Skip to main content

Articles

Page 62 of 65

  1. The Calcium-Sensing Receptor is a key component of Calcium/Parathyroid hormone homeostatic system that helps maintain appropriate plasma Ca2+ concentrations. It also has a number of non-homeostatic functions, inc...

    Authors: Richard Morgan, Benjamin Fairfax and Hardev S Pandha
    Citation: Molecular Cancer 2006 5:51
    Content type: Research Published on:

  2. The mucin MUC16 and the glycosylphosphatidylinositol anchored glycoprotein mesothelin likely facilitate the peritoneal metastasis of ovarian tumors. The biochemical basis and the kinetics of the binding betwee...

    Authors: Jennifer AA Gubbels, Jennifer Belisle, Masanori Onda, Claudine Rancourt, Martine Migneault, Mitchell Ho, Tapan K Bera, Joseph Connor, Bangalore K Sathyanarayana, Byungkook Lee, Ira Pastan and Manish S Patankar
    Citation: Molecular Cancer 2006 5:50
    Content type: Research Published on:

  3. Cervical cancer is the second most common gynecological cancer amongst women world-wide. Despite optimized protocols, standard treatments still face several disadvantages. Therefore, research aims at the devel...

    Authors: Nathalie Cools, Peter Ponsaerts, Marc Lenjou, Griet Nijs, Dirk R Van Bockstaele, Viggo FI Van Tendeloo and Zwi N Berneman
    Citation: Molecular Cancer 2006 5:49
    Content type: Research Published on:

  4. Barrett's esophagus, a risk factor for esophageal adenocarcinoma, is associated with reflux disease. The aim of this study was to assess the expression of bile acid receptors in the esophagus (normal, esophagi...

    Authors: Andrea De Gottardi, Jean-Marc Dumonceau, Fabien Bruttin, Alain Vonlaufen, Isabelle Morard, Laurent Spahr, Laura Rubbia-Brandt, Jean-Louis Frossard, Winand NM Dinjens, Peter S Rabinovitch and Antoine Hadengue
    Citation: Molecular Cancer 2006 5:48
    Content type: Research Published on:

  5. The tumor suppressor gene p53 (TP53) controls numerous signaling pathways and is frequently mutated in human cancers. Novel p53 isoforms suggest alternative splicing as a regulatory feature of p53 activity.

    Authors: Lars O Baumbusch, Simen Myhre, Anita Langerød, Anna Bergamaschi, Stephanie B Geisler, Per E Lønning, Wolfgang Deppert, Irene Dornreiter and Anne-Lise Børresen-Dale
    Citation: Molecular Cancer 2006 5:47
    Content type: Research Published on:

  6. The transmembrane protein c-kit is a receptor tyrosine kinase (KIT) and KIT is expressed in solid tumors and hematological malignancies such as gastrointestinal stromal tumor (GIST), small-cell lung cancer and ch...

    Authors: Akira Yasuda, Hirozumi Sawai, Hiroki Takahashi, Nobuo Ochi, Yoichi Matsuo, Hitoshi Funahashi, Mikinori Sato, Yuji Okada, Hiromitsu Takeyama and Tadao Manabe
    Citation: Molecular Cancer 2006 5:46
    Content type: Research Published on:

  7. Endometrial cancer is the fourth most prominent cancer among all feminine cancers in the Western world. Resveratrol, a natural anti-oxidant found in red wine emerging as a novel anticancer agent, exerts antipr...

    Authors: Émilie Sexton, Céline Van Themsche, Kim Leblanc, Sophie Parent, Pascal Lemoine and Eric Asselin
    Citation: Molecular Cancer 2006 5:45
    Content type: Research Published on:

  9. Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, s...

    Authors: Xiao-Feng Sun and Hong Zhang
    Citation: Molecular Cancer 2006 5:43
    Content type: Review Published on:

  11. Certain types of potassium channels (known as Eag1, KCNH1, Kv10.1) are associated with the production of tumours in patients and in animals. We have now studied the expression pattern of the Eag1 channel in a ...

