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  1. Rac3 is a small GTPase multifunctional protein that regulates cell adhesion, migration, and differentiation. It has been considered as an oncogene in breast cancer; however, its role in esophageal cancer and t...

    Authors: Su Dong, Jing Zhao, Jianxin Wei, Rachel K Bowser, Andrew Khoo, Zhonghui Liu, James D Luketich, Arjun Pennathur, Haichun Ma and Yutong Zhao
    Citation: Molecular Cancer 2014 13:76
    Content type: Research Published on:

  2. PTOV1 is an adaptor protein with functions in diverse processes, including gene transcription and protein translation, whose overexpression is associated with a higher proliferation index and tumor grade in pr...

    Authors: Lide Alaña, Marta Sesé, Verónica Cánovas, Yolanda Punyal, Yolanda Fernández, Ibane Abasolo, Inés de Torres, Cristina Ruiz, Lluís Espinosa, Anna Bigas, Santiago Ramón y Cajal, Pedro L Fernández, Florenci Serras, Montserrat Corominas, Timothy M Thomson and Rosanna Paciucci
    Citation: Molecular Cancer 2014 13:74
    Content type: Research Published on:

  3. More than 50% of cancer patients are recommended to receive radiotherapy. Recommendations are based mainly on clinical and pathological factors and not intrinsic tumour radio-sensitivity. Use of radiotherapy a...

    Authors: Fiona E Langlands, David Dodwell, Andrew M Hanby, Kieran Horgan, Rebecca A Millican-Slater, Valerie Speirs, Eldo T Verghese, Laura Smith and Thomas A Hughes
    Citation: Molecular Cancer 2014 13:73
    Content type: Research Published on:

  4. Medulloblastoma is the most common type of malignant brain tumor that afflicts children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients do poorly with signifi...

    Authors: Peter S Harris, Sujatha Venkataraman, Irina Alimova, Diane K Birks, Ilango Balakrishnan, Brian Cristiano, Andrew M Donson, Adrian M Dubuc, Michael D Taylor, Nicholas K Foreman, Philip Reigan and Rajeev Vibhakar
    Citation: Molecular Cancer 2014 13:72
    Content type: Research Published on:

  5. While the treatment of HER2 over-expressing breast cancer with recent HER-targeted drugs has been highly effective for some patients, primary (also known as innate) or acquired resistance limits the success of...

    Authors: Claire Corcoran, Sweta Rani, Susan Breslin, Martina Gogarty, Irene M Ghobrial, John Crown and Lorraine O’Driscoll
    Citation: Molecular Cancer 2014 13:71
    Content type: Research Published on:

  6. Macroautophagy is a catabolic process that can mediate cell death or survival. Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatment (TR) is known to induce autophagy. H...

    Authors: Kamini Singh, Arishya Sharma, Maria C Mir, Judith A Drazba, Warren D Heston, Cristina Magi-Galluzzi, Donna Hansel, Brian P Rubin, Eric A Klein and Alexandru Almasan
    Citation: Molecular Cancer 2014 13:70
    Content type: Research Published on:

  7. Recent evidence suggests that aromatase may be involved in the pathogenesis of malignant mesothelioma. Here, we evaluated the effect of exemestane, an inhibitor of aromatase, in the treatment of mesothelioma u...

    Authors: Barbara Nuvoli, Sabrina Germoni, Carlotta Morosetti, Raffaela Santoro, Giancarlo Cortese, Serena Masi, Iole Cordone and Rossella Galati
    Citation: Molecular Cancer 2014 13:69
    Content type: Research Published on:

  8. Recent evidence indicates that long noncoding RNAs (lncRNAs) play a critical role in the regulation of cellular processes, such as differentiation, proliferation and metastasis. These lncRNAs are found to be d...

