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  1. We aimed to investigate whether MIR31 is an oncogene in human endometrial cancer and identify the target molecules associated with the malignant phenotype.

    Authors: Takashi Mitamura, Hidemichi Watari, Lei Wang, Hiromi Kanno, Makiko Kitagawa, Mohamed Kamel Hassan, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Shinya Tanaka and Noriaki Sakuragi
    Citation: Molecular Cancer 2014 13:97
    Content type: Research Published on:

    The Erratum to this article has been published in Molecular Cancer 2014 13:140

  2. Ras guanine nucleotide exchange factors (RasGEFs) mediate the activation of the Ras signaling pathway that is over activated in many human cancers. The RasGRP3, an activator of H-Ras and R-Ras protein exerts o...

    Authors: Zsuzsanna Nagy, Ilona Kovács, Miklós Török, Dezső Tóth, György Vereb, Krisztina Buzás, István Juhász, Peter M Blumberg, Tamás Bíró and Gabriella Czifra
    Citation: Molecular Cancer 2014 13:96
    Content type: Research Published on:

  3. Grb2 (Growth factor receptor-bound protein 2) is a key adaptor protein in maintaining the ERK activity via linking Sos1 (Son of sevenless homolog 1) or other proteins to activated RTKs, such as EGFR. Currently, l...

    Authors: Yingying Qu, Qin Chen, Xueping Lai, Changhong Zhu, Cheng Chen, Xian Zhao, Rong Deng, Ming Xu, Haihua Yuan, Yanli Wang, Jianxiu Yu and Jian Huang
    Citation: Molecular Cancer 2014 13:95
    Content type: Research Published on:

  4. It is well known that the activation of Aurora A/B (Aur A/B) or inactivation of BRCA1/2 induces tumor formation. Others and we have reported that the mutual suppression between Aur A/B and BRCA1/2 may manipula...

    Authors: Yan Wang, Ziliang Wang, Zihao Qi, Sheng Yin, Na Zhang, Yang Liu, Mingming Liu, Jiao Meng, Rongyu Zang, Zhen Zhang and Gong Yang
    Citation: Molecular Cancer 2014 13:94
    Content type: Research Published on:

  5. Osteosarcomas are the most common primary malignant tumors of bone, showing complex chromosomal rearrangements with multiple gains and losses. A frequent deletion within the chromosomal region 3q13.31 has been...

    Authors: Tale Barøy, Stine H Kresse, Magne Skårn, Marianne Stabell, Russell Castro, Silje Lauvrak, Antonio Llombart-Bosch, Ola Myklebost and Leonardo A Meza-Zepeda
    Citation: Molecular Cancer 2014 13:93
    Content type: Research Published on:

  6. Accumulating evidence indicates that the long non-coding RNA HOTAIR plays a critical role in cancer progression and metastasis. However, the overall biological role and clinical significance of HOTAIR in gastr...

    Authors: Xiang-hua Liu, Ming Sun, Feng-qi Nie, Ying-bin Ge, Er-bao Zhang, Dan-dan Yin, Rong Kong, Rui Xia, Kai-hua Lu, Jin-hai Li, Wei De, Ke-ming Wang and Zhao-xia Wang
    Citation: Molecular Cancer 2014 13:92
    Content type: Research Published on:

  7. The downstream targets of hypoxia inducible factor-1 alpha (HIF-1α) play an important role in tumor progression and angiogenesis. Therefore, inhibition of HIF-mediated transcription has potential in the treatm...

    Authors: Kelie M Reece, Emily D Richardson, Kristina M Cook, Tessa J Campbell, Stephen T Pisle, Alesia J Holly, David J Venzon, David J Liewehr, Cindy H Chau, Douglas K Price and William D Figg
    Citation: Molecular Cancer 2014 13:91
    Content type: Research Published on:

  9. TFAP2B is a member of the AP2 transcription factor family, which orchestrates a variety of cell processes. However, the roles of TFAP2B in regulating carcinogenesis remain largely unknown. Here, we investigate...

