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  1. C-Myc is a short-lived oncoprotein that is destroyed by ubiquitin-mediated proteolysis. Dysregulated accumulation of c-Myc commonly occurs in human cancers. Some of those cases with the dysregulated c-Myc prot...

    Authors: Jing An, Dong-Yan Yang, Qin-Zhi Xu, Shi-Meng Zhang, Yan-Ying Huo, Zeng-Fu Shang, Yu Wang, De-Chang Wu and Ping-Kun Zhou
    Citation: Molecular Cancer 2008 7:32
  2. The t(6;8) translocation found in rare and agressive myeloproliferative disorders results in a chimeric gene encoding the FOP-FGFR1 fusion protein. This protein comprises the N-terminal region of the centrosom...

    Authors: Hélène Lelièvre, Véronique Chevrier, Anne-Marie Tassin and Daniel Birnbaum
    Citation: Molecular Cancer 2008 7:30
  3. Development of therapies for patients with BRCA1 mutations has been hampered by lack of readily available in vitro and in vivo models. We recently showed that transplantation of transgenic mammary tumors as cell ...

    Authors: Mollie H Wright, Ana I Robles, Jason I Herschkowitz, Melinda G Hollingshead, Miriam R Anver, Charles M Perou and Lyuba Varticovski
    Citation: Molecular Cancer 2008 7:29
  4. Telomerase expression is detectable in 81–95% of breast carcinomas and may serve as a therapeutic target. The objective of this study was to investigate repression of telomerase activity in primary ductal brea...

    Authors: Kimberly A Elliott, Lee F Rickords and J Marcelete Labrum
    Citation: Molecular Cancer 2008 7:28
  5. it is now well established that hypoxia renders tumor cells resistant to radio- but also chemotherapy. However, few elements are currently available as for the mechanisms underlying this protection.

    Authors: Audrey Sermeus, Jean-Philippe Cosse, Marianne Crespin, Veronique Mainfroid, Francoise de Longueville, Noelle Ninane, Martine Raes, Jose Remacle and Carine Michiels
    Citation: Molecular Cancer 2008 7:27
  6. Secretion of human chorionic gonadotropin, especially its beta subunit by malignant trophoblastic tumors and varieties of tumors of different origin is now well documented; however the role of hCG in tumorogen...

    Authors: Anna Jankowska, Samuel I Gunderson, Miroslaw Andrusiewicz, Beata Burczynska, Anna Szczerba, Artur Jarmolowski, Ewa Nowak-Markwitz and Jerzy B Warchol
    Citation: Molecular Cancer 2008 7:26
  7. The development and progression of prostate cancer requires the transformation of normal zinc-accumulating epithelial cells to malignant cells that have lost the ability to accumulate zinc. This metabolic tran...

    Authors: Pei Feng, Tieluo Li, Zhixin Guan, Renty B Franklin and Leslie C Costello
    Citation: Molecular Cancer 2008 7:25
  8. There have been few studies on lymphangiogenesis in the past due to the lack of specific lymphatic endothelial markers, and lymphatic-specific growth factors. Recently, these limitations have been relieved by ...

    Authors: Giles H Cunnick, Wen G Jiang, Tony Douglas-Jones, Gareth Watkins, Kelvin F Gomez, Mike J Morgan, Ashok Subramanian, Kefah Mokbel and Robert E Mansel
    Citation: Molecular Cancer 2008 7:23
  9. Worldwide gastric carcinoma has marked geographical variations and worse outcome in patients from the West compared to the East. Although these differences has been explained by better diagnostic criteria, imp...

    Authors: Francisco J Ossandon, Cynthia Villarroel, Francisco Aguayo, Eudocia Santibanez, Naohide Oue, Wataru Yasui and Alejandro H Corvalan
    Citation: Molecular Cancer 2008 7:22
  10. Aberrant Wnt-signaling caused by mutants of β-catenin, a key regulator of the canonical Wnt-signaling pathway, is frequently detected in cancer. Only recently, it was suggested that in hepatocellular carcinoma...

    Authors: Madeleine Austinat, Ruediger Dunsch, Christian Wittekind, Andrea Tannapfel, Rolf Gebhardt and Frank Gaunitz
    Citation: Molecular Cancer 2008 7:21
  11. Elevated expression of anti-apoptotic Bcl-2 family proteins have been linked to a poor survival rate of patients with Follicular Lymphoma (FL). This prompted us to evaluate a very potent non-peptidic Small-Mol...

