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  1. Content type: Research

    Hepatocellular carcinoma (HCC) is the most common malignant liver tumor with poor clinical outcomes. Increasing amount of long non-coding RNAs (lncRNAs) have been revealed to be implicated in the carcinogenesi...

    Authors: Yufeng Wang, Liu Yang, Tianxiang Chen, Xin Liu, Yang Guo, Qiaojuan Zhu, Xiangmin Tong, Wei Yang, Qiuran Xu, Dongsheng Huang and Kangsheng Tu

    Citation: Molecular Cancer 2019 18:28

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  2. Content type: Research

    Circular RNA (circRNA) represents a broad and diverse endogenous RNAs that can regulate gene expression in cancer. However, the regulation and function of bladder cancer (BC) circRNAs remain largely unknown.

    Authors: Hongwei Su, Tao Tao, Zhao Yang, Xing Kang, Xu Zhang, Danyue Kang, Song Wu and Chong Li

    Citation: Molecular Cancer 2019 18:27

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  3. Content type: Review

    Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one of the most important intracellular pathways, which can be considered as a master regulator for cancer. Enormous e...

    Authors: Jing Yang, Ji Nie, Xuelei Ma, Yuquan Wei, Yong Peng and Xiawei Wei

    Citation: Molecular Cancer 2019 18:26

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  4. Content type: Research

    Circular RNAs (circRNAs) are a class of non-coding RNAs with a loop structure, but its functions remain largely unknown. Growing evidence has revealed that circRNAs play a striking role as functional RNAs in t...

    Authors: Dawei Rong, Chen Lu, Betty Zhang, Kai Fu, Shuli Zhao, Weiwei Tang and Hongyong Cao

    Citation: Molecular Cancer 2019 18:25

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  5. Content type: Letter to the Editor

    Axl receptor tyrosine kinase is involved in the growth and metastasis and is an indicator of poor prognosis in several cancers including lung cancers. Although a mitogen-activated protein kinase (MAPK) pathway...

    Authors: Yoko Tsukita, Naoya Fujino, Eisaku Miyauchi, Ryoko Saito, Fumiyoshi Fujishima, Koji Itakura, Yorihiko Kyogoku, Koji Okutomo, Mitsuhiro Yamada, Tatsuma Okazaki, Hisatoshi Sugiura, Akira Inoue, Yoshinori Okada and Masakazu Ichinose

    Citation: Molecular Cancer 2019 18:24

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  6. Content type: Research

    Increasing studies has found that circular RNAs (circRNAs) play vital roles in cancer progression. But the expression profile and function of circRNAs in triple-negative breast cancer (TNBC) are unclear.

    Authors: Hailin Tang, Xiaojia Huang, Jin Wang, Lu Yang, Yanan Kong, Guanfeng Gao, Lijuan Zhang, Zhe-Sheng Chen and Xiaoming Xie

    Citation: Molecular Cancer 2019 18:23

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  7. Content type: Research

    Though esophageal cancer is three to four times more common among males than females worldwide, this type of cancer still ranks in the top incidence among women, even more than the female specific cancer types...

    Authors: Wei Li, Liyuan Zhang, Binbin Guo, Jieqiong Deng, Siqi Wu, Fang Li, Yirong Wang, Jiachun Lu and Yifeng Zhou

    Citation: Molecular Cancer 2019 18:22

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  9. Content type: Research

    CircRNA has emerged as a new non-coding RNA that plays crucial roles in tumour initiation and development. ‘MiRNA sponge’ is the most reported role played by circRNAs in many tumours. The AKT/mTOR axis is a cl...

    Authors: Xing Zhang, Sen Wang, Haixiao Wang, Jiacheng Cao, Xiaoxu Huang, Zheng Chen, Penghui Xu, Guangli Sun, Jianghao Xu, Jialun Lv and Zekuan Xu

    Citation: Molecular Cancer 2019 18:20

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  10. Content type: Letter to the Editor

    The current histopathological risk-stratification criteria in colorectal cancer (CRC) patients following a curative surgery remain inadequate. In this study, we undertook a systematic, genomewide, biomarker di...

    Authors: Takatoshi Matsuyama, Toshiaki Ishikawa, Naoki Takahashi, Yasuhide Yamada, Masamichi Yasuno, Tatsuyuki Kawano, Hiroyuki Uetake and Ajay Goel

    Citation: Molecular Cancer 2019 18:19

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  11. Content type: Research

    Lysyl oxidase-like 4 (LOXL4) has been found to be dysregulated in several human malignancies, including hepatocellular carcinoma (HCC). However, the role of LOXL4 in HCC progression remains largely unclear. In...

