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  1. Inflammation and cancer have a profound yet ambiguous relationship. Inflammation - especially chronic inflammation - has protumorigenic effects, but inflammatory cells also mediate an immune response against t...

    Authors: Rudi Beyaert, Laurent Beaugerie, Gert Van Assche, Lieve Brochez, Jean-Christophe Renauld, Manuelle Viguier, Veronique Cocquyt, Guy Jerusalem, Jean-Pascal Machiels, Hans Prenen, Pierre Masson, Edouard Louis and Filip De Keyser
    Citation: Molecular Cancer 2013 12:98
    Content type: Review Published on:

  2. PCAF is an important intrinsic histone acetyltransferases. This study tried to establish the effect of PCAF on HCC cell apoptosis.

    Authors: Xin Zheng, Xiaohong Gai, Feihu Ding, Zhongtang Lu, Kangsheng Tu, Yingmin Yao and Qingguang Liu
    Citation: Molecular Cancer 2013 12:96
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2022 21:187

  3. Centromere protein-F (CENP-F) is a large nuclear protein of 367 kDa, which is involved in multiple mitosis-related events such as proper assembly of the kinetochores, stabilization of heterochromatin, chromoso...

    Authors: Simon Welner, Nicole Hartwig Trier, Morten Frisch, Henning Locht, Paul Robert Hansen and Gunnar Houen
    Citation: Molecular Cancer 2013 12:95
    Content type: Research Published on:

  4. Ionizing radiation (IR) is used for patients diagnosed with unresectable non small cell lung cancer (NSCLC), however radiotherapy remains largely palliative due to radioresistance. Cancer stem cells (CSCs), as...

    Authors: Roberto Gomez-Casal, Chitralekha Bhattacharya, Nandita Ganesh, Lisa Bailey, Per Basse, Michael Gibson, Michael Epperly and Vera Levina
    Citation: Molecular Cancer 2013 12:94
    Content type: Research Published on:

  5. Abnormal rates of growth together with metastatic potential and lack of susceptibility to cellular signals leading to apoptosis are widely investigated characteristics of tumors that develop via genetic or epi...

    Authors: Joanna Obacz, Silvia Pastorekova, Borek Vojtesek and Roman Hrstka
    Citation: Molecular Cancer 2013 12:93
    Content type: Review Published on:

  6. In eukaryotes, miR-16 is an important microRNA (miRNA) that is involved in numerous biological processes. However, it is not fully understood how miR-16 executes its physiological functions. In the present stu...

    Authors: Xin Yan, Hongwei Liang, Ting Deng, Kegan Zhu, Suyang Zhang, Nan Wang, Xueyuan Jiang, Xueliang Wang, Rui Liu, Ke Zen, Chen-Yu Zhang, Yi Ba and Xi Chen
    Citation: Molecular Cancer 2013 12:92
    Content type: Research Published on:

  7. Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis, and the enzymes that participate in this process, in particular E3 ubiquitin ligases and deubiquitinases (DUBs),...

    Authors: Iraia García-Santisteban, Godefridus J Peters, Elisa Giovannetti and Jose Antonio Rodríguez
    Citation: Molecular Cancer 2013 12:91
    Content type: Review Published on:

  8. Recent epidemiological studies demonstrate that both active and involuntary exposure to tobacco smoke increase the risk of breast cancer. Little is known, however, about the molecular mechanisms by which conti...

    Authors: Francescopaolo Di Cello, V Lynn Flowers, Huili Li, Briana Vecchio-Pagán, Brent Gordon, Kirsten Harbom, James Shin, Robert Beaty, Wei Wang, Cory Brayton, Stephen B Baylin and Cynthia A Zahnow
    Citation: Molecular Cancer 2013 12:90
    Content type: Research Published on:

  10. Farnesyltransferase inhibitors (FTIs) are anticancer agents with a spectrum of activity in Ras-dependent and independent tumor cellular and xenograph models. How inhibition of protein farnesylation by FTIs res...

    Authors: Giampiero Porcu, Ainslie B Parsons, Daniele Di Giandomenico, Giuseppe Lucisano, Maria Giovanna Mosca, Charles Boone and Antonella Ragnini-Wilson
    Citation: Molecular Cancer 2013 12:88
    Content type: Research Published on:

  11. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with high mutational heterogeneity and a generally poor clinical outcome. Despite implicated roles of deregulated TP53, IGF-2 and Wnt signaling pat...