    Authors: Bernhard Hemmerlein, Rüdiger M Weseloh, Fernanda Mello de Queiroz, Hendrik Knötgen, Araceli Sánchez, María E Rubio, Sabine Martin, Tessa Schliephacke, Marc Jenke, Heinz-Joachim-Radzun, Walter Stühmer and Luis A Pardo
    Citation: Molecular Cancer 2006 5:41
    Content type: Research Published on:

  12. Histone deacetylase inhibitors (HDACIs) have been shown to induce apoptotic and autophagic cell death in vitro and in vivo. The molecular mechanisms that underlie these cytotoxic effects are not yet clearly under...

    Authors: John P Alao, Alexandra V Stavropoulou, Eric W-F Lam and R Charles Coombes
    Citation: Molecular Cancer 2006 5:40
    Content type: Short communication Published on:

  13. Conventional cytogenetic and comparative genomic hybridization (CGH) studies in brain malignancies have shown that glioblastoma multiforme (GBM) is characterized by complex structural and numerical alterations...

    Authors: Yolanda Ruano, Manuela Mollejo, Teresa Ribalta, Concepción Fiaño, Francisca I Camacho, Elena Gómez, Angel Rodríguez de Lope, Jose-Luis Hernández-Moneo, Pedro Martínez and Bárbara Meléndez
    Citation: Molecular Cancer 2006 5:39
    Content type: Research Published on:

  15. Cancer development is accompanied by genetic phenomena like deletion and amplification of chromosome parts or alterations of chromatin structure. It is expected that these mechanisms have a strong effect on re...

    Authors: Eike Staub, Jörn Gröne, Detlev Mennerich, Stefan Röpcke, Irina Klamann, Bernd Hinzmann, Esmeralda Castanos-Velez, Benno Mann, Christian Pilarsky, Thomas Brümmendorf, Birgit Weber, Heinz-Johannes Buhr and André Rosenthal
    Citation: Molecular Cancer 2006 5:37
    Content type: Research Published on:

  16. Neurofibromatosis type 1 (NF1) is the most common hereditary neurocutaneous disorder and it is associated with an elevated risk for malignant tumors of tissues derived from neural crest cells. The NF1 gene is con...

    Authors: Albert Rübben, Birke Bausch and Arjen Nikkels
    Citation: Molecular Cancer 2006 5:36
    Content type: Research Published on:

  17. Uncensored exchange of scientific results hastens progress. Open Access does not stop at the removal of price and permission barriers; still, censorship and reading disabilities, to name a few, hamper access t...

    Authors: Shawn Mathur, Christian Schmidt, Chhaya Das and Philip W Tucker
    Citation: Molecular Cancer 2006 5:35
    Content type: Editorial Published on:

  18. Apoptosis resistance occurs in various tumors. The anti-apoptotic XIAP protein is responsible for inhibiting apoptosis by reducing caspase-3 activation. Our aim is to evaluate whether RNA inhibition against XI...

    Authors: Bart Spee, Martijn DB Jonkers, Brigitte Arends, Gerard R Rutteman, Jan Rothuizen and Louis C Penning
    Citation: Molecular Cancer 2006 5:34
    Content type: Research Published on:

  19. In order to gain new insights into the molecular mechanisms involved in prostate cancer, we performed array-based comparative genomic hybridization (aCGH) on a series of 46 primary prostate carcinomas using a ...

    Authors: Franclim R Ribeiro, Rui Henrique, Merete Hektoen, Marianne Berg, Carmen Jerónimo, Manuel R Teixeira and Ragnhild A Lothe
    Citation: Molecular Cancer 2006 5:33
    Content type: Research Published on:

  20. The aim of the present study was to develop and characterize a novel in vivo cancer gene therapy model in which intra-arterial adenoviral gene delivery can be characterized. In this model, the rat cremaster muscl...

    Authors: Gustavo Cabrera, Stacy L Porvasnik, Paul E DiCorleto, Maria Siemionow and Corey K Goldman
    Citation: Molecular Cancer 2006 5:32
    Content type: Research Published on:

  21. Expression of c-myc proto-oncogene is inappropriate in a wide range of human tumors, and is a downstream target of Ras/Raf/ERK pathway, which promotes c-Myc stability by enhancing c-Myc expression and activity.

