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  1. AMP-activated protein kinase (AMPK) is a key energy sensor that is involved in regulating cell metabolism. Our previous study revealed that the subunits of the heterotimeric AMPK enzyme are diversely expressed...

    Authors: Cuilan Li, Vincent WS Liu, Pui Man Chiu, Kwok-Ming Yao, Hextan YS Ngan and David W Chan
    Citation: Molecular Cancer 2014 13:49
    Content type: Research Published on:

    The Erratum to this article has been published in Molecular Cancer 2014 13:161

  2. A colorectal tumor is not an isolated entity growing in a restricted location of the body. The patient’s gut environment constitutes the framework where the tumor evolves and this relationship promotes and inc...

    Authors: Rebeca Sanz-Pamplona, Antoni Berenguer, David Cordero, David G Molleví, Marta Crous-Bou, Xavier Sole, Laia Paré-Brunet, Elisabet Guino, Ramón Salazar, Cristina Santos, Javier de Oca, Xavier Sanjuan, Francisco Rodriguez-Moranta and Victor Moreno
    Citation: Molecular Cancer 2014 13:46
    Content type: Research Published on:

  3. Gain of function mutations in B-RAF and N-RAS occur frequently in melanoma, leading to mitogen activating protein kinase (MAPK) pathway activation, and this pathway is the target of drugs in development. Our p...

    Authors: Jaykumar Thumar, David Shahbazian, Saadia A Aziz, Lucia B Jilaveanu and Harriet M Kluger
    Citation: Molecular Cancer 2014 13:45
    Content type: Research Published on:

  4. This work aimed to synthesize a cathepsin B (CTSB)-cleavable tumor-targeting prodrug peptide doxorubicin (PDOX) and study the in vivo efficacy and toxicities on an animal model of gastric peritoneal carcinomat...

    Authors: Li Tang, Rui Duan, Yan-jun Zhong, Raymond A Firestone, Ya-ping Hong, Ji-guo Li, Yan-chao Xin, Han-lin Wu and Yan Li
    Citation: Molecular Cancer 2014 13:44
    Content type: Research Published on:

  5. Tumor-associated macrophages (TAMs) are the major component of tumor-infiltrating leukocytes. TAMs are heterogeneous, with distinct phenotypes influenced by the microenvironment surrounding tumor tissues, but ...

    Authors: Min Yang, Jingwei Liu, Jianghua Shao, Yanwen Qin, Qunsheng Ji, Xiaolin Zhang and Jie Du
    Citation: Molecular Cancer 2014 13:43
    Content type: Research Published on:

  6. The prognosis for renal cell carcinoma (RCC) is related to a high rate of metastasis, including 30% of bone metastasis. Characteristic for bone tissue is a high concentration of calcium ions. In this study, we...

    Authors: Elke Joeckel, Tobias Haber, Dirk Prawitt, Kerstin Junker, Christian Hampel, Joachim W Thüroff, Frederik C Roos and Walburgis Brenner
    Citation: Molecular Cancer 2014 13:42
    Content type: Research Published on:

  7. Microtubule stabilizers suppress microtubule dynamics and, at the lowest antiproliferative concentrations, disrupt the function of mitotic spindles, leading to mitotic arrest and apoptosis. At slightly higher ...

    Authors: April L Risinger, Stephen M Riffle, Manu Lopus, Mary A Jordan, Leslie Wilson and Susan L Mooberry
    Citation: Molecular Cancer 2014 13:41
    Content type: Research Published on:

  8. Overexpression of the proinflammatory cytokine IL-1β is associated with diverse diseases, including cancer. Alteration of microRNAs has been observed in cancer cells exposed to proinflammatory cytokines, yet t...

    Authors: Jun Ma, Jun Liu, Zhiming Wang, Xixi Gu, Yue Fan, Wen Zhang, Lili Xu, Jianjun Zhang and Dingfang Cai
    Citation: Molecular Cancer 2014 13:40
    Content type: Research Published on:

  9. Renal cell carcinoma (RCC) is known for its ability to metastasize synchronously or metachronously to various anatomic sites. Distinguishing histologic subtypes of metastatic RCC has become increasingly import...

