang, Si-Liang Chen, Wei-Na Zhang, Hai-Min Sun and Da-Wei Wang

    Citation: Molecular Cancer 2021 20:8

    Content type: Letter to the Editor

    Published on:

  9. Vasculogenic mimicry (VM) is a recently discovered angiogenetic process found in many malignant tumors, and is different from the traditional angiogenetic process involving vascular endothelium. It involves th...

    Authors: Xiaoxu Wei, Yunhua Chen, Xianjie Jiang, Miao Peng, Yiduo Liu, Yongzhen Mo, Daixi Ren, Yuze Hua, Boyao Yu, Yujuan Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Guiyuan Li…

    Citation: Molecular Cancer 2021 20:7

    Content type: Review

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  10. De novo and acquired resistance, which are mainly mediated by genetic alterations, are barriers to effective routine chemotherapy. However, the mechanisms underlying gastric cancer (GC) resistance to chemother...

    Authors: Feifei Zhang, Hui Wang, Jiang Yu, Xueqing Yao, Shibin Yang, Weidong Li, Lijun Xu and Liang Zhao

    Citation: Molecular Cancer 2021 20:6

    Content type: Letter to the Editor

    Published on:

  11. Cytokine release syndrome (CRS) is a systemic inflammatory response characterized by the overexpression of inflammatory genes. Controlling CRS is essential for improving the therapeutic effects of chimeric ant...

    Authors: Ye Wei, Chong Li, Huifang Bian, Wei Qian, Kairui Jin, Tingting Xu, Xiaomao Guo, Xueguan Lu and Fengtao Su

    Citation: Molecular Cancer 2021 20:5

    Content type: Research

    Published on:

  12. Circular RNAs (circRNAs), which are single-stranded closed-loop RNA molecules lacking terminal 5′ caps and 3′ poly(A) tails, are attracting increasing scientific attention for their crucial regulatory roles in...

    Authors: Xiaoqi Yang, Tao Ye, Haoran Liu, Peng Lv, Chen Duan, Xiaoliang Wu, Kehua Jiang, Hongyan Lu, Ding Xia, Ejun Peng, Zhiqiang Chen, Kun Tang and Zhangqun Ye

    Citation: Molecular Cancer 2021 20:4

    Content type: Review

    Published on:

  13. c-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression in mice with only mild and f...

    Authors: Sarah K. Madden, Aline Dantas de Araujo, Mara Gerhardt, David P. Fairlie and Jody M. Mason

    Citation: Molecular Cancer 2021 20:3

    Content type: Review

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  14. Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced d...

    Authors: Ajaz A. Bhat, Sabah Nisar, Selma Maacha, Tatiana Correa Carneiro-Lobo, Sabah Akhtar, Kodappully Sivaraman Siveen, Nissar A. Wani, Arshi Rizwan, Puneet Bagga, Mayank Singh, Ravinder Reddy, Shahab Uddin, Jean-Charles Grivel, Gyan Chand, Michael P. Frenneaux, Mushtaq A. Siddiqi…

    Citation: Molecular Cancer 2021 20:2

    Content type: Review

    Published on:

  15. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ajaz A. Bhat, Salma N. Younes, Syed Shadab Raza, Lubna Zarif, Sabah Nisar, Ikhlak Ahmed, Rashid Mir, Sachin Kumar, Surender K. Sharawat, Sheema Hashem, Imadeldin Elfaki, Michal Kulinski, Shilpa Kuttikrishnan, Kirti S. Prabhu, Abdul Q. Khan, Santosh K. Yadav…

    Citation: Molecular Cancer 2020 19:174

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2020 19:57

  16. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Haihai Liang, Xiaoguang Zhao, Chengyu Wang, Jian Sun, Yingzhun Chen, Guoyuan Wang, Lei Fang, Rui Yang, Mengxue Yu, Yunyan Gu and Hongli Shan

    Citation: Molecular Cancer 2020 19:173

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2018 17:96

  17. Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation...