    Authors: Ming Sun, Xiang-Hua Liu, Ke-Ming Wang, Feng-qi Nie, Rong Kong, Jin-song Yang, Rui Xia, Tong-Peng Xu, Fei-Yan Jin, Zhi-Jun Liu, Jin-fei Chen, Er-Bao Zhang, Wei De and Zhao-Xia Wang
    Citation: Molecular Cancer 2014 13:68
    Content type: Research Published on:

  9. Focal adhesion kinase (FAK) autophosphorylation seems to be a potential therapeutic target but little is known about the role and prognostic value of FAK and pFAK in epithelial ovarian cancer (EOC). Recently, ...

    Authors: Stefanie Aust, Katharina Auer, Anna Bachmayr-Heyda, Carsten Denkert, Jalid Sehouli, Ioana Braicu, Sven Mahner, Sandrina Lambrechts, Ignace Vergote, Christoph Grimm, Reinhard Horvat, Dan Cacsire Castillo-Tong, Robert Zeillinger and Dietmar Pils
    Citation: Molecular Cancer 2014 13:67
    Content type: Research Published on:

  10. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety of human cancer cells, including hepat...

    Authors: Gautam Sethi, Snehajyoti Chatterjee, Peramaiyan Rajendran, Feng Li, Muthu K Shanmugam, Kwong Fai Wong, Alan Prem Kumar, Parijat Senapati, Amit K Behera, Kam Man Hui, Jeelan Basha, Nagashayana Natesh, John M Luk and Tapas K Kundu
    Citation: Molecular Cancer 2014 13:66
    Content type: Research Published on:

  11. The success of using glycolytic inhibitors for cancer treatment relies on better understanding the roles of each frequently deregulated glycolytic genes in cancer. This report analyzed the involvement of a key...

    Authors: Ye Song, Qisheng Luo, Hao Long, Zheng Hu, Tianshi Que, Xi’an Zhang, Zhiyong Li, Gang Wang, Liu Yi, Zhen Liu, WeiYi Fang and Songtao Qi
    Citation: Molecular Cancer 2014 13:65
    Content type: Research Published on:

    The Erratum to this article has been published in Molecular Cancer 2015 13:235

  12. Interferon regulatory factor-1 (IRF-1) is a master regulator of IFN-γ induced gene transcription. Previously we have shown that IRF-1 transcriptionally induces CEACAM1 via an ISRE (Interferon-Stimulated Respon...

    Authors: Kenneth J Dery, Maciej Kujawski, David Grunert, Xiwei Wu, Tung Ngyuen, Celeste Cheung, John H Yim and John E Shively
    Citation: Molecular Cancer 2014 13:64
    Content type: Research Published on:

  13. Epidermal growth factor receptor (EGFR) is amplified in 40% of human glioblastomas. However, most glioblastoma patients respond poorly to anti-EGFR therapy. MicroRNAs can function as either oncogenes or tumor ...

    Authors: Kai-Liang Zhang, Xuan Zhou, Lei Han, Lu-Yue Chen, Ling-Chao Chen, Zhen-Dong Shi, Ming Yang, Yu Ren, Jing-Xuan Yang, Thomas S Frank, Chuan-Bao Zhang, Jun-Xia Zhang, Pei-Yu Pu, Jian-Ning Zhang, Tao Jiang, Eric J Wagner…
    Citation: Molecular Cancer 2014 13:63
    Content type: Research Published on:

  14. Thyroid cancer is the most common endocrine malignancy, and many patients with metastatic differentiated thyroid cancer (DTC), poorly differentiated thyroid cancer (PDTC), and anaplastic thyroid cancer (ATC) f...

    Authors: Jennifer A Morrison, Laura A Pike, Sharon B Sams, Vibha Sharma, Qiong Zhou, Jill J Severson, Aik-Choon Tan, William M Wood and Bryan R Haugen
    Citation: Molecular Cancer 2014 13:62
    Content type: Research Published on:

  15. The RAS/ERK and PI3K/AKT pathways induce oncogenic gene expression programs and are commonly activated together in cancer cells. Often, RAS/ERK signaling is activated by mutation of the RAS or RAF oncogenes, and ...