    Authors: Rongkun Li, Yahui Wang, Xiaoxin Zhang, Mingxuan Feng, Jun Ma, Jun Li, Xiaomei Yang, Fang Fang, Qiang Xia, Zhigang Zhang, Mingyi Shang and Shuheng Jiang

    Citation: Molecular Cancer 2019 18:18

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  12. Content type: Review

    Autophagy is a genetically well-controlled cellular process that is tightly controlled by a set of core genes, including the family of autophagy-related genes (ATG). Autophagy is a “double-edged sword” in tumo...

    Authors: Guan-Min Jiang, Yuan Tan, Hao Wang, Liang Peng, Hong-Tao Chen, Xiao-Jun Meng, Ling-Ling Li, Yan Liu, Wen-Fang Li and Hong Shan

    Citation: Molecular Cancer 2019 18:17

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  13. Content type: Letter to the Editor

    Esophageal squamous cell cancer (ESCC) is a high incidence and mortality disease worldwide. However, specificity and sensitivity of its diagnostic and prognostic biomarkers are still unsatisfactory. Recently, ...

    Authors: Liyuan Fan, Qiang Cao, Jia Liu, Junpeng Zhang and Baosheng Li

    Citation: Molecular Cancer 2019 18:16

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  14. Content type: Research

    The long noncoding RNA (lncRNA) OTUD6B antisense RNA 1 (OTUD6B-AS1) is oriented in an antisense direction to the protein-coding gene OTUD6B on the opposite DNA strand. TCGA database data show that the expressi...

    Authors: Gang Wang, Zi-jian Zhang, Wen-gang Jian, Pan-hong Liu, Wei Xue, Teng-da Wang, Yu-yang Meng, Chao Yuan, Hao-ming Li, Yi-peng Yu, Zhan-xin Liu, Qiong Wu, Da-ming Zhang and Cheng Zhang

    Citation: Molecular Cancer 2019 18:15

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  16. Content type: Letter to the Editor

    Circular RNAs are widely expressed in eukaryotic cells and associated with cancer. However, limited studies to date have focused on the potential role of circRNAs in progression of lung cancer. Data from the c...

    Authors: Lijian Chen, Aruo Nan, Nan Zhang, Yangyang Jia, Xin Li, Yihui Ling, Jiabin Dai, Shaozhu Zhang, Qiaoyuan Yang, Yanni Yi and Yiguo Jiang

    Citation: Molecular Cancer 2019 18:13

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  18. Content type: Research

    MYCN amplification or N-Myc overexpression is found in approximately 40% NEPC and up to 20% CRPC patients. N-Myc has been demonstrated to drive disease progression and hormonal therapeutic resistance of NEPC/CRPC...

    Authors: Yu Yin, Lingfan Xu, Yan Chang, Tao Zeng, Xufeng Chen, Aifeng Wang, Jeff Groth, Wen-Chi Foo, Chaozhao Liang, Hailiang Hu and Jiaoti Huang

    Citation: Molecular Cancer 2019 18:11

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  19. Content type: Review

    Tumor immune escape is an important strategy of tumor survival. There are many mechanisms of tumor immune escape, including immunosuppression, which has become a research hotspot in recent years. The programme...

    Authors: Xianjie Jiang, Jie Wang, Xiangying Deng, Fang Xiong, Junshang Ge, Bo Xiang, Xu Wu, Jian Ma, Ming Zhou, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Can Guo and Zhaoyang Zeng

    Citation: Molecular Cancer 2019 18:10

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  20. Content type: Research

    Breast cancer is one of the most common malignancies and the major cause of cancer-related death in women. Although the importance of PIWI-interacting RNAs (piRNAs) in cancer has been increasingly recognized, ...

    Authors: Liping Tan, Dongmei Mai, Bailin Zhang, Xiaobing Jiang, Jialiang Zhang, Ruihong Bai, Ying Ye, Mei Li, Ling Pan, Jiachun Su, Yanfen Zheng, Zexian Liu, Zhixiang Zuo, Qi Zhao, Xiaoxing Li, Xudong Huang…

    Citation: Molecular Cancer 2019 18:9

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  21. Content type: Letter to the Editor

    In this study, the secondary sequencing was used to profile circRNA expression in the tissue samples from three CRC patients with liver metastasis and three matched CRC patients. After verified some candidates...

