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  1. Cisplatin (CDDP) treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). A better understanding of the mechanisms of CDDP resistance can greatly improve ther...

    Authors: Xiaoxu Huang, Zheng Li, Qiang Zhang, Weizhi Wang, Bowen Li, Lu Wang, Zhipeng Xu, Ailiang Zeng, Xing Zhang, Xuan Zhang, Zhongyuan He, Qiang Li, Guangli Sun, Sen Wang, Qing Li, Linjun Wang…

    Citation: Molecular Cancer 2019 18:71

    Content type: Research

    Published on:

  2. Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endotheli...

    Authors: Jana Plava, Marina Cihova, Monika Burikova, Miroslava Matuskova, Lucia Kucerova and Svetlana Miklikova

    Citation: Molecular Cancer 2019 18:67

    Content type: Review

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  3. Tumor-associated macrophages (TAMs) are major components of tumor microenvironment that frequently associated with tumor metastasis in human cancers. Circulating tumor cell (CTC), originating from primary tumo...

    Authors: Chen Wei, Chaogang Yang, Shuyi Wang, Dongdong Shi, Chunxiao Zhang, Xiaobin Lin, Qing Liu, Rongzhang Dou and Bin Xiong

    Citation: Molecular Cancer 2019 18:64

    Content type: Research

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  4. The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. T...

    Authors: Barbora Peltanova, Martina Raudenska and Michal Masarik

    Citation: Molecular Cancer 2019 18:63

    Content type: Review

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  5. Gastric cancer (GC) is one of the leading causes of cancer-related death in both men and women due to delayed diagnosis and high metastatic frequency. Extracellular vesicles (EVs) are membrane-bound nanovesicl...

    Authors: Tingting Huang, Chunli Song, Lei Zheng, Ligang Xia, Yang Li and Yiwen Zhou

    Citation: Molecular Cancer 2019 18:62

    Content type: Review

    Published on:

  6. Therapy resistance can arise within tumor cells because of genetic or phenotypic changes (intrinsic resistance), or it can be the result of an interaction with the tumor microenvironment (extrinsic resistance)...

    Authors: Teresa Bernadette Steinbichler, József Dudás, Sergej Skvortsov, Ute Ganswindt, Herbert Riechelmann and Ira-Ida Skvortsova

    Citation: Molecular Cancer 2019 18:58

    Content type: Review

    Published on:

  7. CircRNAs, as new members of long noncoding RNAs, have been the focus of recent investigation. CircRNAs feature a closed continuous loop structure without 5′-3′ polarity or a poly A tail. Many studies have repo...

    Authors: Hetian Bai, Kexin Lei, Fei Huang, Zhou Jiang and Xikun Zhou

    Citation: Molecular Cancer 2019 18:56

    Content type: Review

    Published on:

  8. The tumor microenvironment is a complex and dynamic cellular community comprising the tumor epithelium and various tumor-supporting cells such as immune cells, fibroblasts, immunosuppressive cells, adipose cel...

    Authors: Hong Sheng Cheng, Jeannie Xue Ting Lee, Walter Wahli and Nguan Soon Tan

    Citation: Molecular Cancer 2019 18:51

    Content type: Review

    Published on:

  9. Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) ...

    Authors: Xiaojie Bian, Yu-Tian Xiao, Tianqi Wu, Mengfei Yao, Leilei Du, Shancheng Ren and Jianhua Wang

    Citation: Molecular Cancer 2019 18:50

    Content type: Review

    Published on:

  10. It has been well established that circular RNAs (circRNAs) play an important regulatory role during tumor progression. Recent studies have indicated that even though circRNAs generally regulate gene expression...

    Authors: Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu and Jingting Jiang

    Citation: Molecular Cancer 2019 18:47

    Content type: Research

    Published on:

  11. N6-methyladenosine (m6A) modification is the most pervasive modification in mRNA, and has been considered as a new layer of epigenetic regulation on mRNA processing, stability and translation. Despite its func...