    Authors: Reju Korah, James M Healy, John W Kunstman, Annabelle L Fonseca, Amir H Ameri, Manju L Prasad and Tobias Carling
    Citation: Molecular Cancer 2013 12:87
    Content type: Research Published on:

  12. The NF-κB family of transcription factors has an essential role in inflammation and innate immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of cancer initiation and pro...

    Authors: Bastian Hoesel and Johannes A Schmid
    Citation: Molecular Cancer 2013 12:86
    Content type: Review Published on:

  13. The chemokine CXCL12, also known as SDF-1, and its receptor, CXCR4, are overexpressed in prostate cancers and in animal models of prostate-specific PTEN deletion, but their regulation is poorly understood. Los...

    Authors: M Katie Conley-LaComb, Allen Saliganan, Pridvi Kandagatla, Yong Q Chen, Michael L Cher and Sreenivasa R Chinni
    Citation: Molecular Cancer 2013 12:85
    Content type: Research Published on:

  15. Due to frequent mutations in certain cancers, FGFR3 gene is considered as an oncogene. However, in some normal tissues, FGFR3 can limit cell growth and promote cell differentiation. Thus, FGFR3 action appears par...

    Authors: Marie Lafitte, Isabelle Moranvillier, Stéphane Garcia, Evelyne Peuchant, Juan Iovanna, Benoit Rousseau, Pierre Dubus, Véronique Guyonnet-Dupérat, Geneviève Belleannée, Jeanne Ramos, Aurélie Bedel, Hubert de Verneuil, François Moreau-Gaudry and Sandrine Dabernat
    Citation: Molecular Cancer 2013 12:83
    Content type: Research Published on:

  16. Anti-angiogenesis targeting VEGFR2 has been considered as an important strategy for cancer therapy. Tylophorine is known to possess anti-inflammatory and antitumor activity, but its roles in tumor angiogenesis...

    Authors: Sarita Saraswati, Pawan K Kanaujia, Shakti Kumar, Ranjeet Kumar and Abdulqader A Alhaider
    Citation: Molecular Cancer 2013 12:82
    Content type: Research Published on:

  17. Radiation exerts direct antitumor effects and is widely used in clinics, but the efficacy is severely compromised by tumor resistance. Therefore uncovering the mechanism of radioresistance might promote the de...

    Authors: Feng Wei, Yan Liu, Yanhai Guo, An Xiang, Guangyi Wang, Xiaochang Xue and Zifan Lu
    Citation: Molecular Cancer 2013 12:81
    Content type: Research Published on:

  18. Tumor necrosis factor alpha (TNF-α) plays an important role in inflammation, immunity, and defense against infection and clearance of human papillomavirus (HPV). Thus, genetic variants may modulate individual ...

    Authors: Lei Jin, Erich M Sturgis, Yang Zhang, Zhigang Huang, Xicheng Song, Chao Li, Qingyi Wei and Guojun Li
    Citation: Molecular Cancer 2013 12:80
    Content type: Research Published on:

  19. The canonical milk-transmitted mouse mammary tumor virus (MMTV) of C3H mice (C3H-MMTV) rapidly induces tumors in 90% of infected animals by 8 months of age. Pro-viral insertions of C3H-MMTV into genomic DNA re...

    Authors: Robert D Bruno, Sonia M Rosenfield and Gilbert H Smith
    Citation: Molecular Cancer 2013 12:79
    Content type: Short communication Published on:

  22. Activation of receptors for growth factors on lung epithelial cells is essential for transformation into tumor cells, supporting their viability and proliferation. In most lung cancer patients, EGFR is constit...

    Authors: Parnetta Sutton, Jeffrey A Borgia, Philip Bonomi and Janet MD Plate
    Citation: Molecular Cancer 2013 12:76
    Content type: Research Published on:

  23. TMEM16A, also known as Anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. The role of TMEM16A in cancer is not completely understood and no data are available regarding the po...