    Authors: Hanchen Xu, Chunyan Wang, Haiyan Song, Yangxian Xu and Guang Ji

    Citation: Molecular Cancer 2019 18:8

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  22. Content type: Letter to the Editor

    Understanding of intratumor heterogeneity (ITH) among different non-small cell lung cancer (NSCLC) subtypes is necessary. Whether circulating tumor DNA (ctDNA) profile could represent these ITH is still an ope...

    Authors: Yaxiong Zhang, Lianpeng Chang, Yunpeng Yang, Wenfeng Fang, Yanfang Guan, Aiwei Wu, Shaodong Hong, Huaqiang Zhou, Gang Chen, Xi Chen, Shen Zhao, Qiufan Zheng, Hui Pan, Lanjun Zhang, Hao Long, Haoxian Yang…

    Citation: Molecular Cancer 2019 18:7

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  23. Content type: Review

    Covalently closed single-stranded circular RNAs (circRNAs) consist of introns or exons and are widely present in eukaryotic cells. CircRNAs generally have low expression levels and relatively stable structures...

    Authors: Qingfeng Shang, Zhi Yang, Renbing Jia and Shengfang Ge

    Citation: Molecular Cancer 2019 18:6

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  25. Content type: Research

    In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement of initiation and progression of diverse kinds of human ...

    Authors: Rui Yang, Lei Xing, Xiaying Zheng, Yan Sun, Xiaosong Wang and Junxia Chen

    Citation: Molecular Cancer 2019 18:4

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  26. Content type: Research

    Trastuzumab resistance followed by metastasis is a major obstacle for improving the clinical outcome of patients with advanced human epidermal growth factor receptor 2-positive (HER-2+) breast cancer. While lo...

    Authors: Huaying Dong, Jianguo Hu, Kejian Zou, Mulin Ye, Yuanwen Chen, Chengyi Wu, Xin Chen and Mingli Han

    Citation: Molecular Cancer 2019 18:3

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  27. Content type: Letter to the Editor

    Recent studies identified that low levels of tumour suppressor microRNAs (miRNAs) in plasma/serum relate to tumour progression and poor outcomes in cancers. We selected six candidates (miR-126, 133b, 143, 203,...

    Authors: Jun Kiuchi, Shuhei Komatsu, Taisuke Imamura, Keiji Nishibeppu, Katsutoshi Shoda, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Atsushi Shiozaki, Kazuma Okamoto, Hitoshi Fujiwara, Daisuke Ichikawa and Eigo Otsuji

    Citation: Molecular Cancer 2019 18:2

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  28. Content type: Research

    Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, and serves as a conduit for...

    Authors: Yunzhao Chen, Dandan Wang, Hao Peng, Xi Chen, Xueping Han, Jie Yu, Wenjie Wang, Lirong Liang, Zheng Liu, Yi Zheng, Jianming Hu, Lan Yang, Jun Li, Hong Zhou, Xiaobin Cui and Feng Li

    Citation: Molecular Cancer 2019 18:1

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  29. Content type: Review

    Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with high morbidity, relapse and mortality rates. Multipotent mesenchymal stromal cells (MSCs) can be recruited to and become int...

    Authors: Zeli Yin, Keqiu Jiang, Rui Li, Chengyong Dong and Liming Wang

    Citation: Molecular Cancer 2018 17:178

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  30. Content type: Letter to the Editor

    Right-sided colon cancer (RCC) has worse prognosis compared to left-sided colon cancer (LCC) and rectal cancer. The reason for this difference in outcomes is not well understood. We performed comparative somat...

    Authors: Robin Imperial, Zaheer Ahmed, Omer M. Toor, Cihat Erdoğan, Ateeq Khaliq, Paul Case, James Case, Kevin Kennedy, Lee S. Cummings, Niklas Melton, Shahzad Raza, Banu Diri, Ramzi Mohammad, Bassel El-Rayes, Timothy Pluard, Arif Hussain…

    Citation: Molecular Cancer 2018 17:177

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  31. Content type: Research

    Although the genetic spectrum of human colorectal cancer (CRC) is mainly characterized by APC, KRAS and TP53 mutations, driver genes in tumor initiation have not been conclusively demonstrated. In this study, we ...

    Authors: Erfei Chen, Fangfang Yang, Hongjuan He, Qiqi Li, Wei Zhang, Jinliang Xing, Ziqing Zhu, Jingjing Jiang, Hua Wang, Xiaojuan Zhao, Ruitao Liu, Lei Lei, Jing Dong, Yuchen Pei, Ying Yang, Junqiang Pan…

    Citation: Molecular Cancer 2018 17:176

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  32. Content type: Letter to the Editor

    Even when targets responsible for chemoresistance are identified, drug development is often hampered due to the poor druggability of these proteins. We systematically analyzed therapy-resistance with a large-s...

