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  1. KCNJ2/Kir2.1, a member of the classical inwardly rectifying potassium channel family, is commonly expressed in a wide range of tissues and cell types. Previous studies indicated that Kir2.1 may be associated w...

    Authors: Huanxin Liu, Jie Huang, Juan Peng, Xiaoxia Wu, Yan Zhang, Weiliang Zhu and Linlang Guo
    Citation: Molecular Cancer 2015 14:59
    Content type: Research Published on:

  2. Patients with hematogenous metastatic lung cancer displayed significantly increased platelet count and aggregation compared to lung cancer patients without hematogenous metastasis. The mechanism underlying the...

    Authors: Hongwei Liang, Xin Yan, Yi Pan, Yongsheng Wang, Nan Wang, Limin Li, Yuan Liu, Xi Chen, Chen-Yu Zhang, Hongwei Gu and Ke Zen
    Citation: Molecular Cancer 2015 14:58
    Content type: Research Published on:

  3. Epithelial ovarian cancer (EOC) is a significant cause of morbidity and mortality. MicroRNAs play important roles in cancer development and progression. The microRNA miR-211 is localized on intron 6 of the Trpm1 ...

    Authors: Bairong Xia, Shanshan Yang, Tianbo Liu and Ge Lou
    Citation: Molecular Cancer 2015 14:57
    Content type: Research Published on:

  4. Acute myeloid leukemia (AML) is initiated and maintained by a subset of self-renewing leukemia stem cells (LSCs), which contribute to the progression, recurrence and therapeutic resistance of leukemia. However...

    Authors: Yi Zhang, Hai-xuan Chen, Shu-yan Zhou, Shao-xiang Wang, Kai Zheng, Dan-dan Xu, Yu-ting Liu, Xiao-yan Wang, Xiao Wang, Hai-zhao Yan, Li Zhang, Qiu-ying Liu, Wan-qun Chen and Yi-fei Wang
    Citation: Molecular Cancer 2015 14:56
    Content type: Research Published on:

  5. Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator in cancer cell survival, epithelial-mesenchymal transition, and tumorigenesis. Inhibition of EZH2 has become a promising therapeutic option for ...

    Authors: Pingyu Zhang, Xianbin Yang, Xiaoyan Ma, Davis R Ingram, Alexander J Lazar, Keila E Torres and Raphael E Pollock
    Citation: Molecular Cancer 2015 14:55
    Content type: Research Published on:

  6. Squamous cell carcinoma (SCC) is the most common type of tongue and larynx cancer and a common type of lung cancer. In this study, we attempted to specifically evaluate the signaling pathway underlying HGF/Met...

    Authors: Simone Gusenbauer, Emanuele Zanucco, Pjotr Knyazev and Axel Ullrich
    Citation: Molecular Cancer 2015 14:54
    Content type: Short communication Published on:

  7. The type I insulin-like growth factor receptor (IGF-IR) tyrosine kinase promotes the survival of an aggressive subtype of T-cell lymphoma by interacting with nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) ...

    Authors: Deeksha Vishwamitra, Choladda V Curry, Serhan Alkan, Yao-Hua Song, Gary E Gallick, Ahmed O Kaseb, Ping Shi and Hesham M Amin
    Citation: Molecular Cancer 2015 14:53
    Content type: Research Published on:

  8. MicroRNAs (miRNAs) have been reported to play an important role in tumorigenesis. In this study, the role of miR-15a and miR-16-1 in gastric adenocarcinoma (GAC) was investigated.

    Authors: Wei Kang, Joanna HM Tong, Raymond WM Lung, Yujuan Dong, Junhong Zhao, Qiaoyi Liang, Li Zhang, Yi Pan, Weiqin Yang, Jesse CS Pang, Alfred SL Cheng, Jun Yu and Ka Fai To
    Citation: Molecular Cancer 2015 14:52
    Content type: Research Published on:

  9. Long noncoding RNAs (lncRNAs) have emerged recently as a new class of genes that regulate cellular processes, such as cell growth and apoptosis. The SPRY4 intronic transcript 1 (SPRY4-IT1) is a 708-bp lncRNA o...

    Authors: Yongguo Shi, Juan Li, Yangchen Liu, Jie Ding, Yingrui Fan, Yun Tian, Li Wang, Yifan Lian, Keming Wang and Yongqian Shu
    Citation: Molecular Cancer 2015 14:51
    Content type: Research Published on:

  10. Metastasis is a process where only a small subset of cells is capable of successfully migrating to and propagating at secondary sites. TGF-β signalling is widely known for its role in cancer metastasis and is ...