    Authors: Yi Niu, Ziyou Lin, Arabella Wan, Honglei Chen, Heng Liang, Lei Sun, Yuan Wang, Xi Li, Xiao-feng Xiong, Bo Wei, Xiaobin Wu and Guohui Wan

    Citation: Molecular Cancer 2019 18:46

    Content type: Research

    Published on:

  12. Circular RNAs (circRNAs) are a novel type of noncoding RNAs and play important roles in tumorigenesis, including gastric cancer (GC). However, the functions of most circRNAs remain poorly understood. In our st...

    Authors: Lixian Ding, Yuying Zhao, Shuwei Dang, Yue Wang, Xinglong Li, Xiaotong Yu, Zhongsheng Li, Jiufeng Wei, Ming Liu and Guodong Li

    Citation: Molecular Cancer 2019 18:45

    Content type: Research

    Published on:

  13. Circular RNAs are abundant endogenous non-coding RNA with no 5′ cap and 3′ polyadenylation tail that modify liner mRNAs and have no terminal structures. Our knowledge of the biogenesis of circular RNAs has bee...

    Authors: Yang Guo, Jiechao Yang, Qiang Huang, Chiyao Hsueh, Juan Zheng, Chunping Wu, Hui Chen and Liang Zhou

    Citation: Molecular Cancer 2019 18:44

    Content type: Review

    Published on:

  14. Oxaliplatin resistance is a major challenge for treatment of advanced colorectal cancer (CRC). Both acquisition of epithelial-mesenchymal transition (EMT) and suppressed drug accumulation in cancer cells contr...

    Authors: Tong Liu, Xin Zhang, Lutao Du, Yunshan Wang, Xiaoming Liu, Hui Tian, Lili Wang, Peilong Li, Yinghui Zhao, Weili Duan, Yujiao Xie, Zhaowei Sun and Chuanxin Wang

    Citation: Molecular Cancer 2019 18:43

    Content type: Research

    Published on:

  15. Triple-negative breast cancer (TNBC) is a poor prognostic breast cancer with the highest mutations and limited therapeutic choices. Cytokine networking between cancer cells and the tumor microenvironment (TME)...

    Authors: Yueh-Shan Weng, Hong-Yu Tseng, Yen-An Chen, Pei-Chun Shen, Aushia Tanzih Al Haq, Li-Mei Chen, Yi-Chung Tung and Hsin-Ling Hsu

    Citation: Molecular Cancer 2019 18:42

    Content type: Research

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  16. Exosomes are nanosized extracellular vesicles that can be released by almost all types of cells. Initially considered as the garbage bins acting to discard unwanted products of cells, exosomes are now recogniz...

    Authors: Min Fu, Jianmei Gu, Pengcheng Jiang, Hui Qian, Wenrong Xu and Xu Zhang

    Citation: Molecular Cancer 2019 18:41

    Content type: Review

    Published on:

  17. Metastasis is the main cause of lung cancer mortality. Bone marrow-derived mesenchymal stem cells (BMSCs) are a component of the cancer microenvironment and contribute to cancer progression. Intratumoral hypox...

    Authors: Xina Zhang, Buqing Sai, Fan Wang, Lujuan Wang, Yuhui Wang, Leliang Zheng, Guiyuan Li, Jingqun Tang and Juanjuan Xiang

    Citation: Molecular Cancer 2019 18:40

    Content type: Research

    Published on:

  18. A pre-metastatic niche is a microenvironment prepared for the colonization of circulating tumor cells in specific organs. Exosomes are extracellular vesicles with a variety of biological functions. Exosomes pl...

    Authors: Yaxin Guo, Xiang Ji, Jinbo Liu, Dandan Fan, Quanbo Zhou, Chen Chen, Weiwei Wang, Guixian Wang, Haijiang Wang, Weitang Yuan, Zhenyu Ji and Zhenqiang Sun

    Citation: Molecular Cancer 2019 18:39

    Content type: Review

    Published on:

  19. Long intergenic noncoding RNA p21 (lincRNA-p21) is considered a target of wild-type p53, but little is known about its regulation by mutant p53 and its functions during the progression of head and neck squamou...

