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  1. Content type: Research

    Circular RNAs (circRNAs) are a new type of non-coding RNAs and their functions in gastric cancer (GC) remain unclear. Recent studies have revealed that circRNAs play an important role in cancer development and...

    Authors: Hui Liu, Yuan Liu, Zhaolian Bian, Jing Zhang, Rui Zhang, Xiaoyu Chen, Yanxia Huang, Yang Wang and Jinshui Zhu

    Citation: Molecular Cancer 2018 17:151

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  2. Content type: Research

    Lung cancer is the leading cause of cancer related deaths and its incidence is highly correlated with cigarette smoking. Nicotine, the addictive component of tobacco smoke, cannot initiate tumors, but can prom...

    Authors: Courtney M Schaal, Namrata Bora-Singhal, Durairaj Mohan Kumar and Srikumar P Chellappan

    Citation: Molecular Cancer 2018 17:149

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  3. Content type: Review

    Exosomes, extracellular vesicles with diameters ranging from 30 to 150 nm, are widely present in various body fluids. Recently, microRNAs (miRNAs) have been identified in exosomes, the biogenesis, release, and...

    Authors: Zhenqiang Sun, Ke Shi, Shuaixi Yang, Jinbo Liu, Quanbo Zhou, Guixian Wang, Junmin Song, Zhen Li, Zhiyong Zhang and Weitang Yuan

    Citation: Molecular Cancer 2018 17:147

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  4. Content type: Letter to the Editor

    Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer related to asbestos exposure. The discovery of soluble biomarkers with diagnostic/prognostic and/or therapeutic properties would improve the...

    Authors: Patrick Smeele, Sènan Mickaël d’Almeida, Clément Meiller, Anne-Laure Chéné, Charly Liddell, Laurent Cellerin, François Montagne, Sophie Deshayes, Sarah Benziane, Marie-Christine Copin, Paul Hofman, Françoise Le Pimpec-Barthes, Henri Porte, Arnaud Scherpereel, Marc Grégoire, Didier Jean…

    Citation: Molecular Cancer 2018 17:148

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  5. Content type: Research

    Exosomes are extracellular vesicles that mediate cellular communication in health and diseases. Neutrophils could be polarized to a pro-tumor phenotype by tumor. The function of tumor-derived exosomes in neutr...

    Authors: Xu Zhang, Hui Shi, Xiao Yuan, Pengcheng Jiang, Hui Qian and Wenrong Xu

    Citation: Molecular Cancer 2018 17:146

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  6. Content type: Research

    Drug resistance remains an unsolved clinical issue in oncology. Despite promising initial responses obtained with BRAF and MEK kinase inhibitors, resistance to treatment develops within months in virtually all...

    Authors: Giulia Cesi, Demetra Philippidou, Ines Kozar, Yeoun Jin Kim, Francois Bernardin, Guillaume Van Niel, Anke Wienecke-Baldacchino, Paul Felten, Elisabeth Letellier, Sonja Dengler, Dorothee Nashan, Claude Haan and Stephanie Kreis

    Citation: Molecular Cancer 2018 17:145

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  7. Content type: Research

    Circular RNAs (circRNAs) are a new member of noncoding RNAs (ncRNAs) that have recently been described as key regulators of gene expression. Our previous study had identified the negative correlation between c...

    Authors: Fei Xie, Yawei Li, Miao Wang, Chao Huang, Dan Tao, Fuxin Zheng, Hui Zhang, Fuqing Zeng, Xingyuan Xiao and Guosong Jiang

    Citation: Molecular Cancer 2018 17:144

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  8. Content type: Research

    Extracellular communication within the tumor microenvironment plays a critical role in tumor progression. Although exosomes can package into long non-coding RNAs (lncRNAs) to mediate extracellular communicatio...

    Authors: Rui Zheng, Mulong Du, Xiaowei Wang, Weidong Xu, Jiayuan Liang, Wenying Wang, Qiang Lv, Chao Qin, Haiyan Chu, Meilin Wang, Lin Yuan, Jing Qian and Zhengdong Zhang

    Citation: Molecular Cancer 2018 17:143

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  9. Content type: Letter to the Editor

    Recently, expression signatures of exosomal long non-coding RNAs (lncRNAs) have been proposed as potential non-invasive biomarkers for cancer detection. In this study, we aimed to develop a urinary exosome (UE...