    Authors: Rodney B Luwor, Dulani Hakmana, Josephine Iaria, Thao V Nheu, Richard J Simpson and Hong-Jian Zhu
    Citation: Molecular Cancer 2015 14:50
    Content type: Research Published on:

  11. Non alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the United States and worldwide. Our studies have previously shown an increase in metastatic burden in steatotic vs. normal...

    Authors: Alisha M Mendonsa, Michael N VanSaun, Alessandro Ustione, David W Piston, Barbara M Fingleton and David Lee Gorden
    Citation: Molecular Cancer 2015 14:49
    Content type: Research Published on:

  12. Metastasis is a crucial hallmark of cancer progression, which involves numerous factors including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal transition (EMT), tumor angiog...

    Authors: Zhenyi Su, Zuozhang Yang, Yongqing Xu, Yongbin Chen and Qiang Yu
    Citation: Molecular Cancer 2015 14:48
    Content type: Review Published on:

  13. Recent studies have revealed the potential roles of intelectin 1 (ITLN1) in tumorigenesis. However, its functions and underlying mechanisms in neuroblastoma (NB), the most common extracranial solid tumor in ch...

    Authors: Dan Li, Hong Mei, Jiarui Pu, Xuan Xiang, Xiang Zhao, Hongxia Qu, Kai Huang, Liduan Zheng and Qiangsong Tong
    Citation: Molecular Cancer 2015 14:47
    Content type: Research Published on:

  14. Long non-coding RNAs (lncRNAs) can orchestrate oncogenic or tumor-suppressive functions in cancer biology. Accordingly, PCGEM1 and PRNCR1 were implicated in progression of prostate cancer (PCa) as transcriptional...

    Authors: Abhijit Parolia, Francesco Crea, Hui Xue, Yuwei Wang, Fan Mo, Varune Rohan Ramnarine, Hui Hsuan Liu, Dong Lin, Nur Ridzwan Nur Saidy, Pier-Luc Clermont, Hongwei Cheng, Colin Collins, Yuzhuo Wang and Cheryl D Helgason
    Citation: Molecular Cancer 2015 14:46
    Content type: Short communication Published on:

  15. The VEGF pathway has become an important therapeutic target in lung cancer, where VEGF has long been established as a potent pro-angiogenic growth factor expressed by many types of tumors. While Bevacizumab (A...

    Authors: Martin P Barr, Steven G Gray, Kathy Gately, Emily Hams, Padraic G Fallon, Anthony Mitchell Davies, Derek J Richard, Graham P Pidgeon and Kenneth J O’Byrne
    Citation: Molecular Cancer 2015 14:45
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:16

  16. The objective of this study was to investigate the expression and clinical role of 14 genes previously shown to be associated with chemotherapy response and/or progression-free survival in a smaller series of ...

    Authors: Dag Andre Nymoen, Arild Holth, Thea E Hetland Falkenthal, Claes G Tropé and Ben Davidson
    Citation: Molecular Cancer 2015 14:44
    Content type: Research Published on:

  17. IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many...

    Authors: Panagiotis F Christopoulos, Pavlos Msaouel and Michael Koutsilieris
    Citation: Molecular Cancer 2015 14:43
    Content type: Review Published on:

  18. Nucleoporins mediate nucleocytoplasmic exchange of macromolecules and several have been assigned active mitotic functions. Nucleoporins can participate in various mitotic functions like spindle assembly, kinet...

    Authors: Sumana Bhattacharjya, Kumar Singha Roy, Abira Ganguly, Shreya Sarkar, Chinmay K Panda, Dibyendu Bhattacharyya, Nitai P Bhattacharyya and Susanta Roychoudhury
    Citation: Molecular Cancer 2015 14:42
    Content type: Research Published on:

  19. Glioblastoma is the most malignant human brain tumor and has a dismal prognosis; however, some patients show long-term survival. The interaction between the costimulatory molecule OX40 and its ligand OX40L gen...