    Authors: Soon-Ki Hong, Haeseung Lee, Ok-Seon Kwon, Na-Young Song, Hyo-Ju Lee, Seungmin Kang, Jeong-Hwan Kim, Mirang Kim, Wankyu Kim and Hyuk-Jin Cha

    Citation: Molecular Cancer 2018 17:175

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  33. Content type: Research

    Chromatin modification at mitosis is closely related to transcriptional reactivation in the subsequent cell cycle. We reasoned this process is deregulated by oncogenic signals, which would contribute to mitoti...

    Authors: Jingjie Li, Bin Hu, Ting Wang, Wenhua Huang, Chunmin Ma, Qin Zhao, Lingang Zhuo, Tao Zhang and Yuhui Jiang

    Citation: Molecular Cancer 2018 17:174

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  34. Content type: Research

    Liver cancer is one of the most deadly cancers in the world. There are various cells in liver tumor bulk, including liver tumor initiating cells (TICs), which account for liver tumorigenesis, drug resistance, ...

    Authors: Ming Shao, Qiankun Yang, Weitao Zhu, Huifang Jin, Jing Wang, Jie Song, Yongkui Kong and Xianping Lv

    Citation: Molecular Cancer 2018 17:173

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  35. Content type: Research

    Cellular senescence is a state of irreversible cell growth arrest and senescence cells permanently lose proliferation potential. Induction of cellular senescence might be a novel therapy for cancer cells. TRIB...

    Authors: Zhenlin Hou, Kaixuan Guo, Xuling Sun, Fuqing Hu, Qianzhi Chen, Xuelai Luo, Guihua Wang, Junbo Hu and Li Sun

    Citation: Molecular Cancer 2018 17:172

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  36. Content type: Letter to the Editor

    Tumorigenesis is increasingly considered to rely on subclones of cells poised to undergo an epithelial to mesenchymal transition (EMT) program. We and others have provided evidence, however, that the tumorigen...

    Authors: Sofie Otzen Bagger, Branden Michael Hopkinson, Deo Prakash Pandey, Mads Bak, Andreas Vincent Brydholm, Rene Villadsen, Kristian Helin, Lone Rønnov-Jessen, Ole William Petersen and Jiyoung Kim

    Citation: Molecular Cancer 2018 17:171

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  37. Content type: Research

    There is an urgent need to identify new molecular targets for treatment of osteosarcoma. Circular RNAs are a class of endogenous RNAs that are extensively found in mammalian cells and exert critical functions ...

    Authors: Gang Liu, Kangmao Huang, Zhiwei Jie, Yizheng Wu, Junxin Chen, Zizheng Chen, Xiangqian Fang and Shuying Shen

    Citation: Molecular Cancer 2018 17:170

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  38. Content type: Letter to the Editor

    EphB2 and EphA2 control stemness and differentiation in the intestinal mucosa, but the way they cooperate with the complex mechanisms underlying tumor heterogeneity and how they affect the therapeutic outcome ...

    Authors: Mariangela De Robertis, Tommaso Mazza, Caterina Fusilli, Luisa Loiacono, Maria Luana Poeta, Massimo Sanchez, Emanuela Massi, Giuseppe Lamorte, Maria Grazia Diodoro, Edoardo Pescarmona, Emanuela Signori, Graziano Pesole, Angelo Luigi Vescovi, Jesus Garcia-Foncillas and Vito Michele Fazio

    Citation: Molecular Cancer 2018 17:169

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  39. Content type: Review

    Recent studies have shown that on one hand, tumors need to obtain a sufficient energy supply, and on the other hand they must evade the body’s immune surveillance. Because of their metabolic reprogramming char...

    Authors: Yi-an Wang, Xiao-Ling Li, Yong-Zhen Mo, Chun-Mei Fan, Le Tang, Fang Xiong, Can Guo, Bo Xiang, Ming Zhou, Jian Ma, Xi Huang, Xu Wu, Yong Li, Gui-Yuan Li, Zhao-yang Zeng and Wei Xiong

    Citation: Molecular Cancer 2018 17:168

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  40. Content type: Letter to the Editor

    Vasculogenic mimicry (VM) gives rise to tumor neovascularization that is critical for tumor growth and metastasis. Long non-coding RNAs (lncRNAs) have been implicated in diverse and fundamental biological proc...