    Authors: Lingyi Fu, Ke Shi, Jingshu Wang, Wangbing Chen, Dingbo Shi, Yun Tian, Wei Guo, Wendan Yu, Xiangsheng Xiao, Tiebang Kang, Shusen Wang, Wenlin Huang and Wuguo Deng
    Citation: Molecular Cancer 2014 13:89
    Content type: Research Published on:

  10. Wnt proteins are important for developmental processes and certain diseases. WNT5A is a non-canonical Wnt protein that previously has been shown to play a role in the progression of malignant melanoma. High ex...

    Authors: Elin J Ekström, Caroline Bergenfelz, Verena von Bülow, Filiz Serifler, Eric Carlemalm, Göran Jönsson, Tommy Andersson and Karin Leandersson
    Citation: Molecular Cancer 2014 13:88
    Content type: Research Published on:

  11. The Polo-like Kinase 1 (PLK1) protein regulates cell cycle progression and is overexpressed in many malignant tissues. Overexpression is associated with poor prognosis in several cancer entities, whereby expre...

    Authors: Neval Akdeli, Kathrin Riemann, Jana Westphal, Jochen Hess, Winfried Siffert and Hagen S Bachmann
    Citation: Molecular Cancer 2014 13:87
    Content type: Research Published on:

  12. Given the emerging role of microRNA in tumor disease progression, we investigated the association between microRNA expression, liver metastasis and prognosis of colorectal cancer.

    Authors: Dengbo Ji, Zhiguo Chen, Ming Li, Tiancheng Zhan, Yunfeng Yao, Zhiqian Zhang, Jianzhong Xi, Li Yan and Jin Gu
    Citation: Molecular Cancer 2014 13:86
    Content type: Research Published on:

  13. Stimulation of CD40 can augment anti-cancer T cell immune responses by triggering effective activation and maturation of antigen-presenting cells (APCs). Although CD40 agonists have clinical activity in humans...

    Authors: Kim L Brunekreeft, Corinna Strohm, Marloes J Gooden, Anna A Rybczynska, Hans W Nijman, Götz U Grigoleit, Wijnand Helfrich, Edwin Bremer, Daniela Siegmund, Harald Wajant and Marco de Bruyn
    Citation: Molecular Cancer 2014 13:85
    Content type: Research Published on:

  14. E2F1 is the gatekeeper of the cell cycle controlling an analogous balance between proliferation and cell death. E2F1 expression is elevated in advanced prostate cancer. However, it is still unclear that the ro...

    Authors: Zijia Ren, Wenyao Kang, Lihua Wang, Baoliang Sun, Jiajia Ma, Chaogu Zheng, Jie Sun, Zhigang Tian, Xiaoyi Yang and Weihua Xiao
    Citation: Molecular Cancer 2014 13:84
    Content type: Research Published on:

  15. The clinical use of BRAF inhibitors for treatment of metastatic melanoma is limited by the development of drug resistance. In this study we investigated whether co-targeting the MAPK and the PI3K-AKT pathway c...

    Authors: Amanda Lassen, Mohammad Atefi, Lidia Robert, Deborah JL Wong, Michael Cerniglia, Begonya Comin-Anduix and Antoni Ribas
    Citation: Molecular Cancer 2014 13:83
    Content type: Research Published on:

  16. Gallbladder carcinoma (GBC) is highly lethal, and effective treatment will require synergistic anti-tumor management. The study is aimed at investigating the oncolytic value of myxoma virus (MYXV) infection ag...

    Authors: Mingzhe Weng, Wei Gong, Mingzhe Ma, Bingfeng Chu, Yiyu Qin, Mingdi Zhang, Xueqing Lun, Grant McFadden, Peter Forsyth, Yong Yang and Zhiwei Quan
    Citation: Molecular Cancer 2014 13:82
    Content type: Research Published on:

  17. The molecular mechanisms responsible for angiogenesis and abnormal expression of angiogenic factors in gastric cancer, including vascular endothelial growth factor (VEGF), remain unclear. The histone demethyla...