    Authors: Ichiyo Shibahara, Ryuta Saito, Rong Zhang, Masashi Chonan, Takuhiro Shoji, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Masahiko Kanehira, Toshiaki Kikuchi, Takanori So, Takashi Watanabe, Hiroaki Takahashi, Erina Iwabuchi, Yuetsu Tanaka, Yukiko Shibahara…
    Citation: Molecular Cancer 2015 14:41
    Content type: Research Published on:

  20. Cancer cell lines have a prominent role in the initial stages of drug discovery, facilitating high-throughput screening of potential drugs. However, their clinical relevance remains controversial.

    Authors: Samira Jaeger, Miquel Duran-Frigola and Patrick Aloy
    Citation: Molecular Cancer 2015 14:40
    Content type: Short Communication Published on:

  21. Normal epithelial cells and carcinoma cells can acquire invasiveness by epithelial-to-mesenchymal transition (EMT), a process of considerable cellular remodeling. The endosomal/lysosomal compartment is a princ...

    Authors: Ursula Kern, Vladimir Wischnewski, Martin L Biniossek, Oliver Schilling and Thomas Reinheckel
    Citation: Molecular Cancer 2015 14:39
    Content type: Research Published on:

  22. The metastasis-associated in colon cancer 1 (MACC1) gene has been identified as prognostic biomarker for colorectal cancer (CRC). Here, we aimed at the refinement of risk assessment by separate and combined su...

    Authors: Katharina Ilm, Wolfgang Kemmner, Marc Osterland, Susen Burock, Gudrun Koch, Pia Herrmann, Peter M Schlag and Ulrike Stein
    Citation: Molecular Cancer 2015 14:38
    Content type: Short communication Published on:

  23. miR-663 is associated with many important biologic processes, such as the evolution, development, viral infection, inflammatory response, and carcinogenesis among vertebrates. However, the molecular function a...

    Authors: Wenqiao Zang, Yuanyuan Wang, Tao Wang, Yuwen Du, Xiaonan Chen, Min Li and Guoqiang Zhao
    Citation: Molecular Cancer 2015 14:37
    Content type: Research Published on:

    The Retraction Note to this article has been published in Molecular Cancer 2019 18:118

  24. Inflammatory cytokines and transforming growth factor-β (TGF-β) are mutually inhibitory. However, hyperactivation of nuclear factor-κB (NF-κB) and TGF-β signaling both emerge in glioblastoma. Here, we report m...

    Authors: Hui Wang, Jian-Qing Pan, Lun Luo, Xin-jie Ning, Zhuo-Peng Ye, Zhe Yu and Wen-Sheng Li
    Citation: Molecular Cancer 2015 14:2
    Content type: Research Published on:

  25. MicroRNAs (miRNAs) are short, non-coding RNA molecules that play critical roles in human malignancy. However, the regulatory characteristics of miRNAs in triple-negative breast cancer, a phenotype of breast ca...

    Authors: Yao-Yin Chang, Wen-Hung Kuo, Jui-Hui Hung, Chien-Yueh Lee, Yung-Hua Lee, Ya-Chu Chang, Wen-Chun Lin, Cheng-Ying Shen, Chiun-Sheng Huang, Fon-Jou Hsieh, Liang-Chuan Lai, Mong-Hsun Tsai, King-Jen Chang and Eric Y Chuang
    Citation: Molecular Cancer 2015 14:36
    Content type: Research Published on:

  27. Cancer is an exceedingly complex disease that is orchestrated and driven by a combination of multiple aberrantly regulated processes. The nature and depth of involvement of individual events vary between cance...

    Authors: Anna Maria Rusek, Mohammed Abba, Andrzej Eljaszewicz, Marcin Moniuszko, Jacek Niklinski and Heike Allgayer
    Citation: Molecular Cancer 2015 14:34
    Content type: Review Published on:

  28. In complex with its cofactor UAF1, the USP1 deubiquitinase plays an important role in cellular processes related to cancer, including the response to DNA damage. The USP1/UAF1 complex is emerging as a novel ta...

    Authors: Anne Olazabal-Herrero, Iraia García-Santisteban and Jose Antonio Rodríguez
    Citation: Molecular Cancer 2015 14:33
    Content type: Research Published on:

  29. Migration of breast cancer cells out of a duct or lobule is a prerequisite for invasion and metastasis. However, the factors controlling breast cancer cell migration are not fully elucidated. We previously fou...

    Authors: Erica Maria Pimenta and Betsy J Barnes
    Citation: Molecular Cancer 2015 14:32
    Content type: Research Published on:

  30. An increasing amount of evidence has revealed that microRNAs regulate various biological processes, including cell differentiation, cell proliferation, apoptosis, drug resistance, and fat metabolism. Studies h...

