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  2. In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement of initiation and progression of diverse kinds of human ...

    Authors: Rui Yang, Lei Xing, Xiaying Zheng, Yan Sun, Xiaosong Wang and Junxia Chen
    Citation: Molecular Cancer 2019 18:4
    Content type: Research Published on:

  3. Trastuzumab resistance followed by metastasis is a major obstacle for improving the clinical outcome of patients with advanced human epidermal growth factor receptor 2-positive (HER-2+) breast cancer. While lo...

    Authors: Huaying Dong, Jianguo Hu, Kejian Zou, Mulin Ye, Yuanwen Chen, Chengyi Wu, Xin Chen and Mingli Han
    Citation: Molecular Cancer 2019 18:3
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2021 20:87

  4. Recent studies identified that low levels of tumour suppressor microRNAs (miRNAs) in plasma/serum relate to tumour progression and poor outcomes in cancers. We selected six candidates (miR-126, 133b, 143, 203,...

    Authors: Jun Kiuchi, Shuhei Komatsu, Taisuke Imamura, Keiji Nishibeppu, Katsutoshi Shoda, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Atsushi Shiozaki, Kazuma Okamoto, Hitoshi Fujiwara, Daisuke Ichikawa and Eigo Otsuji
    Citation: Molecular Cancer 2019 18:2
    Content type: Letter to the Editor Published on:

  5. Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, and serves as a conduit for...

    Authors: Yunzhao Chen, Dandan Wang, Hao Peng, Xi Chen, Xueping Han, Jie Yu, Wenjie Wang, Lirong Liang, Zheng Liu, Yi Zheng, Jianming Hu, Lan Yang, Jun Li, Hong Zhou, Xiaobin Cui and Feng Li
    Citation: Molecular Cancer 2019 18:1
    Content type: Research Published on:

  6. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with high morbidity, relapse and mortality rates. Multipotent mesenchymal stromal cells (MSCs) can be recruited to and become int...

    Authors: Zeli Yin, Keqiu Jiang, Rui Li, Chengyong Dong and Liming Wang
    Citation: Molecular Cancer 2018 17:178
    Content type: Review Published on:

  7. Right-sided colon cancer (RCC) has worse prognosis compared to left-sided colon cancer (LCC) and rectal cancer. The reason for this difference in outcomes is not well understood. We performed comparative somat...

    Authors: Robin Imperial, Zaheer Ahmed, Omer M. Toor, Cihat ErdoÄŸan, Ateeq Khaliq, Paul Case, James Case, Kevin Kennedy, Lee S. Cummings, Niklas Melton, Shahzad Raza, Banu Diri, Ramzi Mohammad, Bassel El-Rayes, Timothy Pluard, Arif Hussain…
    Citation: Molecular Cancer 2018 17:177
    Content type: Letter to the Editor Published on:

  8. Although the genetic spectrum of human colorectal cancer (CRC) is mainly characterized by APC, KRAS and TP53 mutations, driver genes in tumor initiation have not been conclusively demonstrated. In this study, we ...

    Authors: Erfei Chen, Fangfang Yang, Hongjuan He, Qiqi Li, Wei Zhang, Jinliang Xing, Ziqing Zhu, Jingjing Jiang, Hua Wang, Xiaojuan Zhao, Ruitao Liu, Lei Lei, Jing Dong, Yuchen Pei, Ying Yang, Junqiang Pan…
    Citation: Molecular Cancer 2018 17:176
    Content type: Research Published on:

  9. Even when targets responsible for chemoresistance are identified, drug development is often hampered due to the poor druggability of these proteins. We systematically analyzed therapy-resistance with a large-s...

    Authors: Soon-Ki Hong, Haeseung Lee, Ok-Seon Kwon, Na-Young Song, Hyo-Ju Lee, Seungmin Kang, Jeong-Hwan Kim, Mirang Kim, Wankyu Kim and Hyuk-Jin Cha
    Citation: Molecular Cancer 2018 17:175
    Content type: Letter to the Editor Published on:

  10. Chromatin modification at mitosis is closely related to transcriptional reactivation in the subsequent cell cycle. We reasoned this process is deregulated by oncogenic signals, which would contribute to mitoti...

