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  1. Review

    11q deletion in neuroblastoma: a review of biological and clinical implications

    Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is associated with higher dis...

    Vid Mlakar, Simona Jurkovic Mlakar, Gonzalo Lopez, John M. Maris, Marc Ansari and Fabienne Gumy-Pause

    Molecular Cancer 2017 16:114

    Published on: 29 June 2017

  2. Letter to the Editor

    Dual role for p16 in the metastasis process of HPV positive head and neck cancers

    Several studies show that human papillomavirus (HPV) positive head and neck cancers (HNSCC) are typically characterized by low tumor and high regional node stages, intrinsically indicating high local metastati...

    Rüveyda Dok, Mary Glorieux, Karolina Holacka, Marieke Bamps and Sandra Nuyts

    Molecular Cancer 2017 16:113

    Published on: 29 June 2017

  3. Research

    Long noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling

    Recent evidences showed that long noncoding RNAs (lncRNAs) are frequently dysregulated and play important roles in various cancers. Clear cell renal cell carcinoma (ccRCC) is one of the leading cause of cancer...

    Jia-Kuan Li, Cheng Chen, Jia-Yi Liu, Jia-Zi Shi, Shu-Peng Liu, Bing Liu, Deng-Shuang Wu, Zi-Yu Fang, Yi Bao, Ming-Ming Jiang, Ji-Hang Yuan, Le Qu and Lin-Hui Wang

    Molecular Cancer 2017 16:111

    Published on: 28 June 2017

  4. Letter to the Editor

    PLX8394, a new generation BRAF inhibitor, selectively inhibits BRAF in colonic adenocarcinoma cells and prevents paradoxical MAPK pathway activation

    BRAF inhibitors (BRAFi) are standard of care for the treatment of BRAF V600 mutation-driven metastatic melanoma, but can lead to paradoxical activation of the mitogen-activated protein kinase (MAPK) signalling pa...

    Candani S. A. Tutuka, Miles C. Andrews, John M. Mariadason, Paul Ioannidis, Christopher Hudson, Jonathan Cebon and Andreas Behren

    Molecular Cancer 2017 16:112

    Published on: 28 June 2017

  5. Research

    PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway

    Protein regulator of cytokinesis-1 (PRC1) belongs to the microtubule-associated proteins (MAPs) family, and is involved in cytokinesis. Recent investigations suggest PRC1 involvement in human carcinogenesis, i...

    Ping Zhan, Bin Zhang, Guang-min Xi, Ying Wu, Hong-bing Liu, Ya-fang Liu, Wu-jian Xu, Qing-qing Zhu, Feng Cai, Ze-jun Zhou, Ying-ying Miu, Xiao-xia Wang, Jia-jia Jin, Qian Li, Li-ping Qian, Tang-feng Lv…

    Molecular Cancer 2017 16:108

    Published on: 24 June 2017

  6. Review

    Dysregulated expression of long noncoding RNAs in gynecologic cancers

    Cancers of the female reproductive system include ovarian, uterine, vaginal, cervical and vulvar cancers, which are termed gynecologic cancer. The emergence of long noncoding RNAs (lncRNAs), which are believed...

    Elahe Seyed Hosseini, Matthieu Meryet-Figuiere, Hamed Sabzalipoor, Hamed Haddad Kashani, Hossein Nikzad and Zatollah Asemi

    Molecular Cancer 2017 16:107

    Published on: 21 June 2017

  7. Research

    Antagonizing miR-455-3p inhibits chemoresistance and aggressiveness in esophageal squamous cell carcinoma

    The plasticity of cancer stem cells (CSCs)/tumor-initiating cells (T-ICs) suggests that multiple CSC/T-IC subpopulations exist within a tumor and that multiple oncogenic pathways collaborate to maintain the CS...

    Aibin Liu, Jinrong Zhu, Geyan Wu, Lixue Cao, Zhanyao Tan, Shuxia Zhang, Lili Jiang, Jueheng Wu, Mengfeng Li, Libing Song and Jun Li

    Molecular Cancer 2017 16:106

    Published on: 21 June 2017

  8. Research

    MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway

    Increasing evidences demonstrate that miRNAs contribute to development and progression of hepatocellular carcinoma (HCC). Underexpression of miR-1296 is recently reported to promote growth and metastasis of hu...

