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  1. Chronic Myeloid Leukaemia (CML) is caused by the BCR/ABL1 fusion gene. Both the presence and the levels of BCR/ABL1 expression seem to be critical for CML progression from chronic phase (CP) to blast crisis (B...

    Authors: Nitesh Sharma, Vera Magistroni, Rocco Piazza, Stefania Citterio, Caterina Mezzatesta, Praveen Khandelwal, Alessandra Pirola and Carlo Gambacorti-Passerini
    Citation: Molecular Cancer 2015 14:132
    Content type: Research Published on:

  2. Cross-talk between deregulated signaling pathways in cancer cells causes uncontrolled growth and proliferation. These cancers cells become more aggressive and quickly develop resistance to therapy. Therefore t...

    Authors: Maqbool Ahmed, Azhar R Hussain, Abdul K. Siraj, Shahab Uddin, Nasser Al-Sanea, Fouad Al-Dayel, Mohammed Al-Assiri, Shaham Beg and Khawla S. Al-Kuraya
    Citation: Molecular Cancer 2015 14:131
    Content type: Research Published on:

  3. Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, has shown antitumoral effects in a variety of cell types. In this study, it has been addressed how Bergapten ...

    Authors: Francesca De Amicis, Saveria Aquila, Catia Morelli, Carmela Guido, Marta Santoro, Ida Perrotta, Loredana Mauro, Francesca Giordano, Alessandra Nigro, Sebastiano Andò and Maria L. Panno
    Citation: Molecular Cancer 2015 14:130
    Content type: Research Published on:

  4. Clinical trials designed to test the efficacy of retinoic acid (RA) as an adjuvant for the treatment of solid cancers have been disappointing, primarily due to RA resistance. Estrogen receptor (ER)-negative br...

    Authors: Rong-Zong Liu, Elizabeth Garcia, Darryl D. Glubrecht, Ho Yin Poon, John R. Mackey and Roseline Godbout
    Citation: Molecular Cancer 2015 14:129
    Content type: Research Published on:

  5. Authors: Deborah JL Wong, Lidia Robert, Mohammad S Atefi, Amanda Lassen, Geetha Avarappatt, Michael Cerniglia, Earl Avramis, Jennifer Tsoi, David Foulad, Thomas G Graeber, Begonya Comin-Anduix, Ahmed Samatar, Roger S Lo and Antoni Ribas
    Citation: Molecular Cancer 2015 14:128
    Content type: Erratum Published on:

    The original article was published in Molecular Cancer 2014 13:194

  6. Glioblastoma multiforme (GBM) is one of the most highly metastatic cancers. GBM has been associated with a high level of the mechanistic target of rapamycin complex 2 (mTORC2) activity. We aimed to observe rol...

    Authors: Naphat Chantaravisoot, Piriya Wongkongkathep, Joseph A. Loo, Paul S. Mischel and Fuyuhiko Tamanoi
    Citation: Molecular Cancer 2015 14:127
    Content type: Research Published on:

  7. Defects in programmed cell death, or apoptosis, are a hallmark of cancer. The anti-apoptotic B-cell lymphoma 2 (BCL-2) family proteins, including BCL-2, BCL-XL, and MCL-1 have been characterized as key survival f...

    Authors: Haichao Zhang, John Xue, Paul Hessler, Stephen K. Tahir, Jun Chen, Sha Jin, Andrew J. Souers, Joel D. Leverson and Lloyd T. Lam
    Citation: Molecular Cancer 2015 14:126
    Content type: Research Published on:

  8. RNA binding proteins (RBPs) and microRNAs (miRNAs) are two of the most important post-transcriptional regulators of gene expression, and their aberrant expression contributes to the development of human malign...

    Authors: Tianzhen Wang, Guangyu Wang, Dapeng Hao, Xi Liu, Dong Wang, Ning Ning and Xiaobo Li
    Citation: Molecular Cancer 2015 14:125
    Content type: Review Published on:

  9. Flavonoids are a diverse family of natural phenolic compounds commonly found in fruits and vegetables. Epidemiologic studies showed that flavonoids also reduce the risk of colon cancer. Tectochrysin is one of ...