    Authors: Lisha Wang, Sean R Williamson, Mingsheng Wang, Darrell D Davidson, Shaobo Zhang, Lee Ann Baldridge, Xiang Du and Liang Cheng
    Citation: Molecular Cancer 2014 13:39
    Content type: Research Published on:

  10. Robust ERK1/2 activity, which frequently results from KRAS mutation, invariably occurs in pancreatic ductal adenocarcinoma (PDAC). However, direct interference of KRAS signaling has not led to clinically succe...

    Authors: Zhou Luan, Ying He, Mohamed Alattar, Zhishui Chen and Fan He
    Citation: Molecular Cancer 2014 13:38
    Content type: Research Published on:

  11. A better molecular understanding of prostate carcinogenesis is warranted to devise novel targeted preventive and therapeutic strategies against prostate cancer (PCA), a major cause of mortality among men. Here...

    Authors: Gagan Deep, Anil K Jain, Anand Ramteke, Harold Ting, Kavitha C Vijendra, Subhash C Gangar, Chapla Agarwal and Rajesh Agarwal
    Citation: Molecular Cancer 2014 13:37
    Content type: Research Published on:

  12. The ataxia–telangiectasia mutated (ATM) protein kinase plays a central role in coordinating the cellular response to radiation-induced DNA damage. cAMP signaling regulates various cellular responses including ...

    Authors: Eun-Ah Cho, Eui-Jun Kim, Sahng-June Kwak and Yong-Sung Juhnn
    Citation: Molecular Cancer 2014 13:36
    Content type: Research Published on:

  13. Abnormal activation of the NF-κB pathway is closely related to tumorigenesis and chemoresistance. Therefore, microRNAs that possess the NF-κB inhibitory activity may provide novel targets for anti-cancer thera...

    Authors: Na Zhao, Ruizhi Wang, Liangji Zhou, Ying Zhu, Jiao Gong and Shi-Mei Zhuang
    Citation: Molecular Cancer 2014 13:35
    Content type: Research Published on:

  14. Increased infiltration of CD8+T cells into tumors has a positive impact on survival. Our previous study showed that doxorubicin (Dox) plus interleukin-12 (IL-12) boosted the accumulation of CD8+T cells in tumors ...

    Authors: Jiemiao Hu, Shiguo Zhu, Xueqing Xia, Liangfang Zhang, Eugenie S Kleinerman and Shulin Li
    Citation: Molecular Cancer 2014 13:34
    Content type: Research Published on:

  16. SET/I2PP2A is a multifunctional protein that is up-regulated in head and neck squamous cell carcinoma (HNSCC). The action of SET in HNSCC tumorigenicity is unknown.

    Authors: Lays M Sobral, Lucas O Sousa, Ricardo D Coletta, Hamilton Cabral, Lewis J Greene, Eloiza H Tajara, J Silvio Gutkind, Carlos Curti and Andréia M Leopoldino
    Citation: Molecular Cancer 2014 13:32
    Content type: Research Published on:

  17. The bumetanide (BMT)-sensitive Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) maintains cell volume homeostasis by increasing intracellular K+ and Cl- content via regulatory volume increase (RVI). Expression levels ...

    Authors: Wen Zhu, Gulnaz Begum, Kelli Pointer, Paul A Clark, Sung-Sen Yang, Shih-Hua Lin, Kristopher T Kahle, John S Kuo and Dandan Sun
    Citation: Molecular Cancer 2014 13:31
    Content type: Research Published on:

  19. Recent genome-wide studies have shown that approximately 30% of diffuse large B-cell lymphoma (DLBCL) cases harbor mutations in the histone acetyltransferase (HAT) coactivators p300 or CBP. The majority of the...

    Authors: Leila Haery, Julián G Lugo-Picó, Ryan A Henry, Andrew J Andrews and Thomas D Gilmore
    Citation: Molecular Cancer 2014 13:29
    Content type: Research Published on:

  20. In mammalians, HIF is a master regulator of hypoxia gene expression through direct binding to DNA, while its role in microRNA expression regulation, critical in the hypoxia response, is not elucidated genome w...