    Authors: Shufang Jin, Xi Yang, Jiayi Li, Wenyi Yang, Hailong Ma and Zhiyuan Zhang

    Citation: Molecular Cancer 2019 18:38

    Content type: Research

    Published on:

  20. Extracellular vesicles (EVs) membranes enclose nanosized vesicles with a size range of 30–150 nm and are plentiful in our body in both physiological and pathological conditions. Exosomes, a type of EV, are imp...

    Authors: Yan Xie, Wei Dang, Siwei Zhang, Wenxing Yue, Li Yang, Xingyu Zhai, Qijia Yan and Jianhong Lu

    Citation: Molecular Cancer 2019 18:37

    Content type: Review

    Published on:

  21. Peripheral circulating free DNA (cfDNA) is DNA that is detected in plasma or serum fluid with a cell-free status. For cancer patients, cfDNA not only originates from apoptotic cells but also from necrotic tumo...

    Authors: Lei Zhang, Yiyi Liang, Shifu Li, Fanyuan Zeng, Yongan Meng, Ziwei Chen, Shuang Liu, Yongguang Tao and Fenglei Yu

    Citation: Molecular Cancer 2019 18:36

    Content type: Review

    Published on:

  22. Circular RNA (circRNA) is a group of RNA families generated by RNA circularization, which was discovered ubiquitously across different cancers. However, the internal structure of circRNA is difficult to determ...

    Authors: Jing Feng, Ke Chen, Xin Dong, Xiaolong Xu, Yuxuan Jin, Xinyang Zhang, Wenbo Chen, Yujing Han, Lin Shao, Yang Gao and Chunjiang He

    Citation: Molecular Cancer 2019 18:35

    Content type: Letter to Editor

    Published on:

  23. In lung cancer, antiangiogenic strategies targeting tumor-derived endothelial cells (TECs) afford a survival advantage, but the characteristics of TECs have not been comprehensively elucidated. Herein, high-pu...

    Authors: Huiqin Zhuo, Yan Zhao, Xiao Cheng, Mao Xu, Lin Wang, Lingyun Lin, Zhi Lyu, Xuehui Hong and Jianchun Cai

    Citation: Molecular Cancer 2019 18:34

    Content type: Letter to the Editor

    Published on:

  24. The long non-coding RNA PVT1 (lncRNA PVT1) has been reported to act as an oncogenic regulator of several cancers. However, its expression and function in gallbladder cancer (GBC) remain largely unknown.

    Authors: Jianan Chen, Yan Yu, Hua Li, Qiuyue Hu, Xiaolong Chen, Yuting He, Chen Xue, Fang Ren, Zhigang Ren, Juan Li, Liwen Liu, Zhenfeng Duan, Guangying Cui and Ranran Sun

    Citation: Molecular Cancer 2019 18:33

    Content type: Research

    Published on:

  25. Long noncoding RNAs (lncRNAs) have been indicated to play critical roles in cancer development and progression. LncRNA HOXD cluster antisense RNA1 (HOXD-AS1) has recently been found to be dysregulated in sever...

    Authors: Min-Hui Yang, Li Zhao, Lan Wang, Wen Ou-Yang, Sha-Sha Hu, Wen-Lu Li, Mei-Ling Ai, Yi-Qing Wang, Yue Han, Ting-Ting Li, Yan-Qing Ding and Shuang Wang

    Citation: Molecular Cancer 2019 18:31

    Content type: Research

    Published on:

  26. Ectopic Viral Integration site 1 (EVI1) upregulation is implicated in 10–25% of pediatric acute myeloid leukemia (AML) and has an inferior outcome with current chemotherapy regimens. Here we report that EVI1 u...

    Authors: Nupur Mittal, Liping Li, Yue Sheng, Chao Hu, Fuxing Li, Tongyu Zhu, Xiaohong Qiao and Zhijian Qian

    Citation: Molecular Cancer 2019 18:30

    Content type: Letter to the Editor

    Published on:

  27. The immune system plays important roles in tumor development. According to the immune-editing theory, immune escape is the key to tumor survival, and exploring the mechanisms of tumor immune escape can provide...