    Authors: Ifeoma Ubby, Erica Bussani, Antonio Colonna, Giuseppe Stacul, Martina Locatelli, Paolo Scudieri, Luis Galietta and Franco Pagani
    Citation: Molecular Cancer 2013 12:75
    Content type: Research Published on:

  24. A major barrier to effective treatment of glioblastoma multiforme (GBM) is the invasion of glioma cells into the brain parenchyma rendering local therapies such as surgery and radiation therapy ineffective. GB...

    Authors: Leroi V DeSouza, Ajay Matta, Zia Karim, Joydeep Mukherjee, X Simon Wang, Olga Krakovska, Gelareh Zadeh, Abhijit Guha and KW Michael Siu
    Citation: Molecular Cancer 2013 12:74
    Content type: Research Published on:

  25. To improve the outcome of patients with T-cell acute lymphoblastic leukemia (T-ALL), characterization of the biological features of T-ALL blast cells and the immune status of patients with T-ALL is needed to i...

    Authors: Shaohua Chen, Xin Huang, Haitao Zheng, Suxia Geng, Xiuli Wu, Lijian Yang, Jianyu Weng, Xin Du and Yangqiu Li
    Citation: Molecular Cancer 2013 12:73
    Content type: Short communication Published on:

  26. Insulin is tightly associated with cancer progression; however, mechanistic insights into such observations are poorly understood. Recent studies show that metabolic transformation is critical to cancer cell p...

    Authors: Mohd Askandar Iqbal, Farid Ahmad Siddiqui, Vibhor Gupta, Shilpi Chattopadhyay, Prakasam Gopinath, Bhupender Kumar, Siddharth Manvati, Noor Chaman and Rameshwar NK Bamezai
    Citation: Molecular Cancer 2013 12:72
    Content type: Research Published on:

  27. With high throughput screening, novel therapeutic agents can be efficiently identified. Unfortunately, researchers only resort to in vitro cell viability assays for screening of anticancer drugs for retinoblas...

    Authors: Dong Hyun Jo, Dain Son, Yirang Na, Manyoung Jang, Jae-Hoon Choi, Jin Hyoung Kim, Young Suk Yu, Seung Hyeok Seok and Jeong Hun Kim
    Citation: Molecular Cancer 2013 12:71
    Content type: Research Published on:

  28. Neuroblastoma (NB) tumours are commonly divided into three cytogenetic subgroups. However, by unsupervised principal components analysis of gene expression profiles we recently identified four distinct subgrou...

    Authors: Annica Wilzén, Cecilia Krona, Baldur Sveinbjörnsson, Erik Kristiansson, Daniel Dalevi, Ingrid Øra, Katleen De Preter, Raymond L Stallings, John Maris, Rogier Versteeg, Staffan Nilsson, Per Kogner and Frida Abel
    Citation: Molecular Cancer 2013 12:70
    Content type: Research Published on:

  29. Efficacious application of HER2-targetting agents requires the identification of novel predictive biomarkers. Lapatinib, afatinib and neratinib are tyrosine kinase inhibitors (TKIs) of HER2 and EGFR growth fac...

    Authors: Fiona O’Neill, Stephen F Madden, Martin Clynes, John Crown, Padraig Doolan, Sinéad T Aherne and Robert O’Connor
    Citation: Molecular Cancer 2013 12:69
    Content type: Research Published on:

  31. Inhibitor of differentiation 4 (Id4), a member of the helix-loop-helix family of transcriptional regulators has emerged as a tumor suppressor in prostate cancer. Id4 is expressed in the normal prostate where i...

    Authors: Pankaj Sharma, Ashley Evans Knowell, Swathi Chinaranagari, Shravan Komaragiri, Peri Nagappan, Divya Patel, Mathew C Havrda and Jaideep Chaudhary
    Citation: Molecular Cancer 2013 12:67
    Content type: Research Published on:

  32. Hypoxia plays a vital role in cancer epithelial to mesenchymal transition (EMT) and invasion. However, it is not quite clear how hypoxia may contribute to these events. Here we investigate the role of Hedgehog...

    Authors: Jianjun Lei, Jiguang Ma, Qingyong Ma, Xuqi Li, Han Liu, Qinhong Xu, Wanxing Duan, Qing Sun, Jun Xu, Zheng Wu and Erxi Wu
    Citation: Molecular Cancer 2013 12:66
    Content type: Research Published on:

  33. BCL-2 family proteins BAK and BAX orchestrate outer mitochondrial membrane permeabilization (MOMP) during apoptosis by forming pores in the membrane to release apoptogenic factors that commits a cell to death....