    Authors: Carme Camps, Harpreet K Saini, David R Mole, Hani Choudhry, Martin Reczko, José Afonso Guerra-Assunção, Ya-Min Tian, Francesca M Buffa, Adrian L Harris, Artemis G Hatzigeorgiou, Anton J Enright and Jiannis Ragoussis
    Citation: Molecular Cancer 2014 13:28
    Content type: Research Published on:

  21. The translocation t(9;11)(p22;q23) leading to the leukemogenic fusion gene MLL-AF9 is a frequent translocation in infant acute myeloid leukemia (AML). This study aimed to identify genes and molecular processes do...

    Authors: Katrin K Fleischmann, Philipp Pagel, Irene Schmid and Adelbert A Roscher
    Citation: Molecular Cancer 2014 13:27
    Content type: Research Published on:

  22. DNA methyltransferase 1 (DNMT1) plays a critical role in breast cancer progression. However, the epigenetic mechanism regulating DNMT1 expression remains largely unknown.

    Authors: Da Li, Fang-Fang Bi, Ji-Min Cao, Chen Cao, Bo Liu and Qing Yang
    Citation: Molecular Cancer 2014 13:26
    Content type: Research Published on:

  23. Cancer-testis (CT) antigen genes might promote the progression of multiple myeloma (MM). CT antigens may act as diagnostic and prognostic markers in MM, but their expression levels and clinical implications in...

    Authors: Yao Zhang, Li Bao, Jin Lu, Kai-Yan Liu, Jin-Lan Li, Ya-Zhen Qin, Huan Chen, Ling-Di Li, Yuan Kong, Hong-Xia Shi, Yue-Yun Lai, Yan-Rong Liu, Bin Jiang, Shan-Shan Chen, Xiao-Jun Huang and Guo-Rui Ruan
    Citation: Molecular Cancer 2014 13:25
    Content type: Research Published on:

  24. ADAM17 is one of the main sheddases of the cells and it is responsible for the cleavage and the release of ectodomains of important signaling molecules, such as EGFR ligands. Despite the known crosstalk betwee...

    Authors: Fernando Moreira Simabuco, Rebeca Kawahara, Sami Yokoo, Daniela C Granato, Lucas Miguel, Michelle Agostini, Annelize ZB Aragão, Romênia R Domingues, Isadora L Flores, Carolina CS Macedo, Ricardo Della Coletta, Edgard Graner and Adriana Franco Paes Leme
    Citation: Molecular Cancer 2014 13:24
    Content type: Research Published on:

  25. Recent studies demonstrated that engagement of sodium glucose transporter 1 (SGLT-1) by orally administered D-glucose protects the intestinal mucosa from lipopolysaccharide (LPS)-induced injury. We tested whet...

    Authors: Diego Cardani, Claudia Sardi, Barbara La Ferla, Giuseppe D’Orazio, Michele Sommariva, Fabrizio Marcucci, Daniela Olivero, Elda Tagliabue, Hermann Koepsell, Francesco Nicotra, Andrea Balsari and Cristiano Rumio
    Citation: Molecular Cancer 2014 13:23
    Content type: Research Published on:

  26. The main cause of death of breast cancer patients is not the primary tumor itself but the metastatic disease. Identifying breast cancer-specific signatures for metastasis and learning more about the nature of ...

    Authors: Irem Gurbuz, Jacqueline Ferralli, Tim Roloff, Ruth Chiquet-Ehrismann and Maria B Asparuhova
    Citation: Molecular Cancer 2014 13:22
    Content type: Research Published on:

  27. Cancer is the result of a multistep process of genomic alterations, including mutations in key regulatory proteins that result in loss of balanced gene expression and subsequent malignant transformation. Throu...

    Authors: Shikha Gaur, Linling Chen, Vincent Ann, Wei-Chen Lin, Yafan Wang, Vincent HS Chang, Nan Yong Hsu, Her-Shuyong Shia and Yun Yen
    Citation: Molecular Cancer 2014 13:21
    Content type: Research Published on:

  28. The transcription factor Nrf2 is a key regulator of the cellular antioxidant response, and its activation by chemoprotective agents has been proposed as a potential strategy to prevent cancer. However, activat...

    Authors: Juan M Funes, Stephen Henderson, Rachel Kaufman, James M Flanagan, Mathew Robson, Barbara Pedley, Salvador Moncada and Chris Boshoff
    Citation: Molecular Cancer 2014 13:20
    Content type: Research Published on:

  30. Interleukin-1β (IL-1β) has been implicated in the progression of gastric adenocarcinoma (GA); however, the molecular mechanisms of action of IL-1β in GA are poorly characterized. P38 and JNK are the major MAPK...

