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  1. Content type: Research

    The objective of the present study was to identify human epididymis protein 4 (HE4) interacting proteins and explore the mechanisms underlying their effect on ovarian cancer cell invasion and metastasis.

    Authors: Huiyu Zhuang, Mingzi Tan, Juanjuan Liu, Zhenhua Hu, Dawo Liu, Jian Gao, Liancheng Zhu and Bei Lin

    Citation: Molecular Cancer 2014 13:243

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  2. Content type: Research

    Cetuximab, an anti-EGFR monoclonal antibody, is used to treat several cancers. However, many patients who initially respond to cetuximab acquire resistance. To examine mechanisms of acquired resistance, we dev...

    Authors: Mari Iida, Toni M Brand, Megan M Starr, Evan J Huppert, Neha Luthar, Harsh Bahrar, John P Coan, Hannah E Pearson, Ravi Salgia and Deric L Wheeler

    Citation: Molecular Cancer 2014 13:242

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  3. Content type: Research

    Pim-1 kinase is a proto-oncogene and its dysregulation contributes to tumorigenesis and progression of a variety of malignancies. Pim-1 was suggested as a therapeutic target of cancers. The functional relevanc...

    Authors: Wenshuai Pang, Xin Tian, Fan Bai, Ruiyu Han, Juan Wang, Haitao Shen, Xianghong Zhang, Yueping Liu, Xia Yan, Feng Jiang and Lingxiao Xing

    Citation: Molecular Cancer 2014 13:240

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  4. Content type: Research

    Ovarian cancer has the lowest survival rate of all gynaecologic cancers and is characterised by a lack of early symptoms and frequent late stage diagnosis. There is a paucity of robust molecular markers that a...

    Authors: Stephen F Madden, Colin Clarke, Britta Stordal, Mark S Carey, Russell Broaddus, William M Gallagher, John Crown, Gordon B Mills and Bryan T Hennessy

    Citation: Molecular Cancer 2014 13:241

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  5. Content type: Research

    About 70% of all breast cancers are estrogen receptor alpha positive (ER+) and are treated with antiestrogens. However, 50% of ER + tumors develop resistance to these drugs (endocrine resistance). In endocrine...

    Authors: Ayesha N Shajahan-Haq, Katherine L Cook, Jessica L Schwartz-Roberts, Ahreej E Eltayeb, Diane M Demas, Anni M Warri, Caroline O B Facey, Leena A Hilakivi-Clarke and Robert Clarke

    Citation: Molecular Cancer 2014 13:239

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  6. Content type: Research

    Tumor cell subpopulations can either compete with each other for nutrients and physical space within the tumor niche, or co-operate for enhanced survival, or replicative or metastatic capacities. Recently, we ...

    Authors: Francesca Mateo, Óscar Meca-Cortés, Toni Celià-Terrassa, Yolanda Fernández, Ibane Abasolo, Lourdes Sánchez-Cid, Raquel Bermudo, Amaia Sagasta, Leonardo Rodríguez-Carunchio, Mònica Pons, Verónica Cánovas, Mercedes Marín-Aguilera, Lourdes Mengual, Antonio Alcaraz, Simó Schwartz Jr., Begoña Mellado…

    Citation: Molecular Cancer 2014 13:237

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  7. Content type: Short communication

    Bone metastases arise in nearly 70% of patients with advanced breast cancer, but the complex metastatic process has not been completely clarified yet. RANKL/RANK/OPG pathway modifications and the crosstalk bet...

    Authors: Chiara Arrigoni, Paola De Luca, Mara Gilardi, Sara Previdi, Massimo Broggini and Matteo Moretti

    Citation: Molecular Cancer 2014 13:238

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  8. Content type: Research

    Osteosarcoma is the most common primary malignant tumor in children and young adults, and its treatment requires effective therapeutic approaches because of a high mortality rate for lung metastasis. Epithelia...

    Authors: Chun-Han Hou, Feng-Ling Lin, Sheng-Mon Hou and Ju-Fang Liu

    Citation: Molecular Cancer 2014 13:236

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  9. Content type: Research

    Chemoresistance is a major obstacle to the curative cancer chemotherapy and presents one of the most formidable challenges in both research and management of cancer.

