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  1. Content type: Research

    Liver cancer is one of the most deadly cancers in the world. There are various cells in liver tumor bulk, including liver tumor initiating cells (TICs), which account for liver tumorigenesis, drug resistance, ...

    Authors: Ming Shao, Qiankun Yang, Weitao Zhu, Huifang Jin, Jing Wang, Jie Song, Yongkui Kong and Xianping Lv

    Citation: Molecular Cancer 2018 17:173

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  2. Content type: Research

    Cellular senescence is a state of irreversible cell growth arrest and senescence cells permanently lose proliferation potential. Induction of cellular senescence might be a novel therapy for cancer cells. TRIB...

    Authors: Zhenlin Hou, Kaixuan Guo, Xuling Sun, Fuqing Hu, Qianzhi Chen, Xuelai Luo, Guihua Wang, Junbo Hu and Li Sun

    Citation: Molecular Cancer 2018 17:172

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  3. Content type: Letter to the Editor

    Tumorigenesis is increasingly considered to rely on subclones of cells poised to undergo an epithelial to mesenchymal transition (EMT) program. We and others have provided evidence, however, that the tumorigen...

    Authors: Sofie Otzen Bagger, Branden Michael Hopkinson, Deo Prakash Pandey, Mads Bak, Andreas Vincent Brydholm, Rene Villadsen, Kristian Helin, Lone Rønnov-Jessen, Ole William Petersen and Jiyoung Kim

    Citation: Molecular Cancer 2018 17:171

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  4. Content type: Research

    There is an urgent need to identify new molecular targets for treatment of osteosarcoma. Circular RNAs are a class of endogenous RNAs that are extensively found in mammalian cells and exert critical functions ...

    Authors: Gang Liu, Kangmao Huang, Zhiwei Jie, Yizheng Wu, Junxin Chen, Zizheng Chen, Xiangqian Fang and Shuying Shen

    Citation: Molecular Cancer 2018 17:170

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  5. Content type: Letter to the Editor

    EphB2 and EphA2 control stemness and differentiation in the intestinal mucosa, but the way they cooperate with the complex mechanisms underlying tumor heterogeneity and how they affect the therapeutic outcome ...

    Authors: Mariangela De Robertis, Tommaso Mazza, Caterina Fusilli, Luisa Loiacono, Maria Luana Poeta, Massimo Sanchez, Emanuela Massi, Giuseppe Lamorte, Maria Grazia Diodoro, Edoardo Pescarmona, Emanuela Signori, Graziano Pesole, Angelo Luigi Vescovi, Jesus Garcia-Foncillas and Vito Michele Fazio

    Citation: Molecular Cancer 2018 17:169

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  6. Content type: Review

    Recent studies have shown that on one hand, tumors need to obtain a sufficient energy supply, and on the other hand they must evade the body’s immune surveillance. Because of their metabolic reprogramming char...

    Authors: Yi-an Wang, Xiao-Ling Li, Yong-Zhen Mo, Chun-Mei Fan, Le Tang, Fang Xiong, Can Guo, Bo Xiang, Ming Zhou, Jian Ma, Xi Huang, Xu Wu, Yong Li, Gui-Yuan Li, Zhao-yang Zeng and Wei Xiong

    Citation: Molecular Cancer 2018 17:168

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  7. Content type: Research

    Non-coding RNAs (ncRNAs) have been reported to participate in tumor progression by regulating gene expression. Previous studies showed that protein phosphatase Mg2+/Mn2+ dependent 1F (PPM1F) acts a dual role in c...

    Authors: Hongjian Wang, Wei Chen, Ming Jin, Lidan Hou, Xiaoyu Chen, Rui Zhang, Jing Zhang and Jinshui Zhu

    Citation: Molecular Cancer 2018 17:165

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  8. Content type: Research

    Circular RNAs (circRNAs) have been found to play critical roles in the development and progression of various cancers. However, little is known about the effects of the circular RNA network on glioblastoma mul...