    Authors: Alan A Arnold, Amro Aboukameel, Jianyong Chen, Dajun Yang, Shaomeng Wang, Ayad Al-Katib and Ramzi M Mohammad
    Citation: Molecular Cancer 2008 7:20
  12. Surplus goods, produced by a community, allow individuals to dedicate their efforts to abstract problems, while enjoying the benefits of support from the community. In return, the community benefits from the i...

    Authors: David Covarrubias, Maurice Van Emburgh, Hassan R Naqvi, Christian Schmidt and Shawn Mathur
    Citation: Molecular Cancer 2008 7:18
  13. The resistance of tumour cells to apoptosis is a major contributor to the limited effectiveness of chemotherapies. Insulin-like growth factor I (IGF-I) has potential to protect cancer cells from variety of apo...

    Authors: Shi Yu Yang, Kevin M Sales, Barry J Fuller, Alexander M Seifalian and Marc C Winslet
    Citation: Molecular Cancer 2008 7:17
  14. We have recently shown that curcumin (a diferuloylmethane, the yellow pigment in turmeric) enhances apoptosis-inducing potential of TRAIL in prostate cancer PC-3 cells, and sensitizes TRAIL-resistant LNCaP cells

    Authors: Sharmila Shankar, Suthakar Ganapathy, Qinghe Chen and Rakesh K Srivastava
    Citation: Molecular Cancer 2008 7:16
  15. DNA hypermethylation events and other epimutations occur in many neoplasms, producing gene expression changes that contribute to neoplastic transformation, tumorigenesis, and tumor behavior. Some human cancers...

    Authors: J Devon Roll, Ashley G Rivenbark, Wendell D Jones and William B Coleman
    Citation: Molecular Cancer 2008 7:15
  16. Colorectal cancer (CRC) is one of the most common causes of cancer death throughout the world. In this work our aim was to study the role of the phosphoserine aminotransferase PSAT1 in colorectal cancer develo...

    Authors: Nadia Vié, Virginie Copois, Caroline Bascoul-Mollevi, Vincent Denis, Nicole Bec, Bruno Robert, Caroline Fraslon, Emmanuel Conseiller, Franck Molina, Christian Larroque, Pierre Martineau, Maguy Del Rio and Céline Gongora
    Citation: Molecular Cancer 2008 7:14
  17. The implementation of gene therapy for the treatment of pituitary tumors emerges as a promising complement to surgery and may have distinct advantages over radiotherapy for this type of tumors. Up to now, suic...

    Authors: Gloria M Console, Claudia B Herenu, Gisela A Camihort, Georgina C Luna, Maria I Bracamonte, Gustavo R Morel and Rodolfo G Goya
    Citation: Molecular Cancer 2008 7:13
  18. CD30, a 120 kDa surface phosphorylated protein is a member of tumour necrosis/nerve growth factor receptor (TNF/NGFR) family and constitutively expressed by Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin ly...

    Authors: Minglong Zhou, Faisal M Fadlelmola, Jason B Cohn, Brian Skinnider, Randy D Gascoyne and Diponkar Banerjee
    Citation: Molecular Cancer 2008 7:12
  19. Pancreatic carcinoma usually is a fatal disease with no cure, mainly due to its invasion and metastasis prior to diagnosis. We analyzed the gene expression profiles of paired primary pancreatic tumors and meta...

    Authors: Archana Thakur, Aliccia Bollig, Jiusheng Wu and Dezhong J Liao
    Citation: Molecular Cancer 2008 7:11
  20. Metastatic osteosarcoma (OS) has a very poor prognosis. New treatments are therefore wanted. The conditionally replicative adenovirus Ad5-Δ24RGD has shown promising anti-tumor effects on local cancers, includi...

    Authors: Harm CA Graat, Victor W van Beusechem, Frederik HE Schagen, M Adhiambo Witlox, Eugenie S Kleinerman, Marco N Helder, Winald R Gerritsen, Gertjan JL Kaspers and Paul IJM Wuisman
    Citation: Molecular Cancer 2008 7:9
  21. The disturbance of zinc homeostasis featured with a significant decrease of cellular zinc level was well documented to associate with the development and progression of human prostate malignancy. We have previ...

    Authors: Hua Wei, Mohamed Mokhtar Desouki, Shufei Lin, Dakai Xiao, Renty B Franklin and Pei Feng
    Citation: Molecular Cancer 2008 7:7
  22. Clear cell renal carcinoma (RCC) is the most common and invasive adult renal cancer. For the purpose of identifying RCC biomarkers, we investigated chromosomal regions and individual genes modulated in RCC pat...