    Authors: Francesco Marampon, Carmela Ciccarelli and Bianca M Zani
    Citation: Molecular Cancer 2006 5:31
    Content type: Research Published on:

  22. Carcinogenesis is a multi-step process indicated by several genes up- or down-regulated during tumor progression. This study examined and identified differentially expressed genes in cutaneous squamous cell ca...

    Authors: Ingo Nindl, Chantip Dang, Tobias Forschner, Ralf J Kuban, Thomas Meyer, Wolfram Sterry and Eggert Stockfleth
    Citation: Molecular Cancer 2006 5:30
    Content type: Research Published on:

  23. MicroRNAs (miRNAs) are short non-coding RNA molecules playing regulatory roles by repressing translation or cleaving RNA transcripts. Although the number of verified human miRNA is still expanding, only few ha...

    Authors: E Bandrés, E Cubedo, X Agirre, R Malumbres, R Zárate, N Ramirez, A Abajo, A Navarro, I Moreno, M Monzó and J García-Foncillas
    Citation: Molecular Cancer 2006 5:29
    Content type: Research Published on:

  24. Transcriptional silencing associated with aberrant promoter methylation has been established as an alternate pathway for the development of cancer by inactivating tumor suppressor genes. TMS1 (Target of Methylati...

    Authors: Partha M Das, Kavitha Ramachandran, Jane VanWert, Larry Ferdinand, Gopal Gopisetty, Isildinha M Reis and Rakesh Singal
    Citation: Molecular Cancer 2006 5:28
    Content type: Research Published on:

  26. Disrupting the balance of histone lysine methylation alters the expression of genes involved in tumorigenesis including proto-oncogenes and cell cycle regulators. Methylation of lysine residues is commonly cat...

    Authors: Mark A Brown, Robert J Sims III, Paul D Gottlieb and Philip W Tucker
    Citation: Molecular Cancer 2006 5:26
    Content type: Research Published on:

  27. The evolutionary conserved cyclin-dependent kinase phosphatase hCdc14A has been shown to play potential roles in the regulation of mitotic exit and in the centrosome duplication cycle. We have recently shown t...

    Authors: Michelle T Paulsen, Adrienne M Starks, Frederick A Derheimer, Sheela Hanasoge, Liwu Li, Jack E Dixon and Mats Ljungman
    Citation: Molecular Cancer 2006 5:25
    Content type: Research Published on:

  28. Recent studies indicate that microRNAs (miRNAs) are mechanistically involved in the development of various human malignancies, suggesting that they represent a promising new class of cancer biomarkers. However...

    Authors: Michael D Mattie, Christopher C Benz, Jessica Bowers, Kelly Sensinger, Linda Wong, Gary K Scott, Vita Fedele, David Ginzinger, Robert Getts and Chris Haqq
    Citation: Molecular Cancer 2006 5:24
    Content type: Research Published on:

  29. The Helicase-Like Transcription Factor (HLTF/SMARCA3) belongs to the family of SWI/SNF proteins that use the energy of ATP hydrolysis to remodel chromatin in a variety of cellular processes. Several SWI/SNF ge...

    Authors: Gaël Debauve, Denis Nonclercq, Fabrice Ribaucour, Murielle Wiedig, Cécile Gerbaux, Oberdan Leo, Guy Laurent, Fabrice Journé, Alexandra Belayew and Gérard Toubeau
    Citation: Molecular Cancer 2006 5:23
    Content type: Research Published on:

  30. Gene-targeted iMycEμ mice that carry a His6-tagged mouse Myc(c-myc)cDNA, MycHis, just 5' of the immunoglobulin heavy-chain enhancer, Eμ, are prone to B cell and plasma cell neoplasms, such as lymphoblastic B-cell...