    Authors: Renjie Wang, Sai Zhang, Xuyi Chen, Nan Li, Jianwei Li, Ruichao Jia, Yuanqing Pan and Haiqian Liang

    Citation: Molecular Cancer 2018 17:166

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  9. Content type: Letter to the Editor

    Vasculogenic mimicry (VM) gives rise to tumor neovascularization that is critical for tumor growth and metastasis. Long non-coding RNAs (lncRNAs) have been implicated in diverse and fundamental biological proc...

    Authors: Zhenzi Peng, Jun Wang, Bin Shan, Bin Li, Wei Peng, Yeping Dong, Wenwen Shi, Wenyuan Zhao, Dan He, Minghao Duan, Yuanda Cheng, Chunfang Zhang and Chaojun Duan

    Citation: Molecular Cancer 2018 17:167

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  10. Content type: Review

    BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes expression regulation. Inhibition of B...

    Authors: Benedetta Donati, Eugenia Lorenzini and Alessia Ciarrocchi

    Citation: Molecular Cancer 2018 17:164

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  11. Content type: Letter to the Editor

    tRNA-derived small non-coding RNAs (tsncRNAs), a class of newly defined small non-coding RNA, have been considered to be involved in various cellular biological processes through regulating gene expression at ...

    Authors: Eric Y. Peng, Yang Shu, Yuke Wu, Feier Zeng, Shuangyan Tan, Yun Deng, Yiqi Deng, Haining Chen, Lei Zhu and Heng Xu

    Citation: Molecular Cancer 2018 17:163

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  12. Content type: Research

    Increasing evidence has revealed that circular RNAs (circRNAs) play crucial roles in cancer biology. However, the role and underlying regulatory mechanisms of circFNDC3B in bladder cancer (BC) remain unknown.

    Authors: Hongwei Liu, Junming Bi, Wei Dong, Meihua Yang, Juanyi Shi, Ning Jiang, Tianxin Lin and Jian Huang

    Citation: Molecular Cancer 2018 17:161

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  13. Content type: Letter to the Editor

    LncRNAs are involved in the initiation and progression of cancer. However, the molecular mechanism and diverse clinical prognosis of MIR31HG in head and neck squamous cell carcinoma (HNSCC) are still unclear. ...

    Authors: Ru Wang, Zhihong Ma, Ling Feng, Yifan Yang, Chen Tan, Qian Shi, Meng Lian, Shizhi He, Hongzhi Ma and Jugao Fang

    Citation: Molecular Cancer 2018 17:162

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  14. Content type: Research

    Recent studies indicate that circular RNA (circRNA) plays a pivotal role in cancer progression. Here, we sought to investigate its role in breast cancer.

    Authors: Kaixuan Zeng, Bangshun He, Burton B. Yang, Tao Xu, Xiaoxiang Chen, Mu Xu, Xiangxiang Liu, Huiling Sun, Yuqin Pan and Shukui Wang

    Citation: Molecular Cancer 2018 17:160

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  15. Content type: Review

    Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the infla...

    Authors: Maryam Moossavi, Negin Parsamanesh, Afsane Bahrami, Stephen L. Atkin and Amirhossein Sahebkar

    Citation: Molecular Cancer 2018 17:158

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  16. Content type: Letter to the Editor

    Tob1, a Tob/BTG anti-proliferative protein family member, functions as a tumour suppressor in many cancers. Here, we reveal a unique oncogenic role of Tob1 in colon cancer. Tob1 expression was upregulated duri...

    Authors: Dandan Li, Li Xiao, Yuetan Ge, Yu Fu, Wenqing Zhang, Hanwei Cao, Binbin Chen, Haibin Wang, Yan-yan Zhan and Tianhui Hu

    Citation: Molecular Cancer 2018 17:159

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  17. Content type: Research

    Although microRNAs (miRNAs) were revealed as crucial modulators in tumor metastasis and target therapy, our understanding of their roles in metastatic renal cell carcinoma (mRCC) and Sunitinib treatment was li...