    Authors: Qiaojia Huang, Fenghua Lan, Xiaoting Wang, Yinghao Yu, Xuenong Ouyang, Feng Zheng, Junyong Han, Youdong Lin, Yanchuan Xie, Feilai Xie, Wei Liu, Xiaoli Yang, Han Wang, Lihong Dong, Lie Wang and Jianming Tan
    Citation: Molecular Cancer 2014 13:18
    Content type: Research Published on:

  31. T674I FIP1L1-PDGFRα in a subset of chronic eosinophilic leukemia (CEL) is a gatekeeper mutation that is resistant to many tyrosine kinase inhibitors (TKIs) (e.g., imatinib, nilotinib and dasatinib), similar to...

    Authors: Yanli Jin, Ke Ding, Honglin Li, Mengzhu Xue, Xiaoke Shi, Chengyan Wang and Jingxuan Pan
    Citation: Molecular Cancer 2014 13:17
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2021 20:137

  32. Tumor spreading is the major threat for cancer patients. The recently published anti-cancer drug salinomycin raised hope for an improved treatment by targeting therapy-refractory cancer stem cells. However, an...

    Authors: Florian Kopp, Adam Hermawan, Prajakta Shirish Oak, Annika Herrmann, Ernst Wagner and Andreas Roidl
    Citation: Molecular Cancer 2014 13:16
    Content type: Short communication Published on:

  33. Pancreatic cancer is a lethal disease due to the high incidence of metastasis at the time of detection. CD133 expression in clinical pancreatic cancer correlates with poor prognosis and metastasis. However, th...

    Authors: Qiang Ding, Yumi Miyazaki, Koichiro Tsukasa, Shyuichiro Matsubara, Makoto Yoshimitsu and Sonshin Takao
    Citation: Molecular Cancer 2014 13:15
    Content type: Research Published on:

  34. Deregulated energetics is a property of most cancer cells. This phenomenon, known as the Warburg Effect or aerobic glycolysis, is characterized by increased glucose uptake, lactate export and extracellular aci...

    Authors: Roger A Vaughan, Nicholas P Gannon, Randi Garcia-Smith, Yamhilette Licon-Munoz, Miguel A Barberena, Marco Bisoffi and Kristina A Trujillo
    Citation: Molecular Cancer 2014 13:14
    Content type: Research Published on:

  35. The advent of effective targeted therapeutics has led to increasing emphasis on precise biomarkers for accurate patient stratification. Here, we describe the role of ACK1, a non-receptor tyrosine kinase in abr...

    Authors: Daniel SW Tan, Benjamin Haaland, Jia Min Gan, Su Chin Tham, Indrajit Sinha, Eng Huat Tan, Kiat Hon Lim, Angela Takano, Sai Sakktee Krisna, Minn Minn Myint Thu, Hoe Peng Liew, Axel Ullrich, Wan-Teck Lim and Boon Tin Chua
    Citation: Molecular Cancer 2014 13:13
    Content type: Research Published on:

  36. Although tumor hypoxia poses challenges against conventional cancer treatments, it provides a therapeutic target for hypoxia-activated drugs. Here, we studied the effect of the hypoxia-activated synthetic quin...

    Authors: Khaled Ghattass, Sally El-Sitt, Kazem Zibara, Saide Rayes, Makhluf J Haddadin, Marwan El-Sabban and Hala Gali-Muhtasib
    Citation: Molecular Cancer 2014 13:12
    Content type: Research Published on:

  37. Defects in the DNA mismatch repair (MMR) protein MLH1 are frequently observed in sporadic and hereditary colorectal cancers (CRC). Affected tumors generate much less metastatic potential than the MLH1 proficie...

    Authors: Inga Hinrichsen, Benjamin Philipp Ernst, Franziska Nuber, Sandra Passmann, Dieter Schäfer, Verena Steinke, Nicolaus Friedrichs, Guido Plotz, Stefan Zeuzem and Angela Brieger
    Citation: Molecular Cancer 2014 13:11
    Content type: Research Published on:

  38. Tumor cell migration and metastasis require dynamic rearrangements of the actin cytoskeleton. Interestingly, the F-actin cross-linking and stabilizing protein L-plastin, originally described as a leukocyte spe...

