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Research
Glioma stem cells (GSCs) are a major cause of the frequent relapse observed in glioma, due to their high drug resistance and their differentiation potential. Therefore, understanding the molecular mechanisms g...
Molecular Cancer 2017 16:140
Published on: 22 August 2017
Research
The aberrant expression of microRNA-140-5p (miR-140-5p) has been described in gastric cancer (GC). However, the role of miR-140-5p in GC remains unclear. In this study, the prognostic relevance of miR-140-5p i...
Molecular Cancer 2017 16:139
Published on: 17 August 2017
Research
There is increasing evidence in support of the role of lncRNAs in tumor cell proliferation, differentiation and apoptosis.
Molecular Cancer 2017 16:138
Published on: 17 August 2017
Review
Expression of high levels of immune cells including neutrophils has been associated with detrimental outcome in several solid tumors and new strategies to decrease their presence and activity are currently und...
Molecular Cancer 2017 16:137
Published on: 15 August 2017
Research
Several of the thousands of human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in hepatocellular carcinoma (HCC) remains poorly understood.
Molecular Cancer 2017 16:136
Published on: 14 August 2017
Research
RAB GTPases are important in the regulation of membrane trafficking and cell movement. Recently, exocytic RABs have received increasing attention in cancer research. However, the functional roles of exocytic R...
Molecular Cancer 2017 16:135
Published on: 7 August 2017
Review
RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention. In the development of RNAi-based therapies, nanoparticle...
Molecular Cancer 2017 16:134
Published on: 28 July 2017
Research
Protein-tyrosine phosphatase MEG2 (MEG2) is a classic tyrosine-specific protein tyrosine phosphatase (PTP). It has been reported that MEG2 participates in the carcinogenesis of the breast and liver. However, f...
Molecular Cancer 2017 16:133
Published on: 26 July 2017
Research
Although gemcitabine-based chemotherapy has been established as a core multimodal therapy for non-small cell lung cancer (NSCLC) treatment, its clinical efficacy remains limited by the development of acquired ...
Molecular Cancer 2017 16:132
Published on: 25 July 2017
Research
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated mortality worldwide with an overall five-year survival rate less than 7%. Accumulating evidence has revealed the cancer ...
Molecular Cancer 2017 16:131
Published on: 24 July 2017
Review
Long-noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides and do not code for proteins. However, this class of RNAs plays pivotal regulatory roles. The mechanism of their ac...
Molecular Cancer 2017 16:130
Published on: 24 July 2017
Research
Few long noncoding RNAs (lncRNAs) that act as oncogenic genes in breast cancer have been identified.
Molecular Cancer 2017 16:129
Published on: 24 July 2017
Research
Despite accumulating evidence that long noncoding RNAs (lncRNAs) are associated with cancer development in multiple types of cancer, the biological roles of many lncRNAs in human hepatocellular carcinoma (HCC)...
Molecular Cancer 2017 16:125
Published on: 19 July 2017
Research
Long non-coding RNAs (lncRNAs) play a variety of cellular roles, including regulation of transcription and translation, leading to alterations in gene expression. Some lncRNAs modulate the expression of chromo...
Molecular Cancer 2017 16:126
Published on: 19 July 2017
Review
The WW domain is composed of 38 to 40 semi-conserved amino acids shared with structural, regulatory, and signaling proteins. WW domain-binding protein 2 (WBP2), as a binding partner of WW domain protein, inter...
Molecular Cancer 2017 16:128
Published on: 19 July 2017
Research
Epidermal growth factor receptor (EGFR), a well-known oncogenic driver, contributes to the initiation and progression of a wide range of cancer types. Aberrant lipid metabolism including highly produced monoun...
Molecular Cancer 2017 16:127
Published on: 19 July 2017
Research
The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study FOXP3 expression and regulation, function and clinical implication in human non-small cell lung cancer (NSCLC).
Molecular Cancer 2017 16:124
Published on: 17 July 2017
Research
Aberrant microRNA expression has been implicated in metastasis of cancers. MiR-661 accelerates proliferation and invasion of breast cancer and ovarian cancer, while impedes that of glioma. Its role in non smal...
Molecular Cancer 2017 16:122
Published on: 17 July 2017
Research
Recently, it has been reported that long non-coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2), a novel tumor suppressor, participates in regulating the carcinogenesis and suppresses tumor progress...
Molecular Cancer 2017 16:123
Published on: 17 July 2017
Retraction Note
Molecular Cancer 2017 16:121
Published on: 17 July 2017
The original article was published in Molecular Cancer 2013 12:34
Research
Pancreatic cancer is a devastating disease that is characterized by persistent hypoxia. The roles of hypoxia-inducible factor-2α (hif-2α) are different to those of hif-1α, although both are critical for tumor ...
Molecular Cancer 2017 16:119
Published on: 14 July 2017
Research
Clonal competition in cancer describes the process in which the progeny of a cell clone supersedes or succumbs to other competing clones due to differences in their functional characteristics, mostly based on ...
Molecular Cancer 2017 16:120
Published on: 14 July 2017
Research
The function of a new long non-coding RNA linc00673 remains unclear. While identified as an oncogenic player in non-small cell lung cancer (NSCLC), linc00673 was found to be anti-oncogenic in pancreatic ductal...
Molecular Cancer 2017 16:118
Published on: 11 July 2017
Research
The primary issue arising from prostate cancer (PCa) is its high prevalence to metastasize to bone, which severely affects the quality of life and survival time of PCa patients. miR-210-3p is a well-documented...
Molecular Cancer 2017 16:117
Published on: 10 July 2017
Letter to the Editor
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with constitutive activation of the MAPKinase RAS-RAF-MEK-ERK cell signaling pathway. We analyzed 9 LCH cases without BRAF ...
Molecular Cancer 2017 16:115
Published on: 6 July 2017