    Authors: Wei Zhai, Saiyang Li, Jin Zhang, Yonghui Chen, Junjie Ma, Wen Kong, Dongkui Gong, Junhua Zheng, Wei Xue and Yunfei Xu

    Citation: Molecular Cancer 2018 17:157

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  18. Content type: Letter to the Editor

    Emerging evidence supports the pivotal roles of cancer-associated cachexia in breast cancer progression. However, the mediators and mechanisms that mediate cancer-induced cachexia remain unclear. Here, we show...

    Authors: Qi Wu, Si Sun, Zhiyu Li, Qian Yang, Bei Li, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Changhua Yang, Juanjuan Li and Shengrong Sun

    Citation: Molecular Cancer 2018 17:155

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  19. Content type: Review

    Thyroid cancer incidence is increasing at an alarming rate, almost tripling every decade. In 2017, it was the fifth most common cancer in women. Although the majority of thyroid tumors are curable, about 2–3% ...

    Authors: Shikha Saini, Kiara Tulla, Ajay V. Maker, Kenneth D. Burman and Bellur S. Prabhakar

    Citation: Molecular Cancer 2018 17:154

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  20. Content type: Research

    Dysregulated histone methyltransferase G9a may represent a potential cancer therapeutic target. The roles of G9a in tumorigenesis and therapeutics are not well understood in non-small cell lung cancer (NSCLC)....

    Authors: Keqiang Zhang, Jinhui Wang, Lu Yang, Yate-Ching Yuan, Tommy R. Tong, Jun Wu, Xinwei Yun, Melissa Bonner, Rajendra Pangeni, Zheng Liu, Tiger Yuchi, Jae Y. Kim and Dan J. Raz

    Citation: Molecular Cancer 2018 17:153

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  21. Content type: Letter to the Editor

    Overcoming multidrug resistance has always been a major challenge in cancer treatment. Recent evidence suggested epithelial-mesenchymal transition plays a role in MDR, but the mechanism behind this link remain...

    Authors: Maegan Miang Kee Lim, Jonathan Wei Kiat Wee, Jen Chi Soong, Damien Chua, Wei Ren Tan, Marco Lizwan, Yinliang Li, Ziqiang Teo, Wilson Wen Bin Goh, Pengcheng Zhu and Nguan Soon Tan

    Citation: Molecular Cancer 2018 17:152

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  22. Content type: Research

    Circular RNAs (circRNAs) are a new type of non-coding RNAs and their functions in gastric cancer (GC) remain unclear. Recent studies have revealed that circRNAs play an important role in cancer development and...

    Authors: Hui Liu, Yuan Liu, Zhaolian Bian, Jing Zhang, Rui Zhang, Xiaoyu Chen, Yanxia Huang, Yang Wang and Jinshui Zhu

    Citation: Molecular Cancer 2018 17:151

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  23. Content type: Research

    Lung cancer is the leading cause of cancer related deaths and its incidence is highly correlated with cigarette smoking. Nicotine, the addictive component of tobacco smoke, cannot initiate tumors, but can prom...

    Authors: Courtney M Schaal, Namrata Bora-Singhal, Durairaj Mohan Kumar and Srikumar P Chellappan

    Citation: Molecular Cancer 2018 17:149

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  24. Content type: Review

    Exosomes, extracellular vesicles with diameters ranging from 30 to 150 nm, are widely present in various body fluids. Recently, microRNAs (miRNAs) have been identified in exosomes, the biogenesis, release, and...

    Authors: Zhenqiang Sun, Ke Shi, Shuaixi Yang, Jinbo Liu, Quanbo Zhou, Guixian Wang, Junmin Song, Zhen Li, Zhiyong Zhang and Weitang Yuan

    Citation: Molecular Cancer 2018 17:147

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  25. Content type: Letter to the Editor

    Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer related to asbestos exposure. The discovery of soluble biomarkers with diagnostic/prognostic and/or therapeutic properties would improve the...

