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  1. Methionine aminopeptidase 2 (MetAP2) is a bifunctional protein that plays a critical role in the regulation of post-translational processing and protein synthesis. MetAP2 is overexpressed in human colon cancer...

    Authors: Ponniah Selvakumar, Ashakumary Lakshmikuttyamma, Umashankar Das, Hari N Pati, Jonathan R Dimmock and Rajendra K Sharma
    Citation: Molecular Cancer 2009 8:65
    Content type: Short communication Published on:

  3. Germline mono-allelic promoter hypermethylation of the MLH1 or MSH2 gene in families with hereditary nonpolyposis colorectal cancer has recently been reported. The purpose of this study was to evaluate if germlin...

    Authors: Hidetaka Yamada, Kazuya Shinmura, Masanori Goto, Moriya Iwaizumi, Hiroyuki Konno, Hideki Kataoka, Masami Yamada, Takachika Ozawa, Toshihiro Tsuneyoshi, Fumihiko Tanioka and Haruhiko Sugimura
    Citation: Molecular Cancer 2009 8:63
    Content type: Research Published on:

  4. We have demonstrated that the stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system is involved in the establishment of lymph node metastasis in oral squamous cell carcinoma (SCC). Chemotherapy is a power...

    Authors: Daisuke Uchida, Tomitaro Onoue, Nasima-Mila Begum, Nobuyuki Kuribayashi, Yoshifumi Tomizuka, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto
    Citation: Molecular Cancer 2009 8:62
    Content type: Research Published on:

  5. Differential mRNA splicing and alternative promoter usage of the TP73 gene results in the expression of multiple NH2-truncated isoforms that act as oncogenes. Abundant levels of these p73 variants in a variety of...

    Authors: Stephan Emmrich, Weiwei Wang, Katja John, Wenzhong Li and Brigitte M Pützer
    Citation: Molecular Cancer 2009 8:61
    Content type: Research Published on:

  6. Lats1 (large tumor suppressor 1) codes for a serine/threonine kinase that plays a role in the progression through mitosis. Genetic studies demonstrated that the loss of LATS1 in mouse, and of its ortholog wts (wa...

    Authors: Rania Siam, Ryoko Harada, Chantal Cadieux, Robert Battat, Charles Vadnais and Alain Nepveu
    Citation: Molecular Cancer 2009 8:60
    Content type: Research Published on:

  7. Calcium signaling plays an important role in B lymphocyte survival and activation, and is critically dependent on the inositol-1,4,5-tris-phosphate-induced release of calcium stored in the endoplasmic reticulum (...

    Authors: Olivier Dellis, Atousa Arbabian, Jean-Philippe Brouland, Tünde Kovàcs, Martin Rowe, Christine Chomienne, Irène Joab and Béla Papp
    Citation: Molecular Cancer 2009 8:59
    Content type: Research Published on:

  8. Akt/PKB is a serine/threonine kinase that has attracted much attention because of its central role in regulating cell proliferation, survival, motility and angiogenesis. Activation of Akt in breast cancer port...

    Authors: Luisa Pecorari, Oriano Marin, Chiara Silvestri, Olivia Candini, Elena Rossi, Clara Guerzoni, Sara Cattelani, Samanta A Mariani, Francesca Corradini, Giovanna Ferrari-Amorotti, Laura Cortesi, Rita Bussolari, Giuseppe Raschellà, Massimo R Federico and Bruno Calabretta
    Citation: Molecular Cancer 2009 8:58
    Content type: Research Published on:

  9. The progression of all cancers is characterized by increased-cell proliferation and decreased-apoptosis. The androgen-independent prostate cancer (AIPC) is the terminal stage of the disease. Many chemokines an...

    Authors: Rajendra K Singh and Bal L Lokeshwar
    Citation: Molecular Cancer 2009 8:57
    Content type: Research Published on:

  10. Multidrug resistance (MDR) is frequently observed after prolonged treatment in human hepatoma with conventional anti-tumor drugs, and photodynamic therapy (PDT) is a recently suggested alternative to overcome ...

    Authors: Patrick Ming-Kuen Tang, Dong-Mei Zhang, Ngoc-Ha Bui Xuan, Stephen Kwok-Wing Tsui, Mary Miu-Yee Waye, Siu-Kai Kong, Wing-Ping Fong and Kwok-Pui Fung
    Citation: Molecular Cancer 2009 8:56
    Content type: Research Published on:

  11. Deproteinized DNA from eukaryotic and prokaryotic cells still contains a low-molecular weight peptidic fraction which can be dissociated by alkalinization of the medium. This fraction inhibits RNA transcriptio...