    Authors: Seong-Su Han, Liangping Peng, Seung-Tae Chung, Wendy DuBois, Sung-Ho Maeng, Arthur L Shaffer, Michael B Sporn and Siegfried Janz
    Citation: Molecular Cancer 2006 5:22
    Content type: Research Published on:

  31. There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of ...

    Authors: Danielle Lejeune, Mohammad Hasanuzzaman, Amanda Pitcock, Joseph Francis and Inder Sehgal
    Citation: Molecular Cancer 2006 5:21
    Content type: Short communication Published on:

  32. Treatment of cells with the anti-cancer drug 5-fluorouracil (5-FU) causes DNA damage, which in turn affects cell proliferation and survival. Two stable wild-type TP53 5-FU-resistant cell lines, ContinB and Contin...

    Authors: Paula M De Angelis, Debbie H Svendsrud, Katherine L Kravik and Trond Stokke
    Citation: Molecular Cancer 2006 5:20
    Content type: Research Published on:

  33. 2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex®) that lacks COX-2-inhibitory function. However, despite its inability to block CO...

    Authors: Peter Pyrko, Nathaniel Soriano, Adel Kardosh, Yen-Ting Liu, Jasim Uddin, Nicos A Petasis, Florence M Hofman, Ching-Shih Chen, Thomas C Chen and Axel H Schönthal
    Citation: Molecular Cancer 2006 5:19
    Content type: Research Published on:

  34. Chromosomal aberrations of BCL11A at 2p16.1 have been reported in a variety of B-cell malignancies and its deficiency in mice leads to a profound block in B-cell development.

    Authors: Hui Liu, Gregory C Ippolito, Jason K Wall, Teresa Niu, Loren Probst, Baeck-Seung Lee, Karen Pulford, Alison H Banham, Luke Stockwin, Arthur L Shaffer, Louis M Staudt, Chhaya Das, Martin JS Dyer and Philip W Tucker
    Citation: Molecular Cancer 2006 5:18
    Content type: Research Published on:

  36. Cervical Cancer (CC) exhibits highly complex genomic alterations. These include hemizygous deletions at 4p15.3, 10q24, 5q35, 3p12.3, and 11q24, the chromosomal sites of Slit-Robo pathway genes. However, no can...

    Authors: Gopeshwar Narayan, Chandra Goparaju, Hugo Arias-Pulido, Andreas M Kaufmann, Achim Schneider, Matthias Dürst, Mahesh Mansukhani, Bhavana Pothuri and Vundavalli V Murty
    Citation: Molecular Cancer 2006 5:16
    Content type: Research Published on:

  37. Squamous cell carcinoma (SCC) of the skin is the most aggressive form of non-melanoma skin cancer (NMSC), and is the single most commonly diagnosed cancer in the U.S., with over one million new cases reported ...

    Authors: Weihong Yin, Satish Cheepala, Jennifer N Roberts, Keith Syson-Chan, John DiGiovanni and John L Clifford
    Citation: Molecular Cancer 2006 5:15
    Content type: Research Published on:

  38. In prostate cancer, normal citrate-producing glandular secretory epithelial cells undergo a metabolic transformation to malignant citrate-oxidizing cells. m-Aconitase is the critical step involved in this alte...

    Authors: Keshav K Singh, Mohamed M Desouki, Renty B Franklin and Leslie C Costello
    Citation: Molecular Cancer 2006 5:14
    Content type: Research Published on:

  39. Fenofibrate, an agonist of PPAR-alpha, in doses above 25 μM, inhibits proliferation and induces apoptosis in Ishikawa endometrial cancer cells. We show that these effects are potentiated by retinoic acid, an a...

    Authors: Samir A Saidi, Cathrine M Holland, D Stephen Charnock-Jones and Stephen K Smith
    Citation: Molecular Cancer 2006 5:13
    Content type: Research Published on:

  40. Retinoic acid suppresses cell growth and promotes cell differentiation, and pharmacological retinoic acid receptor (RAR) activation is anti-tumorigenic. This begs the question of whether chronic physiological ...

    Authors: Tara S Kupumbati, Giorgio Cattoretti, Christine Marzan, Eduardo F Farias, Reshma Taneja and Rafael Mira-y-Lopez
    Citation: Molecular Cancer 2006 5:12
    Content type: Research Published on:

  41. Early detection of a premalignant or cancerous oral lesion promises to improve the survival and the morbidity of patients suffering from these conditions. Cytological study of oral cells is a non-aggressive te...

