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  1. Content type: Research

    Non-coding RNAs (ncRNAs) have been shown to regulate gene expression involved in tumor progression of multiple malignancies. Our previous studies indicated that large tumor suppressor kinase 1 (LATS1), a core ...

    Authors: Jing Zhang, Hui Liu, Lidan Hou, Ge Wang, Rui Zhang, Yanxia Huang, Xiaoyu Chen and Jinshui Zhu

    Citation: Molecular Cancer 2017 16:151

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  2. Content type: Research

    Abnormal expression of numerous long non-coding RNAs (lncRNAs) has been reported in esophageal squamous cell carcinoma (ESCC) recently, but the great majority of their roles and mechanisms remain largely uncle...

    Authors: Yuanyuan Wu, Liwen Hu, Yan Liang, Juan Li, Kai Wang, Xuedan Chen, Hui Meng, Xingying Guan, Kang Yang and Yun Bai

    Citation: Molecular Cancer 2017 16:150

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  3. Content type: Research

    The Ghrelin-system is a complex, pleiotropic family composed of several peptides, including native-ghrelin and its In1-ghrelin splicing variant, and receptors (GHSR 1a/b), which are dysregulated in various end...

    Authors: Daniel Hormaechea-Agulla, Manuel D. Gahete, Juan M. Jiménez-Vacas, Enrique Gómez-Gómez, Alejandro Ibáñez-Costa, Fernando L-López, Esther Rivero-Cortés, André Sarmento-Cabral, José Valero-Rosa, Julia Carrasco-Valiente, Rafael Sánchez-Sánchez, Rosa Ortega-Salas, María M. Moreno, Natia Tsomaia, Steve M. Swanson, Michael D. Culler…

    Citation: Molecular Cancer 2017 16:146

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  4. Content type: Review

    Exosomes are emerging as a new type of cancer biomarkers. Exosome is a bilayered nano-sized vesicle secreted by various living cells in all body fluids. Based on the expanding albeit incomplete knowledge of th...

    Authors: Weihua Li, Chuanyun Li, Tong Zhou, Xiuhong Liu, Xiaoni Liu, Xiuhui Li and Dexi Chen

    Citation: Molecular Cancer 2017 16:145

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  5. Content type: Review

    The present review aimed to assess the role of exosomal miRNAs in cancer-associated fibroblasts (CAFs), normal fibroblasts (NFs), and cancer cells. The roles of exosomal miRNAs and miRNA dysregulation in CAF f...

    Authors: Fengming Yang, Zhiqiang Ning, Ling Ma, Weitao Liu, Chuchu Shao, Yongqian Shu and Hua Shen

    Citation: Molecular Cancer 2017 16:148

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  6. Content type: Research

    Phospholipid phosphatase 4 (PPAPDC1A or PLPP4) has been demonstrated to be involved in the malignant process of many cancers. The purpose of this study was to investigate the clinical significance and biologic...

    Authors: Xin Zhang, Lan Zhang, Bihua Lin, Xingxing Chai, Ronggang Li, Yuehua Liao, Xinghui Deng, Qiongru Liu, Wenli Yang, Yubo Cai, Wei Zhou, Zhichao Lin, Wenhai Huang, Meigong Zhong, Fangyong Lei, Jinhua Wu…

    Citation: Molecular Cancer 2017 16:147

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  7. Content type: Erratum

    Authors: Wei Lu, Honghe Zhang, Yuequn Niu, Yongfeng Wu, Wenjie Sun, Hongyi Li, Jianlu Kong, Kefeng Ding, Han-Ming Shen, Han Wu, Dajing Xia and Yihua Wu

    Citation: Molecular Cancer 2017 16:144

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    The original article was published in Molecular Cancer 2017 16:118

  8. Content type: Research

    To overcome the hostile hypoxic microenvironment of solid tumors, tumor cells secrete a large number of non-coding RNA-containing exosomes that facilitate tumor development and metastasis. However, the precise...

    Authors: Mei Xue, Wei Chen, An Xiang, Ruiqi Wang, He Chen, Jingjing Pan, Huan Pang, Hongli An, Xiang Wang, Huilian Hou and Xu Li

    Citation: Molecular Cancer 2017 16:143

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  9. Content type: Research

    Emerging studies show that long noncoding RNAs (lncRNAs) play important roles in carcinogenesis and cancer progression. The lncRNA ZEB1 antisense 1 (ZEB1-AS1) derives from the promoter region of ZEB1 and we st...