    Authors: Nagarathinam Selvaraj, Justin A Budka, Mary W Ferris, Travis J Jerde and Peter C Hollenhorst
    Citation: Molecular Cancer 2014 13:61
    Content type: Research Published on:

  16. Although cytotoxic T lymphocytes (CTLs) play a major role in eradicating cancer cells during immunotherapy, the cancer-associated immunosuppressive microenvironment often limits the success of such therapies. ...

    Authors: Li-Sheng Chang, Chih-Hsiang Leng, Yi-Chen Yeh, Chiao-Chieh Wu, Hsin-Wei Chen, Hai-Mei Huang and Shih-Jen Liu
    Citation: Molecular Cancer 2014 13:60
    Content type: Research Published on:

  17. Matrine, a clinical drug in China, has been used to treat viral hepatitis, cardiac arrhythmia and skin inflammations. Matrine also exhibits chemotherapeutic potential through its ability to trigger cancer cell...

    Authors: Huan Zhou, Minying Xu, Ya Gao, Zhigang Deng, Hanwei Cao, Wenqing Zhang, Qiao Wang, Bing Zhang, Gang Song, Yanyan Zhan and Tianhui Hu
    Citation: Molecular Cancer 2014 13:59
    Content type: Research Published on:

  18. HIF-1α and CXCR4/CXCL12 have crucial roles in the metastatic process of colorectal cancer. Our aim was to study the significance of targeting HIF-1α and the CXCR4/CXCL12 axis in colorectal cancer to prevent th...

    Authors: Benoît Romain, Muriel Hachet-Haas, Serge Rohr, Cécile Brigand, Jean-Luc Galzi, Marie-Pierre Gaub, Erwan Pencreach and Dominique Guenot
    Citation: Molecular Cancer 2014 13:58
    Content type: Research Published on:

  19. Cancer treatment using gold (I) complexes is becoming popular. In this study, a gold (I) N-heterocyclic complex designated as complex 3 was synthesized, its cytotoxicity was examined, and its anti-melanoma activi...

    Authors: Abhishek Nandy, Sumit Kumar Dey, Sujata Das, Rudra Narayan Munda, Joydev Dinda and Krishna Das Saha
    Citation: Molecular Cancer 2014 13:57
    Content type: Research Published on:

  21. An important clinical challenge in prostate cancer therapy is the inevitable transition from androgen-sensitive to castration-resistant and metastatic prostate cancer. Albeit the androgen receptor (AR) signali...

    Authors: Ping Li, Ru Yang and Wei-Qiang Gao
    Citation: Molecular Cancer 2014 13:55
    Content type: Review Published on:

  22. Hypoxia- and Myc-dependent transcriptional regulatory pathways are frequently deregulated in cancer cells. These pathways converge in many cellular responses, but the underlying molecular mechanisms are unclear.

    Authors: Reidun Aesoy, Katarina Gradin, Kathrine S Aasrud, Erling A Hoivik, Jorge L Ruas, Lorenz Poellinger and Marit Bakke
    Citation: Molecular Cancer 2014 13:54
    Content type: Research Published on:

  23. Ranpirnase (Rap) is an amphibian ribonuclease with reported antitumor activity, minimal toxicity, and negligible immunogenicity in clinical studies, but the unfavorable pharmacokinetics and suboptimal efficacy...

    Authors: Donglin Liu, Thomas M Cardillo, Yang Wang, Edmund A Rossi, David M Goldenberg and Chien-Hsing Chang
    Citation: Molecular Cancer 2014 13:53
    Content type: Research Published on:

  24. MicroRNA-21 (miR-21) is associated with the development of solid tumors progression including breast cancer. In this study we investigated matrix hyaluronan (HA)-CD44 (a primary HA receptor) interaction with c...