    Authors: Jingjie Li, Bin Hu, Ting Wang, Wenhua Huang, Chunmin Ma, Qin Zhao, Lingang Zhuo, Tao Zhang and Yuhui Jiang
    Citation: Molecular Cancer 2018 17:174
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2019 18:172

  11. Liver cancer is one of the most deadly cancers in the world. There are various cells in liver tumor bulk, including liver tumor initiating cells (TICs), which account for liver tumorigenesis, drug resistance, ...

    Authors: Ming Shao, Qiankun Yang, Weitao Zhu, Huifang Jin, Jing Wang, Jie Song, Yongkui Kong and Xianping Lv
    Citation: Molecular Cancer 2018 17:173
    Content type: Research Published on:

  12. Cellular senescence is a state of irreversible cell growth arrest and senescence cells permanently lose proliferation potential. Induction of cellular senescence might be a novel therapy for cancer cells. TRIB...

    Authors: Zhenlin Hou, Kaixuan Guo, Xuling Sun, Fuqing Hu, Qianzhi Chen, Xuelai Luo, Guihua Wang, Junbo Hu and Li Sun
    Citation: Molecular Cancer 2018 17:172
    Content type: Research Published on:

  13. Tumorigenesis is increasingly considered to rely on subclones of cells poised to undergo an epithelial to mesenchymal transition (EMT) program. We and others have provided evidence, however, that the tumorigen...

    Authors: Sofie Otzen Bagger, Branden Michael Hopkinson, Deo Prakash Pandey, Mads Bak, Andreas Vincent Brydholm, Rene Villadsen, Kristian Helin, Lone Rønnov-Jessen, Ole William Petersen and Jiyoung Kim
    Citation: Molecular Cancer 2018 17:171
    Content type: Letter to the Editor Published on:

  14. There is an urgent need to identify new molecular targets for treatment of osteosarcoma. Circular RNAs are a class of endogenous RNAs that are extensively found in mammalian cells and exert critical functions ...

    Authors: Gang Liu, Kangmao Huang, Zhiwei Jie, Yizheng Wu, Junxin Chen, Zizheng Chen, Xiangqian Fang and Shuying Shen
    Citation: Molecular Cancer 2018 17:170
    Content type: Research Published on:

  15. EphB2 and EphA2 control stemness and differentiation in the intestinal mucosa, but the way they cooperate with the complex mechanisms underlying tumor heterogeneity and how they affect the therapeutic outcome ...

    Authors: Mariangela De Robertis, Tommaso Mazza, Caterina Fusilli, Luisa Loiacono, Maria Luana Poeta, Massimo Sanchez, Emanuela Massi, Giuseppe Lamorte, Maria Grazia Diodoro, Edoardo Pescarmona, Emanuela Signori, Graziano Pesole, Angelo Luigi Vescovi, Jesus Garcia-Foncillas and Vito Michele Fazio
    Citation: Molecular Cancer 2018 17:169
    Content type: Letter to the Editor Published on:

  16. Recent studies have shown that on one hand, tumors need to obtain a sufficient energy supply, and on the other hand they must evade the body’s immune surveillance. Because of their metabolic reprogramming char...

    Authors: Yi-an Wang, Xiao-Ling Li, Yong-Zhen Mo, Chun-Mei Fan, Le Tang, Fang Xiong, Can Guo, Bo Xiang, Ming Zhou, Jian Ma, Xi Huang, Xu Wu, Yong Li, Gui-Yuan Li, Zhao-yang Zeng and Wei Xiong
    Citation: Molecular Cancer 2018 17:168
    Content type: Review Published on:

  17. Vasculogenic mimicry (VM) gives rise to tumor neovascularization that is critical for tumor growth and metastasis. Long non-coding RNAs (lncRNAs) have been implicated in diverse and fundamental biological proc...