    Authors: Abul Azad and Alan Storey
    Citation: Molecular Cancer 2013 12:65
    Content type: Short communication Published on:

  34. Prostate cancer (PCa) cell lines and tissues differentially express CXCR5, which positively correlate with PCa progression, and mediate PCa cell migration and invasion following interaction with CXCL13. Howeve...

    Authors: Christelle P El-Haibi, Praveen Sharma, Rajesh Singh, Pranav Gupta, Dennis D Taub, Shailesh Singh and James W Lillard, Jr
    Citation: Molecular Cancer 2013 12:64
    Content type: Research Published on:

  35. Insulin like growth factor binding proteins modulate the mitogenic and pro survival effects of IGF. Elevated expression of IGFBP2 is associated with progression of tumors that include prostate, ovarian, glioma...

    Authors: Priyanka Sehgal, Neeraj Kumar, Varuvar Rajesh Praveen Kumar, Shilpa Patil, Animesh Bhattacharya, Manavalan Vijaya Kumar, Geetashree Mukherjee and Paturu Kondaiah
    Citation: Molecular Cancer 2013 12:63
    Content type: Research Published on:

  36. Exosomes can be viewed as complex “messages” packaged to survive trips to other cells in the local microenvironment and, through body fluids, to distant sites. A large body of evidence indicates a pro-metastat...

    Authors: Germana Rappa, Javier Mercapide, Fabio Anzanello, Robert M Pope and Aurelio Lorico
    Citation: Molecular Cancer 2013 12:62
    Content type: Research Published on:

  37. Aberrant activation of the proto-oncogene B-cell lymphoma/leukemia 11A (BCL11A) has been implicated in the pathogenesis of leukemia and lymphoma. However, the clinical significance of BCL11A in non-small cell lun...

    Authors: Ben-yuan Jiang, Xu-chao Zhang, Jian Su, Wei Meng, Xue-ning Yang, Jin-ji Yang, Qing Zhou, Zhi-yong Chen, Zhi-hong Chen, Zhi Xie, Shi-liang Chen and Yi-long Wu
    Citation: Molecular Cancer 2013 12:61
    Content type: Research Published on:

  38. Nectin-2 is a Ca2+-independent cell-cell adhesion molecule that is one of the plasma membrane components of adherens junctions. However, little has been reported about the involvement of Nectin-2 in cancer.

    Authors: Tsutomu Oshima, Shuji Sato, Junichi Kato, Yuki Ito, Takahiro Watanabe, Isamu Tsuji, Akira Hori, Tomofumi Kurokawa and Toshio Kokubo
    Citation: Molecular Cancer 2013 12:60
    Content type: Research Published on:

  39. Prolactin (PRL) is essential for normal mammary gland development. PRL promotes mammary tumor formation in rodents and elevated serum prolactin is associated with increased risk of estrogen-receptor positive b...

    Authors: Takahiro Sato, Thai H Tran, Amy R Peck, Chengbao Liu, Adam Ertel, Justin Lin, Lynn M Neilson and Hallgeir Rui
    Citation: Molecular Cancer 2013 12:59
    Content type: Research Published on:

  40. The nitro-chloromethylbenzindoline prodrug nitro-CBI-DEI appears a promising candidate for the anti-cancer strategy gene-directed enzyme prodrug therapy, based on its ability to be converted to a highly cytoto...

    Authors: Laura K Green, Sophie P Syddall, Kendall M Carlin, Glenn D Bell, Christopher P Guise, Alexandra M Mowday, Michael P Hay, Jeffrey B Smaill, Adam V Patterson and David F Ackerley
    Citation: Molecular Cancer 2013 12:58
    Content type: Short communication Published on:

  41. Cancer of unknown or uncertain primary is a major diagnostic and clinical challenge, since identifying the tissue-of-origin of metastases is crucial for selecting optimal treatment. MicroRNAs are a family of n...

