Sort by
Previous Page Page 1 of 79 Next Page
  1. Research

    Role of MEK partner-1 in cancer stemness through MEK/ERK pathway in cancerous neural stem cells, expressing EGFRviii

    Glioma stem cells (GSCs) are a major cause of the frequent relapse observed in glioma, due to their high drug resistance and their differentiation potential. Therefore, understanding the molecular mechanisms g...

    Soo-Jung Kwon, Ok-Seon Kwon, Keun-Tae Kim, Young-Hyun Go, Si-in Yu, Byeong-ha Lee, Hiroyuki Miyoshi, Eunsel Oh, Seung-Ju Cho and Hyuk-Jin Cha

    Molecular Cancer 2017 16:140

    Published on: 22 August 2017

  2. Research

    miR-140-5p suppresses the proliferation, migration and invasion of gastric cancer by regulating YES1

    The aberrant expression of microRNA-140-5p (miR-140-5p) has been described in gastric cancer (GC). However, the role of miR-140-5p in GC remains unclear. In this study, the prognostic relevance of miR-140-5p i...

    Zheng Fang, Shuai Yin, Ruochuan Sun, Shangxin Zhang, Min Fu, Youliang Wu, Tao Zhang, Junaid Khaliq and Yongxiang Li

    Molecular Cancer 2017 16:139

    Published on: 17 August 2017

  3. Review

    Neutrophils in cancer: prognostic role and therapeutic strategies

    Expression of high levels of immune cells including neutrophils has been associated with detrimental outcome in several solid tumors and new strategies to decrease their presence and activity are currently und...

    Alberto Ocana, Cristina Nieto-Jiménez, Atanasio Pandiella and Arnoud J Templeton

    Molecular Cancer 2017 16:137

    Published on: 15 August 2017

  4. Research

    STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4

    Several of the thousands of human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in hepatocellular carcinoma (HCC) remains poorly understood.

    Hui Wang, Xisong Huo, Xin-Rong Yang, Jia He, Lijun Cheng, Na Wang, Xuan Deng, Haojie Jin, Ning Wang, Cun Wang, Fangyu Zhao, Jingyuan Fang, Ming Yao, Jia Fan and Wenxin Qin

    Molecular Cancer 2017 16:136

    Published on: 14 August 2017

  5. Research

    Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis

    RAB GTPases are important in the regulation of membrane trafficking and cell movement. Recently, exocytic RABs have received increasing attention in cancer research. However, the functional roles of exocytic R...

    Yu-Chan Chang, Chia-Yi Su, Ming-Huang Chen, Wei-Shone Chen, Chi-Long Chen and Michael Hsiao

    Molecular Cancer 2017 16:135

    Published on: 7 August 2017

  6. Review

    Nano-based delivery of RNAi in cancer therapy

    RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention. In the development of RNAi-based therapies, nanoparticle...

    Yong Xin, Min Huang, Wen Wen Guo, Qian Huang, Long zhen Zhang and Guan Jiang

    Molecular Cancer 2017 16:134

    Published on: 28 July 2017

  7. Research

    MEG2 is regulated by miR-181a-5p and functions as a tumour suppressor gene to suppress the proliferation and migration of gastric cancer cells

    Protein-tyrosine phosphatase MEG2 (MEG2) is a classic tyrosine-specific protein tyrosine phosphatase (PTP). It has been reported that MEG2 participates in the carcinogenesis of the breast and liver. However, f...

    Zhijian Liu, Feng Sun, Yeting Hong, Yanqing Liu, Min Fen, Kai Yin, Xiaolong Ge, Feng Wang, Xi Chen and Wenxian Guan

    Molecular Cancer 2017 16:133

    Published on: 26 July 2017

  8. Research

    Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p

    Although gemcitabine-based chemotherapy has been established as a core multimodal therapy for non-small cell lung cancer (NSCLC) treatment, its clinical efficacy remains limited by the development of acquired ...