    Authors: Zhenzi Peng, Jun Wang, Bin Shan, Bin Li, Wei Peng, Yeping Dong, Wenwen Shi, Wenyuan Zhao, Dan He, Minghao Duan, Yuanda Cheng, Chunfang Zhang and Chaojun Duan
    Citation: Molecular Cancer 2018 17:167
    Content type: Letter to the Editor Published on:

  18. Circular RNAs (circRNAs) have been found to play critical roles in the development and progression of various cancers. However, little is known about the effects of the circular RNA network on glioblastoma mul...

    Authors: Renjie Wang, Sai Zhang, Xuyi Chen, Nan Li, Jianwei Li, Ruichao Jia, Yuanqing Pan and Haiqian Liang
    Citation: Molecular Cancer 2018 17:166
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:153

  19. Non-coding RNAs (ncRNAs) have been reported to participate in tumor progression by regulating gene expression. Previous studies showed that protein phosphatase Mg2+/Mn2+ dependent 1F (PPM1F) acts a dual role in c...

    Authors: Hongjian Wang, Wei Chen, Ming Jin, Lidan Hou, Xiaoyu Chen, Rui Zhang, Jing Zhang and Jinshui Zhu
    Citation: Molecular Cancer 2018 17:165
    Content type: Research Published on:

  20. BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes expression regulation. Inhibition of B...

    Authors: Benedetta Donati, Eugenia Lorenzini and Alessia Ciarrocchi
    Citation: Molecular Cancer 2018 17:164
    Content type: Review Published on:

  21. tRNA-derived small non-coding RNAs (tsncRNAs), a class of newly defined small non-coding RNA, have been considered to be involved in various cellular biological processes through regulating gene expression at ...

    Authors: Eric Y. Peng, Yang Shu, Yuke Wu, Feier Zeng, Shuangyan Tan, Yun Deng, Yiqi Deng, Haining Chen, Lei Zhu and Heng Xu
    Citation: Molecular Cancer 2018 17:163
    Content type: Letter to the Editor Published on:

  22. LncRNAs are involved in the initiation and progression of cancer. However, the molecular mechanism and diverse clinical prognosis of MIR31HG in head and neck squamous cell carcinoma (HNSCC) are still unclear. ...

    Authors: Ru Wang, Zhihong Ma, Ling Feng, Yifan Yang, Chen Tan, Qian Shi, Meng Lian, Shizhi He, Hongzhi Ma and Jugao Fang
    Citation: Molecular Cancer 2018 17:162
    Content type: Letter to the Editor Published on:

  23. Increasing evidence has revealed that circular RNAs (circRNAs) play crucial roles in cancer biology. However, the role and underlying regulatory mechanisms of circFNDC3B in bladder cancer (BC) remain unknown.

    Authors: Hongwei Liu, Junming Bi, Wei Dong, Meihua Yang, Juanyi Shi, Ning Jiang, Tianxin Lin and Jian Huang
    Citation: Molecular Cancer 2018 17:161
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:124

  24. Recent studies indicate that circular RNA (circRNA) plays a pivotal role in cancer progression. Here, we sought to investigate its role in breast cancer.

    Authors: Kaixuan Zeng, Bangshun He, Burton B. Yang, Tao Xu, Xiaoxiang Chen, Mu Xu, Xiangxiang Liu, Huiling Sun, Yuqin Pan and Shukui Wang
    Citation: Molecular Cancer 2018 17:160
    Content type: Research Published on:

  25. Tob1, a Tob/BTG anti-proliferative protein family member, functions as a tumour suppressor in many cancers. Here, we reveal a unique oncogenic role of Tob1 in colon cancer. Tob1 expression was upregulated duri...

    Authors: Dandan Li, Li Xiao, Yuetan Ge, Yu Fu, Wenqing Zhang, Hanwei Cao, Binbin Chen, Haibin Wang, Yan-yan Zhan and Tianhui Hu
    Citation: Molecular Cancer 2018 17:159
    Content type: Letter to the Editor Published on:

  26. Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the infla...