    Authors: George Pentheroudakis, Nicholas Pavlidis, George Fountzilas, Dimitrios Krikelis, Anna Goussia, Aikaterini Stoyianni, Mats Sanden, Brianna St Cyr, Noga Yerushalmi, Hila Benjamin, Eti Meiri, Ayelet Chajut, Shai Rosenwald, Ranit Aharonov and Yael Spector
    Citation: Molecular Cancer 2013 12:57
    Content type: Research Published on:

  42. The Epithelial Cell Adhesion Molecule (EpCAM) has been shown to be strongly expressed in human breast cancer and cancer stem cells and its overexpression has been supposed to support tumor progression and meta...

    Authors: Agnieszka Martowicz, Johannes Rainer, Julien Lelong, Gilbert Spizzo, Guenther Gastl and Gerold Untergasser
    Citation: Molecular Cancer 2013 12:56
    Content type: Research Published on:

  43. Osteosarcoma (OS) is the most common primary bone malignancy with a high propensity for local invasion and distant metastasis. Limited by the severe toxicity of conventional agents, the therapeutic bottleneck ...

    Authors: Tao Ji, Carol Lin, Lauren S Krill, Ramez Eskander, Yi Guo, Xiaolin Zi and Bang H Hoang
    Citation: Molecular Cancer 2013 12:55
    Content type: Research Published on:

  44. Urokinase (uPA) and its receptor (uPAR) play an important role in tumour growth and metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumour...

    Authors: Yuli Lin, Nana Peng, Jianping Li, Hongqin Zhuang and Zi-Chun Hua
    Citation: Molecular Cancer 2013 12:54
    Content type: Research Published on:

  45. Nasopharyngeal carcinoma (NPC) is a common malignant tumor in southern China and Southeast Asia, but its molecular mechanisms of pathogenesis are poorly understood. Our previous work has demonstrated that BCAT1 m...

    Authors: Wen Zhou, Xiangling Feng, Caiping Ren, Xingjun Jiang, Weidong Liu, Wei Huang, Zhihong Liu, Zan Li, Liang Zeng, Lei Wang, Bin Zhu, Jia Shi, Jie Liu, Chang Zhang, Yanyu Liu and Kaitai Yao
    Citation: Molecular Cancer 2013 12:53
    Content type: Research Published on:

  46. Circulating microRNAs (miRNAs) have been found in many body fluids and represent reliable markers of several physio-pathological disorders, including cancer. In some cases, circulating miRNAs have been evaluat...

    Authors: Serena Lucotti, Giuseppe Rainaldi, Monica Evangelista and Milena Rizzo
    Citation: Molecular Cancer 2013 12:52
    Content type: Research Published on:

  48. Approximately 1,000 microRNAs (miRs) are present in the human genome; however, little is known about the regulation of miR transcription. Because miR levels are deregulated in chronic lymphocytic leukemia (CLL...

    Authors: Uri Rozovski, George A Calin, Tetsuro Setoyama, Lucilla D’Abundo, David M Harris, Ping Li, Zhiming Liu, Srdana Grgurevic, Alessandra Ferrajoli, Stefan Faderl, Jan A Burger, Susan O’Brien, William G Wierda, Michael J Keating and Zeev Estrov
    Citation: Molecular Cancer 2013 12:50
    Content type: Short communication Published on:

  49. Deficiency in tuberin results in activation the mTOR pathway and leads to accumulation of cell matrix proteins. The mechanisms by which tuberin regulates fibrosis in kidney angiomyolipomas (AMLs) of tuberous s...

    Authors: Sitai Liang, Gabriela Cuevas, Shaza Tizani, Tiffanie Salas, Huijuan Liu, Baojie Li and Samy L Habib
    Citation: Molecular Cancer 2013 12:49
    Content type: Research Published on:

  50. Dysregulation of the PI3Kinase/AKT pathway is involved in the pathogenesis of many human malignancies. In acute leukemia, the AKT pathway is frequently activated, however mutations in the PI3K/AKT pathway are ...

    Authors: Kerstin Maria Kampa-Schittenhelm, Michael Charles Heinrich, Figen Akmut, Katharina Henriette Rasp, Barbara Illing, Hartmut Döhner, Konstanze Döhner and Marcus Matthias Schittenhelm
    Citation: Molecular Cancer 2013 12:46
    Content type: Research Published on:
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Molecular Cancer

ISSN: 1476-4598