    Authors: Shixin Duan, Weihua Guo, Zuxing Xu, Yunbo He, Chuting Liang, Yongzhen Mo, Yian Wang, Fang Xiong, Can Guo, Yong Li, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong and Fuyan Wang

    Citation: Molecular Cancer 2019 18:29

    Content type: Review

    Published on:

  28. Hepatocellular carcinoma (HCC) is the most common malignant liver tumor with poor clinical outcomes. Increasing amount of long non-coding RNAs (lncRNAs) have been revealed to be implicated in the carcinogenesi...

    Authors: Yufeng Wang, Liu Yang, Tianxiang Chen, Xin Liu, Yang Guo, Qiaojuan Zhu, Xiangmin Tong, Wei Yang, Qiuran Xu, Dongsheng Huang and Kangsheng Tu

    Citation: Molecular Cancer 2019 18:28

    Content type: Research

    Published on:

  29. Circular RNA (circRNA) represents a broad and diverse endogenous RNAs that can regulate gene expression in cancer. However, the regulation and function of bladder cancer (BC) circRNAs remain largely unknown.

    Authors: Hongwei Su, Tao Tao, Zhao Yang, Xing Kang, Xu Zhang, Danyue Kang, Song Wu and Chong Li

    Citation: Molecular Cancer 2019 18:27

    Content type: Research

    Published on:

  30. Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one of the most important intracellular pathways, which can be considered as a master regulator for cancer. Enormous e...

    Authors: Jing Yang, Ji Nie, Xuelei Ma, Yuquan Wei, Yong Peng and Xiawei Wei

    Citation: Molecular Cancer 2019 18:26

    Content type: Review

    Published on:

  31. Circular RNAs (circRNAs) are a class of non-coding RNAs with a loop structure, but its functions remain largely unknown. Growing evidence has revealed that circRNAs play a striking role as functional RNAs in t...

    Authors: Dawei Rong, Chen Lu, Betty Zhang, Kai Fu, Shuli Zhao, Weiwei Tang and Hongyong Cao

    Citation: Molecular Cancer 2019 18:25

    Content type: Research

    Published on:

  32. Axl receptor tyrosine kinase is involved in the growth and metastasis and is an indicator of poor prognosis in several cancers including lung cancers. Although a mitogen-activated protein kinase (MAPK) pathway...

    Authors: Yoko Tsukita, Naoya Fujino, Eisaku Miyauchi, Ryoko Saito, Fumiyoshi Fujishima, Koji Itakura, Yorihiko Kyogoku, Koji Okutomo, Mitsuhiro Yamada, Tatsuma Okazaki, Hisatoshi Sugiura, Akira Inoue, Yoshinori Okada and Masakazu Ichinose

    Citation: Molecular Cancer 2019 18:24

    Content type: Letter to the Editor

    Published on:

  33. Increasing studies has found that circular RNAs (circRNAs) play vital roles in cancer progression. But the expression profile and function of circRNAs in triple-negative breast cancer (TNBC) are unclear.

    Authors: Hailin Tang, Xiaojia Huang, Jin Wang, Lu Yang, Yanan Kong, Guanfeng Gao, Lijuan Zhang, Zhe-Sheng Chen and Xiaoming Xie

    Citation: Molecular Cancer 2019 18:23

    Content type: Research

    Published on:

  34. Though esophageal cancer is three to four times more common among males than females worldwide, this type of cancer still ranks in the top incidence among women, even more than the female specific cancer types...

    Authors: Wei Li, Liyuan Zhang, Binbin Guo, Jieqiong Deng, Siqi Wu, Fang Li, Yirong Wang, Jiachun Lu and Yifeng Zhou

    Citation: Molecular Cancer 2019 18:22

    Content type: Research

    Published on:

  35. CircRNA has emerged as a new non-coding RNA that plays crucial roles in tumour initiation and development. ‘MiRNA sponge’ is the most reported role played by circRNAs in many tumours. The AKT/mTOR axis is a cl...