    Authors: Wenjing Su, Miao Xu, Xueqin Chen, Ni Chen, Jing Gong, Ling Nie, Ling Li, Xinglan Li, Mengni Zhang and Qiao Zhou

    Citation: Molecular Cancer 2017 16:142

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  10. Content type: Research

    Aberrant expression of microRNAs in different human cancer types has been widely reported. MiR-218 acts as a tumor suppressor in diverse human cancer types impacting regulation of multiple genes in oncogenic p...

    Authors: Yan Yang, Lili Ding, Qun Hu, Jia Xia, Junjie Sun, Xudong Wang, Hua Xiong, Deepak Gurbani, Lianbo Li, Yan Liu and Aiguo Liu

    Citation: Molecular Cancer 2017 16:141

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  11. Content type: Research

    Glioma stem cells (GSCs) are a major cause of the frequent relapse observed in glioma, due to their high drug resistance and their differentiation potential. Therefore, understanding the molecular mechanisms g...

    Authors: Soo-Jung Kwon, Ok-Seon Kwon, Keun-Tae Kim, Young-Hyun Go, Si-in Yu, Byeong-ha Lee, Hiroyuki Miyoshi, Eunsel Oh, Seung-Ju Cho and Hyuk-Jin Cha

    Citation: Molecular Cancer 2017 16:140

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  12. Content type: Research

    The aberrant expression of microRNA-140-5p (miR-140-5p) has been described in gastric cancer (GC). However, the role of miR-140-5p in GC remains unclear. In this study, the prognostic relevance of miR-140-5p i...

    Authors: Zheng Fang, Shuai Yin, Ruochuan Sun, Shangxin Zhang, Min Fu, Youliang Wu, Tao Zhang, Junaid Khaliq and Yongxiang Li

    Citation: Molecular Cancer 2017 16:139

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  13. Content type: Review

    Expression of high levels of immune cells including neutrophils has been associated with detrimental outcome in several solid tumors and new strategies to decrease their presence and activity are currently und...

    Authors: Alberto Ocana, Cristina Nieto-Jiménez, Atanasio Pandiella and Arnoud J Templeton

    Citation: Molecular Cancer 2017 16:137

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  14. Content type: Research

    Several of the thousands of human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in hepatocellular carcinoma (HCC) remains poorly understood.

    Authors: Hui Wang, Xisong Huo, Xin-Rong Yang, Jia He, Lijun Cheng, Na Wang, Xuan Deng, Haojie Jin, Ning Wang, Cun Wang, Fangyu Zhao, Jingyuan Fang, Ming Yao, Jia Fan and Wenxin Qin

    Citation: Molecular Cancer 2017 16:136

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  15. Content type: Research

    RAB GTPases are important in the regulation of membrane trafficking and cell movement. Recently, exocytic RABs have received increasing attention in cancer research. However, the functional roles of exocytic R...

    Authors: Yu-Chan Chang, Chia-Yi Su, Ming-Huang Chen, Wei-Shone Chen, Chi-Long Chen and Michael Hsiao

    Citation: Molecular Cancer 2017 16:135

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  16. Content type: Review

    RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention. In the development of RNAi-based therapies, nanoparticle...

    Authors: Yong Xin, Min Huang, Wen Wen Guo, Qian Huang, Long zhen Zhang and Guan Jiang

    Citation: Molecular Cancer 2017 16:134

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  17. Content type: Research

    Protein-tyrosine phosphatase MEG2 (MEG2) is a classic tyrosine-specific protein tyrosine phosphatase (PTP). It has been reported that MEG2 participates in the carcinogenesis of the breast and liver. However, f...

    Authors: Zhijian Liu, Feng Sun, Yeting Hong, Yanqing Liu, Min Fen, Kai Yin, Xiaolong Ge, Feng Wang, Xi Chen and Wenxian Guan

    Citation: Molecular Cancer 2017 16:133

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  18. Content type: Research

    Although gemcitabine-based chemotherapy has been established as a core multimodal therapy for non-small cell lung cancer (NSCLC) treatment, its clinical efficacy remains limited by the development of acquired ...