    Authors: Mi Hee Park, Ji Eun Hong, Eun Sook Park, Hee Sung Yoon, Doo Won Seo, Byung Kook Hyun, Sang-Bae Han, Young Won Ham, Bang Yeon Hwang and Jin Tae Hong
    Citation: Molecular Cancer 2015 14:124
    Content type: Research Published on:

  10. Although matrix metalloproteinase (MMP)-7 expression is correlated with increased metastatic potential in human colon cancer cells, the underlying molecular mechanism of invasive phenotype remains unknown. In ...

    Authors: Suhrid Banskota, Sushil C. Regmi and Jung-Ae Kim
    Citation: Molecular Cancer 2015 14:123
    Content type: Research Published on:

  11. Docetaxel is the first chemotherapy agent approved for treatment of metastatic castration-resistant prostate cancer (mCRPC). The limited survival benefit associated with the quick emergence of resistance and s...

    Authors: Styliani Karanika, Theodoros Karantanos, Shinji Kurosaka, Jianxiang Wang, Takahiro Hirayama, Guang Yang, Sanghee Park, Alexei A. Golstov, Ryuta Tanimoto, Likun Li and Timothy C. Thompson
    Citation: Molecular Cancer 2015 14:122
    Content type: Research Published on:

  12. Glioblastomas are invasive therapy resistant brain tumors with extremely poor prognosis. The Glioma initiating cell (GIC) population contributes to therapeutic resistance and tumor recurrence. Targeting GIC-as...

    Authors: Mrinal Joel, Awais A. Mughal, Zanina Grieg, Wayne Murrell, Sheryl Palmero, Birthe Mikkelsen, Hege B. Fjerdingstad, Cecilie J. Sandberg, Jinan Behnan, Joel C. Glover, Iver A. Langmoen and Biljana Stangeland
    Citation: Molecular Cancer 2015 14:121
    Content type: Research Published on:

  13. Claudins are a family of tight junction (TJ) membrane proteins involved in a broad spectrum of human diseases including cancer. Claudin-7 is a unique TJ membrane protein in that it has a strong basolateral mem...

    Authors: Zhe Lu, Do Hyung Kim, Junming Fan, Qun Lu, Kathryn Verbanac, Lei Ding, Randall Renegar and Yan-Hua Chen
    Citation: Molecular Cancer 2015 14:120
    Content type: Research Published on:

  14. Carbonic anhydrase (CA) IX is a surface-expressed protein that is upregulated by the hypoxia inducible factor (HIF) and represents a prototypic tumor-associated antigen that is overexpressed on renal cell carc...

    Authors: De-Kuan Chang, Raymond J. Moniz, Zhongyao Xu, Jiusong Sun, Sabina Signoretti, Quan Zhu and Wayne A. Marasco
    Citation: Molecular Cancer 2015 14:119
    Content type: Research Published on:

  16. Osteoprotegerin (OPG) is a secreted protein and member of the Tumor Necrosis Factor (TNF) Receptor superfamily. OPG has been well characterized as a regulator of bone metabolism which acts by blocking osteocla...

    Authors: Michael Weichhaus, Stephanie Tsang Mui Chung and Linda Connelly
    Citation: Molecular Cancer 2015 14:117
    Content type: Review Published on:

  17. Present study provides clinical evidence of existence of a functional loop involving miR-21 and let-7a as potential regulators of aberrant STAT3 signaling recently reported by our group in an experimental setu...

    Authors: Gauri Shishodia, Shirish Shukla, Yogesh Srivastava, Shashank Masaldan, Sumita Mehta, Suresh Bhambhani, Shashi Sharma, Ravi Mehrotra, Bhudev Chandra Das and Alok Chandra Bharti
    Citation: Molecular Cancer 2015 14:116
    Content type: Research Published on:

  18. The expression of the chemokine receptor CCR6 has been previously correlated with higher grades and stages of breast cancer and decreased relapse-free survival. Also, its cognate chemokine ligand CCL20 has bee...