    Authors: Maryam Moossavi, Negin Parsamanesh, Afsane Bahrami, Stephen L. Atkin and Amirhossein Sahebkar
    Citation: Molecular Cancer 2018 17:158
    Content type: Review Published on:

  27. Although microRNAs (miRNAs) were revealed as crucial modulators in tumor metastasis and target therapy, our understanding of their roles in metastatic renal cell carcinoma (mRCC) and Sunitinib treatment was li...

    Authors: Wei Zhai, Saiyang Li, Jin Zhang, Yonghui Chen, Junjie Ma, Wen Kong, Dongkui Gong, Junhua Zheng, Wei Xue and Yunfei Xu
    Citation: Molecular Cancer 2018 17:157
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2022 21:96

  29. Emerging evidence supports the pivotal roles of cancer-associated cachexia in breast cancer progression. However, the mediators and mechanisms that mediate cancer-induced cachexia remain unclear. Here, we show...

    Authors: Qi Wu, Si Sun, Zhiyu Li, Qian Yang, Bei Li, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Changhua Yang, Juanjuan Li and Shengrong Sun
    Citation: Molecular Cancer 2018 17:155
    Content type: Letter to the Editor Published on:

  30. Thyroid cancer incidence is increasing at an alarming rate, almost tripling every decade. In 2017, it was the fifth most common cancer in women. Although the majority of thyroid tumors are curable, about 2–3% ...

    Authors: Shikha Saini, Kiara Tulla, Ajay V. Maker, Kenneth D. Burman and Bellur S. Prabhakar
    Citation: Molecular Cancer 2018 17:154
    Content type: Review Published on:

  31. Dysregulated histone methyltransferase G9a may represent a potential cancer therapeutic target. The roles of G9a in tumorigenesis and therapeutics are not well understood in non-small cell lung cancer (NSCLC)....

    Authors: Keqiang Zhang, Jinhui Wang, Lu Yang, Yate-Ching Yuan, Tommy R. Tong, Jun Wu, Xinwei Yun, Melissa Bonner, Rajendra Pangeni, Zheng Liu, Tiger Yuchi, Jae Y. Kim and Dan J. Raz
    Citation: Molecular Cancer 2018 17:153
    Content type: Research Published on:

  32. Overcoming multidrug resistance has always been a major challenge in cancer treatment. Recent evidence suggested epithelial-mesenchymal transition plays a role in MDR, but the mechanism behind this link remain...

    Authors: Maegan Miang Kee Lim, Jonathan Wei Kiat Wee, Jen Chi Soong, Damien Chua, Wei Ren Tan, Marco Lizwan, Yinliang Li, Ziqiang Teo, Wilson Wen Bin Goh, Pengcheng Zhu and Nguan Soon Tan
    Citation: Molecular Cancer 2018 17:152
    Content type: Letter to the Editor Published on:

  33. Circular RNAs (circRNAs) are a new type of non-coding RNAs and their functions in gastric cancer (GC) remain unclear. Recent studies have revealed that circRNAs play an important role in cancer development and...

    Authors: Hui Liu, Yuan Liu, Zhaolian Bian, Jing Zhang, Rui Zhang, Xiaoyu Chen, Yanxia Huang, Yang Wang and Jinshui Zhu
    Citation: Molecular Cancer 2018 17:151
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2019 18:117

  35. Lung cancer is the leading cause of cancer related deaths and its incidence is highly correlated with cigarette smoking. Nicotine, the addictive component of tobacco smoke, cannot initiate tumors, but can prom...

    Authors: Courtney M Schaal, Namrata Bora-Singhal, Durairaj Mohan Kumar and Srikumar P Chellappan
    Citation: Molecular Cancer 2018 17:149
    Content type: Research Published on:

  36. Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer related to asbestos exposure. The discovery of soluble biomarkers with diagnostic/prognostic and/or therapeutic properties would improve the...