    Authors: Feng Wei, Chengyuan Ma, Tong Zhou, Xuechao Dong, Qinghua Luo, Li Geng, Lijuan Ding, Yandong Zhang, Li Zhang, Nan Li, Yang Li and Yan Liu

    Citation: Molecular Cancer 2017 16:132

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  19. Content type: Research

    Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated mortality worldwide with an overall five-year survival rate less than 7%. Accumulating evidence has revealed the cancer ...

    Authors: Ke Chen, Weikun Qian, Zhengdong Jiang, Liang Cheng, Jie Li, Liankang Sun, Cancan Zhou, Luping Gao, Meng Lei, Bin Yan, Junyu Cao, Wanxing Duan and Qingyong Ma

    Citation: Molecular Cancer 2017 16:131

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  20. Content type: Review

    Long-noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides and do not code for proteins. However, this class of RNAs plays pivotal regulatory roles. The mechanism of their ac...

    Authors: Chunmei Fan, Yanyan Tang, Jinpeng Wang, Fang Xiong, Can Guo, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Fang Wei, Liting Yang, Yi He, Ming Zhou, Xiaoling Li, Guiyuan Li, Wei Xiong and Zhaoyang Zeng

    Citation: Molecular Cancer 2017 16:130

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  21. Content type: Research

    Despite accumulating evidence that long noncoding RNAs (lncRNAs) are associated with cancer development in multiple types of cancer, the biological roles of many lncRNAs in human hepatocellular carcinoma (HCC)...

    Authors: Shan Lu, Jiansheng Zhou, Yimin Sun, Nan Li, Mingyong Miao, Binghua Jiao and Huan Chen

    Citation: Molecular Cancer 2017 16:125

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  22. Content type: Research

    Long non-coding RNAs (lncRNAs) play a variety of cellular roles, including regulation of transcription and translation, leading to alterations in gene expression. Some lncRNAs modulate the expression of chromo...

    Authors: Thilini R. Fernando, Jorge R. Contreras, Matteo Zampini, Norma I. Rodriguez-Malave, Michael O. Alberti, Jaime Anguiano, Tiffany M. Tran, Jayanth K. Palanichamy, Jasmine Gajeton, Nolan M. Ung, Cody J. Aros, Ella V. Waters, David Casero, Giuseppe Basso, Martina Pigazzi and Dinesh S. Rao

    Citation: Molecular Cancer 2017 16:126

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  23. Content type: Review

    The WW domain is composed of 38 to 40 semi-conserved amino acids shared with structural, regulatory, and signaling proteins. WW domain-binding protein 2 (WBP2), as a binding partner of WW domain protein, inter...

    Authors: Shuai Chen, Han Wang, Yu-Fan Huang, Ming-Li Li, Jiang-Hong Cheng, Peng Hu, Chuan-Hui Lu, Ya Zhang, Na Liu, Chi-Meng Tzeng and Zhi-Ming Zhang

    Citation: Molecular Cancer 2017 16:128

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  24. Content type: Research

    Epidermal growth factor receptor (EGFR), a well-known oncogenic driver, contributes to the initiation and progression of a wide range of cancer types. Aberrant lipid metabolism including highly produced monoun...

    Authors: Jiqin Zhang, Fei Song, Xiaojing Zhao, Hua Jiang, Xiuqi Wu, Biao Wang, Min Zhou, Mi Tian, Bizhi Shi, Huamao Wang, Yuanhui Jia, Hai Wang, Xiaorong Pan and Zonghai Li

    Citation: Molecular Cancer 2017 16:127

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  25. Content type: Research

    The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study FOXP3 expression and regulation, function and clinical implication in human non-small cell lung cancer (NSCLC).

    Authors: Shucai Yang, Yi Liu, Ming-Yue Li, Calvin S. H. Ng, Sheng-li Yang, Shanshan Wang, Chang Zou, Yujuan Dong, Jing Du, Xiang Long, Li-Zhong Liu, Innes Y. P. Wan, Tony Mok, Malcolm J. Underwood and George G. Chen

    Citation: Molecular Cancer 2017 16:124

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  26. Content type: Research

    Aberrant microRNA expression has been implicated in metastasis of cancers. MiR-661 accelerates proliferation and invasion of breast cancer and ovarian cancer, while impedes that of glioma. Its role in non smal...