    Authors: Wei-Yi Zhou, Ze-Rong Cai, Jia Liu, De-Shen Wang, Huai-Qiang Ju and Rui-Hua Xu

    Citation: Molecular Cancer 2020 19:172

    Content type: Review

    Published on:

  18. N6-methyladenosine (m6A) is the most prevalent messenger RNA modification in mammalian cells. However, the disease relevant function of m6A on specific oncogenic long non-coding RNAs (ncRNAs) is not well under...

    Authors: Simeng Wen, Yulei Wei, Chong Zen, Wei Xiong, Yuanjie Niu and Yu Zhao

    Citation: Molecular Cancer 2020 19:171

    Content type: Research

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  19. Accumulating evidence has revealed significant roles for N6-methyladenosine (m 6 A) modification in the development of various cancers. We previously demonstrated an oncogenic role of m 6 A-modified CUB domain...

    Authors: Xiaoling Ying, Xu Jiang, Haiqing Zhang, Bixia Liu, Yapeng Huang, Xiaowei Zhu, Defeng Qi, Gang Yuan, Junhang Luo and Weidong Ji

    Citation: Molecular Cancer 2020 19:169

    Content type: Letter to the Editor

    Published on:

  20. Hypoxic stress plays a pivotal role in cancer progression; however, how hypoxia drives tumors to become more aggressive or metastatic and adaptive to adverse environmental stress is still poorly understood. In...

    Authors: Songwen Ju, Feng Wang, Yirong Wang and Songguang Ju

    Citation: Molecular Cancer 2020 19:168

    Content type: Letter to the Editor

    Published on:

  21. Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant tumor in head and neck. Autophagy and circular RNAs (circRNAs) play critical roles in cancer progression and chemoresistance. Howeve...

    Authors: Wei Gao, Huina Guo, Min Niu, Xiwang Zheng, Yuliang Zhang, Xuting Xue, Yunfeng Bo, Xiaoya Guan, Zhongxun Li, Yujia Guo, Long He, Yu Zhang, Li Li, Jimin Cao and Yongyan Wu

    Citation: Molecular Cancer 2020 19:166

    Content type: Research

    Published on:

  22. Circular RNA (circRNAs) and hypoxia have been found to play the key roles in the pathogenesis and progression of cancer including colorectal cancer (CRC). However, the expressions and functions of the specific...

    Authors: Liang-Yan Chen, Lian Wang, Yue-Xiang Ren, Zheng Pang, Yao Liu, Xiao-Dong Sun, Jian Tu, Zheng Zhi, Yan Qin, Li-Na Sun and Jian-Ming Li

    Citation: Molecular Cancer 2020 19:164

    Content type: Research

    Published on:

  23. Accumulating evidence suggests that the primary and acquired resistance of hepatocellular carcinoma (HCC) to sorafenib is mediated by multiple molecular, cellular, and microenvironmental mechanisms. Understand...

    Authors: Junjie Xu, Zhe Wan, Minyue Tang, Zhongjie Lin, Shi Jiang, Lin Ji, Kirill Gorshkov, Qijiang Mao, Shunjie Xia, Dong Cen, Junhao Zheng, Xiao Liang and Xiujun Cai

    Citation: Molecular Cancer 2020 19:163

    Content type: Research

    Published on:

  24. Targeting T cell receptor β-chain constant region 1 (TRBC1) CAR-T could specifically kill TRBC1+ T-cell malignancies. However, over-expressed CARs on anti-TRBC1 CAR transduced TRBC1+ T cells (CAR-C1) bound to ...

    Authors: Chaoting Zhang, Heyilimu Palashati, Zhuona Rong, Ningjing Lin, Luyan Shen, Ying Liu, Shance Li, Bentong Yu, Wenjun Yang and Zheming Lu

    Citation: Molecular Cancer 2020 19:162

    Content type: Letter to the Editor

    Published on:

  25. Trastuzumab resistance in HER2-positive breast cancer is associated with a poorer prognosis. HSP90 is thought to play a major role in such resistance, but N-terminal inhibitors of this target have had little s...