    Authors: Xing Zhang, Sen Wang, Haixiao Wang, Jiacheng Cao, Xiaoxu Huang, Zheng Chen, Penghui Xu, Guangli Sun, Jianghao Xu, Jialun Lv and Zekuan Xu

    Citation: Molecular Cancer 2019 18:20

    Content type: Research

    Published on:

  36. The current histopathological risk-stratification criteria in colorectal cancer (CRC) patients following a curative surgery remain inadequate. In this study, we undertook a systematic, genomewide, biomarker di...

    Authors: Takatoshi Matsuyama, Toshiaki Ishikawa, Naoki Takahashi, Yasuhide Yamada, Masamichi Yasuno, Tatsuyuki Kawano, Hiroyuki Uetake and Ajay Goel

    Citation: Molecular Cancer 2019 18:19

    Content type: Letter to the Editor

    Published on:

  37. Lysyl oxidase-like 4 (LOXL4) has been found to be dysregulated in several human malignancies, including hepatocellular carcinoma (HCC). However, the role of LOXL4 in HCC progression remains largely unclear. In...

    Authors: Rongkun Li, Yahui Wang, Xiaoxin Zhang, Mingxuan Feng, Jun Ma, Jun Li, Xiaomei Yang, Fang Fang, Qiang Xia, Zhigang Zhang, Mingyi Shang and Shuheng Jiang

    Citation: Molecular Cancer 2019 18:18

    Content type: Research

    Published on:

  38. Autophagy is a genetically well-controlled cellular process that is tightly controlled by a set of core genes, including the family of autophagy-related genes (ATG). Autophagy is a “double-edged sword” in tumo...

    Authors: Guan-Min Jiang, Yuan Tan, Hao Wang, Liang Peng, Hong-Tao Chen, Xiao-Jun Meng, Ling-Ling Li, Yan Liu, Wen-Fang Li and Hong Shan

    Citation: Molecular Cancer 2019 18:17

    Content type: Review

    Published on:

  39. Esophageal squamous cell cancer (ESCC) is a high incidence and mortality disease worldwide. However, specificity and sensitivity of its diagnostic and prognostic biomarkers are still unsatisfactory. Recently, ...

    Authors: Liyuan Fan, Qiang Cao, Jia Liu, Junpeng Zhang and Baosheng Li

    Citation: Molecular Cancer 2019 18:16

    Content type: Letter to the Editor

    Published on:

    The Correction to this article has been published in Molecular Cancer 2019 18:121

  40. The long noncoding RNA (lncRNA) OTUD6B antisense RNA 1 (OTUD6B-AS1) is oriented in an antisense direction to the protein-coding gene OTUD6B on the opposite DNA strand. TCGA database data show that the expressi...

    Authors: Gang Wang, Zi-jian Zhang, Wen-gang Jian, Pan-hong Liu, Wei Xue, Teng-da Wang, Yu-yang Meng, Chao Yuan, Hao-ming Li, Yi-peng Yu, Zhan-xin Liu, Qiong Wu, Da-ming Zhang and Cheng Zhang

    Citation: Molecular Cancer 2019 18:15

    Content type: Research

    Published on:

  41. Circular RNAs are widely expressed in eukaryotic cells and associated with cancer. However, limited studies to date have focused on the potential role of circRNAs in progression of lung cancer. Data from the c...

    Authors: Lijian Chen, Aruo Nan, Nan Zhang, Yangyang Jia, Xin Li, Yihui Ling, Jiabin Dai, Shaozhu Zhang, Qiaoyuan Yang, Yanni Yi and Yiguo Jiang

    Citation: Molecular Cancer 2019 18:13

    Content type: Letter to the Editor

    Published on:

  42. MYCN amplification or N-Myc overexpression is found in approximately 40% NEPC and up to 20% CRPC patients. N-Myc has been demonstrated to drive disease progression and hormonal therapeutic resistance of NEPC/CRPC...

    Authors: Yu Yin, Lingfan Xu, Yan Chang, Tao Zeng, Xufeng Chen, Aifeng Wang, Jeff Groth, Wen-Chi Foo, Chaozhao Liang, Hailiang Hu and Jiaoti Huang

    Citation: Molecular Cancer 2019 18:11

    Content type: Research

    Published on:

    The Correction to this article has been published in Molecular Cancer 2019 18:107

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