    Authors: Patrick Smeele, Sènan Mickaël d’Almeida, Clément Meiller, Anne-Laure Chéné, Charly Liddell, Laurent Cellerin, François Montagne, Sophie Deshayes, Sarah Benziane, Marie-Christine Copin, Paul Hofman, Françoise Le Pimpec-Barthes, Henri Porte, Arnaud Scherpereel, Marc Grégoire, Didier Jean…

    Citation: Molecular Cancer 2018 17:148

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  26. Content type: Research

    Exosomes are extracellular vesicles that mediate cellular communication in health and diseases. Neutrophils could be polarized to a pro-tumor phenotype by tumor. The function of tumor-derived exosomes in neutr...

    Authors: Xu Zhang, Hui Shi, Xiao Yuan, Pengcheng Jiang, Hui Qian and Wenrong Xu

    Citation: Molecular Cancer 2018 17:146

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  27. Content type: Research

    Drug resistance remains an unsolved clinical issue in oncology. Despite promising initial responses obtained with BRAF and MEK kinase inhibitors, resistance to treatment develops within months in virtually all...

    Authors: Giulia Cesi, Demetra Philippidou, Ines Kozar, Yeoun Jin Kim, Francois Bernardin, Guillaume Van Niel, Anke Wienecke-Baldacchino, Paul Felten, Elisabeth Letellier, Sonja Dengler, Dorothee Nashan, Claude Haan and Stephanie Kreis

    Citation: Molecular Cancer 2018 17:145

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  28. Content type: Research

    Circular RNAs (circRNAs) are a new member of noncoding RNAs (ncRNAs) that have recently been described as key regulators of gene expression. Our previous study had identified the negative correlation between c...

    Authors: Fei Xie, Yawei Li, Miao Wang, Chao Huang, Dan Tao, Fuxin Zheng, Hui Zhang, Fuqing Zeng, Xingyuan Xiao and Guosong Jiang

    Citation: Molecular Cancer 2018 17:144

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  29. Content type: Research

    Extracellular communication within the tumor microenvironment plays a critical role in tumor progression. Although exosomes can package into long non-coding RNAs (lncRNAs) to mediate extracellular communicatio...

    Authors: Rui Zheng, Mulong Du, Xiaowei Wang, Weidong Xu, Jiayuan Liang, Wenying Wang, Qiang Lv, Chao Qin, Haiyan Chu, Meilin Wang, Lin Yuan, Jing Qian and Zhengdong Zhang

    Citation: Molecular Cancer 2018 17:143

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  30. Content type: Letter to the Editor

    Recently, expression signatures of exosomal long non-coding RNAs (lncRNAs) have been proposed as potential non-invasive biomarkers for cancer detection. In this study, we aimed to develop a urinary exosome (UE...

    Authors: Yao Zhan, Lutao Du, Lishui Wang, Xiumei Jiang, Shujun Zhang, Juan Li, Keqiang Yan, Weili Duan, Yinghui Zhao, Lili Wang, Yunshan Wang and Chuanxin Wang

    Citation: Molecular Cancer 2018 17:142

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  31. Content type: Research

    Mounting evidence demonstrates that long noncoding RNAs (lncRNAs) have critical roles during the initiation and progression of cancers. In this study, we report that the small nucleolar RNA host gene 1 (SNHG1)...

    Authors: Mu Xu, Xiaoxiang Chen, Kang Lin, Kaixuan Zeng, Xiangxiang Liu, Bei Pan, Xueni Xu, Tao Xu, Xiuxiu Hu, Li Sun, Bangshun He, Yuqin Pan, Huiling Sun and Shukui Wang

    Citation: Molecular Cancer 2018 17:141

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  32. Content type: Research

    TGF-β promotes tumor invasion and metastasis through inducing epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) are recognized as functional non-coding RNA...

    Authors: Longqiang Wang, Xin Tong, Zhengyu Zhou, Shengjie Wang, Zhe Lei, Tianze Zhang, Zeyi Liu, Yuanyuan Zeng, Chang Li, Jun Zhao, Zhiyue Su, Cuijuan Zhang, Xia Liu, Guangquan Xu and Hong-Tao Zhang

    Citation: Molecular Cancer 2018 17:140

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  33. Content type: Research

    Proteogenomic characterization and integrative and comparative genomic analysis provide a functional context to annotate genomic abnormalities with prognostic value.