    Authors: Lupeng Li, Lixiang Wang, Ping Song, Xue Geng, Xiuming Liang, Minran Zhou, Yangyang Wang, Chunyan Chen, Jihui Jia and Jiping Zeng
    Citation: Molecular Cancer 2014 13:81
    Content type: Research Published on:

  18. While microRNAs (miRNAs) are extensively studied in post-transcriptional regulation of gene expressions in many biological processes, cellular miRNA-mediated regulation of viral genes remains unclear. In parti...

    Authors: Hyun Min Jung, Brittany L Phillips and Edward KL Chan
    Citation: Molecular Cancer 2014 13:80
    Content type: Research Published on:

  19. Acute myeloid leukaemia (AML) is characterised by the halt in maturation of myeloid progenitor cells, combined with uncontrolled proliferation and abnormal survival, leading to the accumulation of immature bla...

    Authors: Catalina A Palma, Dima Al Sheikha, Teck Khai Lim, Adam Bryant, Thi Thanh Vu, Vivek Jayaswal and David D F Ma
    Citation: Molecular Cancer 2014 13:79
    Content type: Research Published on:

  21. M3 and M1 subtype muscarinic receptors are co-expressed in normal and neoplastic intestinal epithelial cells. In mice, ablating Chrm3, the gene encoding M3R, robustly attenuates intestinal tumor formation. Here w...

    Authors: Kunrong Cheng, Guofeng Xie, Sandeep Khurana, Jonathon Heath, Cinthia B Drachenberg, Jennifer Timmons, Nirish Shah and Jean-Pierre Raufman
    Citation: Molecular Cancer 2014 13:77
    Content type: Research Published on:

  22. Rac3 is a small GTPase multifunctional protein that regulates cell adhesion, migration, and differentiation. It has been considered as an oncogene in breast cancer; however, its role in esophageal cancer and t...

    Authors: Su Dong, Jing Zhao, Jianxin Wei, Rachel K Bowser, Andrew Khoo, Zhonghui Liu, James D Luketich, Arjun Pennathur, Haichun Ma and Yutong Zhao
    Citation: Molecular Cancer 2014 13:76
    Content type: Research Published on:

  23. Porphyrin TMPyP4 (P4) and its C14H28-alkyl derivative (C14) are G-quadruplex binders and singlet oxygen (1O2) generators. In contrast, TMPyP2 (P2) produces 1O2 but it is not a G-quadruplex binder. As their photos...

    Authors: Valentina Rapozzi, Sonia Zorzet, Marina Zacchigna, Emilia Della Pietra, Susanna Cogoi and Luigi E Xodo
    Citation: Molecular Cancer 2014 13:75
    Content type: Research Published on:

  24. PTOV1 is an adaptor protein with functions in diverse processes, including gene transcription and protein translation, whose overexpression is associated with a higher proliferation index and tumor grade in pr...

    Authors: Lide Alaña, Marta Sesé, Verónica Cánovas, Yolanda Punyal, Yolanda Fernández, Ibane Abasolo, Inés de Torres, Cristina Ruiz, Lluís Espinosa, Anna Bigas, Santiago Ramón y Cajal, Pedro L Fernández, Florenci Serras, Montserrat Corominas, Timothy M Thomson and Rosanna Paciucci
    Citation: Molecular Cancer 2014 13:74
    Content type: Research Published on:

  25. More than 50% of cancer patients are recommended to receive radiotherapy. Recommendations are based mainly on clinical and pathological factors and not intrinsic tumour radio-sensitivity. Use of radiotherapy a...

    Authors: Fiona E Langlands, David Dodwell, Andrew M Hanby, Kieran Horgan, Rebecca A Millican-Slater, Valerie Speirs, Eldo T Verghese, Laura Smith and Thomas A Hughes
    Citation: Molecular Cancer 2014 13:73
    Content type: Research Published on:

  26. Medulloblastoma is the most common type of malignant brain tumor that afflicts children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients do poorly with signifi...