    Authors: Loretta Mancinelli, Paula M De Angelis, Lucia Annulli, Valentina Padovini, Kjell Elgjo and Gian Luigi Gianfranceschi
    Citation: Molecular Cancer 2009 8:55
    Content type: Research Published on:

  12. The Warburg phenotype in cancer cells has been long recognized, but there is still limited insight in the consecutive metabolic alterations that characterize its establishment. We obtained better understanding...

    Authors: Ad JC de Groof, Mariska M te Lindert, Michiel MT van Dommelen, Min Wu, Marieke Willemse, Amy L Smift, Mike Winer, Frank Oerlemans, Helma Pluk, Jack AM Fransen and Bé Wieringa
    Citation: Molecular Cancer 2009 8:54
    Content type: Research Published on:

  13. The family of 14-3-3 proteins plays an important role in cancer biology by interfering with intracellular signalling pathways and cell cycle checkpoints. The 14-3-3σ isoform acts as a tumor suppressor and is o...

    Authors: Julia Schultz, Saleh M Ibrahim, Julio Vera and Manfred Kunz
    Citation: Molecular Cancer 2009 8:53
    Content type: Research Published on:

  14. RNF139/TRC8 is a potential tumor suppressor gene with similarity to PTCH, a tumor suppressor implicated in basal cell carcinomas and glioblastomas. TRC8 has the potential to act in a novel regulatory relationship...

    Authors: Stefania Gimelli, Silvana Beri, Harry A Drabkin, Claudio Gambini, Andrea Gregorio, Patrizia Fiorio, Orsetta Zuffardi, Robert M Gemmill, Roberto Giorda and Giorgio Gimelli
    Citation: Molecular Cancer 2009 8:52
    Content type: Research Published on:

  15. PI3K/AKTsignaling pathway plays an important role in cell growth, proliferation, and tumorgenesis of various malignancies. This signaling pathway has been shown to be frequently altered in several human cancer...

    Authors: Jehad Abubaker, Prashant Bavi, Wael Al-Haqawi, Zeenath Jehan, Adnan Munkarah, Shahab Uddin and Khawla S Al-Kuraya
    Citation: Molecular Cancer 2009 8:51
    Content type: Research Published on:

  16. Oral cancer develops through a series of histopathological stages: through mild (low grade), moderate, and severe (high grade) dysplasia to carcinoma in situ and then invasive disease. Early detection of those or...

    Authors: Cathie Garnis, Raj Chari, Timon PH Buys, Lewei Zhang, Raymond T Ng, Miriam P Rosin and Wan L Lam
    Citation: Molecular Cancer 2009 8:50
    Content type: Research Published on:

  18. DNA repair genes critically regulate the cellular response to chemotherapy and epigenetic regulation of these genes may be influenced by chemotherapy exposure. Restoration of BRCA1 and BRCA2 mediates resistanc...

    Authors: Elizabeth M Swisher, Rachel M Gonzalez, Toshiyasu Taniguchi, Rochelle L Garcia, Tom Walsh, Barbara A Goff and Piri Welcsh
    Citation: Molecular Cancer 2009 8:48
    Content type: Research Published on:

  19. Reovirus type 3 Dearing strain (ReoT3D) has an inherent propensity to preferentially infect and destroy cancer cells. The oncolytic activity of ReoT3D as a single agent has been demonstrated in vitro and in vivo ...

    Authors: Shizuko Sei, Jodie K Mussio, Quan-en Yang, Kunio Nagashima, Ralph E Parchment, Matthew C Coffey, Robert H Shoemaker and Joseph E Tomaszewski
    Citation: Molecular Cancer 2009 8:47
    Content type: Research Published on:

  20. We isolate and culture carcinoma-associated fibroblasts (CAFs) from primary tumour (CAFpt), CAFs from corresponding synchronous liver metastasis (CAFlm) as well as normal colonic fibroblasts (NCF) from the sam...

    Authors: David G Molleví, Alvaro Aytes, Mireia Berdiel, Laura Padullés, Maria Martínez-Iniesta, Xavier Sanjuan, Ramon Salazar and Alberto Villanueva
    Citation: Molecular Cancer 2009 8:46
    Content type: Short communication Published on:

  21. Novel therapies are necessary to improve outcomes for patients with squamous cell carcinomas (SCC) of the head and neck. Historically, vaccinia virus was administered widely to humans as a vaccine and led to t...

