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Review
Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is associated with higher dis...
Molecular Cancer 2017 16:114
Published on: 29 June 2017
Letter to the Editor
Several studies show that human papillomavirus (HPV) positive head and neck cancers (HNSCC) are typically characterized by low tumor and high regional node stages, intrinsically indicating high local metastati...
Molecular Cancer 2017 16:113
Published on: 29 June 2017
Research
Recent evidences showed that long noncoding RNAs (lncRNAs) are frequently dysregulated and play important roles in various cancers. Clear cell renal cell carcinoma (ccRCC) is one of the leading cause of cancer...
Molecular Cancer 2017 16:111
Published on: 28 June 2017
Letter to the Editor
BRAF inhibitors (BRAFi) are standard of care for the treatment of BRAF V600 mutation-driven metastatic melanoma, but can lead to paradoxical activation of the mitogen-activated protein kinase (MAPK) signalling pa...
Molecular Cancer 2017 16:112
Published on: 28 June 2017
Research
Glioma is one of the most frequent intracranial malignant tumors. LncRNAs have been identified as new modulators in the origination and progression of glioma.
Molecular Cancer 2017 16:110
Published on: 26 June 2017
Research
BC200 is a long non-coding RNA expressed at high levels in the brain and elevated in a variety of tumour types. BC200 has a hypothesized role in translational regulation; however, to date the functional role o...
Molecular Cancer 2017 16:109
Published on: 26 June 2017
Research
Protein regulator of cytokinesis-1 (PRC1) belongs to the microtubule-associated proteins (MAPs) family, and is involved in cytokinesis. Recent investigations suggest PRC1 involvement in human carcinogenesis, i...
Molecular Cancer 2017 16:108
Published on: 24 June 2017
Review
Cancers of the female reproductive system include ovarian, uterine, vaginal, cervical and vulvar cancers, which are termed gynecologic cancer. The emergence of long noncoding RNAs (lncRNAs), which are believed...
Molecular Cancer 2017 16:107
Published on: 21 June 2017
Research
The plasticity of cancer stem cells (CSCs)/tumor-initiating cells (T-ICs) suggests that multiple CSC/T-IC subpopulations exist within a tumor and that multiple oncogenic pathways collaborate to maintain the CS...
Molecular Cancer 2017 16:106
Published on: 21 June 2017
Research
Hypoxia is a characteristic of breast tumours indicating poor prognosis. Based on the assumption that those genes which are up-regulated under hypoxia in cell-lines are expected to be predictors of poor progno...
Molecular Cancer 2017 16:105
Published on: 15 June 2017
Research
Oct4, a key stemness transcription factor, is overexpressed in lung cancer. Here, we reveal a novel transcription regulation of long non-coding RNAs (lncRNAs) by Oct4. LncRNAs have emerged as important players...
Molecular Cancer 2017 16:104
Published on: 14 June 2017
Research
Increasing evidences demonstrate that miRNAs contribute to development and progression of hepatocellular carcinoma (HCC). Underexpression of miR-1296 is recently reported to promote growth and metastasis of hu...
Molecular Cancer 2017 16:103
Published on: 12 June 2017
Research
Most melanoma patients with BRAFV600E positive tumors respond well to a combination of BRAF kinase and MEK inhibitors. However, some patients are intrinsically resistant while the majority of patients eventually ...
Molecular Cancer 2017 16:102
Published on: 8 June 2017
Review
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary tumor in the central nervous system. One of the most widely used chemotherapeutic drugs for GBM is temozolomide, which is a DNA...
Molecular Cancer 2017 16:100
Published on: 7 June 2017
Letter to the Editor
Uterine smooth muscle tumors range from benign leiomyomas to malignant leiomyosarcomas. Based on numerous molecular studies, leiomyomas and leiomyosarcomas mostly lack shared mutations and the majority of tumo...
Molecular Cancer 2017 16:101
Published on: 7 June 2017
Research
Cancer immunotherapy offers a promising approach in cancer treatment. The adenosine A2A receptor (A2AR) could protect cancerous tissues from immune clearance via inhibiting T cells response. To date, the role ...
Molecular Cancer 2017 16:99
Published on: 7 June 2017
Research
Deregulations of long non-coding RNAs (lncRNAs) have been implicated in cancer initiation and progression. Current methods can only capture differential expression of lncRNAs at the population level and ignore...
Molecular Cancer 2017 16:98
Published on: 6 June 2017
Letter to the Editor
Advanced ovarian cancer is very responsive to first line platinum therapy, however almost invariably it relapses with a resistant disease. We have reported that patient derived ovarian xenografts (PDXs), indep...
Molecular Cancer 2017 16:97
Published on: 30 May 2017
Research
Current evidence indicates that miR-608 is widely down-regulated in various malignant tumors including liver cancer, colon cancer, lung cancer and glioma, and acts as a tumor suppressor by inhibiting cell prol...
Molecular Cancer 2017 16:96
Published on: 26 May 2017
Research
Neuroblastoma is the most common solid tumor in childhood and develops from undifferentiated progenitor cells of the sympathetic nervous system. In neuronal tumor cells DNA-damaging chemotherapeutic agents act...
Molecular Cancer 2017 16:95
Published on: 25 May 2017
Review
Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5′ cap or a 3′ Poly A tail. Although the mechanisms of circular RNAs’ generatio...
Molecular Cancer 2017 16:94
Published on: 23 May 2017
Research
The MET receptor tyrosine kinase represents a promising target in cancer. PIK3CA activating mutations are common in several tumor types and can potentially confer resistance to anti-receptor tyrosine kinase th...
Molecular Cancer 2017 16:93
Published on: 22 May 2017
Review
Ovarian cancer (OC) is one of the three types of malignant tumors in the female reproductive system, and epithelial ovarian cancer (EOC) is its most typical form. Due to the asymptomatic nature of the early st...
Molecular Cancer 2017 16:92
Published on: 15 May 2017
Research
Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response (UPR). Extensive and acute ER stress directs the U...
Molecular Cancer 2017 16:91
Published on: 12 May 2017
Research
Hematological and neurological expressed 1 (HN1) is upregulated in many tumors, but the role of HN1 in breast cancer progression and its regulatory mechanism have not been well understood.
Molecular Cancer 2017 16:90
Published on: 11 May 2017