    Feng Wei, Chengyuan Ma, Tong Zhou, Xuechao Dong, Qinghua Luo, Li Geng, Lijuan Ding, Yandong Zhang, Li Zhang, Nan Li, Yang Li and Yan Liu

    Molecular Cancer 2017 16:132

    Published on: 25 July 2017

  9. Research

    Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer

    Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated mortality worldwide with an overall five-year survival rate less than 7%. Accumulating evidence has revealed the cancer ...

    Ke Chen, Weikun Qian, Zhengdong Jiang, Liang Cheng, Jie Li, Liankang Sun, Cancan Zhou, Luping Gao, Meng Lei, Bin Yan, Junyu Cao, Wanxing Duan and Qingyong Ma

    Molecular Cancer 2017 16:131

    Published on: 24 July 2017

  10. Review

    Role of long non-coding RNAs in glucose metabolism in cancer

    Long-noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides and do not code for proteins. However, this class of RNAs plays pivotal regulatory roles. The mechanism of their ac...

    Chunmei Fan, Yanyan Tang, Jinpeng Wang, Fang Xiong, Can Guo, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Fang Wei, Liting Yang, Yi He, Ming Zhou, Xiaoling Li, Guiyuan Li, Wei Xiong and Zhaoyang Zeng

    Molecular Cancer 2017 16:130

    Published on: 24 July 2017

  11. Research

    The noncoding RNA HOXD-AS1 is a critical regulator of the metastasis and apoptosis phenotype in human hepatocellular carcinoma

    Despite accumulating evidence that long noncoding RNAs (lncRNAs) are associated with cancer development in multiple types of cancer, the biological roles of many lncRNAs in human hepatocellular carcinoma (HCC)...

    Shan Lu, Jiansheng Zhou, Yimin Sun, Nan Li, Mingyong Miao, Binghua Jiao and Huan Chen

    Molecular Cancer 2017 16:125

    Published on: 19 July 2017

  12. Research

    The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia

    Long non-coding RNAs (lncRNAs) play a variety of cellular roles, including regulation of transcription and translation, leading to alterations in gene expression. Some lncRNAs modulate the expression of chromo...

    Thilini R. Fernando, Jorge R. Contreras, Matteo Zampini, Norma I. Rodriguez-Malave, Michael O. Alberti, Jaime Anguiano, Tiffany M. Tran, Jayanth K. Palanichamy, Jasmine Gajeton, Nolan M. Ung, Cody J. Aros, Ella V. Waters, David Casero, Giuseppe Basso, Martina Pigazzi and Dinesh S. Rao

    Molecular Cancer 2017 16:126

    Published on: 19 July 2017

  13. Review

    WW domain-binding protein 2: an adaptor protein closely linked to the development of breast cancer

    The WW domain is composed of 38 to 40 semi-conserved amino acids shared with structural, regulatory, and signaling proteins. WW domain-binding protein 2 (WBP2), as a binding partner of WW domain protein, inter...

    Shuai Chen, Han Wang, Yu-Fan Huang, Ming-Li Li, Jiang-Hong Cheng, Peng Hu, Chuan-Hui Lu, Ya Zhang, Na Liu, Chi-Meng Tzeng and Zhi-Ming Zhang

    Molecular Cancer 2017 16:128

    Published on: 19 July 2017

  14. Research

    EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer

    Epidermal growth factor receptor (EGFR), a well-known oncogenic driver, contributes to the initiation and progression of a wide range of cancer types. Aberrant lipid metabolism including highly produced monoun...

    Jiqin Zhang, Fei Song, Xiaojing Zhao, Hua Jiang, Xiuqi Wu, Biao Wang, Min Zhou, Mi Tian, Bizhi Shi, Huamao Wang, Yuanhui Jia, Hai Wang, Xiaorong Pan and Zonghai Li

    Molecular Cancer 2017 16:127

    Published on: 19 July 2017

  15. Research

    FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

    The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study FOXP3 expression and regulation, function and clinical implication in human non-small cell lung cancer (NSCLC).