    Authors: Peter S Harris, Sujatha Venkataraman, Irina Alimova, Diane K Birks, Ilango Balakrishnan, Brian Cristiano, Andrew M Donson, Adrian M Dubuc, Michael D Taylor, Nicholas K Foreman, Philip Reigan and Rajeev Vibhakar
    Citation: Molecular Cancer 2014 13:72
    Content type: Research Published on:

  27. While the treatment of HER2 over-expressing breast cancer with recent HER-targeted drugs has been highly effective for some patients, primary (also known as innate) or acquired resistance limits the success of...

    Authors: Claire Corcoran, Sweta Rani, Susan Breslin, Martina Gogarty, Irene M Ghobrial, John Crown and Lorraine O’Driscoll
    Citation: Molecular Cancer 2014 13:71
    Content type: Research Published on:

  28. Macroautophagy is a catabolic process that can mediate cell death or survival. Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatment (TR) is known to induce autophagy. H...

    Authors: Kamini Singh, Arishya Sharma, Maria C Mir, Judith A Drazba, Warren D Heston, Cristina Magi-Galluzzi, Donna Hansel, Brian P Rubin, Eric A Klein and Alexandru Almasan
    Citation: Molecular Cancer 2014 13:70
    Content type: Research Published on:

  29. Recent evidence suggests that aromatase may be involved in the pathogenesis of malignant mesothelioma. Here, we evaluated the effect of exemestane, an inhibitor of aromatase, in the treatment of mesothelioma u...

    Authors: Barbara Nuvoli, Sabrina Germoni, Carlotta Morosetti, Raffaela Santoro, Giancarlo Cortese, Serena Masi, Iole Cordone and Rossella Galati
    Citation: Molecular Cancer 2014 13:69
    Content type: Research Published on:

  30. Recent evidence indicates that long noncoding RNAs (lncRNAs) play a critical role in the regulation of cellular processes, such as differentiation, proliferation and metastasis. These lncRNAs are found to be d...

    Authors: Ming Sun, Xiang-Hua Liu, Ke-Ming Wang, Feng-qi Nie, Rong Kong, Jin-song Yang, Rui Xia, Tong-Peng Xu, Fei-Yan Jin, Zhi-Jun Liu, Jin-fei Chen, Er-Bao Zhang, Wei De and Zhao-Xia Wang
    Citation: Molecular Cancer 2014 13:68
    Content type: Research Published on:

  31. Focal adhesion kinase (FAK) autophosphorylation seems to be a potential therapeutic target but little is known about the role and prognostic value of FAK and pFAK in epithelial ovarian cancer (EOC). Recently, ...

    Authors: Stefanie Aust, Katharina Auer, Anna Bachmayr-Heyda, Carsten Denkert, Jalid Sehouli, Ioana Braicu, Sven Mahner, Sandrina Lambrechts, Ignace Vergote, Christoph Grimm, Reinhard Horvat, Dan Cacsire Castillo-Tong, Robert Zeillinger and Dietmar Pils
    Citation: Molecular Cancer 2014 13:67
    Content type: Research Published on:

  32. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety of human cancer cells, including hepat...

    Authors: Gautam Sethi, Snehajyoti Chatterjee, Peramaiyan Rajendran, Feng Li, Muthu K Shanmugam, Kwong Fai Wong, Alan Prem Kumar, Parijat Senapati, Amit K Behera, Kam Man Hui, Jeelan Basha, Nagashayana Natesh, John M Luk and Tapas K Kundu
    Citation: Molecular Cancer 2014 13:66
    Content type: Research Published on:

  33. The success of using glycolytic inhibitors for cancer treatment relies on better understanding the roles of each frequently deregulated glycolytic genes in cancer. This report analyzed the involvement of a key...

    Authors: Ye Song, Qisheng Luo, Hao Long, Zheng Hu, Tianshi Que, Xi’an Zhang, Zhiyong Li, Gang Wang, Liu Yi, Zhen Liu, WeiYi Fang and Songtao Qi
    Citation: Molecular Cancer 2014 13:65
    Content type: Research Published on:

    The Erratum to this article has been published in Molecular Cancer 2015 13:235

  34. Interferon regulatory factor-1 (IRF-1) is a master regulator of IFN-γ induced gene transcription. Previously we have shown that IRF-1 transcriptionally induces CEACAM1 via an ISRE (Interferon-Stimulated Respon...