    Authors: Hui Deng, Lei Lv, Yang Li, Cheng Zhang, Fang Meng, Youguang Pu, Jun Xiao, Liting Qian, Weidong Zhao, Qi Liu, Daming Zhang, Yingwei Wang, Hongyu Zhang, Yinghua He and Jingde Zhu

    Citation: Molecular Cancer 2014 13:234

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  10. Content type: Research

    GPRC5A is a retinoic acid inducible gene that is preferentially expressed in lung tissue. Gprc5a– knockout mice develop spontaneous lung cancer, indicating Gprc5a is a lung tumor suppressor gene. GPRC5A expressio...

    Authors: Xiaofeng Lin, Shuangshuang Zhong, Xiaofeng Ye, Yueling Liao, Feng Yao, Xiaohua Yang, Beibei Sun, Jie Zhang, Qi Li, Yong Gao, Yifan Wang, Jingyi Liu, Baohui Han, Y Eugene Chin, Binhua P Zhou and Jiong Deng

    Citation: Molecular Cancer 2014 13:233

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  11. Content type: Research

    Patients suffering from brain tumours such as glioblastoma and medulloblastoma have poor prognosis with a median survival of less than a year. Identifying alternative molecular targets would enable us to devel...

    Authors: Resham Lal Gurung, Hui Kheng Lim, Shriram Venkatesan, Phoebe Su Wen Lee and M Prakash Hande

    Citation: Molecular Cancer 2014 13:232

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  12. Content type: Research

    Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Pemetrexed, a multi-target folate antagonist, has demonstrated efficacy in NSCLC histological subtypes characterized b...

    Authors: Donatella Del Bufalo, Marianna Desideri, Teresa De Luca, Marta Di Martile, Chiara Gabellini, Valentina Monica, Simone Busso, Adriana Eramo, Ruggero De Maria, Michele Milella and Daniela Trisciuoglio

    Citation: Molecular Cancer 2014 13:230

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  13. Content type: Research

    The AKT/mammalian target of rapamycin (mTOR) signaling pathway is regulated by 17α-estradiol (E2) signaling and mediates E2-induced proliferation and progesterone receptor (PgR) expression in breast cancer.

    Authors: Elizabeth C Martin, Lyndsay V Rhodes, Steven Elliott, Adrienne E Krebs, Kenneth P Nephew, Erik K Flemington, Bridgette M Collins-Burow and Matthew E Burow

    Citation: Molecular Cancer 2014 13:229

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  14. Content type: Research

    The lastly identified claudin-low (CL) subtype of breast cancer (BC) remains poorly described as compared to the other molecular subtypes. We provide a comprehensive characterization of the largest series of C...

    Authors: Renaud Sabatier, Pascal Finetti, Arnaud Guille, José Adelaide, Max Chaffanet, Patrice Viens, Daniel Birnbaum and François Bertucci

    Citation: Molecular Cancer 2014 13:228

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  15. Content type: Research

    A remolded microenvironment in hepatocellular carcinoma (HCC) caused by abnormally expressed matricellular proteins could promote HCC progression. The cell-matrix interactions mediated by integrins play an imp...

    Authors: Ming-Xuan Feng, Ming-Ze Ma, Ying Fu, Jun Li, Tao Wang, Feng Xue, Jian-Jun Zhang, Wen-Xin Qin, Jian-Ren Gu, Zhi-Gang Zhang and Qiang Xia

    Citation: Molecular Cancer 2014 13:226

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  16. Content type: Research

    FOXO transcription factors control cellular levels of reactive oxygen species (ROS) which critically contribute to cell survival and cell death in neuroblastoma. In the present study we investigated the regula...