    Authors: Liqun Chen and Lilly Y W Bourguignon
    Citation: Molecular Cancer 2014 13:52
    Content type: Research Published on:

  25. MiR-17-92 cluster and its paralogues have emerged as crucial regulators of many oncogenes and tumor suppressors. Transforming growth factor-β receptor II (TGFβR2), as an important tumor suppressor, is involved...

    Authors: Xiaoming Lyu, Weiyi Fang, Longmei Cai, Hang Zheng, Yanfen Ye, Lan Zhang, Jinbang li, Hong Peng, William C S Cho, Ena Wang, Francesco M Marincola, Kaitai Yao, Hongbing Cai, Jiliang Li and Xin Li
    Citation: Molecular Cancer 2014 13:51
    Content type: Research Published on:

  26. Drug resistance is a significant problem in the treatment of ovarian cancer and can be caused by multiple mechanisms. Inhibition of apoptosis by the inhibitor of apoptosis proteins (IAPs) represents one such m...

    Authors: Gunjal Garg, Suwanna Vangveravong, Chenbo Zeng, Lynne Collins, Mary Hornick, Yassar Hashim, David Piwnica-Worms, Matthew A Powell, David G Mutch, Robert H Mach, William G Hawkins and Dirk Spitzer
    Citation: Molecular Cancer 2014 13:50
    Content type: Research Published on:

  27. AMP-activated protein kinase (AMPK) is a key energy sensor that is involved in regulating cell metabolism. Our previous study revealed that the subunits of the heterotimeric AMPK enzyme are diversely expressed...

    Authors: Cuilan Li, Vincent WS Liu, Pui Man Chiu, Kwok-Ming Yao, Hextan YS Ngan and David W Chan
    Citation: Molecular Cancer 2014 13:49
    Content type: Research Published on:

    The Erratum to this article has been published in Molecular Cancer 2014 13:161

  28. Nuclear factor-erythroid 2-related factor 2 (Nrf2) has emerged as a novel target for the prevention of colorectal cancer (CRC). Many chemopreventive compounds associated with Nrf2 activation are effective in p...

    Authors: Yang Yang, Xueting Cai, Jie Yang, Xiaoyan Sun, Chunping Hu, Zhanpeng Yan, Xiaojun Xu, Wuguang Lu, Xiaoning Wang and Peng Cao
    Citation: Molecular Cancer 2014 13:48
    Content type: Research Published on:

  29. We aimed to better discriminate metastasized (lymphogen/occult/both combined) from non-metastasized seminoma based on post-transcriptional changes examined in the peripheral blood.

    Authors: Christian G Ruf, Daniela Dinger, Matthias Port, Hans-Ulrich Schmelz, Walter Wagner, Cord Matthies, Bertram Müller-Myhsok, Viktor Meineke and Michael Abend
    Citation: Molecular Cancer 2014 13:47
    Content type: Research Published on:

  30. A colorectal tumor is not an isolated entity growing in a restricted location of the body. The patient’s gut environment constitutes the framework where the tumor evolves and this relationship promotes and inc...

    Authors: Rebeca Sanz-Pamplona, Antoni Berenguer, David Cordero, David G Molleví, Marta Crous-Bou, Xavier Sole, Laia Paré-Brunet, Elisabet Guino, Ramón Salazar, Cristina Santos, Javier de Oca, Xavier Sanjuan, Francisco Rodriguez-Moranta and Victor Moreno
    Citation: Molecular Cancer 2014 13:46
    Content type: Research Published on:

  31. Gain of function mutations in B-RAF and N-RAS occur frequently in melanoma, leading to mitogen activating protein kinase (MAPK) pathway activation, and this pathway is the target of drugs in development. Our p...

    Authors: Jaykumar Thumar, David Shahbazian, Saadia A Aziz, Lucia B Jilaveanu and Harriet M Kluger
    Citation: Molecular Cancer 2014 13:45
    Content type: Research Published on:

  32. This work aimed to synthesize a cathepsin B (CTSB)-cleavable tumor-targeting prodrug peptide doxorubicin (PDOX) and study the in vivo efficacy and toxicities on an animal model of gastric peritoneal carcinomat...