    Authors: Patrick Smeele, Sènan Mickaël d’Almeida, Clément Meiller, Anne-Laure Chéné, Charly Liddell, Laurent Cellerin, François Montagne, Sophie Deshayes, Sarah Benziane, Marie-Christine Copin, Paul Hofman, Françoise Le Pimpec-Barthes, Henri Porte, Arnaud Scherpereel, Marc Grégoire, Didier Jean…
    Citation: Molecular Cancer 2018 17:148
    Content type: Letter to the Editor Published on:

  37. Exosomes, extracellular vesicles with diameters ranging from 30 to 150 nm, are widely present in various body fluids. Recently, microRNAs (miRNAs) have been identified in exosomes, the biogenesis, release, and...

    Authors: Zhenqiang Sun, Ke Shi, Shuaixi Yang, Jinbo Liu, Quanbo Zhou, Guixian Wang, Junmin Song, Zhen Li, Zhiyong Zhang and Weitang Yuan
    Citation: Molecular Cancer 2018 17:147
    Content type: Review Published on:

  38. Exosomes are extracellular vesicles that mediate cellular communication in health and diseases. Neutrophils could be polarized to a pro-tumor phenotype by tumor. The function of tumor-derived exosomes in neutr...

    Authors: Xu Zhang, Hui Shi, Xiao Yuan, Pengcheng Jiang, Hui Qian and Wenrong Xu
    Citation: Molecular Cancer 2018 17:146
    Content type: Research Published on:

  39. Drug resistance remains an unsolved clinical issue in oncology. Despite promising initial responses obtained with BRAF and MEK kinase inhibitors, resistance to treatment develops within months in virtually all...

    Authors: Giulia Cesi, Demetra Philippidou, Ines Kozar, Yeoun Jin Kim, Francois Bernardin, Guillaume Van Niel, Anke Wienecke-Baldacchino, Paul Felten, Elisabeth Letellier, Sonja Dengler, Dorothee Nashan, Claude Haan and Stephanie Kreis
    Citation: Molecular Cancer 2018 17:145
    Content type: Research Published on:

  40. Circular RNAs (circRNAs) are a new member of noncoding RNAs (ncRNAs) that have recently been described as key regulators of gene expression. Our previous study had identified the negative correlation between c...

    Authors: Fei Xie, Yawei Li, Miao Wang, Chao Huang, Dan Tao, Fuxin Zheng, Hui Zhang, Fuqing Zeng, Xingyuan Xiao and Guosong Jiang
    Citation: Molecular Cancer 2018 17:144
    Content type: Research Published on:

  41. Extracellular communication within the tumor microenvironment plays a critical role in tumor progression. Although exosomes can package into long non-coding RNAs (lncRNAs) to mediate extracellular communicatio...

    Authors: Rui Zheng, Mulong Du, Xiaowei Wang, Weidong Xu, Jiayuan Liang, Wenying Wang, Qiang Lv, Chao Qin, Haiyan Chu, Meilin Wang, Lin Yuan, Jing Qian and Zhengdong Zhang
    Citation: Molecular Cancer 2018 17:143
    Content type: Research Published on:

  42. Recently, expression signatures of exosomal long non-coding RNAs (lncRNAs) have been proposed as potential non-invasive biomarkers for cancer detection. In this study, we aimed to develop a urinary exosome (UE...

    Authors: Yao Zhan, Lutao Du, Lishui Wang, Xiumei Jiang, Shujun Zhang, Juan Li, Keqiang Yan, Weili Duan, Yinghui Zhao, Lili Wang, Yunshan Wang and Chuanxin Wang
    Citation: Molecular Cancer 2018 17:142
    Content type: Letter to the Editor Published on:

  43. Mounting evidence demonstrates that long noncoding RNAs (lncRNAs) have critical roles during the initiation and progression of cancers. In this study, we report that the small nucleolar RNA host gene 1 (SNHG1)...