    Authors: Jung Min Park, Yoon-Jae Kim, Soeun Park, Minsu Park, Lee Farrand, Cong-Truong Nguyen, Jihyae Ann, Gibeom Nam, Hyun-Ju Park, Jeewoo Lee, Ji Young Kim and Jae Hong Seo

    Citation: Molecular Cancer 2020 19:161

    Content type: Letter to the Editor

    Published on:

  26. One unmet challenge in lung cancer diagnosis is to accurately differentiate lung cancer from other lung diseases with similar clinical symptoms and radiological features, such as pulmonary tuberculosis (TB). T...

    Authors: Wanjun Gu, Junchao Shi, Hui Liu, Xudong Zhang, Jin J. Zhou, Musheng Li, Dandan Zhou, Rui Li, Jingzhu Lv, Guoxia Wen, Shanshan Zhu, Ting Qi, Wei Li, Xiaojing Wang, Zhaohua Wang, Hua Zhu…

    Citation: Molecular Cancer 2020 19:159

    Content type: Letter to the Editor

    Published on:

  27. Emerging evidence has shown that circular RNAs (circRNAs) play a crucial regulatory role in the occurrence and development of cancer. Exploring the roles and mechanisms of circRNAs in tumorigenesis and progres...

    Authors: Cunying Ma, Xiaoying Wang, Fenghua Yang, Yichen Zang, Jiansong Liu, Xinyi Wang, Xia Xu, Wenjuan Li, Jihui Jia and Zhifang Liu

    Citation: Molecular Cancer 2020 19:157

    Content type: Research

    Published on:

  28. Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs) and can modulate gene expression by binding to miRNAs; further, circRNAs have been shown to participate in several pathological processes. Howeve...

    Authors: Lei Peng, Huaiming Sang, Shuchun Wei, Yuanyuan Li, Duochen Jin, Xudong Zhu, Xuan Li, Yini Dang and Guoxin Zhang

    Citation: Molecular Cancer 2020 19:156

    Content type: Research

    Published on:

  29. Accumulating evidence suggests that dysregulation of transcriptional enhancers plays a significant role in cancer pathogenesis. Herein, we performed a genome-wide discovery of enhancer elements in colorectal c...

    Authors: Kunitoshi Shigeyasu, Shusuke Toden, Tsuyoshi Ozawa, Takatoshi Matsuyama, Takeshi Nagasaka, Toshiaki Ishikawa, Debashis Sahoo, Pradipta Ghosh, Hiroyuki Uetake, Toshiyoshi Fujiwara and Ajay Goel

    Citation: Molecular Cancer 2020 19:155

    Content type: Letter to the Editor

    Published on:

  30. A more common and noninvasive predicting biomarker for programmed cell death 1 (PD-1) antibody remains to be explored. We assessed 46 patients with advanced gastric cancer who received PD-1 antibody immunother...

    Authors: Ying Jin, Dong-Liang Chen, Feng Wang, Chao-pin Yang, Xu-Xian Chen, Jin-qi You, Jin-Sheng Huang, Yang Shao, Dong-Qin Zhu, Yu-Ming Ouyang, Hui-Yan Luo, Zhi-Qiang Wang, Feng-Hua Wang, Yu-Hong Li, Rui-Hua Xu and Dong-Sheng Zhang

    Citation: Molecular Cancer 2020 19:154

    Content type: Letter to the Editor

    Published on:

  31. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Renjie Wang, Sai Zhang, Xuyi Chen, Nan Li, Jianwei Li, Ruichao Jia, Yuanqing Pan and Haiqian Liang

    Citation: Molecular Cancer 2020 19:153

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2018 17:166

  32. N6-methyladenosine (m6A) is the most abundant modification in mRNA of humans. Emerging evidence has supported the fact that m6A is comprehensively involved in various diseases especially cancers. As a crucial rea...