    Authors: Sarah T. Boyle, Jessica W. Faulkner, Shaun R. McColl and Marina Kochetkova
    Citation: Molecular Cancer 2015 14:115
    Content type: Research Published on:

  19. Redox stress is a hallmark of the rewired metabolic phenotype of cancer. The underlying dysregulation of reactive oxygen species (ROS) is interconnected with abnormal mitochondrial biogenesis and function. In ...

    Authors: Christian Prinz, Elena Vasyutina, Gregor Lohmann, Alexandra Schrader, Steffen Romanski, Christoph Hirschhäuser, Petra Mayer, Corazon Frias, Carmen D. Herling, Michael Hallek, Hans-Günther Schmalz, Aram Prokop, Dimitrios Mougiakakos and Marco Herling
    Citation: Molecular Cancer 2015 14:114
    Content type: Research Published on:

  20. Therapeutic interventions in the insulin-like growth factor receptor (IGF-1R) pathway were expected to provide clinical benefits; however, IGF-1R tyrosine kinase inhibitors (TKIs) have shown limited antitumor ...

    Authors: Hye-Young Min, Hye Jeong Yun, Ji-Sun Lee, Hyo-Jong Lee, Jaebeom Cho, Hyun-Ji Jang, Shin-Hyung Park, Diane Liu, Seung-Hyun Oh, J. Jack Lee, Ignacio I. Wistuba and Ho-Young Lee
    Citation: Molecular Cancer 2015 14:113
    Content type: Research Published on:

  21. Much effort has been devoted to determining how metastatic cells and microenvironment reciprocally interact. However, the role of biological stimuli of microenvironment in controlling molecular events in bone ...

    Authors: Paola Bendinelli, Paola Maroni, Emanuela Matteucci and Maria Alfonsina Desiderio
    Citation: Molecular Cancer 2015 14:112
    Content type: Research Published on:

    The Retraction Note to this article has been published in Molecular Cancer 2020 19:126

  22. Integrins and enzymes of the eicosanoid pathway are both well-established contributors to cancer. However, this is the first report of the interdependence of the two signaling systems. In a screen for proteins...

    Authors: Keqin Tang, Yinlong Cai, Sangeeta Joshi, Elizabeth Tovar, Stephanie C. Tucker, Krishna Rao Maddipati, John D. Crissman, William T. Repaskey and Kenneth V. Honn
    Citation: Molecular Cancer 2015 14:111
    Content type: Research Published on:

  23. Gene therapy has been an attractive paradigm for cancer treatment. However, cancer gene therapy has been challenged by the inherent limitation of vectors that are able to deliver therapeutic genes to tumors sp...

    Authors: Teerapong Yata, Eugene L. Q. Lee, Keittisak Suwan, Nelofer Syed, Paladd Asavarut and Amin Hajitou
    Citation: Molecular Cancer 2015 14:110
    Content type: Research Published on:

  24. Human pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies in the world and despite great efforts in research types of treatment remain limited. A frequently detected a...

    Authors: Bianca T. Hofmann, Laura Schlüter, Philip Lange, Baris Mercanoglu, Florian Ewald, Aljonna Fölster, Aeint-Steffen Picksak, Sönke Harder, Alexander T. El Gammal, Katharina Grupp, Cenap Güngör, Astrid Drenckhan, Hartmut Schlüter, Christoph Wagener, Jakob R. Izbicki, Manfred Jücker…
    Citation: Molecular Cancer 2015 14:109
    Content type: Research Published on:

  25. Urothelial carcinoma (UC) is the fifth most common cancer in the developed world. Delineation of differentiation subtypes in UC highlighted the importance of aberrant differentiation. Understanding underlying ...

    Authors: Judith Heubach, Juliana Monsior, René Deenen, Günter Niegisch, Tibor Szarvas, Christian Niedworok, Wolfgang Arthur Schulz and Michèle Janine Hoffmann
    Citation: Molecular Cancer 2015 14:108
    Content type: Research Published on:

  26. Dysregulated expression of Kallikrein-related peptidase 6 (KLK6) is a common feature for many human malignancies and numerous studies evaluated KLK6 as a promising biomarker for early diagnosis or unfavorable ...