    Authors: Stefan Salcher, Judith Hagenbuchner, Kathrin Geiger, Maximilian A Seiter, Johannes Rainer, Reinhard Kofler, Martin Hermann, Ursula Kiechl-Kohlendorfer, Michael J Ausserlechner and Petra Obexer

    Citation: Molecular Cancer 2014 13:224

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  17. Content type: Research

    Thrombospondins (THBSs) are a family of multidomain and secreted matricellular Ca2+-binding glycoproteins which has at least five members encoded by independent genes. As a THBSs family member, Thrombospondin2 (T...

    Authors: Ruochuan Sun, Jifeng Wu, Yuanyuan Chen, Mingdian Lu, Shangxin Zhang, Daru Lu and Yongxiang Li

    Citation: Molecular Cancer 2014 13:225

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  18. Content type: Research

    About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk with unfavorable prognosis. In the framework of the European Network for Individualized Treatment in EC (ENITEC), we invest...

    Authors: Lorena Alonso-Alconada, Laura Muinelo-Romay, Kadri Madissoo, Antonio Diaz-Lopez, Camilla Krakstad, Jone Trovik, Elisabeth Wik, Dharani Hapangama, Lieve Coenegrachts, Amparo Cano, Antonio Gil-Moreno, Luis Chiva, Juan Cueva, Maria Vieito, Eugenia Ortega, Javier Mariscal…

    Citation: Molecular Cancer 2014 13:223

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  19. Content type: Research

    The metastasis of hematogenous cancer cells is associated with abnormal glycosylation such as sialyl lewis antigens. Although the hepatitis B virus X protein (HBx) plays important role in liver disease, the pr...

    Authors: Tae-Wook Chung, Seok-Jo Kim, Hee-Jung Choi, Kwon-Ho Song, Un-Ho Jin, Dae-Yeul Yu, Je-Kyung Seong, Jong-Guk Kim, Keuk-Jun Kim, Jeong-Heon Ko, Ki-Tae Ha, Young-Choon Lee and Cheorl-Ho Kim

    Citation: Molecular Cancer 2014 13:222

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  20. Content type: Research

    Cancer cells in the advanced stage show aberrant antioxidant capacity to detoxify excessive ROS resulting in the compensation for intrinsic oxidative stress and therapeutic resistance. PDAC is one of the most ...

    Authors: Xinlai Cheng, Palvo Holenya, Suzan Can, Hamed Alborzinia, Riccardo Rubbiani, Ingo Ott and Stefan Wölfl

    Citation: Molecular Cancer 2014 13:221

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  21. Content type: Research

    ERBB3, one of the four members of the ErbB family of receptor tyrosine kinases, plays an important role in breast cancer etiology and progression. In the present study, we aimed to identify novel miRNAs that c...

    Authors: Xin Yan, Xi Chen, Hongwei Liang, Ting Deng, Weixu Chen, Suyang Zhang, Minghui Liu, Xiujuan Gao, Yanqing Liu, Chihao Zhao, Xueliang Wang, Nan Wang, Jialu Li, Rui Liu, Ke Zen, Chen-Yu Zhang…

    Citation: Molecular Cancer 2014 13:220

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  22. Content type: Research

    MicroRNA-196 (miR-196), which is highly up-regulated in oral cancer cells, has been reported to be aberrantly expressed in several cancers; however, the significance of miR-196 in oral cancer has not yet been ...

    Authors: Ya-Ching Lu, Joseph T Chang, Chun-Ta Liao, Chung-Jan Kang, Shiang-Fu Huang, I-How Chen, Chi-Che Huang, Yu-Chen Huang, Wen-Ho Chen, Chi-Ying Tsai, Hung-Ming Wang, Tzu-Chen Yen, Guo-Rung You, Chang-Hsu Chiang and Ann-Joy Cheng

    Citation: Molecular Cancer 2014 13:218

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  23. Content type: Research

    Synthetic double-stranded RNA poly(I:C) is a useful immune adjuvant and exhibits direct antitumor effects against several types of cancers. In this study, we elucidated the mechanisms underlying the effects in...