    Authors: Yao Zhan, Lutao Du, Lishui Wang, Xiumei Jiang, Shujun Zhang, Juan Li, Keqiang Yan, Weili Duan, Yinghui Zhao, Lili Wang, Yunshan Wang and Chuanxin Wang

    Citation: Molecular Cancer 2018 17:142

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  10. Content type: Research

    Mounting evidence demonstrates that long noncoding RNAs (lncRNAs) have critical roles during the initiation and progression of cancers. In this study, we report that the small nucleolar RNA host gene 1 (SNHG1)...

    Authors: Mu Xu, Xiaoxiang Chen, Kang Lin, Kaixuan Zeng, Xiangxiang Liu, Bei Pan, Xueni Xu, Tao Xu, Xiuxiu Hu, Li Sun, Bangshun He, Yuqin Pan, Huiling Sun and Shukui Wang

    Citation: Molecular Cancer 2018 17:141

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  11. Content type: Research

    TGF-β promotes tumor invasion and metastasis through inducing epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) are recognized as functional non-coding RNA...

    Authors: Longqiang Wang, Xin Tong, Zhengyu Zhou, Shengjie Wang, Zhe Lei, Tianze Zhang, Zeyi Liu, Yuanyuan Zeng, Chang Li, Jun Zhao, Zhiyue Su, Cuijuan Zhang, Xia Liu, Guangquan Xu and Hong-Tao Zhang

    Citation: Molecular Cancer 2018 17:140

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  12. Content type: Research

    Proteogenomic characterization and integrative and comparative genomic analysis provide a functional context to annotate genomic abnormalities with prognostic value.

    Authors: Yu-Shui Ma, Tao Huang, Xiao-Ming Zhong, Hong-Wei Zhang, Xian-Ling Cong, Hong Xu, Gai-Xia Lu, Fei Yu, Shao-Bo Xue, Zhong-Wei Lv and Da Fu

    Citation: Molecular Cancer 2018 17:139

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  13. Content type: Letter to the Editor

    CircRNA expression profiles for gastric cancer (GC) were screened using plasma samples from 10 GC patients with different TNM stages and 5 healthy individuals as controls. Results showed lower expression of ci...

    Authors: Weiwei Tang, Kai Fu, Handong Sun, Dawei Rong, Hanjin Wang and Hongyong Cao

    Citation: Molecular Cancer 2018 17:137

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  14. Content type: Letter to the Editor

    Oncogenic fusion gene Echinoderm Microtubule-associated protein-Like 4-Anaplastic Lymphoma Kinase (EML4-ALK) contributes to tumorigenesis of a subset of non-small cell lung cancer (NSCLC). Recently, we demonstrat...

    Authors: Shuangyan Tan, Dan Sun, Wenchen Pu, Qiheng Gou, Chenglin Guo, Youling Gong, Jiao Li, Yu-Quan Wei, Lunxu Liu, Yun Zhao and Yong Peng

    Citation: Molecular Cancer 2018 17:138

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  15. Content type: Research

    Androgen receptor (AR) is expressed in 60%~ 70% oestrogen receptor (ER)-negative breast cancer (BC) cases and promotes the growth of this cancer subtype. Expression of prostate-derived Ets factor (PDEF), a tra...

    Authors: Lu Cao, Cong Xu, Guomin Xiang, Fang Liu, Xiaozhen Liu, Congying Li, Jing Liu, Qingxiang Meng, Jiao Jiao and Yun Niu

    Citation: Molecular Cancer 2018 17:136

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  16. Content type: Correction

    After the publication of this work [1] an error was noticed in Fig. 7e, in which the incorrect information is shown. The updated figure included in this correction now shows the quantification of tumor microve...

    Authors: Fuqing Hu, Haijie Li, Lu Liu, Feng Xu, Senyan Lai, Xuelai Luo, Junbo Hu and Xi Yang

    Citation: Molecular Cancer 2018 17:135

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    The original article was published in Molecular Cancer 2018 17:107

  17. Content type: Review

    In contrast to normal cells, which use the aerobic oxidation of glucose as their main energy production method, cancer cells prefer to use anaerobic glycolysis to maintain their growth and survival, even under...

    Authors: Xiaodong Zhang, Haiying Zhao, Yan Li, Di Xia, Liang Yang, Yingbo Ma and Hangyu Li

    Citation: Molecular Cancer 2018 17:134

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  18. Content type: Letter to the Editor

    Glioblastoma (GBM) is the most aggressive type of primary brain tumours. Anti-angiogenic therapies (AAT), such as bevacizumab, have been developed to target the tumour blood supply. However, GBM presents mecha...