    Authors: Kenneth J Dery, Maciej Kujawski, David Grunert, Xiwei Wu, Tung Ngyuen, Celeste Cheung, John H Yim and John E Shively
    Citation: Molecular Cancer 2014 13:64
    Content type: Research Published on:

  35. Epidermal growth factor receptor (EGFR) is amplified in 40% of human glioblastomas. However, most glioblastoma patients respond poorly to anti-EGFR therapy. MicroRNAs can function as either oncogenes or tumor ...

    Authors: Kai-Liang Zhang, Xuan Zhou, Lei Han, Lu-Yue Chen, Ling-Chao Chen, Zhen-Dong Shi, Ming Yang, Yu Ren, Jing-Xuan Yang, Thomas S Frank, Chuan-Bao Zhang, Jun-Xia Zhang, Pei-Yu Pu, Jian-Ning Zhang, Tao Jiang, Eric J Wagner…
    Citation: Molecular Cancer 2014 13:63
    Content type: Research Published on:

  36. Thyroid cancer is the most common endocrine malignancy, and many patients with metastatic differentiated thyroid cancer (DTC), poorly differentiated thyroid cancer (PDTC), and anaplastic thyroid cancer (ATC) f...

    Authors: Jennifer A Morrison, Laura A Pike, Sharon B Sams, Vibha Sharma, Qiong Zhou, Jill J Severson, Aik-Choon Tan, William M Wood and Bryan R Haugen
    Citation: Molecular Cancer 2014 13:62
    Content type: Research Published on:

  37. The RAS/ERK and PI3K/AKT pathways induce oncogenic gene expression programs and are commonly activated together in cancer cells. Often, RAS/ERK signaling is activated by mutation of the RAS or RAF oncogenes, and ...

    Authors: Nagarathinam Selvaraj, Justin A Budka, Mary W Ferris, Travis J Jerde and Peter C Hollenhorst
    Citation: Molecular Cancer 2014 13:61
    Content type: Research Published on:

  38. Although cytotoxic T lymphocytes (CTLs) play a major role in eradicating cancer cells during immunotherapy, the cancer-associated immunosuppressive microenvironment often limits the success of such therapies. ...

    Authors: Li-Sheng Chang, Chih-Hsiang Leng, Yi-Chen Yeh, Chiao-Chieh Wu, Hsin-Wei Chen, Hai-Mei Huang and Shih-Jen Liu
    Citation: Molecular Cancer 2014 13:60
    Content type: Research Published on:

  39. Matrine, a clinical drug in China, has been used to treat viral hepatitis, cardiac arrhythmia and skin inflammations. Matrine also exhibits chemotherapeutic potential through its ability to trigger cancer cell...

    Authors: Huan Zhou, Minying Xu, Ya Gao, Zhigang Deng, Hanwei Cao, Wenqing Zhang, Qiao Wang, Bing Zhang, Gang Song, Yanyan Zhan and Tianhui Hu
    Citation: Molecular Cancer 2014 13:59
    Content type: Research Published on:

  40. HIF-1α and CXCR4/CXCL12 have crucial roles in the metastatic process of colorectal cancer. Our aim was to study the significance of targeting HIF-1α and the CXCR4/CXCL12 axis in colorectal cancer to prevent th...

    Authors: Benoît Romain, Muriel Hachet-Haas, Serge Rohr, Cécile Brigand, Jean-Luc Galzi, Marie-Pierre Gaub, Erwan Pencreach and Dominique Guenot
    Citation: Molecular Cancer 2014 13:58
    Content type: Research Published on:

  41. Cancer treatment using gold (I) complexes is becoming popular. In this study, a gold (I) N-heterocyclic complex designated as complex 3 was synthesized, its cytotoxicity was examined, and its anti-melanoma activi...