    Authors: Ravi Mehrotra, Anurag Gupta, Mamta Singh and Rahela Ibrahim
    Citation: Molecular Cancer 2006 5:11
    Content type: Review Published on:

    The Retraction Note to this article has been published in Molecular Cancer 2012 11:57

  42. Helicobacter pylori (H. pylori) causes gastritis and intestinal metaplasia (IM) that may evolve to gastric carcinoma. The objective of this study was to compare the profile of mucins in the progressive stages of

    Authors: Subramani Durai Babu, Venkataraman Jayanthi, Niranjali Devaraj, Celso A Reis and Halagowder Devaraj
    Citation: Molecular Cancer 2006 5:10
    Content type: Research Published on:

  43. Genetic studies associated the CAPB locus with familial risk of brain and prostate cancers. We have identified HSPG2 (Perlecan) as a candidate gene for CAPB. Previously we have linked Perlecan to Hedgehog signali...

    Authors: Milton W Datta, Ana Maria Hernandez, Michael J Schlicht, Andrea J Kahler, Amy M DeGueme, Rajiv Dhir, Rajal B Shah, Cindy Farach-Carson, Andrea Barrett and Sumana Datta
    Citation: Molecular Cancer 2006 5:9
    Content type: Research Published on:

  44. Cyclin D1 is an important regulator of G1-S phase cell cycle transition and has been shown to be important for breast cancer development. GSK3β phosphorylates cyclin D1 on Thr-286, resulting in enhanced ubiqui...

    Authors: John P Alao, Alexandra V Stavropoulou, Eric W-F Lam, R Charles Coombes and David M Vigushin
    Citation: Molecular Cancer 2006 5:8
    Content type: Research Published on:

  45. The cyclin D1 proto-oncogene is an important regulator of G1 to S-phase transition and an important cofactor for several transcription factors in numerous cell types. Studies on neonatal cardiomyocytes and pos...

    Authors: John P Alao, Simon C Gamble, Alexandra V Stavropoulou, Karen M Pomeranz, Eric W-F Lam, R Charles Coombes and David M Vigushin
    Citation: Molecular Cancer 2006 5:7
    Content type: Research Published on:

  47. Cancer growth, invasion and metastasis are highly related to tumor-associated neovasculature. The presence and progression of endothelial cells in cancer is chaotic, unorganized, and angiogenic vessels are les...

    Authors: Finie Hunter, Jianwu Xie, Cameron Trimble, Monica Bur and King CP Li
    Citation: Molecular Cancer 2006 5:5
    Content type: Research Published on:

  49. Polymorphisms or mutations in hypoxia inducible factor-1 alpha (HIF-1alpha) that increases its activity and stability under normoxia have recently been identified. Likewise, disruption of the TSC1/TSC2 complex...

    Authors: Carla Hebert, Kathleen Norris, Pallavi Parashar, Robert A Ord, Nikolaos G Nikitakis and John J Sauk
    Citation: Molecular Cancer 2006 5:3
    Content type: Research Published on:

  50. BRAF is a member of RAF family of serine/threonine kinases and mediates cellular responses to growth signals through the RAS-RAF-MAP kinase pathway. Activating mutations in BRAF have recently been found in about ...

    Authors: Wei Qi Li, Kazuyuki Kawakami, Andrew Ruszkiewicz, Graeme Bennett, James Moore and Barry Iacopetta
    Citation: Molecular Cancer 2006 5:2
    Content type: Research Published on:
Submit manuscript

Annual Journal Metrics

  • 2022 Citation Impact
    37.3 - 2-year Impact Factor
    33.1 - 5-year Impact Factor
    5.740 - SNIP (Source Normalized Impact per Paper)
    8.703 - SJR (SCImago Journal Rank)

    2023 Speed
    5 days submission to first editorial decision for all manuscripts (Median)
    91 days submission to accept (Median)

    2023 Usage 
    3,569,666 downloads
    2,070 Altmetric mentions 

Follow

Molecular Cancer

ISSN: 1476-4598