    Authors: Zhenkun Yu, Sen Li, Peter Brader, Nanhai Chen, Yong A Yu, Qian Zhang, Aladar A Szalay, Yuman Fong and Richard J Wong
    Citation: Molecular Cancer 2009 8:45
    Content type: Research Published on:

  23. Survivin is a dual function protein. It inhibits the apoptosis of cells by inhibiting caspases, and also promotes cell growth by stabilizing microtubules during mitosis. Over-expression of survivin has been de...

    Authors: Chun Hei Antonio Cheung, Huang-Hui Chen, Ching-Chuan Kuo, Chi-Yen Chang, Mohane S Coumar, Hsing-Pang Hsieh and Jang-Yang Chang
    Citation: Molecular Cancer 2009 8:43
    Content type: Research Published on:

  24. The Ras-assocation family (RASSF) of tumour suppressor genes (TSGs) contains 10 members that encode proteins containing Ras-assocation (RA) domains. Several members of the RASSF family are frequently epigeneti...

    Authors: Luke B Hesson, Thomas L Dunwell, Wendy N Cooper, Daniel Catchpoole, Anna T Brini, Raffaella Chiaramonte, Mike Griffiths, Andrew D Chalmers, Eamonn R Maher and Farida Latif
    Citation: Molecular Cancer 2009 8:42
    Content type: Research Published on:

  25. Metabolic perturbations arising from malignant transformation have not been systematically characterized in human lung cancers in situ. Stable isotope resolved metabolomic analysis (SIRM) enables functional analy...

    Authors: Teresa WM Fan, Andrew N Lane, Richard M Higashi, Mohamed A Farag, Hong Gao, Michael Bousamra and Donald M Miller
    Citation: Molecular Cancer 2009 8:41
    Content type: Research Published on:

  26. The zebrafish has become an important model for cancer research. Several cancer models have been established by transgenic expression of human or mouse oncogenes in zebrafish. Since it is amenable to efficient...

    Authors: Bensheng Ju, Jan Spitsbergen, Christopher J Eden, Michael R Taylor and Wenbiao Chen
    Citation: Molecular Cancer 2009 8:40
    Content type: Short communication Published on:

  27. Manipulating apoptotic resistance represents an important strategy for the treatment of hormone refractory prostate cancer. We hypothesised that the Inhibitor of Apoptosis (IAP) Proteins may be mediating this ...

    Authors: Catherine Gill, Catherine Dowling, Amanda J O'Neill and R William G Watson
    Citation: Molecular Cancer 2009 8:39
    Content type: Research Published on:

  28. Tuberous sclerosis (TSC) is a hamartoma syndrome in which renal and lung tumors cause the greatest morbidity. Loss of either TSC1 or TSC2 in TSC hamartomas leads to activation of mTORC1 and suppression of AKT....

    Authors: Kristen Pollizzi, Izabela Malinowska-Kolodziej, Michael Stumm, Heidi Lane and David Kwiatkowski
    Citation: Molecular Cancer 2009 8:38
    Content type: Research Published on:

  29. Pancreatic cancer (PaCa) is a fatal human cancer due to its exceptional resistance to all current anticancer therapies. The cytoprotective enzyme heme oxygenase-1 (HO-1) is significantly overexpressed in PaCa ...

    Authors: Philipp Nuhn, Beat M Künzli, René Hennig, Tomas Mitkus, Tadas Ramanauskas, Rainer Nobiling, Stefan C Meuer, Helmut Friess and Pascal O Berberat
    Citation: Molecular Cancer 2009 8:37
    Content type: Research Published on:

  30. The HMGA2 gene encodes a protein that alters chromatin structure. Deregulation, typically through chromosomal rearrangements, of HMGA2 has an important role in the development of several mesenchymal neoplasms. Th...

    Authors: Hammurabi Bartuma, Ioannis Panagopoulos, Anna Collin, Domenico Trombetta, Henryk A Domanski, Nils Mandahl and Fredrik Mertens
    Citation: Molecular Cancer 2009 8:36
    Content type: Research Published on:

  31. Dysregulated Notch signalling is believed to play an important role in the development and maintenance of T cell leukaemia. At a cellular level, Notch signalling promotes proliferation and inhibits apoptosis o...