    Authors: Mu Xu, Xiaoxiang Chen, Kang Lin, Kaixuan Zeng, Xiangxiang Liu, Bei Pan, Xueni Xu, Tao Xu, Xiuxiu Hu, Li Sun, Bangshun He, Yuqin Pan, Huiling Sun and Shukui Wang
    Citation: Molecular Cancer 2018 17:141
    Content type: Research Published on:

  44. TGF-β promotes tumor invasion and metastasis through inducing epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) are recognized as functional non-coding RNA...

    Authors: Longqiang Wang, Xin Tong, Zhengyu Zhou, Shengjie Wang, Zhe Lei, Tianze Zhang, Zeyi Liu, Yuanyuan Zeng, Chang Li, Jun Zhao, Zhiyue Su, Cuijuan Zhang, Xia Liu, Guangquan Xu and Hong-Tao Zhang
    Citation: Molecular Cancer 2018 17:140
    Content type: Research Published on:

  45. Proteogenomic characterization and integrative and comparative genomic analysis provide a functional context to annotate genomic abnormalities with prognostic value.

    Authors: Yu-Shui Ma, Tao Huang, Xiao-Ming Zhong, Hong-Wei Zhang, Xian-Ling Cong, Hong Xu, Gai-Xia Lu, Fei Yu, Shao-Bo Xue, Zhong-Wei Lv and Da Fu
    Citation: Molecular Cancer 2018 17:139
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2019 18:72

  46. Oncogenic fusion gene Echinoderm Microtubule-associated protein-Like 4-Anaplastic Lymphoma Kinase (EML4-ALK) contributes to tumorigenesis of a subset of non-small cell lung cancer (NSCLC). Recently, we demonstrat...

    Authors: Shuangyan Tan, Dan Sun, Wenchen Pu, Qiheng Gou, Chenglin Guo, Youling Gong, Jiao Li, Yu-Quan Wei, Lunxu Liu, Yun Zhao and Yong Peng
    Citation: Molecular Cancer 2018 17:138
    Content type: Letter to the Editor Published on:

  47. CircRNA expression profiles for gastric cancer (GC) were screened using plasma samples from 10 GC patients with different TNM stages and 5 healthy individuals as controls. Results showed lower expression of ci...

    Authors: Weiwei Tang, Kai Fu, Handong Sun, Dawei Rong, Hanjin Wang and Hongyong Cao
    Citation: Molecular Cancer 2018 17:137
    Content type: Letter to the Editor Published on:

  48. Androgen receptor (AR) is expressed in 60%~ 70% oestrogen receptor (ER)-negative breast cancer (BC) cases and promotes the growth of this cancer subtype. Expression of prostate-derived Ets factor (PDEF), a tra...

    Authors: Lu Cao, Cong Xu, Guomin Xiang, Fang Liu, Xiaozhen Liu, Congying Li, Jing Liu, Qingxiang Meng, Jiao Jiao and Yun Niu
    Citation: Molecular Cancer 2018 17:136
    Content type: Research Published on:

  49. After the publication of this work [1] an error was noticed in Fig. 7e, in which the incorrect information is shown. The updated figure included in this correction now shows the quantification of tumor microve...

    Authors: Fuqing Hu, Haijie Li, Lu Liu, Feng Xu, Senyan Lai, Xuelai Luo, Junbo Hu and Xi Yang
    Citation: Molecular Cancer 2018 17:135
    Content type: Correction Published on:

    The original article was published in Molecular Cancer 2018 17:107

  50. In contrast to normal cells, which use the aerobic oxidation of glucose as their main energy production method, cancer cells prefer to use anaerobic glycolysis to maintain their growth and survival, even under...

    Authors: Xiaodong Zhang, Haiying Zhao, Yan Li, Di Xia, Liang Yang, Yingbo Ma and Hangyu Li
    Citation: Molecular Cancer 2018 17:134
    Content type: Review Published on:
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