    Authors: Thomas Simon, Sotiria Pinioti, Pascale Schellenberger, Vinothini Rajeeve, Franz Wendler, Pedro R. Cutillas, Alice King, Justin Stebbing and Georgios Giamas

    Citation: Molecular Cancer 2018 17:132

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  19. Content type: Letter to the Editor

    RUNX1 encodes a Runt-related transcription factor that is critical for hematopoiesis. In this study, through a combinatorial molecular approach, we characterized a novel t(5;21)(q13;q22) translocation involving R...

    Authors: Chi-Keung Cheng, Terry H. Y. Wong, Thomas S. K. Wan, Angela Z. Wang, Natalie P. H. Chan, Nelson C. N. Chan, Chi-Kong Li and Margaret H. L. Ng

    Citation: Molecular Cancer 2018 17:133

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  20. Content type: Letter to the Editor

    Liquid biopsy by genotyping circulating tumor DNA (ctDNA) has provided a non-invasive approach in assessing tumor genomic alterations in clinical oncology. However, emerging evidence in clinical settings has s...

    Authors: Qiaomei Guo, Junlei Wang, Jianfeng Xiao, Lin Wang, Xiaomeng Hu, Wenjun Yu, Gang Song, Jiatao Lou and JianFeng Chen

    Citation: Molecular Cancer 2018 17:131

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  21. Content type: Letter to the Editor

    Chronic myeloid leukemia (CML) is a clonal disease characterized by the presence of the constitutively active tyrosine kinase BCR-ABL oncoprotein. Although BCR-ABL is crucially important for pathogenesis and t...

    Authors: Chengwu Zeng, Sichu Liu, Shuai Lu, Xibao Yu, Jing Lai, Yifan Wu, Shaohua Chen, Liang Wang, Zhi Yu, Gengxin Luo and Yangqiu Li

    Citation: Molecular Cancer 2018 17:130

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  22. Content type: Review

    Programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) is a negative modulatory signaling pathway for activation of T cell. It is acknowledged that PD-1/PD-L1 axis plays a crucial role in ...

    Authors: Ming Yi, Dechao Jiao, Hanxiao Xu, Qian Liu, Weiheng Zhao, Xinwei Han and Kongming Wu

    Citation: Molecular Cancer 2018 17:129

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  23. Content type: Letter to the Editor

    Pheochromocytomas (PCCs) and paragangliomas (PGLs) are the most heritable endocrine tumors. Genetic testing for 12 driver susceptibility genes is recommended in all PCC and PGL cases. However, detection of som...

    Authors: Liang Wang, Ying Li, Xin Guan, Jingyuan Zhao, Liming Shen and Jing Liu

    Citation: Molecular Cancer 2018 17:128

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  24. Content type: Research

    Gastric cancer (GC) is a common malignancy and frequent cause of cancer-related death. Long non-coding RNAs (lncRNAs) have emerged as important regulators and tissue-specific biomarkers of multiple cancers, in...

    Authors: Xian-Zi Yang, Tian-Tian Cheng, Qing-Jun He, Zi-Ying Lei, Jun Chi, Zhen Tang, Quan-Xing Liao, Hong Zhang, Li-Si Zeng and Shu-Zhong Cui

    Citation: Molecular Cancer 2018 17:126

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  25. Content type: Letter to the Editor

    The long noncoding RNA ANRIL has been found to be abnormally expressed and play important roles in different cancers. However, the expression and function of ANRIL in acute myeloid leukemia (AML) remain to be ...

    Authors: Lin-Yu Sun, Xiao-Juan Li, Yu-Meng Sun, Wei Huang, Ke Fang, Cai Han, Zhen-Hua Chen, Xue-Qun Luo, Yue-Qin Chen and Wen-Tao Wang

    Citation: Molecular Cancer 2018 17:127

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  26. Content type: Research

    The prognosis for esophageal squamous cell carcinoma (ESCC) patients with lymph node metastasis (LNM) is still dismal. Elucidation of the LNM associated genomic alteration and underlying molecular mechanisms m...

    Authors: Weimin Zhang, Ruoxi Hong, Lin Li, Yan Wang, Peina Du, Yunwei Ou, Zitong Zhao, Xuefeng Liu, Wenchang Xiao, Dezuo Dong, Qingnan Wu, Jie Chen, Yongmei Song and Qimin Zhan

    Citation: Molecular Cancer 2018 17:125

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  27. Content type: Letter to the Editor

    Tip110, an important regulator of several oncogenic proteins, was significantly downregulated in human metastatic melanoma cells exposed to a hypoxic condition. Therefore, in this study, we set to determine wh...