    Authors: Nicholas Chadwick, Leo Zeef, Virginia Portillo, Carl Fennessy, Fiona Warrander, Sarah Hoyle and Anne-Marie Buckle
    Citation: Molecular Cancer 2009 8:35
    Content type: Research Published on:

  32. Wee1 is a tyrosine kinase regulating S-G2 cell cycle transition through the inactivating phosphorylation of CDC2. The inhibition of Wee1 kinase by a selective small molecule inhibitor significantly enhances th...

    Authors: Shinji Mizuarai, Kazunori Yamanaka, Hiraku Itadani, Tsuyoshi Arai, Toshihide Nishibata, Hiroshi Hirai and Hidehito Kotani
    Citation: Molecular Cancer 2009 8:34
    Content type: Research Published on:

  33. Studies in mammary cancer demonstrated that moderately high concentrations of molecular iodine (I2) have a antiproliferative and apoptotic effect either in vivo as in vitro, however the cellular intermediated inv...

    Authors: Carmen Aceves, Pablo García-Solís, Omar Arroyo-Helguera, Laura Vega-Riveroll, Guadalupe Delgado and Brenda Anguiano
    Citation: Molecular Cancer 2009 8:33
    Content type: Research Published on:

  34. The Warburg effect has been found in a wide spectrum of human cancers, however the underlying mechanisms are still unclear. This study aims to explore the role of cellular oxidative stress in relation to glyco...

    Authors: Dong-yun Shi, Fei-zhou Xie, Chao Zhai, Jeremy S Stern, Yang Liu and Shan-lin Liu
    Citation: Molecular Cancer 2009 8:32
    Content type: Research Published on:

  35. Renal cell carcinoma (RCC) is histopathologically heterogeneous with clear cell and papillary the most common subtypes. The most frequent molecular abnormality in clear cell RCC is VHL inactivation but promoter m...

    Authors: Fiona E McRonald, Mark R Morris, Dean Gentle, Laura Winchester, Dilair Baban, Jiannis Ragoussis, Noel W Clarke, Michael D Brown, Takeshi Kishida, Masahiro Yao, Farida Latif and Eamonn R Maher
    Citation: Molecular Cancer 2009 8:31
    Content type: Research Published on:

  36. Cancer cells secrete bioactive peptides that act in an autocrine or paracrine fashion affecting tumor growth and metastasis. Corticotropin-releasing factor (CRF), a hypothalamic neuropeptide that controls the ...

    Authors: Ariadne Androulidaki, Erini Dermitzaki, Maria Venihaki, Effie Karagianni, Olga Rassouli, Erini Andreakou, Christos Stournaras, Andrew N Margioris and Christos Tsatsanis
    Citation: Molecular Cancer 2009 8:30
    Content type: Research Published on:

  37. This study aimed to investigate squamous cellular carcinoma antigen (SCCA) in serum and in tumoral and paired peritumoral tissues. We studied 27 patients with liver cirrhosis (LC) and 55 with HCC: 20 with a si...

    Authors: Paolo Trerotoli, Emilia Fransvea, Umberto Angelotti, Giovanni Antonaci, Luigi Lupo, Antonio Mazzocca, Anita Mangia, Salvatore Antonaci and Gianluigi Giannelli
    Citation: Molecular Cancer 2009 8:29
    Content type: Research Published on:

  38. High expression of P-glycoprotein is one of the well-known mechanisms of chemoresistance in chondrosarcomas. However, the role of antiapoptotic proteins, a common mechanism responsible for chemoresistance in o...

    Authors: Dae Won Kim, Kyung-Ok Kim, Mike J Shin, Jung Hee Ha, Sung Wook Seo, Jay Yang and Francis Y Lee
    Citation: Molecular Cancer 2009 8:28
    Content type: Research Published on:

  39. Retinoids have been studied extensively for their potential as therapeutic and chemopreventive agents for a variety of cancers, including nonmelanoma skin cancer (NMSC). Despite their use for many years, the m...

    Authors: Satish B Cheepala, Weihong Yin, Zanobia Syed, Jennifer N Gill, Alaina McMillian, Heather E Kleiner, Mark Lynch, Rasiah Loganantharaj, Marjan Trutschl, Urska Cvek and John L Clifford
    Citation: Molecular Cancer 2009 8:27
    Content type: Research Published on:

  40. Ovarian cancer is the leading cause of mortality from gynecological malignancies, often undetectable in early stages. The difficulty of detecting the disease in its early stages and the propensity of ovarian c...