    Authors: Xi Chen, Shuo Chen, Yin-Ling Xiu, Kai-Xuan Sun, Zhi-Hong Zong and Yang Zhao
    Citation: Molecular Cancer 2015 14:31
    Content type: Research Published on:

  31. Members of the inhibitor of DNA-binding (ID) family of helix-loop-helix proteins have been causally implicated in the pathogenesis of several types of B-cell lineage malignancy, either on the basis of mutation...

    Authors: Sarah Weiler, Jolaolu A Ademokun and John D Norton
    Citation: Molecular Cancer 2015 14:30
    Content type: Research Published on:

  33. The epithelial–mesenchymal transition (EMT) is crucial for the invasion and metastasis of breast cancer. However, how Notch signaling regulates the EMT process and invasion in breast cancer remains largely unk...

    Authors: Shan Shao, Xiaoai Zhao, Xiaojin Zhang, Minna Luo, Xiaoxiao Zuo, Shangke Huang, Ying Wang, Shanzhi Gu and Xinhan Zhao
    Citation: Molecular Cancer 2015 14:28
    Content type: Research Published on:

  34. Approximately 20% of melanomas contain a mutation in NRAS. However no direct inhibitor of NRAS is available. One of the main signaling pathways downstream of NRAS is the MAPK pathway. In this study we investig...

    Authors: Mohammad Atefi, Bjoern Titz, Earl Avramis, Charles Ng, Deborah JL Wong, Amanda Lassen, Michael Cerniglia, Helena Escuin-Ordinas, David Foulad, Begonya Comin-Anduix, Thomas G Graeber and Antoni Ribas
    Citation: Molecular Cancer 2015 14:27
    Content type: Research Published on:

  35. Kruppel-like factor 4 (KLF4) induces tumorigenesis or suppresses tumor growth in a tissue-dependent manner. However, the roles of KLF4 in hematological malignancies and the mechanisms of action are not fully u...

    Authors: Wei Li, Zhiwu Jiang, Tianzhong Li, Xinru Wei, Yi Zheng, Donghai Wu, Lijian Yang, Shaohua Chen, Bing Xu, Mei Zhong, Jue Jiang, Yufeng Hu, Hexiu Su, Minjie Zhang, Xiaojun Huang, Suxia Geng…
    Citation: Molecular Cancer 2015 14:26
    Content type: Research Published on:

  37. Tumor metastasis is responsible for 90% of cancer-related deaths. Recently, a strong link between microRNA dysregulation and human cancers has been established. However, the molecular mechanisms through which ...

    Authors: Rainelli B Koumangoye, Thomas Andl, Kenneth J Taubenslag, Steven T Zilberman, Chase J Taylor, Holli A Loomans and Claudia D Andl
    Citation: Molecular Cancer 2015 14:24
    Content type: Research Published on:

  38. The underlying mechanisms of carcinogenesis and gender disparity in hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) remain unclear. Recently, we reported a novel HCC-related W4P/R mutation in th...

    Authors: Seoung-Ae Lee, Hong Kim, You-Sub Won, Seung-Hyeok Seok, YiRang Na, Han-Bo Shin, Kyung-Soo Inn and Bum-Joon Kim
    Citation: Molecular Cancer 2015 14:23
    Content type: Research Published on:

  39. Several clinical and pathological factors have an impact on the prognosis of colorectal cancer (CRC), but they are not yet adequate for risk assessment. We aimed to identify a molecular signature that can reli...

    Authors: Lisha Wang, Xiaohan Shen, Zhimin Wang, Xiuying Xiao, Ping Wei, Qifeng Wang, Fei Ren, Yiqin Wang, Zebing Liu, Weiqi Sheng, Wei Huang, Xiaoyan Zhou and Xiang Du
    Citation: Molecular Cancer 2015 14:22
    Content type: Research Published on:

  40. The poor prognosis and minimally successful treatments of malignant glioma indicate a challenge to identify new therapeutic targets which impact glioma progression. Neurotensin (NTS) and its high affinity rece...