    Authors: Khalid Amine Timani, Balázs Győrffy, Ying Liu, Khalid S. Mohammad and Johnny J. He

    Citation: Molecular Cancer 2018 17:124

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  28. Content type: Review

    As a novel class of endogenous RNAs, circRNAs, have a covalently closed continuous loop, with neither a 5’to 3’polarity, nor a polyadenylated tail. Numerous circRNAs have been characterized by abundance, stabi...

    Authors: Xianglun Cui, Jianxun Wang, Zongjun Guo, Mengyang Li, Mingyu Li, Si Liu, Haoran Liu, Wenjing Li, Xunhua Yin, Jiaping Tao and Wenhua Xu

    Citation: Molecular Cancer 2018 17:123

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  29. Content type: Research

    We have recently shown that radiotherapy may not only be a successful local and regional treatment but, when combined with MSCs, may also be a novel systemic cancer therapy. This study aimed to investigate the...

    Authors: Virgínea de Araujo Farias, Francisco O’Valle, Santiago Serrano-Saenz, Per Anderson, Eduardo Andrés, Jesús López-Peñalver, Isabel Tovar, Ana Nieto, Ana Santos, Francisco Martín, José Expósito, F. Javier Oliver and José Mariano Ruiz de Almodóvar

    Citation: Molecular Cancer 2018 17:122

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  30. Content type: Letter to the Editor

    Genome-scale CRISPR-Cas9 Knockout Screening was applied to investigate novel targets in imatinib-resistant gastrointestinal stromal tumor (GIST). 20 genes and 2 miRNAs have been selected by total reads of sgRN...

    Authors: Jie Cao, Jianchang Wei, Ping Yang, Tong Zhang, Zhuanpeng Chen, Feng He, Fang Wei, Huacui Chen, He Hu, Junbin Zhong, Zhi Yang, Wensong Cai, Wanglin Li and Qiang Wang

    Citation: Molecular Cancer 2018 17:121

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  31. Content type: Review

    Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology.

    Authors: Chuchu Shao, Fengming Yang, Suyu Miao, Weitao Liu, Chaoshan Wang, Yongqian Shu and Hua Shen

    Citation: Molecular Cancer 2018 17:120

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  32. Content type: Research

    Ovarian cancer (OvCa) is one of the most common malignant diseases of the female reproductive system in the world. The majority of OvCa is diagnosed with metastasis in the abdominal cavity. Epithelial-to-mesen...

    Authors: Haihai Liang, Tong Yu, Yue Han, Hua Jiang, Chengyu Wang, Tianyi You, Xiaoguang Zhao, Huitong Shan, Rui Yang, Lida Yang, Hongli Shan and Yunyan Gu

    Citation: Molecular Cancer 2018 17:119

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  33. Content type: Review

    In recent years, thyroid malignances have become more prevalent, especially among women. The most common sporadic types of thyroid tumors of follicular origin include papillary, follicular and anaplastic thyro...

    Authors: Natalia Pstrąg, Katarzyna Ziemnicka, Hans Bluyssen and Joanna Wesoły

    Citation: Molecular Cancer 2018 17:116

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  34. Content type: Research

    Deregulation of microtubules and centrosome integrity is response for the initiation and progression of human cancers. Sperm-associated antigen 5 (SPAG5) is essential for the spindle apparatus organization and...

    Authors: Yu-Feng Yang, Mei-Fang Zhang, Qiu-Hong Tian, Jia Fu, Xia Yang, Chris Zhiyi Zhang and Hong Yang

    Citation: Molecular Cancer 2018 17:117

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  35. Content type: Review

    The ubiquitin-proteasome system (UPS) is involved in multiple aspects of cellular processes, such as cell cycle progression, cellular differentiation, and survival (Davis RJ et al., Cancer Cell 26:455-64, 2014...

    Authors: Chien-Hung Yeh, Marcia Bellon and Christophe Nicot

    Citation: Molecular Cancer 2018 17:115

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  36. Content type: Letter to the Editor

    Exosome production from cancer-associated fibroblasts seems to be an important driver of tumor progression. We report the first in-depth biotype characterization of ncRNAs, analyzed by Next Generation Sequenci...

    Authors: Mercedes Herrera, Carlos Llorens, Marta Rodríguez, Alberto Herrera, Ricardo Ramos, Beatriz Gil, Antonio Candia, María Jesús Larriba, Pilar Garre, Julie Earl, Mercedes Rodríguez-Garrote, Trinidad Caldés, Félix Bonilla, Alfredo Carrato, Vanesa García-Barberán and Cristina Peña

    Citation: Molecular Cancer 2018 17:114

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  37. Content type: Research

    Chemotherapeutic agents that modulate cell cycle checkpoints and/or tumor-specific pathways have shown immense promise in preclinical and clinical studies aimed at anti-cancer therapy. MASTL (Greatwall in Xeno...