    Qiuran Xu, Xin Liu, Zhikui Liu, Zhenyu Zhou, Yufeng Wang, Jianfeng Tu, Lijie Li, Hangxing Bao, Liu Yang and Kangsheng Tu

    Molecular Cancer 2017 16:103

    Published on: 12 June 2017

  9. Review

    Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development

    Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary tumor in the central nervous system. One of the most widely used chemotherapeutic drugs for GBM is temozolomide, which is a DNA...

    Hua-fu Zhao, Jing Wang, Wei Shao, Chang-peng Wu, Zhong-ping Chen, Shing-shun Tony To and Wei-ping Li

    Molecular Cancer 2017 16:100

    Published on: 7 June 2017

  10. Letter to the Editor

    Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors

    Uterine smooth muscle tumors range from benign leiomyomas to malignant leiomyosarcomas. Based on numerous molecular studies, leiomyomas and leiomyosarcomas mostly lack shared mutations and the majority of tumo...

    Netta Mäkinen, Kati Kämpjärvi, Norma Frizzell, Ralf Bützow and Pia Vahteristo

    Molecular Cancer 2017 16:101

    Published on: 7 June 2017

  11. Research

    Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

    Cancer immunotherapy offers a promising approach in cancer treatment. The adenosine A2A receptor (A2AR) could protect cancerous tissues from immune clearance via inhibiting T cells response. To date, the role ...

    Si-Rui Ma, Wei-Wei Deng, Jian-Feng Liu, Liang Mao, Guang-Tao Yu, Lin-Lin Bu, Ashok B. Kulkarni, Wen-Feng Zhang and Zhi-Jun Sun

    Molecular Cancer 2017 16:99

    Published on: 7 June 2017

  12. Research

    Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma

    Deregulations of long non-coding RNAs (lncRNAs) have been implicated in cancer initiation and progression. Current methods can only capture differential expression of lncRNAs at the population level and ignore...

    Fuduan Peng, Ruiping Wang, Yuanyuan Zhang, Zhangxiang Zhao, Wenbin Zhou, Zhiqiang Chang, Haihai Liang, Wenyuan Zhao, Lishuang Qi, Zheng Guo and Yunyan Gu

    Molecular Cancer 2017 16:98

    Published on: 6 June 2017

  13. Letter to the Editor

    Combination of paclitaxel, bevacizumab and MEK162 in second line treatment in platinum-relapsing patient derived ovarian cancer xenografts

    Advanced ovarian cancer is very responsive to first line platinum therapy, however almost invariably it relapses with a resistant disease. We have reported that patient derived ovarian xenografts (PDXs), indep...

    Francesca Ricci, Federica Guffanti, Giovanna Damia and Massimo Broggini

    Molecular Cancer 2017 16:97

    Published on: 30 May 2017

  14. Research

    MicroRNA-608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway

    Current evidence indicates that miR-608 is widely down-regulated in various malignant tumors including liver cancer, colon cancer, lung cancer and glioma, and acts as a tumor suppressor by inhibiting cell prol...

    Zhen Liang, Xiao Wang, Xin Xu, Bo Xie, Alin Ji, Shuai Meng, Shiqi Li, Yi Zhu, Jian Wu, Zhenghui Hu, Yiwei Lin, Xiangyi Zheng, Liping Xie and Ben Liu

    Molecular Cancer 2017 16:96

    Published on: 26 May 2017

  15. Review

    CircRNA: functions and properties of a novel potential biomarker for cancer

    Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5′ cap or a 3′ Poly A tail. Although the mechanisms of circular RNAs’ generatio...

    Shujuan Meng, Hecheng Zhou, Ziyang Feng, Zihao Xu, Ying Tang, Peiyao Li and Minghua Wu

    Molecular Cancer 2017 16:94

    Published on: 23 May 2017

  16. Research

    PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models

    The MET receptor tyrosine kinase represents a promising target in cancer. PIK3CA activating mutations are common in several tumor types and can potentially confer resistance to anti-receptor tyrosine kinase th...

    Lluís Nisa, Pascal Häfliger, Michaela Poliaková, Roland Giger, Paola Francica, Daniel Matthias Aebersold, Roch-Philippe Charles, Yitzhak Zimmer and Michaela Medová

    Molecular Cancer 2017 16:93

    Published on: 22 May 2017

  17. Research

    PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy

    Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response (UPR). Extensive and acute ER stress directs the U...

    Iris C. Salaroglio, Elisa Panada, Enrico Moiso, Ilaria Buondonno, Paolo Provero, Menachem Rubinstein, Joanna Kopecka and Chiara Riganti

    Molecular Cancer 2017 16:91

    Published on: 12 May 2017

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