    Authors: Abhishek Nandy, Sumit Kumar Dey, Sujata Das, Rudra Narayan Munda, Joydev Dinda and Krishna Das Saha
    Citation: Molecular Cancer 2014 13:57
    Content type: Research Published on:

  43. An important clinical challenge in prostate cancer therapy is the inevitable transition from androgen-sensitive to castration-resistant and metastatic prostate cancer. Albeit the androgen receptor (AR) signali...

    Authors: Ping Li, Ru Yang and Wei-Qiang Gao
    Citation: Molecular Cancer 2014 13:55
    Content type: Review Published on:

  44. Hypoxia- and Myc-dependent transcriptional regulatory pathways are frequently deregulated in cancer cells. These pathways converge in many cellular responses, but the underlying molecular mechanisms are unclear.

    Authors: Reidun Aesoy, Katarina Gradin, Kathrine S Aasrud, Erling A Hoivik, Jorge L Ruas, Lorenz Poellinger and Marit Bakke
    Citation: Molecular Cancer 2014 13:54
    Content type: Research Published on:

  45. Ranpirnase (Rap) is an amphibian ribonuclease with reported antitumor activity, minimal toxicity, and negligible immunogenicity in clinical studies, but the unfavorable pharmacokinetics and suboptimal efficacy...

    Authors: Donglin Liu, Thomas M Cardillo, Yang Wang, Edmund A Rossi, David M Goldenberg and Chien-Hsing Chang
    Citation: Molecular Cancer 2014 13:53
    Content type: Research Published on:

  46. MicroRNA-21 (miR-21) is associated with the development of solid tumors progression including breast cancer. In this study we investigated matrix hyaluronan (HA)-CD44 (a primary HA receptor) interaction with c...

    Authors: Liqun Chen and Lilly Y W Bourguignon
    Citation: Molecular Cancer 2014 13:52
    Content type: Research Published on:

  47. MiR-17-92 cluster and its paralogues have emerged as crucial regulators of many oncogenes and tumor suppressors. Transforming growth factor-β receptor II (TGFβR2), as an important tumor suppressor, is involved...

    Authors: Xiaoming Lyu, Weiyi Fang, Longmei Cai, Hang Zheng, Yanfen Ye, Lan Zhang, Jinbang li, Hong Peng, William C S Cho, Ena Wang, Francesco M Marincola, Kaitai Yao, Hongbing Cai, Jiliang Li and Xin Li
    Citation: Molecular Cancer 2014 13:51
    Content type: Research Published on:

  48. Drug resistance is a significant problem in the treatment of ovarian cancer and can be caused by multiple mechanisms. Inhibition of apoptosis by the inhibitor of apoptosis proteins (IAPs) represents one such m...

    Authors: Gunjal Garg, Suwanna Vangveravong, Chenbo Zeng, Lynne Collins, Mary Hornick, Yassar Hashim, David Piwnica-Worms, Matthew A Powell, David G Mutch, Robert H Mach, William G Hawkins and Dirk Spitzer
    Citation: Molecular Cancer 2014 13:50
    Content type: Research Published on:

  49. Nuclear factor-erythroid 2-related factor 2 (Nrf2) has emerged as a novel target for the prevention of colorectal cancer (CRC). Many chemopreventive compounds associated with Nrf2 activation are effective in p...

    Authors: Yang Yang, Xueting Cai, Jie Yang, Xiaoyan Sun, Chunping Hu, Zhanpeng Yan, Xiaojun Xu, Wuguang Lu, Xiaoning Wang and Peng Cao
    Citation: Molecular Cancer 2014 13:48
    Content type: Research Published on:

  50. We aimed to better discriminate metastasized (lymphogen/occult/both combined) from non-metastasized seminoma based on post-transcriptional changes examined in the peripheral blood.

    Authors: Christian G Ruf, Daniela Dinger, Matthias Port, Hans-Ulrich Schmelz, Walter Wagner, Cord Matthies, Bertram Müller-Myhsok, Viktor Meineke and Michael Abend
    Citation: Molecular Cancer 2014 13:47
    Content type: Research Published on:
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Molecular Cancer

ISSN: 1476-4598