    Authors: Ingrid Cifola, Roberta Spinelli, Luca Beltrame, Clelia Peano, Ester Fasoli, Stefano Ferrero, Silvano Bosari, Stefano Signorini, Francesco Rocco, Roberto Perego, Vanessa Proserpio, Francesca Raimondo, Paolo Mocarelli and Cristina Battaglia
    Citation: Molecular Cancer 2008 7:6
  23. Pancreatic cancer is the 4th leading cause of death from cancer in the U.S. The opioid growth factor (OGF; [Met5]-enkephalin) and the OGF receptor form an inhibitory growth regulatory system involved in the patho...

    Authors: Fan Cheng, Patricia J McLaughlin, Michael F Verderame and Ian S Zagon
    Citation: Molecular Cancer 2008 7:5
  24. It is increasingly clear that complex networks of relationships between genes and/or proteins govern neoplastic processes. Our understanding of these networks is expanded by the use of functional genomic and p...

    Authors: Christopher A Maxwell, Víctor Moreno, Xavier Solé, Laia Gómez, Pilar Hernández, Ander Urruticoechea and Miguel Angel Pujana
    Citation: Molecular Cancer 2008 7:4
  25. Cervical carcinogenesis is a multistep process initiated by "high risk" human papillomaviruses (HR-HPV), most commonly HPV16. The infection per se is, however, not sufficient to induce malignant conversion. Trans...

    Authors: Jose Diaz-Chavez, Rogelio Hernandez-Pando, Paul F Lambert and Patricio Gariglio
    Citation: Molecular Cancer 2008 7:3
  26. Hodgkin lymphoma (HL) and Anaplastic Large Cell Lymphoma (ALCL), are forms of malignant lymphoma defined by unique morphologic, immunophenotypic, genotypic, and clinical characteristics, but both overexpress C...

    Authors: Faisal M Fadlelmola, Minglong Zhou, Ronald J de Leeuw, Nirpjit S Dosanjh, Karynn Harmer, David Huntsman, Wan L Lam and Diponkar Banerjee
    Citation: Molecular Cancer 2008 7:2
  27. A wide variety of animal models have been used to study human breast cancer. Murine, feline and canine mammary tumor cell lines have been studied for several decades and have been shown to have numerous aspect...

    Authors: Julie A Sharp, Sonia L Mailer, Peter C Thomson, Christophe Lefèvre and Kevin R Nicholas
    Citation: Molecular Cancer 2008 7:1
  28. Bone gamma-carboxyglutamate protein (BGLAP; osteocalcin) is a small, highly conserved molecule first identified in the mineralized matrix of bone. It has been implicated in the pathophysiology of various malig...

    Authors: Hany Kayed, Sandor Bekasi, Shereen Keleg, Christoph W Michalski, Thomas Giese, Helmut Friess and Jörg Kleeff
    Citation: Molecular Cancer 2007 6:83
  29. Retinoids are potent growth inhibitory and differentiating agents in a variety of cancer cell types. We have shown that retinoids induce growth arrest in all pancreatic cancer cell lines studied, regardless of...

    Authors: Brahmchetna Singh, Richard F Murphy, Xian-Zhong Ding, Alexandra B Roginsky, Richard H Bell Jr and Thomas E Adrian
    Citation: Molecular Cancer 2007 6:82
  30. Recently, periostin (POSTN), a gene encoding a protein with similarity to the fasciclin family and involved in cell survival and angiogenesis, has emerged as a promising marker for tumor progression in various ty...

    Authors: Gaëlle Tilman, Marina Mattiussi, Francis Brasseur, Nicolas van Baren and Anabelle Decottignies
    Citation: Molecular Cancer 2007 6:80
  31. Colorectal tumors have characteristic genome-wide expression patterns that allow their distinction from normal colon epithelia and facilitate clinical prognosis. The expression heterogeneity within a primary c...

    Authors: Eike Staub, Joern Groene, Maya Heinze, Detlev Mennerich, Stefan Roepcke, Irina Klaman, Bernd Hinzmann, Esmeralda Castanos-Velez, Christian Pilarsky, Benno Mann, Thomas Brümmendorf, Birgit Weber, Heinz-Johannes Buhr and André Rosenthal
    Citation: Molecular Cancer 2007 6:79
  32. Immunity, based on a natural and an educated system, is responsible for recognition and elimination of infectious particles, cellular waste, modified self and transformed cells. This dual system guarantees tha...