    Authors: Feiye Liu, Yanjun Cai, Xiaoxiang Rong, Jinzhang Chen, Dayong Zheng, Lu Chen, Junyi Zhang, Rongcheng Luo, Peng Zhao and Jian Ruan

    Citation: Molecular Cancer 2017 16:122

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  27. Content type: Research

    Recently, it has been reported that long non-coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2), a novel tumor suppressor, participates in regulating the carcinogenesis and suppresses tumor progress...

    Authors: Yufeng Wang, Zhikui Liu, Bowen Yao, Qing Li, Liang Wang, Cong Wang, Changwei Dou, Meng Xu, Qingguang Liu and Kangsheng Tu

    Citation: Molecular Cancer 2017 16:123

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  28. Content type: Research

    Pancreatic cancer is a devastating disease that is characterized by persistent hypoxia. The roles of hypoxia-inducible factor-2α (hif-2α) are different to those of hif-1α, although both are critical for tumor ...

    Authors: Qi Zhang, Yu Lou, Jingying Zhang, Qihan Fu, Tao Wei, Xu Sun, Qi Chen, Jiaqi Yang, Xueli Bai and Tingbo Liang

    Citation: Molecular Cancer 2017 16:119

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  29. Content type: Research

    Clonal competition in cancer describes the process in which the progeny of a cell clone supersedes or succumbs to other competing clones due to differences in their functional characteristics, mostly based on ...

    Authors: Kerstin Cornils, Lars Thielecke, Doreen Winkelmann, Tim Aranyossy, Mathias Lesche, Andreas Dahl, Ingo Roeder, Boris Fehse and Ingmar Glauche

    Citation: Molecular Cancer 2017 16:120

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  30. Content type: Research

    The function of a new long non-coding RNA linc00673 remains unclear. While identified as an oncogenic player in non-small cell lung cancer (NSCLC), linc00673 was found to be anti-oncogenic in pancreatic ductal...

    Authors: Wei Lu, Honghe Zhang, Yuequn Niu, Yongfeng Wu, Wenjie Sun, Hongyi Li, Jianlu Kong, Kefeng Ding, Han-Ming Shen, Han Wu, Dajing Xia and Yihua Wu

    Citation: Molecular Cancer 2017 16:118

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    The Erratum to this article has been published in Molecular Cancer 2017 16:144

  31. Content type: Research

    The primary issue arising from prostate cancer (PCa) is its high prevalence to metastasize to bone, which severely affects the quality of life and survival time of PCa patients. miR-210-3p is a well-documented...

    Authors: Dong Ren, Qing Yang, Yuhu Dai, Wei Guo, Hong Du, Libing Song and Xinsheng Peng

    Citation: Molecular Cancer 2017 16:117

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  32. Content type: Research

    Colorectal cancer (CRC) cell lines are widely used pre-clinical model systems. Comprehensive insights into their molecular characteristics may improve model selection for biomedical studies.

    Authors: Kaja C. G. Berg, Peter W. Eide, Ina A. Eilertsen, Bjarne Johannessen, Jarle Bruun, Stine A. Danielsen, Merete Bjørnslett, Leonardo A. Meza-Zepeda, Mette Eknæs, Guro E. Lind, Ola Myklebost, Rolf I. Skotheim, Anita Sveen and Ragnhild A. Lothe

    Citation: Molecular Cancer 2017 16:116

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  33. Content type: Letter to the Editor

    Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with constitutive activation of the MAPKinase RAS-RAF-MEK-ERK cell signaling pathway. We analyzed 9 LCH cases without BRAF ...

    Authors: Sébastien Héritier, Zofia Hélias-Rodzewicz, Rikhia Chakraborty, Amel G. Sengal, Christine Bellanné-Chantelot, Caroline Thomas, Anne Moreau, Sylvie Fraitag, Carl E. Allen, Jean Donadieu and Jean-François Emile

    Citation: Molecular Cancer 2017 16:115

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  34. Content type: Review

    Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is associated with higher dis...

    Authors: Vid Mlakar, Simona Jurkovic Mlakar, Gonzalo Lopez, John M. Maris, Marc Ansari and Fabienne Gumy-Pause

    Citation: Molecular Cancer 2017 16:114

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  35. Content type: Letter to the Editor

    Several studies show that human papillomavirus (HPV) positive head and neck cancers (HNSCC) are typically characterized by low tumor and high regional node stages, intrinsically indicating high local metastati...

