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  1. Review

    Novel insights into chromosomal conformations in cancer

    Exploring gene function is critical for understanding the complexity of life. DNA sequences and the three-dimensional organization of chromatin (chromosomal interactions) are considered enigmatic factors under...

    Ruobing Jia, Peiwei Chai, He Zhang and Xianqun Fan

    Molecular Cancer 2017 16:173

    Published on: 17 November 2017

  2. Research

    Knockdown of SOX2OT inhibits the malignant biological behaviors of glioblastoma stem cells via up-regulating the expression of miR-194-5p and miR-122

    Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) in the biological behaviors of glioblastoma stem cells (GSCs). Here, we elucidated the function and possible molecular...

    Rui Su, Shuo Cao, Jun Ma, Yunhui Liu, Xiaobai Liu, Jian Zheng, Jiajia Chen, Libo Liu, Heng Cai, Zhen Li, Lini Zhao, Qianru He and Yixue Xue

    Molecular Cancer 2017 16:171

    Published on: 13 November 2017

  3. Research

    Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation

    Lung cancer is the leading cause of cancer death worldwide. However, the molecular mechanisms underlying lung cancer development have not been fully understood. The functions of histone deacetylases (HDACs), a...

    Yubin Lei, Lingling Liu, Shujing Zhang, Shicheng Guo, Xiaoqing Li, Jiucun Wang, Bo Su, Yuchao Fang, Xiaofeng Chen, Hengning Ke and Wufan Tao

    Molecular Cancer 2017 16:170

    Published on: 10 November 2017

  4. Research

    Long noncoding RNA NORAD, a novel competing endogenous RNA, enhances the hypoxia-induced epithelial-mesenchymal transition to promote metastasis in pancreatic cancer

    Pancreatic cancer, one of the top two most fatal cancers, is characterized by a desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and inducing the epithelial-to-mesenchymal transit...

    Hongzhe Li, Xinjing Wang, Chenlei Wen, Zhen Huo, Weishen Wang, Qian Zhan, Dongfeng Cheng, Hao Chen, Xiaxing Deng, Chenghong Peng and Baiyong Shen

    Molecular Cancer 2017 16:169

    Published on: 9 November 2017

  5. Letter to the Editor

    Validation and comparison of the molecular classifications of pancreatic carcinomas

    Four molecular classifications of pancreatic ductal adenocarcinoma (PDAC), biologically and clinically relevant and based on gene expression profiles, were established in the recent years, including the Collis...

    David J. Birnbaum, Pascal Finetti, Daniel Birnbaum, Emilie Mamessier and François Bertucci

    Molecular Cancer 2017 16:168

    Published on: 6 November 2017

  6. Research

    miR-92b-3p acts as a tumor suppressor by targeting Gabra3 in pancreatic cancer

    MicroRNAs (miRNAs) can act as oncogenes or tumor suppressors by controlling cell proliferation, differentiation, metastasis and apoptosis, and miRNA dysregulation is involved in the development of pancreatic c...

    Manmei Long, Ming Zhan, Sunwang Xu, Ruimeng Yang, Wei Chen, Shilei Zhang, Yongheng Shi, Qiao He, Man Mohan, Qiang Liu and Jian Wang

    Molecular Cancer 2017 16:167

    Published on: 27 October 2017

  7. Research

    LncRNA RP11-436H11.5, functioning as a competitive endogenous RNA, upregulates BCL-W expression by sponging miR-335-5p and promotes proliferation and invasion in renal cell carcinoma

    Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in tumorigenesis. Here, we report a novel lncRNA, RP11-436H11.5, that regulates renal cell carcinoma (RCC) cell prolifera...

    Kefeng Wang, Wei Jin, Yan Song and Xiang Fei

    Molecular Cancer 2017 16:166

    Published on: 25 October 2017

  8. Review

    Dysregulated long noncoding RNAs (lncRNAs) in hepatocellular carcinoma: implications for tumorigenesis, disease progression, and liver cancer stem cells

    Hepatocellular carcinoma (HCC) is one of the most common malignant tumours with a poor prognosis worldwide. While early stage tumours can be treated with curative approaches such as liver transplantation or su...