    Authors: Li Tang, Rui Duan, Yan-jun Zhong, Raymond A Firestone, Ya-ping Hong, Ji-guo Li, Yan-chao Xin, Han-lin Wu and Yan Li
    Citation: Molecular Cancer 2014 13:44
    Content type: Research Published on:

  33. Tumor-associated macrophages (TAMs) are the major component of tumor-infiltrating leukocytes. TAMs are heterogeneous, with distinct phenotypes influenced by the microenvironment surrounding tumor tissues, but ...

    Authors: Min Yang, Jingwei Liu, Jianghua Shao, Yanwen Qin, Qunsheng Ji, Xiaolin Zhang and Jie Du
    Citation: Molecular Cancer 2014 13:43
    Content type: Research Published on:

  34. The prognosis for renal cell carcinoma (RCC) is related to a high rate of metastasis, including 30% of bone metastasis. Characteristic for bone tissue is a high concentration of calcium ions. In this study, we...

    Authors: Elke Joeckel, Tobias Haber, Dirk Prawitt, Kerstin Junker, Christian Hampel, Joachim W Thüroff, Frederik C Roos and Walburgis Brenner
    Citation: Molecular Cancer 2014 13:42
    Content type: Research Published on:

  35. Microtubule stabilizers suppress microtubule dynamics and, at the lowest antiproliferative concentrations, disrupt the function of mitotic spindles, leading to mitotic arrest and apoptosis. At slightly higher ...

    Authors: April L Risinger, Stephen M Riffle, Manu Lopus, Mary A Jordan, Leslie Wilson and Susan L Mooberry
    Citation: Molecular Cancer 2014 13:41
    Content type: Research Published on:

  36. Overexpression of the proinflammatory cytokine IL-1β is associated with diverse diseases, including cancer. Alteration of microRNAs has been observed in cancer cells exposed to proinflammatory cytokines, yet t...

    Authors: Jun Ma, Jun Liu, Zhiming Wang, Xixi Gu, Yue Fan, Wen Zhang, Lili Xu, Jianjun Zhang and Dingfang Cai
    Citation: Molecular Cancer 2014 13:40
    Content type: Research Published on:

  37. Renal cell carcinoma (RCC) is known for its ability to metastasize synchronously or metachronously to various anatomic sites. Distinguishing histologic subtypes of metastatic RCC has become increasingly import...

    Authors: Lisha Wang, Sean R Williamson, Mingsheng Wang, Darrell D Davidson, Shaobo Zhang, Lee Ann Baldridge, Xiang Du and Liang Cheng
    Citation: Molecular Cancer 2014 13:39
    Content type: Research Published on:

  38. Robust ERK1/2 activity, which frequently results from KRAS mutation, invariably occurs in pancreatic ductal adenocarcinoma (PDAC). However, direct interference of KRAS signaling has not led to clinically succe...

    Authors: Zhou Luan, Ying He, Mohamed Alattar, Zhishui Chen and Fan He
    Citation: Molecular Cancer 2014 13:38
    Content type: Research Published on:

  39. A better molecular understanding of prostate carcinogenesis is warranted to devise novel targeted preventive and therapeutic strategies against prostate cancer (PCA), a major cause of mortality among men. Here...

    Authors: Gagan Deep, Anil K Jain, Anand Ramteke, Harold Ting, Kavitha C Vijendra, Subhash C Gangar, Chapla Agarwal and Rajesh Agarwal
    Citation: Molecular Cancer 2014 13:37
    Content type: Research Published on:

  40. The ataxia–telangiectasia mutated (ATM) protein kinase plays a central role in coordinating the cellular response to radiation-induced DNA damage. cAMP signaling regulates various cellular responses including ...