    Authors: H Peter Vollmers and Stephanie Brändlein
    Citation: Molecular Cancer 2007 6:78
  33. Neoplastic cells increase glycolysis in order to produce anabolic precursors and energy within the hypoxic environment of a tumor. Ras signaling is activated in several cancers and has been found to regulate m...

    Authors: Sucheta Telang, Andrew N Lane, Kristin K Nelson, Sengodagounder Arumugam and Jason Chesney
    Citation: Molecular Cancer 2007 6:77
  34. Although a high level of functional voltage-gated sodium channel (VGSC) expression has been found in strongly metastatic human and rat prostate cancer (PCa) cells, the mechanism(s) responsible for the upregula...

    Authors: Pinar Uysal-Onganer and Mustafa BA Djamgoz
    Citation: Molecular Cancer 2007 6:76
  35. The studies on cancer-stem-cells (CSCs) have attracted so much attention in recent years as possible therapeutic implications. This study was carried out to investigate the gene expression profile of CSCs in h...

    Authors: Dong-Cheol Seo, Ji-Min Sung, Hee-Jung Cho, Hee Yi, Kun-Ho Seo, In-Soo Choi, Dong-Ku Kim, Jin-Suk Kim, Abd El-Aty AM and Ho-Chul Shin
    Citation: Molecular Cancer 2007 6:75
  36. GPI anchor attachment is catalyzed by the GPI transamidase (GPIT) complex. GAA1, PIG-T and PIG-U are the three of five GPIT subunits. Previous studies demonstrated amplification and overexpression of GPIT subunit...

    Authors: Wei-Wen Jiang, Marianna Zahurak, Zeng-Tong Zhou, Hannah Lui Park, Zhong-Min Guo, Guo-Jun Wu, David Sidransky, Barry Trink and Joseph A Califano
    Citation: Molecular Cancer 2007 6:74
  37. Bortezomib is a novel anti-cancer agent which has shown promising activity in non-small lung cancer (NSCLC) patients. However, only a subset of patients respond to this treatment. We show that NSCLC cell lines...

    Authors: Jens Voortman, Agnieszka Chęcińska and Giuseppe Giaccone
    Citation: Molecular Cancer 2007 6:73
  38. Enhanced osteoblast-dependent osteoclastogenesis due to inhibition of Wnt/β-catenin signaling in bone morphogenic protein (BMP)-driven osteoprogenitors has been repeatedly implicated in the natural history of ...

    Authors: Ken-ichi Fujita and Siegfried Janz
    Citation: Molecular Cancer 2007 6:71
  39. Lung cancer is the number one cancer killer of both men and women in the United States. Three quarters of lung cancer patients are diagnosed with regionally or distantly disseminated disease; their 5-year surv...

    Authors: Jeffrey A Tsou, Janice S Galler, Kimberly D Siegmund, Peter W Laird, Sally Turla, Wendy Cozen, Jeffrey A Hagen, Michael N Koss and Ite A Laird-Offringa
    Citation: Molecular Cancer 2007 6:70
  40. Histone deacetylase inhibitors (HDACIs) have many effects on cancer cells, such as growth inhibition, induction of cell death, differentiation, and anti-angiogenesis, all with a wide therapeutic index. However...

    Authors: Selena Kuljaca, Tao Liu, Andrew EL Tee, Michelle Haber, Murray D Norris, Tanya Dwarte and Glenn M Marshall
    Citation: Molecular Cancer 2007 6:68
  41. Ph-positive leukemias are caused by the aberrant fusion of the BCR and ABL genes. Nilotinib is a selective Bcr/Abl tyrosine kinase inhibitor related to imatinib, which is widely used to treat chronic myelogenous ...

    Authors: Pavinder Kaur, Niklas Feldhahn, Bin Zhang, Daniel Trageser, Markus Müschen, Veerle Pertz, John Groffen and Nora Heisterkamp
    Citation: Molecular Cancer 2007 6:67
  42. The incidence of malignant pleural mesothelioma (MPM) is associated with exposure to asbestos, and projections suggest that the yearly number of deaths in Western Europe due to MPM will increase until 2020. De...

    Authors: Larisa L Belyanskaya, Thomas M Marti, Sally Hopkins-Donaldson, Stefanie Kurtz, Emanuela Felley-Bosco and Rolf A Stahel
    Citation: Molecular Cancer 2007 6:66

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