    Xiaoqi Huo, Shuanglin Han, Guang Wu, Olivier Latchoumanin, Gang Zhou, Lionel Hebbard, Jacob George and Liang Qiao

    Molecular Cancer 2017 16:165

    Published on: 23 October 2017

  9. Letter to the Editor

    Profiling, clinicopathological correlation and functional validation of specific long non-coding RNAs for hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive malignancies worldwide. Studies seeking to advance the overall understanding of lncRNA profiling in HCC remain rare.

    Jian Yao, Lingjiao Wu, Xiaohua Meng, Huanxia Yang, Shujun Ni, Qiangfeng Wang, Jiawei Zhou, Qiong Zhang, Kunkai Su, Li Shao, Qingyi Cao, Mingding Li, Fusheng Wu and Lanjuan Li

    Molecular Cancer 2017 16:164

    Published on: 23 October 2017

  10. Research

    Reprogramming of stromal fibroblasts by SNAI2 contributes to tumor desmoplasia and ovarian cancer progression

    Molecular profiling in ovarian cancer (OC) revealed that the desmoplasia subtype presented the poorest prognosis, highlighting the contribution of stromal fibroblasts in tumor progression. This study aimed to ...

    Zongyuan Yang, Xin Yang, Sen Xu, Ping Jin, Xiaoting Li, Xiao Wei, Dan Liu, Kecheng Huang, Sixiang Long, Ya Wang, Chaoyang Sun, Gang Chen, Junbo Hu, Li Meng, Ding Ma and Qinglei Gao

    Molecular Cancer 2017 16:163

    Published on: 17 October 2017

  11. Research

    A long non-coding RNA HOTTIP expression is associated with disease progression and predicts outcome in small cell lung cancer patients

    Despite progress in treatment of small cell lung cancer (SCLC), the biology of the tumor still remains poorly understood. Recently, we globally investigated the contributions of lncRNA in SCLC with a special f...

    Yanqin Sun, Yuanyuan Zhou, Yifeng Bai, Qiongyao Wang, Jiarong Bao, Yingshan Luo, Ying Guo and Linlang Guo

    Molecular Cancer 2017 16:162

    Published on: 17 October 2017

  12. Letter to the Editor

    Evaluation on the diagnostic and prognostic values of long non-coding RNA BLACAT1 in common types of human cancer

    A growing number of evidence has indicated that long non-coding RNAs (lncRNA) may have many functions in the development and progression of cancer, and cloud serve as good diagnostic and prognostic biomarkers ...

    Xiaoli Chen, Meiyu Dai, Hongzhen Zhu, Jinwan Li, Zhizhuo Huang, Xuexiang Liu, Yujie Huang, Jingfan Chen and Shengming Dai

    Molecular Cancer 2017 16:160

    Published on: 16 October 2017

  13. Research

    Monitoring multiple myeloma by idiotype-specific peptide binders of tumor-derived exosomes

    Tumor-derived exosomes (TDEs) play a pivotal role in tumor establishment and progression, and are emerging biomarkers for tumor diagnosis in personalized medicine. To date, there is a lack of efficient technol...

    Enrico Iaccino, Selena Mimmi, Vincenzo Dattilo, Fabiola Marino, Patrizio Candeloro, Antonio Di Loria, Danilo Marimpietri, Antonio Pisano, Francesco Albano, Eleonora Vecchio, Simona Ceglia, Gaetanina Golino, Antonio Lupia, Giuseppe Fiume, Ileana Quinto and Giuseppe Scala

    Molecular Cancer 2017 16:159

    Published on: 13 October 2017

  14. Research

    Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas

    N-myc (and STAT) interactor (NMI) plays vital roles in tumor growth, progression, and metastasis. In this study, we identified NMI as a potential tumor suppressor in lung cancer and explored its molecular mech...