    Authors: Nanae Harashima, Takafumi Minami, Hirotsugu Uemura and Mamoru Harada

    Citation: Molecular Cancer 2014 13:217

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  24. Content type: Research

    Emerging evidence suggests that small nucleolar RNAs (snoRNAs) are involved in tumorigenesis. The roles of small nucleolar RNA 113–1 (SNORD113-1) on the development of hepatocellular carcinoma (HCC) remain unk...

    Authors: Gang Xu, Fang Yang, Cui-Ling Ding, Lan-Juan Zhao, Hao Ren, Ping Zhao, Wen Wang and Zhong-Tian Qi

    Citation: Molecular Cancer 2014 13:216

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  25. Content type: Research

    Prostate cancer (PCa) is the second leading cause of cancer mortality of men in Western countries. The androgen receptor (AR) and AR-agonists (androgens) are required for the development and progression of the...

    Authors: Julia Roediger, Wiebke Hessenkemper, Sophie Bartsch, Marina Manvelyan, Soeren S Huettner, Thomas Liehr, Mohsen Esmaeili, Susan Foller, Iver Petersen, Marc-Oliver Grimm and Aria Baniahmad

    Citation: Molecular Cancer 2014 13:214

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  26. Content type: Research

    The DEK gene is highly expressed in a wide range of cancer cells, and a recurrent translocation partner in acute myeloid leukemia. While DEK has been identified as one of the most abundant proteins in human ch...

    Authors: Carl Sandén, Linnea Järvstråt, Andreas Lennartsson, Per Ludvik Brattås, Björn Nilsson and Urban Gullberg

    Citation: Molecular Cancer 2014 13:215

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  27. Content type: Research

    Tumor-initiating cells (TICs), aka “cancer stem cells”, are believed to fuel tumors and to sustain therapy resistance and systemic metastasis. Breast cancer is the first human carcinoma in which a subpopulatio...

    Authors: Felicia Leccia, Luigi Del Vecchio, Elisabetta Mariotti, Rosa Di Noto, Anne-Pierre Morel, Alain Puisieux, Francesco Salvatore and Stéphane Ansieau

    Citation: Molecular Cancer 2014 13:213

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  28. Content type: Short communication

    p57Kip2, a cyclin-dependent kinase inhibitor, is considered to be a candidate tumor suppressor gene that has been implicated in Beckwith-Wiedemann syndrome and sporadic cancers. In addition, decreased expression ...

    Authors: Sweta Mishra, Chun-Lin Lin, Tim H-M Huang, Hakim Bouamar and Lu-Zhe Sun

    Citation: Molecular Cancer 2014 13:212

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  29. Content type: Research

    Radiation therapy is one of the most effective therapeutic tools for brain metastasis. However, it is inevitable that some cancer cells become resistant to radiation. This study is focused on the identificatio...

    Authors: Seung Ho Choi, Heekyoung Yang, Seung Ho Lee, Joo-Hyun Ki, Do-Hyun Nam and Hae Yong Yoo

    Citation: Molecular Cancer 2014 13:211

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  30. Content type: Research

    Increased incidence of lung cancer among pulmonary tuberculosis patients suggests mycobacteria-induced tumorigenic response in the host. The alveolar epithelial cells, candidate cells that form lung adenocarci...

    Authors: Sahana Holla, Devram Sampat Ghorpade, Vikas Singh, Kushagra Bansal and Kithiganahalli Narayanaswamy Balaji

    Citation: Molecular Cancer 2014 13:210

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  31. Content type: Research

    Early in cancer development, tumour cells express vascular endothelial growth factor (VEGF), a secreted molecule that is important in all stages of angiogenesis, an essential process that provides nutrients an...

    Authors: Jaime G Fernández, Diego A Rodríguez, Manuel Valenzuela, Claudia Calderon, Ulises Urzúa, David Munroe, Carlos Rosas, David Lemus, Natalia Díaz, Mathew C Wright, Lisette Leyton, Julio C Tapia and Andrew FG Quest

    Citation: Molecular Cancer 2014 13:209

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  32. Content type: Research

    Prostate cancer (PCa) bone metastasis can be markedly enhanced by increased receptor activator of NF kappa-B ligand (RANKL) expression in PCa cells. Molecular mechanisms that account for the increased predilec...