    Authors: Srijayaprakash Babu Uppada, Saiprasad Gowrikumar, Rizwan Ahmad, Balawant Kumar, Bryan Szeglin, Xi Chen, J. Joshua Smith, Surinder K. Batra, Amar B. Singh and Punita Dhawan

    Citation: Molecular Cancer 2018 17:111

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  38. Content type: Letter to the Editor

    The aim of this study was to uncover the pathogenic relevance and the underlying molecular mechanism of a novel CDH1 variant found in a Hereditary Diffuse Gastric Cancer family (p.L13_L15del), which affects the s...

    Authors: Joana Figueiredo, Soraia Melo, Kimberley Gamet, Tanis Godwin, Susana Seixas, João M. Sanches, Parry Guilford and Raquel Seruca

    Citation: Molecular Cancer 2018 17:112

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  39. Content type: Research

    Long non-coding RNAs (lncRNAs) function as key molecules in cancer progression. The lncRNA CYTOR plays oncogenic roles in multiple types of cancer, yet the detailed molecular mechanisms of those roles remain u...

    Authors: Xue Wang, Hongfei Yu, Wenjie Sun, Jianlu Kong, Lei Zhang, Jinlong Tang, Jingyu Wang, Enping Xu, Maode Lai and Honghe Zhang

    Citation: Molecular Cancer 2018 17:110

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  40. Content type: Review

    Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality. Therefore, it is both...

    Authors: Qilian Yang, Yuqing Yang, Nianxin Zhou, Kexin Tang, Wayne Bond Lau, Bonnie Lau, Wei Wang, Lian Xu, Zhengnan Yang, Shuang Huang, Xin Wang, Tao Yi, Xia Zhao, Yuquan Wei, Hongjing Wang, Linjie Zhao…

    Citation: Molecular Cancer 2018 17:109

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  41. Content type: Research

    Gastrointestinal stromal tumour (GIST) is the most common soft tissue sarcoma. The identification of the molecular mechanisms regulating GIST progression is vital for its treatment and prevention. Increasing r...

    Authors: Fuqing Hu, Haijie Li, Lu Liu, Feng Xu, Senyan Lai, Xuelai Luo, Junbo Hu and Xi Yang

    Citation: Molecular Cancer 2018 17:107

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    The Correction to this article has been published in Molecular Cancer 2018 17:135

  42. Content type: Review

    Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microenvironment induced by interactions between pancreatic epithelial/cancer cell...

    Authors: Bo Ren, Ming Cui, Gang Yang, Huanyu Wang, Mengyu Feng, Lei You and Yupei Zhao

    Citation: Molecular Cancer 2018 17:108

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  43. Content type: Research

    A better understanding of the molecular mechanism involving lncRNA-miRNA-mRNA network underlying glioma genesis is beneficial to the treatment of glioma. This study was designed to investigate the role of lncR...

    Authors: Ke Zhou, Chi Zhang, Hui Yao, Xuewen Zhang, Youxin Zhou, Yanjun Che and Yulun Huang

    Citation: Molecular Cancer 2018 17:105

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  44. Content type: Review

    FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA damage and tumorigenesis....

    Authors: Ying Liu, Xiang Ao, Wei Ding, Murugavel Ponnusamy, Wei Wu, Xiaodan Hao, Wanpeng Yu, Yifei Wang, Peifeng Li and Jianxun Wang

    Citation: Molecular Cancer 2018 17:104

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  45. Content type: Review

    Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides. Recent advances in the non-protein coding part of human genome analysis have discovered extensive transcription of large RNA tran...

    Authors: Tao Xu, Chang-ming Lin, Shu-qi Cheng, Jie Min, Li Li, Xiao-ming Meng, Cheng Huang, Lei Zhang, Zi-yu Deng and Jun Li

    Citation: Molecular Cancer 2018 17:103

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  46. Content type: Research

    Patients with colorectal cancer (CRC) have a high incidence of regional and distant metastases. Although metastasis is the main cause of CRC-related death, its molecular mechanisms remain largely unknown.

    Authors: Yi Pan, Joanna Hung Man Tong, Raymond Wai Ming Lung, Wei Kang, Johnny Sheung Him Kwan, Wing Po Chak, Ka Yee Tin, Lau Ying Chung, Feng Wu, Simon Siu Man Ng, Tony Wing Chung Mak, Jun Yu, Kwok Wai Lo, Anthony Wing Hung Chan and Ka Fai To

    Citation: Molecular Cancer 2018 17:102

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