    Authors: Yu-Shui Ma, Tao Huang, Xiao-Ming Zhong, Hong-Wei Zhang, Xian-Ling Cong, Hong Xu, Gai-Xia Lu, Fei Yu, Shao-Bo Xue, Zhong-Wei Lv and Da Fu

    Citation: Molecular Cancer 2018 17:139

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  34. Content type: Letter to the Editor

    CircRNA expression profiles for gastric cancer (GC) were screened using plasma samples from 10 GC patients with different TNM stages and 5 healthy individuals as controls. Results showed lower expression of ci...

    Authors: Weiwei Tang, Kai Fu, Handong Sun, Dawei Rong, Hanjin Wang and Hongyong Cao

    Citation: Molecular Cancer 2018 17:137

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  35. Content type: Letter to the Editor

    Oncogenic fusion gene Echinoderm Microtubule-associated protein-Like 4-Anaplastic Lymphoma Kinase (EML4-ALK) contributes to tumorigenesis of a subset of non-small cell lung cancer (NSCLC). Recently, we demonstrat...

    Authors: Shuangyan Tan, Dan Sun, Wenchen Pu, Qiheng Gou, Chenglin Guo, Youling Gong, Jiao Li, Yu-Quan Wei, Lunxu Liu, Yun Zhao and Yong Peng

    Citation: Molecular Cancer 2018 17:138

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  36. Content type: Research

    Androgen receptor (AR) is expressed in 60%~ 70% oestrogen receptor (ER)-negative breast cancer (BC) cases and promotes the growth of this cancer subtype. Expression of prostate-derived Ets factor (PDEF), a tra...

    Authors: Lu Cao, Cong Xu, Guomin Xiang, Fang Liu, Xiaozhen Liu, Congying Li, Jing Liu, Qingxiang Meng, Jiao Jiao and Yun Niu

    Citation: Molecular Cancer 2018 17:136

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  37. Content type: Correction

    After the publication of this work [1] an error was noticed in Fig. 7e, in which the incorrect information is shown. The updated figure included in this correction now shows the quantification of tumor microve...

    Authors: Fuqing Hu, Haijie Li, Lu Liu, Feng Xu, Senyan Lai, Xuelai Luo, Junbo Hu and Xi Yang

    Citation: Molecular Cancer 2018 17:135

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    The original article was published in Molecular Cancer 2018 17:107

  38. Content type: Review

    In contrast to normal cells, which use the aerobic oxidation of glucose as their main energy production method, cancer cells prefer to use anaerobic glycolysis to maintain their growth and survival, even under...

    Authors: Xiaodong Zhang, Haiying Zhao, Yan Li, Di Xia, Liang Yang, Yingbo Ma and Hangyu Li

    Citation: Molecular Cancer 2018 17:134

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  39. Content type: Letter to the Editor

    Glioblastoma (GBM) is the most aggressive type of primary brain tumours. Anti-angiogenic therapies (AAT), such as bevacizumab, have been developed to target the tumour blood supply. However, GBM presents mecha...

    Authors: Thomas Simon, Sotiria Pinioti, Pascale Schellenberger, Vinothini Rajeeve, Franz Wendler, Pedro R. Cutillas, Alice King, Justin Stebbing and Georgios Giamas

    Citation: Molecular Cancer 2018 17:132

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  40. Content type: Letter to the Editor

    RUNX1 encodes a Runt-related transcription factor that is critical for hematopoiesis. In this study, through a combinatorial molecular approach, we characterized a novel t(5;21)(q13;q22) translocation involving R...

    Authors: Chi-Keung Cheng, Terry H. Y. Wong, Thomas S. K. Wan, Angela Z. Wang, Natalie P. H. Chan, Nelson C. N. Chan, Chi-Kong Li and Margaret H. L. Ng

    Citation: Molecular Cancer 2018 17:133

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  41. Content type: Letter to the Editor

    Liquid biopsy by genotyping circulating tumor DNA (ctDNA) has provided a non-invasive approach in assessing tumor genomic alterations in clinical oncology. However, emerging evidence in clinical settings has s...