    Jingshu Wang, Kun Zou, Xu Feng, Miao Chen, Cong Li, Ranran Tang, Yang Xuan, Meihua Luo, Wangbing Chen, Huijuan Qiu, Ge Qin, Yixin Li, Changlin Zhang, Binyi Xiao, Lan Kang, Tiebang Kang…

    Molecular Cancer 2017 16:158

    Published on: 12 October 2017

  15. Research

    SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis

    MicroRNAs (miRNAs) are important regulators involved in diverse physiological and pathological processes including cancer. SUMO (small ubiquitin-like modifier) is a reversible protein modifier. We recently fou...

    Haihua Yuan, Rong Deng, Xian Zhao, Ran Chen, Guofang Hou, Hailong Zhang, Yanli Wang, Ming Xu, Bin Jiang and Jianxiu Yu

    Molecular Cancer 2017 16:157

    Published on: 11 October 2017

  16. Letter to the Editor

    Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes

    The aim of this study was to identify microRNAs in urinary exosomes that are differently expressed in prostate cancer patients and healthy donors. For this purpose, RNA was extracted from urinary exosomes from...

    Marta Rodríguez, Cristina Bajo-Santos, Nina P. Hessvik, Susanne Lorenz, Bastian Fromm, Viktor Berge, Kirsten Sandvig, Aija Linē and Alicia Llorente

    Molecular Cancer 2017 16:156

    Published on: 5 October 2017

  17. Research

    A novel mechanism of lncRNA and miRNA interaction: CCAT2 regulates miR-145 expression by suppressing its maturation process in colon cancer cells

    Although both long and micro RNAs are emerging as important functional components in colorectal cancer (CRC) progression and metastasis, the mechanism of their interaction remains poorly understood. CCAT2 (Col...

    Yingjie Yu, Pratima Nangia-Makker, Lulu Farhana and Adhip P. N. Majumdar

    Molecular Cancer 2017 16:155

    Published on: 30 September 2017

  18. Research

    Overexpression of lncRNA IGFBP4–1 reprograms energy metabolism to promote lung cancer progression

    Reprogrammed energy metabolism as an emerging hallmark of cancer has recently drawn special attention since it facilitate cell growth and proliferation. Recently, long noncoding RNAs (lncRNAs) have been served...

    Binyao Yang, Lisha Zhang, Yi Cao, Shuai Chen, Jun Cao, Di Wu, Jiansong Chen, Huali Xiong, Zihua Pan, Fuman Qiu, Jinbin Chen, Xiaoxuan Ling, Maosheng Yan, Suli Huang, Shiyu Zhou, Tiegang Li…

    Molecular Cancer 2017 16:154

    Published on: 25 September 2017

  19. Research

    Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression

    Non-coding RNAs (ncRNAs) have been shown to regulate gene expression involved in tumor progression of multiple malignancies. Our previous studies indicated that large tumor suppressor kinase 1 (LATS1), a core ...

    Jing Zhang, Hui Liu, Lidan Hou, Ge Wang, Rui Zhang, Yanxia Huang, Xiaoyu Chen and Jinshui Zhu

    Molecular Cancer 2017 16:151

    Published on: 11 September 2017

  20. Review

    Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer

    TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification. TMEM16A exp...

    Hui Wang, Liang Zou, Ke Ma, Jiankun Yu, Huizhe Wu, Minjie Wei and Qinghuan Xiao

    Molecular Cancer 2017 16:152

    Published on: 11 September 2017

  21. Research

    Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2

    Abnormal expression of numerous long non-coding RNAs (lncRNAs) has been reported in esophageal squamous cell carcinoma (ESCC) recently, but the great majority of their roles and mechanisms remain largely uncle...

    Yuanyuan Wu, Liwen Hu, Yan Liang, Juan Li, Kai Wang, Xuedan Chen, Hui Meng, Xingying Guan, Kang Yang and Yun Bai

    Molecular Cancer 2017 16:150

    Published on: 30 August 2017

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