    Authors: Carola H. Schrader, Markus Kolb, Karim Zaoui, Christa Flechtenmacher, Niels Grabe, Klaus-Josef Weber, Thomas Hielscher, Peter K. Plinkert and Jochen Hess
    Citation: Molecular Cancer 2015 14:107
    Content type: Research Published on:

  27. Gastrointestinal (GI) cancers are a major cause of cancer-related deaths. During the last two decades, several studies have shown amplification and overexpression of Aurora kinase A (AURKA) in several GI malig...

    Authors: Ahmed Katsha, Abbes Belkhiri, Laura Goff and Wael El-Rifai
    Citation: Molecular Cancer 2015 14:106
    Content type: Review Published on:

  28. Na/K-ATPase (NKA) is inhibited by perillyl alcohol (POH), a monoterpene used in the treatment of tumors, including brain tumors. The NKA α1 subunit is known to be superexpressed in glioblastoma cells (GBM). This ...

    Authors: Diogo Gomes Garcia, Hugo Caire de Castro-Faria-Neto, Camila Ignácio da Silva, Kauê Francisco Correa de Souza e Souza, Cassiano Felippe Gonçalves-de-Albuquerque, Adriana Ribeiro Silva, Lidia Maria da Fonte de Amorim, Aline Soares Freire, Ricardo Erthal Santelli, Luan Pereira Diniz, Flávia Carvalho Alcantara Gomes, Mauro Velho de Castro Faria and Patrícia Burth
    Citation: Molecular Cancer 2015 14:105
    Content type: Research Published on:

  29. Immunotherapy has been extensively pursed as a promising strategy for the treatment of cancer. Pattern-recognition receptors (PRRs) play important roles in triggering activation of innate and adaptive immunity...

    Authors: Jung Eun Koo, Seung Won Shin, Soong Ho Um and Joo Young Lee
    Citation: Molecular Cancer 2015 14:104
    Content type: Research Published on:

  30. Melanoma is notorious for its propensity to metastasize, which makes treatment extremely difficult. Receptor tyrosine kinase c-Met is activated in human melanoma and is involved in melanoma progression and met...

    Authors: Hui-Hui Cao, Chi-Yan Cheng, Tao Su, Xiu-Qiong Fu, Hui Guo, Ting Li, Anfernee Kai-Wing Tse, Hiu-Yee Kwan, Hua Yu and Zhi-Ling Yu
    Citation: Molecular Cancer 2015 14:103
    Content type: Research Published on:

  31. Restin belongs to MAGE superfamily and is known as MAGE H1. Restin was firstly cloned from HL-60 cells treated with all-trans retinoic acid (ATRA). Previous studies showed a pro-apoptotic role of Restin in sev...

    Authors: Zhenduo Lu, Dechuang Jiao, Jianghua Qiao, Sen Yang, Min Yan, Shude Cui and Zhenzhen Liu
    Citation: Molecular Cancer 2015 14:102
    Content type: Research Published on:

  32. Autophagy is a major cellular process by which cytoplasmic components such as damaged organelles and misfolded proteins are recycled. Although low levels of autophagy occur in cells under basal conditions, cer...

    Authors: Changchang Liu, Elise P DeRoo, Catherine Stecyk, Margaret Wolsey, Mateusz Szuchnicki and Engda G Hagos
    Citation: Molecular Cancer 2015 14:101
    Content type: Research Published on:

  33. The EGFR signaling pathway is frequently activated in human ovarian cancer and associated with poor prognosis. However, inhibition of EGFR signaling in patients with recurrent ovarian cancer has been disappoin...

    Authors: Wei Wen, Jun Wu, Lucy Liu, Yan Tian, Ralf Buettner, Meng-Yin Hsieh, David Horne, Thanh H Dellinger, Ernest S Han, Richard Jove and John H Yim
    Citation: Molecular Cancer 2015 14:100
    Content type: Research Published on:

  34. We previously reported the identification of ONC201/TIC10, a novel small molecule inducer of the human TRAIL gene that improves efficacy-limiting properties of recombinant TRAIL and is in clinical trials in ad...