    Authors: Shabnam Ziaee and Leland WK Chung

    Citation: Molecular Cancer 2014 13:208

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  33. Content type: Research

    Hypoxia induced by antiangiogenic agents is linked to the generation of cancer stem cells (CSCs) and treatment failure through unknown mechanisms. The generation of endothelial cell-independent microcirculatio...

    Authors: Danfang Zhang, Baocun Sun, Xiulan Zhao, Yuemei Ma, Ru Ji, Qiang Gu, Xueyi Dong, Jing Li, Fang Liu, Xiaohua Jia, Xue Leng, Chong Zhang, Ran Sun and Jiadong Chi

    Citation: Molecular Cancer 2014 13:207

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  34. Content type: Research

    MicroRNAs are endogenous small noncoding RNAs that are functionally involved in numerous critical cellular processes including tumorigenesis. Data mining using a microRNA array database suggested that let-7d m...

    Authors: Boxing Su, Wei Zhao, Bentao Shi, Zhongyuan Zhang, Xi Yu, Feng Xie, Zhongqiang Guo, Xiaoyu Zhang, Jin Liu, Qi Shen, Jinghua Wang, Xuesong Li, Zhiqian Zhang and Liqun Zhou

    Citation: Molecular Cancer 2014 13:206

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  35. Content type: Research

    Human T-cell leukemia virus type 1 (HTLV-I) is a human retrovirus associated with adult T-cell leukemia (ATL), an aggressive CD4 T-cell proliferative disease with dismal prognosis. The long latency preceding t...

    Authors: Hassiba Chaib-Mezrag, Delphine Lemaçon, Hélène Fontaine, Marcia Bellon, Xue Tao Bai, Marjorie Drac, Arnaud Coquelle and Christophe Nicot

    Citation: Molecular Cancer 2014 13:205

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  36. Content type: Research

    Despite modern advances in treatment, skin cancer is still one of the most common causes of death in the western countries. Chemotherapy plays an important role in melanoma management. Tamoxifen has been used ...

    Authors: Naoshad Mohammad, Parmanand Malvi, Avtar Singh Meena, Shivendra Vikram Singh, Balkrishna Chaube, Garikapati Vannuruswamy, Mahesh J Kulkarni and Manoj Kumar Bhat

    Citation: Molecular Cancer 2014 13:204

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  37. Content type: Research

    Gamabufotalin (CS-6), a major bufadienolide of Chansu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. However, the underlying mechanism of CS-6 involved in a...

    Authors: Zhenlong Yu, Wei Guo, Xiaochi Ma, Baojing Zhang, Peipei Dong, Lin Huang, Xiuli Wang, Chao Wang, Xiaokui Huo, Wendan Yu, Canhui Yi, Yao Xiao, Wenjing Yang, Yu Qin, Yuhui Yuan, Songshu Meng…

    Citation: Molecular Cancer 2014 13:203

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  38. Content type: Research

    In our previous studies we reported a panel of 24 miRNAs that allowed discrimination between blood of lung tumor patients independent of the histological subtype and blood of healthy controls with an accuracy ...

    Authors: Petra Leidinger, Christina Backes, Michael Blatt, Andreas Keller, Hanno Huwer, Philipp Lepper, Robert Bals and Eckart Meese

    Citation: Molecular Cancer 2014 13:202

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  39. Content type: Research

    Thymoquinone (TQ) was shown to reduce tumor growth in several cancer models both in vitro and in vivo. So far only a few targets of TQ, including protein kinases have been identified. Considering that kinases are...

    Authors: Chirine El-Baba, Vijayalakshmi Mahadevan, Fabian B Fahlbusch, Suma Mohan S, Tilman T Rau, Hala Gali-Muhtasib and Regine Schneider-Stock

    Citation: Molecular Cancer 2014 13:201

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  40. Content type: Research

    The serine protease Granzyme B (GzB) is primarily expressed by cytotoxic T lymphocytes and natural killer cells, and functions in allowing these cells to induce apoptosis in virally-infected or transformed cel...