    Authors: Qing Ouyang, Xueyang Gong, Hualiang Xiao, Ji Zhou, Minhui Xu, Yun Dai, Lunshan Xu, Hua Feng, Hongjuan Cui and Liang Yi
    Citation: Molecular Cancer 2015 14:21
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2022 21:162

  41. The study aims to evaluate the expression and activity of glycogen synthase kinase 3 isoforms α/β (GSK3α/β) and to assess their oncogenic potential through a correlation with the expression of cyclin D1 and p5...

    Authors: Rajakishore Mishra, Siddavaram Nagini and Ajay Rana
    Citation: Molecular Cancer 2015 14:20
    Content type: Research Published on:

  42. Receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) is a chondroitin sulphate (CS) transmembrane protein tyrosine phosphatase and is a receptor for pleiotrophin (PTN). RPTPβ/ζ interacts with ανβ3 on the cel...

    Authors: Marina Koutsioumpa, Evangelia Poimenidi, Evangelia Pantazaka, Christina Theodoropoulou, Angeliki Skoura, Vasileios Megalooikonomou, Nelly Kieffer, Jose Courty, Shuji Mizumoto, Kazuyuki Sugahara and Evangelia Papadimitriou
    Citation: Molecular Cancer 2015 14:19
    Content type: Research Published on:

  43. Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic v...

    Authors: Bensheng Ju, Wenbiao Chen, Brent A Orr, Jan M Spitsbergen, Sujuan Jia, Christopher J Eden, Hannah E Henson and Michael R Taylor
    Citation: Molecular Cancer 2015 14:18
    Content type: Research Published on:

  44. The Wnt/beta-catenin and the Hedgehog (Hh) pathway interact in various cell types while eliciting opposing or synergistic cellular effects. Both pathways are known as exclusive drivers of two distinct molecula...

    Authors: Jenny Zinke, Fabian T Schneider, Patrick N Harter, Sonja Thom, Nicole Ziegler, Rune Toftgård, Karl H Plate and Stefan Liebner
    Citation: Molecular Cancer 2015 14:17
    Content type: Short communication Published on:

  45. TR4 nuclear receptor 4 (TR4) plays an important role in macrophages-associated foam cell formation of cardiovascular diseases and infiltrating macrophages are critical for prostate cancer (PCa) progression. Ho...

    Authors: Xianfan Ding, Dong-Rong Yang, Liqun Xia, Bide Chen, Shicheng Yu, Yuanjie Niu, Mingchao Wang, Gonghui Li and Chawnshang Chang
    Citation: Molecular Cancer 2015 14:16
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:97

  47. Voltage-gated Na+ channels (VGSCs) are heteromeric protein complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits. VGSCs are classically expressed in electrically excitable cells, e...

    Authors: Michaela Nelson, Ming Yang, Adam A Dowle, Jerry R Thomas and William J Brackenbury
    Citation: Molecular Cancer 2015 14:13
    Content type: Short communication Published on:

  48. S100A7 (Psoriasin) is an inflammatory protein known to be upregulated in breast cancer. However, the role of S100A7 in breast cancer has been elusive, since both pro- and anti-proliferative roles have been rep...

    Authors: Helong Zhao, Tasha Wilkie, Yadwinder Deol, Amita Sneh, Akaansha Ganju, Mustafa Basree, Mohd W Nasser and Ramesh K Ganju
    Citation: Molecular Cancer 2015 14:11
    Content type: Research Published on:

    The Erratum to this article has been published in Molecular Cancer 2015 14:195

  49. High-grade gliomas are one of the most invasive and therapy-resistant cancers. We have recently shown that noncanonical NF-κB/RelB signaling is a potent driver of tumorigenesis and invasion in the aggressive, ...

    Authors: Evan M Cherry, Dong W Lee, Ji-Ung Jung and Raquel Sitcheran
    Citation: Molecular Cancer 2015 14:9
    Content type: Research Published on:

  50. Ubiquitination is a highly dynamic and reversible process with a central role in cell homeostasis. Deregulation of several deubiquitinating enzymes has been linked to tumor development but their specific role ...

    Authors: Diego Iglesias-Gato, Yin-Choy Chuan, Ning Jiang, Charlotte Svensson, Jing Bao, Indranil Paul, Lars Egevad, Benedikt M Kessler, Pernilla Wikström, Yuanjie Niu and Amilcar Flores-Morales
    Citation: Molecular Cancer 2015 14:8
    Content type: Research Published on:

    The Erratum to this article has been published in Molecular Cancer 2015 14:88

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Molecular Cancer

ISSN: 1476-4598