    Shucai Yang, Yi Liu, Ming-Yue Li, Calvin S. H. Ng, Sheng-li Yang, Shanshan Wang, Chang Zou, Yujuan Dong, Jing Du, Xiang Long, Li-Zhong Liu, Innes Y. P. Wan, Tony Mok, Malcolm J. Underwood and George G. Chen

    Molecular Cancer 2017 16:124

    Published on: 17 July 2017

  16. Research

    MiR-661 promotes tumor invasion and metastasis by directly inhibiting RB1 in non small cell lung cancer

    Aberrant microRNA expression has been implicated in metastasis of cancers. MiR-661 accelerates proliferation and invasion of breast cancer and ovarian cancer, while impedes that of glioma. Its role in non smal...

    Feiye Liu, Yanjun Cai, Xiaoxiang Rong, Jinzhang Chen, Dayong Zheng, Lu Chen, Junyi Zhang, Rongcheng Luo, Peng Zhao and Jian Ruan

    Molecular Cancer 2017 16:122

    Published on: 17 July 2017

  17. Research

    Long non-coding RNA CASC2 suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells through CASC2/miR-367/FBXW7 axis

    Recently, it has been reported that long non-coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2), a novel tumor suppressor, participates in regulating the carcinogenesis and suppresses tumor progress...

    Yufeng Wang, Zhikui Liu, Bowen Yao, Qing Li, Liang Wang, Cong Wang, Changwei Dou, Meng Xu, Qingguang Liu and Kangsheng Tu

    Molecular Cancer 2017 16:123

    Published on: 17 July 2017

  18. Research

    Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

    Pancreatic cancer is a devastating disease that is characterized by persistent hypoxia. The roles of hypoxia-inducible factor-2α (hif-2α) are different to those of hif-1α, although both are critical for tumor ...

    Qi Zhang, Yu Lou, Jingying Zhang, Qihan Fu, Tao Wei, Xu Sun, Qi Chen, Jiaqi Yang, Xueli Bai and Tingbo Liang

    Molecular Cancer 2017 16:119

    Published on: 14 July 2017

  19. Research

    Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion

    Clonal competition in cancer describes the process in which the progeny of a cell clone supersedes or succumbs to other competing clones due to differences in their functional characteristics, mostly based on ...

    Kerstin Cornils, Lars Thielecke, Doreen Winkelmann, Tim Aranyossy, Mathias Lesche, Andreas Dahl, Ingo Roeder, Boris Fehse and Ingmar Glauche

    Molecular Cancer 2017 16:120

    Published on: 14 July 2017

  20. Research

    Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p

    The function of a new long non-coding RNA linc00673 remains unclear. While identified as an oncogenic player in non-small cell lung cancer (NSCLC), linc00673 was found to be anti-oncogenic in pancreatic ductal...

    Wei Lu, Honghe Zhang, Yuequn Niu, Yongfeng Wu, Wenjie Sun, Hongyi Li, Jianlu Kong, Kefeng Ding, Han-Ming Shen, Han Wu, Dajing Xia and Yihua Wu

    Molecular Cancer 2017 16:118

    Published on: 11 July 2017

  21. Letter to the Editor

    New somatic BRAF splicing mutation in Langerhans cell histiocytosis

    Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with constitutive activation of the MAPKinase RAS-RAF-MEK-ERK cell signaling pathway. We analyzed 9 LCH cases without BRAF ...

    Sébastien Héritier, Zofia Hélias-Rodzewicz, Rikhia Chakraborty, Amel G. Sengal, Christine Bellanné-Chantelot, Caroline Thomas, Anne Moreau, Sylvie Fraitag, Carl E. Allen, Jean Donadieu and Jean-François Emile

    Molecular Cancer 2017 16:115

    Published on: 6 July 2017

Previous Page Page 1 of 79 Next Page