    Authors: Joshua E Allen, Gabriel Krigsfeld, Luv Patel, Patrick A Mayes, David T Dicker, Gen Sheng Wu and Wafik S El-Deiry
    Citation: Molecular Cancer 2015 14:99
    Content type: Research Published on:

  35. Acquired drug resistance is one of the major reasons for failing cancer therapies. Although the reasons are not fully understood, they may be related to the presence of cancer stem cells (CSCs). We have report...

    Authors: Yingjie Yu, Pratima Nangia-Makker, Lulu Farhana, Sindhu G. Rajendra, Edi Levi and Adhip PN Majumdar
    Citation: Molecular Cancer 2015 14:98
    Content type: Research Published on:

  36. Homeobox genes encode transcription factors that control patterning of virtually all organ systems including the vasculature. Tumor angiogenesis is stimulated by several homeobox genes that are overexpressed i...

    Authors: Bon Trinh, Song Yi Ko, Dhwani Haria, Nicolas Barengo and Honami Naora
    Citation: Molecular Cancer 2015 14:97
    Content type: Research Published on:

  37. Salivary Adenoid cystic carcinoma (SACC) patients with local invasion and lung metastasis are often resistant to conventional therapy such as operation, chemotherapy and radiotherapy. To explore the underling ...

    Authors: Lijuan Sun, Bodu Liu, Zhaoyu Lin, Yandan Yao, Yanyang Chen, Yang Li, Jianing Chen, Dongsheng Yu, Zhangui Tang, Bosheng Wang, Shuguang Zeng, Song Fan, Youyuan Wang, Yilin Li, Erwei Song and Jinsong Li
    Citation: Molecular Cancer 2015 14:96
    Content type: Research Published on:

  38. Recent evidence suggests an important role of protein phosphatase 4 (PP4C) in the progression of several cancers, including breast cancer, lung cancer and pancreatic ductal adenocarcinoma. However, the contrib...

    Authors: Xinxiang Li, Lei Liang, Liyong Huang, Xiaoji Ma, Dawei Li and Sanjun Cai
    Citation: Molecular Cancer 2015 14:95
    Content type: Research Published on:

  39. Irinotecan is a camptothecin analogue currently used in clinical practice to treat advanced colorectal cancer. However, acquired resistance mediated by the drug efflux pump ABCG2 is a recognized problem. We re...

    Authors: David Westover, Xiang Ling, Hong Lam, Jacob Welch, Chunyang Jin, Celine Gongora, Maguy Del Rio, Mansukh Wani and Fengzhi Li
    Citation: Molecular Cancer 2015 14:92
    Content type: Research Published on:

  40. Previous studies identified microRNAs (miRNAs) and messenger RNAs with significantly different expression between normal pancreas and pancreatic cancer (PDAC) tissues. Due to technological limitations of micro...

    Authors: Sören Müller, Susanne Raulefs, Philipp Bruns, Fabian Afonso-Grunz, Anne Plötner, Rolf Thermann, Carsten Jäger, Anna Melissa Schlitter, Bo Kong, Ivonne Regel, W Kurt Roth, Björn Rotter, Klaus Hoffmeier, Günter Kahl, Ina Koch, Fabian J Theis…
    Citation: Molecular Cancer 2015 14:94
    Content type: Research Published on:

    The Erratum to this article has been published in Molecular Cancer 2015 14:144

  41. Rb1 is the most frequently mutated gene in the pediatric cancer retinoblastoma, and its loss causes E2F transcription factors to induce proliferation related genes. However, high E2F levels fol...

    Authors: Chencheng Xie, Huarui Lu, Alice Nomura, Eric Allan Hanse, Colleen Lynn Forster, Josh Berken Parker, Michael Andrew Linden, Chris Karasch and Timothy Curtis Hallstrom
    Citation: Molecular Cancer 2015 14:93
    Content type: Research Published on:

  42. KLF5 is a basic transcriptional factor that regulates multiple physiopathological processes. Our recent study showed that deletion of Klf5 in mouse prostate promotes tumorigenesis initiated by the deletion of Pte...