    Authors: Sanjeev Kumar, Christopher S Bryant, Sreedhar Chamala, Aamer Qazi, Shelly Seward, Jagannath Pal, Christopher P Steffes, Donald W Weaver, Robert Morris, John M Malone, Masood A Shammas, Madhu Prasad and Ramesh B Batchu
    Citation: Molecular Cancer 2009 8:26
    Content type: Research Published on:

  41. A variety of arginine-rich peptide sequences similar to those found in viral proteins have been conjugated to other molecules to facilitate their transport into the cytoplasm and nucleus of targeted cells. The...

    Authors: Rod Balhorn, Saphon Hok, Sally DeNardo, Arutselvan Natarajan, Gary Mirick, Michele Corzett and Gerald DeNardo
    Citation: Molecular Cancer 2009 8:25
    Content type: Research Published on:

  42. DNA repair deficient tumor cells have been shown to accumulate high levels of DNA damage. Consequently, these cells become hyper-dependent on DNA damage response pathways, including the CHK1-kinase-mediated re...

    Authors: Clark C Chen, Richard D Kennedy, Samuel Sidi, A Thomas Look and Alan D'Andrea
    Citation: Molecular Cancer 2009 8:24
    Content type: Research Published on:

  43. The low molecular weight compound, PRIMA-1MET restores the transcriptional transactivation function of certain p53 mutants in tumor cells. We have previously shown that PRIMA-1MET induces nucleolar translocation ...

    Authors: György Stuber, Emilie Flaberg, Gabor Petranyi, Rita Ötvös, Nina Rökaeus, Elena Kashuba, Klas G Wiman, George Klein and Laszlo Szekely
    Citation: Molecular Cancer 2009 8:23
    Content type: Research Published on:

  44. Helicobacter pylori is a crucial determining factor in the pathogenesis of benign and neoplastic gastric diseases. Cyclooxygenase-2 (Cox-2) is the inducible key enzyme of arachidonic acid metabolism and is a cent...

    Authors: Anna K Walduck, Matthias Weber, Christian Wunder, Stefan Juettner, Manfred Stolte, Michael Vieth, Bertram Wiedenmann, Thomas F Meyer, Michael Naumann and Michael Hoecker
    Citation: Molecular Cancer 2009 8:22
    Content type: Research Published on:

  47. δ-Catenin is a unique member of β-catenin/armadillo domain superfamily proteins and its primary expression is restricted to the brain. However, δ-catenin is upregulated in human prostatic adenocarcinomas, alth...

    Authors: Yan Zeng, Agustin Abdallah, Jian-Ping Lu, Tao Wang, Yan-Hua Chen, David M Terrian, Kwonseop Kim and Qun Lu
    Citation: Molecular Cancer 2009 8:19
    Content type: Research Published on:

  48. EBV lytic cycle activators, such as phorbol esters, anti-immunoglobulin, transforming growth factor β (TGFβ), sodium butyrate, induce apoptosis in EBV-negative but not in EBV-positive Burkitt's lymphoma (BL) c...

    Authors: Giulia Matusali, Giuseppe Arena, Alessandra De Leo, Livia Di Renzo and Elena Mattia
    Citation: Molecular Cancer 2009 8:18
    Content type: Research Published on:

  49. Metastatic melanoma has a high mortality rate and suboptimal therapeutic options. Molecular targeting may be beneficial using the rexinoid LGD1069, a retinoid × receptor selective agonist, and thiazolidinedion...

    Authors: Joshua P Klopper, Vibha Sharma, Andrew Berenz, William R Hays, Michele Loi, Umarani Pugazhenthi, Sherif Said and Bryan R Haugen
    Citation: Molecular Cancer 2009 8:16
    Content type: Research Published on:

  50. Scaffold Attachment Factor B1 (SAFB1) is a multifunctional protein which has been implicated in breast cancer previously. We recently generated SAFB1 knockout mice (SAFB1-/-), but pleiotropic phenotypes including...

    Authors: Benny Abraham Kaipparettu, Klaudia M Dobrzycka, Ora Britton, Adrian V Lee, Alan J Herron, Yi Li, Michael T Lewis, Daniel Medina and Steffi Oesterreich
    Citation: Molecular Cancer 2009 8:15
    Content type: Research Published on:
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Molecular Cancer

ISSN: 1476-4598