    Authors: Zhenzi Peng, Jun Wang, Bin Shan, Bin Li, Wei Peng, Yeping Dong, Wenwen Shi, Wenyuan Zhao, Dan He, Minghao Duan, Yuanda Cheng, Chunfang Zhang and Chaojun Duan

    Citation: Molecular Cancer 2018 17:167

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  41. Content type: Research

    Circular RNAs (circRNAs) have been found to play critical roles in the development and progression of various cancers. However, little is known about the effects of the circular RNA network on glioblastoma mul...

    Authors: Renjie Wang, Sai Zhang, Xuyi Chen, Nan Li, Jianwei Li, Ruichao Jia, Yuanqing Pan and Haiqian Liang

    Citation: Molecular Cancer 2018 17:166

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  42. Content type: Research

    Non-coding RNAs (ncRNAs) have been reported to participate in tumor progression by regulating gene expression. Previous studies showed that protein phosphatase Mg2+/Mn2+ dependent 1F (PPM1F) acts a dual role in c...

    Authors: Hongjian Wang, Wei Chen, Ming Jin, Lidan Hou, Xiaoyu Chen, Rui Zhang, Jing Zhang and Jinshui Zhu

    Citation: Molecular Cancer 2018 17:165

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  43. Content type: Review

    BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes expression regulation. Inhibition of B...

    Authors: Benedetta Donati, Eugenia Lorenzini and Alessia Ciarrocchi

    Citation: Molecular Cancer 2018 17:164

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  44. Content type: Letter to the Editor

    tRNA-derived small non-coding RNAs (tsncRNAs), a class of newly defined small non-coding RNA, have been considered to be involved in various cellular biological processes through regulating gene expression at ...

    Authors: Eric Y. Peng, Yang Shu, Yuke Wu, Feier Zeng, Shuangyan Tan, Yun Deng, Yiqi Deng, Haining Chen, Lei Zhu and Heng Xu

    Citation: Molecular Cancer 2018 17:163

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  45. Content type: Letter to the Editor

    LncRNAs are involved in the initiation and progression of cancer. However, the molecular mechanism and diverse clinical prognosis of MIR31HG in head and neck squamous cell carcinoma (HNSCC) are still unclear. ...

    Authors: Ru Wang, Zhihong Ma, Ling Feng, Yifan Yang, Chen Tan, Qian Shi, Meng Lian, Shizhi He, Hongzhi Ma and Jugao Fang

    Citation: Molecular Cancer 2018 17:162

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  46. Content type: Research

    Increasing evidence has revealed that circular RNAs (circRNAs) play crucial roles in cancer biology. However, the role and underlying regulatory mechanisms of circFNDC3B in bladder cancer (BC) remain unknown.

    Authors: Hongwei Liu, Junming Bi, Wei Dong, Meihua Yang, Juanyi Shi, Ning Jiang, Tianxin Lin and Jian Huang

    Citation: Molecular Cancer 2018 17:161

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  47. Content type: Research

    Recent studies indicate that circular RNA (circRNA) plays a pivotal role in cancer progression. Here, we sought to investigate its role in breast cancer.

    Authors: Kaixuan Zeng, Bangshun He, Burton B. Yang, Tao Xu, Xiaoxiang Chen, Mu Xu, Xiangxiang Liu, Huiling Sun, Yuqin Pan and Shukui Wang

    Citation: Molecular Cancer 2018 17:160

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  48. Content type: Letter to the Editor

    Tob1, a Tob/BTG anti-proliferative protein family member, functions as a tumour suppressor in many cancers. Here, we reveal a unique oncogenic role of Tob1 in colon cancer. Tob1 expression was upregulated duri...

    Authors: Dandan Li, Li Xiao, Yuetan Ge, Yu Fu, Wenqing Zhang, Hanwei Cao, Binbin Chen, Haibin Wang, Yan-yan Zhan and Tianhui Hu

    Citation: Molecular Cancer 2018 17:159

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  49. Content type: Review

    Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the infla...

    Authors: Maryam Moossavi, Negin Parsamanesh, Afsane Bahrami, Stephen L. Atkin and Amirhossein Sahebkar

    Citation: Molecular Cancer 2018 17:158

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  50. Content type: Research

    Although microRNAs (miRNAs) were revealed as crucial modulators in tumor metastasis and target therapy, our understanding of their roles in metastatic renal cell carcinoma (mRCC) and Sunitinib treatment was li...

    Authors: Wei Zhai, Saiyang Li, Jin Zhang, Yonghui Chen, Junjie Ma, Wen Kong, Dongkui Gong, Junhua Zheng, Wei Xue and Yunfei Xu

    Citation: Molecular Cancer 2018 17:157

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Molecular Cancer

ISSN: 1476-4598