    Authors: Eun-Ah Cho, Eui-Jun Kim, Sahng-June Kwak and Yong-Sung Juhnn
    Citation: Molecular Cancer 2014 13:36
    Content type: Research Published on:

  41. Abnormal activation of the NF-κB pathway is closely related to tumorigenesis and chemoresistance. Therefore, microRNAs that possess the NF-κB inhibitory activity may provide novel targets for anti-cancer thera...

    Authors: Na Zhao, Ruizhi Wang, Liangji Zhou, Ying Zhu, Jiao Gong and Shi-Mei Zhuang
    Citation: Molecular Cancer 2014 13:35
    Content type: Research Published on:

  42. Increased infiltration of CD8+T cells into tumors has a positive impact on survival. Our previous study showed that doxorubicin (Dox) plus interleukin-12 (IL-12) boosted the accumulation of CD8+T cells in tumors ...

    Authors: Jiemiao Hu, Shiguo Zhu, Xueqing Xia, Liangfang Zhang, Eugenie S Kleinerman and Shulin Li
    Citation: Molecular Cancer 2014 13:34
    Content type: Research Published on:

  44. SET/I2PP2A is a multifunctional protein that is up-regulated in head and neck squamous cell carcinoma (HNSCC). The action of SET in HNSCC tumorigenicity is unknown.

    Authors: Lays M Sobral, Lucas O Sousa, Ricardo D Coletta, Hamilton Cabral, Lewis J Greene, Eloiza H Tajara, J Silvio Gutkind, Carlos Curti and Andréia M Leopoldino
    Citation: Molecular Cancer 2014 13:32
    Content type: Research Published on:

  45. The bumetanide (BMT)-sensitive Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) maintains cell volume homeostasis by increasing intracellular K+ and Cl- content via regulatory volume increase (RVI). Expression levels ...

    Authors: Wen Zhu, Gulnaz Begum, Kelli Pointer, Paul A Clark, Sung-Sen Yang, Shih-Hua Lin, Kristopher T Kahle, John S Kuo and Dandan Sun
    Citation: Molecular Cancer 2014 13:31
    Content type: Research Published on:

  47. Recent genome-wide studies have shown that approximately 30% of diffuse large B-cell lymphoma (DLBCL) cases harbor mutations in the histone acetyltransferase (HAT) coactivators p300 or CBP. The majority of the...

    Authors: Leila Haery, Julián G Lugo-Picó, Ryan A Henry, Andrew J Andrews and Thomas D Gilmore
    Citation: Molecular Cancer 2014 13:29
    Content type: Research Published on:

  48. In mammalians, HIF is a master regulator of hypoxia gene expression through direct binding to DNA, while its role in microRNA expression regulation, critical in the hypoxia response, is not elucidated genome w...

    Authors: Carme Camps, Harpreet K Saini, David R Mole, Hani Choudhry, Martin Reczko, José Afonso Guerra-Assunção, Ya-Min Tian, Francesca M Buffa, Adrian L Harris, Artemis G Hatzigeorgiou, Anton J Enright and Jiannis Ragoussis
    Citation: Molecular Cancer 2014 13:28
    Content type: Research Published on:

  49. The translocation t(9;11)(p22;q23) leading to the leukemogenic fusion gene MLL-AF9 is a frequent translocation in infant acute myeloid leukemia (AML). This study aimed to identify genes and molecular processes do...

    Authors: Katrin K Fleischmann, Philipp Pagel, Irene Schmid and Adelbert A Roscher
    Citation: Molecular Cancer 2014 13:27
    Content type: Research Published on:

  50. DNA methyltransferase 1 (DNMT1) plays a critical role in breast cancer progression. However, the epigenetic mechanism regulating DNMT1 expression remains largely unknown.

    Authors: Da Li, Fang-Fang Bi, Ji-Min Cao, Chen Cao, Bo Liu and Qing Yang
    Citation: Molecular Cancer 2014 13:26
    Content type: Research Published on:
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Molecular Cancer

ISSN: 1476-4598