    Authors: Rüveyda Dok, Mary Glorieux, Karolina Holacka, Marieke Bamps and Sandra Nuyts

    Citation: Molecular Cancer 2017 16:113

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  36. Content type: Research

    Recent evidences showed that long noncoding RNAs (lncRNAs) are frequently dysregulated and play important roles in various cancers. Clear cell renal cell carcinoma (ccRCC) is one of the leading cause of cancer...

    Authors: Jia-Kuan Li, Cheng Chen, Jia-Yi Liu, Jia-Zi Shi, Shu-Peng Liu, Bing Liu, Deng-Shuang Wu, Zi-Yu Fang, Yi Bao, Ming-Ming Jiang, Ji-Hang Yuan, Le Qu and Lin-Hui Wang

    Citation: Molecular Cancer 2017 16:111

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  37. Content type: Letter to the Editor

    BRAF inhibitors (BRAFi) are standard of care for the treatment of BRAF V600 mutation-driven metastatic melanoma, but can lead to paradoxical activation of the mitogen-activated protein kinase (MAPK) signalling pa...

    Authors: Candani S. A. Tutuka, Miles C. Andrews, John M. Mariadason, Paul Ioannidis, Christopher Hudson, Jonathan Cebon and Andreas Behren

    Citation: Molecular Cancer 2017 16:112

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  38. Content type: Research

    BC200 is a long non-coding RNA expressed at high levels in the brain and elevated in a variety of tumour types. BC200 has a hypothesized role in translational regulation; however, to date the functional role o...

    Authors: Evan P. Booy, Ewan KS McRae, Amit Koul, Francis Lin and Sean A. McKenna

    Citation: Molecular Cancer 2017 16:109

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  39. Content type: Research

    Protein regulator of cytokinesis-1 (PRC1) belongs to the microtubule-associated proteins (MAPs) family, and is involved in cytokinesis. Recent investigations suggest PRC1 involvement in human carcinogenesis, i...

    Authors: Ping Zhan, Bin Zhang, Guang-min Xi, Ying Wu, Hong-bing Liu, Ya-fang Liu, Wu-jian Xu, Qing-qing Zhu, Feng Cai, Ze-jun Zhou, Ying-ying Miu, Xiao-xia Wang, Jia-jia Jin, Qian Li, Li-ping Qian, Tang-feng Lv…

    Citation: Molecular Cancer 2017 16:108

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  40. Content type: Review

    Cancers of the female reproductive system include ovarian, uterine, vaginal, cervical and vulvar cancers, which are termed gynecologic cancer. The emergence of long noncoding RNAs (lncRNAs), which are believed...

    Authors: Elahe Seyed Hosseini, Matthieu Meryet-Figuiere, Hamed Sabzalipoor, Hamed Haddad Kashani, Hossein Nikzad and Zatollah Asemi

    Citation: Molecular Cancer 2017 16:107

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  41. Content type: Research

    The plasticity of cancer stem cells (CSCs)/tumor-initiating cells (T-ICs) suggests that multiple CSC/T-IC subpopulations exist within a tumor and that multiple oncogenic pathways collaborate to maintain the CS...

    Authors: Aibin Liu, Jinrong Zhu, Geyan Wu, Lixue Cao, Zhanyao Tan, Shuxia Zhang, Lili Jiang, Jueheng Wu, Mengfeng Li, Libing Song and Jun Li

    Citation: Molecular Cancer 2017 16:106

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  42. Content type: Research

    Hypoxia is a characteristic of breast tumours indicating poor prognosis. Based on the assumption that those genes which are up-regulated under hypoxia in cell-lines are expected to be predictors of poor progno...

    Authors: Basel Abu-Jamous, Francesca M. Buffa, Adrian L. Harris and Asoke K. Nandi

    Citation: Molecular Cancer 2017 16:105

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  43. Content type: Research

    Oct4, a key stemness transcription factor, is overexpressed in lung cancer. Here, we reveal a novel transcription regulation of long non-coding RNAs (lncRNAs) by Oct4. LncRNAs have emerged as important players...

    Authors: Jayu Jen, Yen-An Tang, Ying-Hung Lu, Che-Chung Lin, Wu-Wei Lai and Yi-Ching Wang

    Citation: Molecular Cancer 2017 16:104

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