    Authors: Jiangfeng Li, Haiyun Xie, Yufan Ying, Hong Chen, Huaqing Yan, Liujia He, Mingjie Xu, Xin Xu, Zhen Liang, Ben Liu, Xiao Wang, Xiangyi Zheng and Liping Xie

    Citation: Molecular Cancer 2020 19:152

    Content type: Research

    Published on:

  33. Circulating cell-free DNA (cfDNA) analysis is an important tool for cancer monitoring. The patient-specific mutations identified in colorectal cancer (CRC) tissues are usually used to design the cfDNA analysis...

    Authors: Yu-Min Yeh, Peng-Chan Lin, Chung-Ta Lee, Shang-Hung Chen, Bo-Wen Lin, Shao-Chieh Lin, Po-Chuan Chen, Ren-Hao Chan and Meng-Ru Shen

    Citation: Molecular Cancer 2020 19:150

    Content type: Letter to the Editor

    Published on:

  34. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Junming Bi, Hongwei Liu, Wei Dong, Weibin Xie, Qingqing He, Zijian Cai, Jian Huang and Tianxin Lin

    Citation: Molecular Cancer 2020 19:148

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:133

  35. The highly intra-tumoral heterogeneity and complex cell origination of prostate cancer greatly limits the utility of traditional bulk RNA sequencing in finding better biomarker for disease diagnosis and strati...

    Authors: Xiaoshi Ma, Jinan Guo, Kaisheng Liu, Lipeng Chen, Dale Liu, Shaowei Dong, Jinquan Xia, Qiaoyun Long, Yongjian Yue, Pan Zhao, Fengyan Hu, Zhangang Xiao, Xinghua Pan, Kefeng Xiao, Zhiqiang Cheng, Zunfu Ke…

    Citation: Molecular Cancer 2020 19:147

    Content type: Research

    Published on:

  36. As a point of convergence for numerous oncogenic signaling pathways, signal transducer and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune response. STAT3 is broadly hyperac...

    Authors: Sailan Zou, Qiyu Tong, Bowen Liu, Wei Huang, Yan Tian and Xianghui Fu

    Citation: Molecular Cancer 2020 19:145

    Content type: Review

    Published on:

  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Lu Wang, Guang Yang, Danfeng Zhao, Jiaqi Wang, Yang Bai, Qiang Peng, Hongzhi Wang, Ruizhe Fang, Guang Chen, Zhichao Wang, Keliang Wang, Guangbin Li, Yinhui Yang, Ziqi Wang, Pengyu Guo, Li Peng…

    Citation: Molecular Cancer 2020 19:144

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:86

  38. Very few proteins encoded by the presumed non-coding RNA transcripts have been identified. Their cellular functions remain largely unknown. This study identifies the tumor-suppressor function of a novel microp...

    Authors: Min Kang, Bo Tang, Jixi Li, Ziyan Zhou, Kang Liu, Rensheng Wang, Ziyan Jiang, Fangfang Bi, David Patrick, Dongin Kim, Anirban K. Mitra and Yang Yang-Hartwich

    Citation: Molecular Cancer 2020 19:143

    Content type: Research

    Published on:

  39. Triple negative breast cancer (TNBC) remains the most challenging breast cancer subtype so far. Specific therapeutic approaches have rarely achieved clinical improvements in treatment of TNBC patients and effe...

    Authors: Jie Li, Maoguang Ma, Xuesong Yang, Maolei Zhang, Jingyan Luo, Huangkai Zhou, Nunu Huang, Feizhe Xiao, Bingquan Lai, Weiming Lv and Nu Zhang

    Citation: Molecular Cancer 2020 19:142

    Content type: Research

    Published on:

  40. Immunotherapy (IO) has revolutionized the therapy landscape of non-small cell lung cancer (NSCLC), significantly prolonging the overall survival (OS) of advanced stage patients. Over the recent years IO therap...

    Authors: Lena Horvath, Bernard Thienpont, Liyun Zhao, Dominik Wolf and Andreas Pircher

    Citation: Molecular Cancer 2020 19:141

    Content type: Review

    Published on:

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