    Authors: Joel D Pearson, Jingxi Zhang, Zuoqiao Wu, Kayla D Thew, Katelynn J Rowe, Julinor TC Bacani and Robert J Ingham

    Citation: Molecular Cancer 2014 13:199

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    The Erratum to this article has been published in Molecular Cancer 2016 15:19

  41. Content type: Research

    N-Myc Interactor is an inducible protein whose expression is compromised in advanced stage breast cancer. Downregulation of NMI, a gatekeeper of epithelial phenotype, in breast tumors promotes mesenchymal, inv...

    Authors: Jack W Rostas III, Hawley C Pruitt, Brandon J Metge, Aparna Mitra, Sarah K Bailey, Sejong Bae, Karan P Singh, Daniel J Devine, Donna L Dyess, William O Richards, J Allan Tucker, Lalita A Shevde and Rajeev S Samant

    Citation: Molecular Cancer 2014 13:200

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  42. Content type: Research

    Recent advances have revealed a significant contribution of chemokines and their receptors in tumor growth, survival after chemotherapy, and organ-specific metastasis. The CXC chemokine receptor-7 (CXCR7) is t...

    Authors: Nicole Salazar, Daniel Muñoz, Georgios Kallifatidis, Rajendra K Singh, Mercè Jordà and Bal L Lokeshwar

    Citation: Molecular Cancer 2014 13:198

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  43. Content type: Research

    Ambiguity in malignant transformation of glioma has made prognostic diagnosis very challenging. Tumor malignant transformation is closely correlated with specific alterations of the metabolic profile. Explorat...

    Authors: Wei Shao, Jinping Gu, Caihua Huang, Dan Liu, Huiying Huang, Zicheng Huang, Zhen Lin, Wensheng Yang, Kun Liu, Donghai Lin and Tianhai Ji

    Citation: Molecular Cancer 2014 13:197

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  44. Content type: Research

    Development of novel adjuvant therapy to eradicate tumor angiogenesis and metastasis is a pressing need for patients with advanced hepatocellular carcinoma (HCC). We aimed to investigate the clinical relevance...

    Authors: Kevin Tak-Pan Ng, Aimin Xu, Qiao Cheng, Dong Yong Guo, Zophia Xue-Hui Lim, Chris Kin-Wai Sun, Jeffrey Hon-Sing Fung, Ronnie Tung-Ping Poon, Sheung Tat Fan, Chung Mau Lo and Kwan Man

    Citation: Molecular Cancer 2014 13:196

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  45. Content type: Research

    Transducin β-like 1 X-linked receptor 1 (TBL1XR1) is an important transcriptional cofactor involved in the regulation of many signaling pathways, and is associated with carcinogenesis and tumor progression. Ho...

    Authors: Shu-Peng Chen, Qi Yang, Chan-Juan Wang, Long-Juan Zhang, Yi Fang, Fang-Yong Lei, Shu Wu, Li-Bing Song, Xiang Guo and Ling Guo

    Citation: Molecular Cancer 2014 13:195

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  46. Content type: Research

    In melanoma, dysregulation of the MAPK pathway, usually via BRAF V600 or NRAS Q61 somatic mutations, leads to constitutive ERK signali...

    Authors: Deborah JL Wong, Lidia Robert, Mohammad S Atefi, Amanda Lassen, Geetha Avarappatt, Michael Cerniglia, Earl Avramis, Jennifer Tsoi, David Foulad, Thomas G Graeber, Begonya Comin-Anduix, Ahmed Samatar, Roger S Lo and Antoni Ribas

    Citation: Molecular Cancer 2014 13:194

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    The Erratum to this article has been published in Molecular Cancer 2015 14:128

  47. Content type: Research

    MicroRNAs (miRNAs) have been identified as important posttranscriptional regulators involved in various biological and pathological processes of cells, but their association with tumor chemoresistance has not ...

    Authors: Jipeng Li, Yiping Wang, Yulan Song, Zhongming Fu and Wanjun Yu

    Citation: Molecular Cancer 2014 13:193

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