    Authors: Qiaomei Guo, Junlei Wang, Jianfeng Xiao, Lin Wang, Xiaomeng Hu, Wenjun Yu, Gang Song, Jiatao Lou and JianFeng Chen

    Citation: Molecular Cancer 2018 17:131

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  42. Content type: Letter to the Editor

    Chronic myeloid leukemia (CML) is a clonal disease characterized by the presence of the constitutively active tyrosine kinase BCR-ABL oncoprotein. Although BCR-ABL is crucially important for pathogenesis and t...

    Authors: Chengwu Zeng, Sichu Liu, Shuai Lu, Xibao Yu, Jing Lai, Yifan Wu, Shaohua Chen, Liang Wang, Zhi Yu, Gengxin Luo and Yangqiu Li

    Citation: Molecular Cancer 2018 17:130

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  43. Content type: Review

    Programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) is a negative modulatory signaling pathway for activation of T cell. It is acknowledged that PD-1/PD-L1 axis plays a crucial role in ...

    Authors: Ming Yi, Dechao Jiao, Hanxiao Xu, Qian Liu, Weiheng Zhao, Xinwei Han and Kongming Wu

    Citation: Molecular Cancer 2018 17:129

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  44. Content type: Letter to the Editor

    Pheochromocytomas (PCCs) and paragangliomas (PGLs) are the most heritable endocrine tumors. Genetic testing for 12 driver susceptibility genes is recommended in all PCC and PGL cases. However, detection of som...

    Authors: Liang Wang, Ying Li, Xin Guan, Jingyuan Zhao, Liming Shen and Jing Liu

    Citation: Molecular Cancer 2018 17:128

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  45. Content type: Research

    Gastric cancer (GC) is a common malignancy and frequent cause of cancer-related death. Long non-coding RNAs (lncRNAs) have emerged as important regulators and tissue-specific biomarkers of multiple cancers, in...

    Authors: Xian-Zi Yang, Tian-Tian Cheng, Qing-Jun He, Zi-Ying Lei, Jun Chi, Zhen Tang, Quan-Xing Liao, Hong Zhang, Li-Si Zeng and Shu-Zhong Cui

    Citation: Molecular Cancer 2018 17:126

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  46. Content type: Letter to the Editor

    The long noncoding RNA ANRIL has been found to be abnormally expressed and play important roles in different cancers. However, the expression and function of ANRIL in acute myeloid leukemia (AML) remain to be ...

    Authors: Lin-Yu Sun, Xiao-Juan Li, Yu-Meng Sun, Wei Huang, Ke Fang, Cai Han, Zhen-Hua Chen, Xue-Qun Luo, Yue-Qin Chen and Wen-Tao Wang

    Citation: Molecular Cancer 2018 17:127

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  47. Content type: Research

    The prognosis for esophageal squamous cell carcinoma (ESCC) patients with lymph node metastasis (LNM) is still dismal. Elucidation of the LNM associated genomic alteration and underlying molecular mechanisms m...

    Authors: Weimin Zhang, Ruoxi Hong, Lin Li, Yan Wang, Peina Du, Yunwei Ou, Zitong Zhao, Xuefeng Liu, Wenchang Xiao, Dezuo Dong, Qingnan Wu, Jie Chen, Yongmei Song and Qimin Zhan

    Citation: Molecular Cancer 2018 17:125

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  48. Content type: Letter to the Editor

    Tip110, an important regulator of several oncogenic proteins, was significantly downregulated in human metastatic melanoma cells exposed to a hypoxic condition. Therefore, in this study, we set to determine wh...

    Authors: Khalid Amine Timani, Balázs Győrffy, Ying Liu, Khalid S. Mohammad and Johnny J. He

    Citation: Molecular Cancer 2018 17:124

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