    Authors: Xinpei Ci, Changsheng Xing, Baotong Zhang, Zhiqian Zhang, Jenny Jianping Ni, Wei Zhou and Jin-Tang Dong
    Citation: Molecular Cancer 2015 14:91
    Content type: Research Published on:

  43. Accumulating evidence suggests that some long noncoding RNAs (lncRNAs) are involved in certain diseases, such as cancer. The lncRNA, CCDC26, is related to childhood acute myeloid leukemia (AML) because its copy n...

    Authors: Tetsuo Hirano, Ryoko Yoshikawa, Hironori Harada, Yuka Harada, Atsuhiko Ishida and Takeshi Yamazaki
    Citation: Molecular Cancer 2015 14:90
    Content type: Research Published on:

  44. In chronic myeloid leukemia, the identification of individual BCR-ABL1 fusions is required for the development of personalized medicine approach for minimal residual disease monitoring at the DNA level. Next gene...

    Authors: Jana Linhartova, Lenka Hovorkova, Simona Soverini, Adela Benesova, Monika Jaruskova, Hana Klamova, Jan Zuna and Katerina Machova Polakova
    Citation: Molecular Cancer 2015 14:89
    Content type: Letter to the Editor Published on:

  45. Authors: Diego Iglesias-Gato, Yin-Choy Chuan, Ning Jiang, Charlotte Svensson, Jing Bao, Zhiqun Shang, Indranil Paul, Lars Egevad, Benedikt M Kessler, Pernilla Wikström, Yuanjie Niu and Amilcar Flores-Morales
    Citation: Molecular Cancer 2015 14:88
    Content type: Erratum Published on:

    The original article was published in Molecular Cancer 2015 14:8

  46. Infection with Human papillomaviruses (HPVs) leads to the development of a wide-range of cancers, accounting for 5% of all human cancers. A prominent example is cervical cancer, one of the leading causes of ca...

    Authors: Lifang Zhang, Jianhong Wu, Ming Tat Ling, Liang Zhao and Kong-Nan Zhao
    Citation: Molecular Cancer 2015 14:87
    Content type: Review Published on:

  47. Neuropilin 2 (NRP2) isa multi-functional co-receptor to many receptors, including VEGF receptor, c-Met and others. NRP2 has recently been implicated in tumor angiogenesis, growth, and metastasis of many other ...

    Authors: Tao Ji, Yi Guo, Kapjun Kim, Peter McQueen, Samia Ghaffar, Alexander Christ, Carol Lin, Ramez Eskander, Xiaolin Zi and Bang H Hoang
    Citation: Molecular Cancer 2015 14:86
    Content type: Research Published on:

  48. Among women worldwide, breast cancer is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths. Improved understanding of breast tumourigenesis may facilitate the development...

    Authors: Anthony J Apostoli, Jennifer M Roche, Mark M Schneider, Sandip K SenGupta, Michael A Di Lena, Rachel E Rubino, Nichole T Peterson and Christopher JB Nicol
    Citation: Molecular Cancer 2015 14:85
    Content type: Research Published on:

  49. Chemoresistance is a major obstacle in successfully treating cancers, and the mechanisms responsible for drug resistance are still far from understood. Carbonic anhydrase 9 (CA9) has been shown to be upregulat...

    Authors: Guopei Zheng, Cong Peng, Xiaoting Jia, Yixue Gu, Zhijie Zhang, Yingen Deng, Chengkun Wang, Nan Li, Jiang Yin, Xiaorong Liu, Minying Lu, Hailin Tang and Zhimin He
    Citation: Molecular Cancer 2015 14:84
    Content type: Research Published on:

  50. Head and neck cancer (HNC) is a highly invasive cancer. Aurora-A has been reported for a number of malignancies. However, the identity of downstream effectors responsible for its aggressive phenotype in HNC re...

    Authors: Chang-Han Chen, Alice YW Chang, Shau-Hsuan Li, Hsin-Ting Tsai, Li-Yen Shiu, Li-Jen Su, Wen-Lung Wang, Tai-Jen Chiu, Sheng-Dean Luo, Tai-Lin Huang and Chih-Yen Chien
    Citation: Molecular Cancer 2015 14:83
    Content type: Research Published on:
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Molecular Cancer

ISSN: 1476-4598