    Authors: Selina M Riplinger, Guido H Wabnitz, Henning Kirchgessner, Beate Jahraus, Felix Lasitschka, Bianca Schulte, Gabri van der Pluijm, Geertje van der Horst, Günter J Hämmerling, Inaam Nakchbandi and Yvonne Samstag
    Citation: Molecular Cancer 2014 13:10
    Content type: Research Published on:

  39. Alternative pre-mRNA splicing (AS) widely expands proteome diversity through the combinatorial assembly of exons. The analysis of AS on a large scale, by using splice-sensitive microarrays, is a highly efficie...

    Authors: Marine Pesson, Béatrice Eymin, Pierre De La Grange, Brigitte Simon and Laurent Corcos
    Citation: Molecular Cancer 2014 13:9
    Content type: Research Published on:

  40. Accumulating evidence suggests a tumor suppressive role for miR-34a in human carcinogenesis. However, its precise biological role remains largely elusive. This study aimed to reveal the association of the miR-...

    Authors: Heng Li, Gan Yu, Runlin Shi, Bin Lang, Xianguo Chen, Ding Xia, Haibing Xiao, Xiaolin Guo, Wei Guan, Zhangqun Ye, Wei Xiao and Hua Xu
    Citation: Molecular Cancer 2014 13:8
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2022 21:155

    The Erratum to this article has been published in Molecular Cancer 2014 13:183

  41. Traditional systemic chemotherapy does not provide survival benefits in patients with hepatocellular carcinoma (HCC). Molecular targeted therapy shows promise for HCC treatment, however, the duration of effect...

    Authors: Jian Kong, Fandong Kong, Jun Gao, Qiangbo Zhang, Shuying Dong, Fang Gu, Shan Ke, Bing Pan, Qiang Shen, Huichuan Sun, Lemin Zheng and Wenbing Sun
    Citation: Molecular Cancer 2014 13:7
    Content type: Research Published on:

  42. MicroRNAs (miRNAs), small noncoding RNA molecules can function as oncogenes or tumor suppressors in tumorigenesis. Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers worldwide with a 5-ye...

    Authors: Yi-Chen Yen, Shine-Gwo Shiah, Hsiao-Chien Chu, Yuan-Ming Hsu, Jenn-Ren Hsiao, Jang-Yang Chang, Wen-Chun Hung, Chun-Ta Liao, Ann-Joy Cheng, Ya-Ching Lu and Ya-Wen Chen
    Citation: Molecular Cancer 2014 13:6
    Content type: Research Published on:

  43. Acute lymphoblastic leukemia (ALL) is the most frequently occurring malignant neoplasm in children. Despite advances in treatment and outcomes for ALL patients, the pathogenesis of the disease remains unclear....

    Authors: Han Zhang, Lin Zhu, Huacheng He, Shanshan Zhu, Wei Zhang, Xiao Liu, Xiaoxi Zhao, Chao Gao, Mei Mei, Shilai Bao and Huyong Zheng
    Citation: Molecular Cancer 2014 13:5
    Content type: Research Published on:

  45. We previously identified that the CpG island-associated promoter of the novel lincRNA ZNF300P1 (also known as LOC134466) is frequently hypermethylated and silenced in ovarian cancer tissues. However, the function...

    Authors: Brian Gloss, Kim Moran-Jones, Vita Lin, Maria Gonzalez, James Scurry, Neville F Hacker, Robert L Sutherland, Susan J Clark and Goli Samimi
    Citation: Molecular Cancer 2014 13:3
    Content type: Research Published on:

  46. To explore whether combining inhibitors that target the insulin-like growth factor receptor (IGFR)/PI3K/Akt/mTOR signaling pathway (vertical blockade) can improve treatment efficacy for hepatocellular carcinom...

    Authors: Da-Liang Ou, Bin-Shyun Lee, Liang-In Lin, Jun-Yang Liou, Sheng-Chieh Liao, Chiun Hsu and Ann-Lii Cheng
    Citation: Molecular Cancer 2014 13:2
    Content type: Research Published on:

  47. Development of resistance to androgen deprivation therapy (ADT) is a major obstacle for the management of advanced prostate cancer. Therapies with androgen receptor (AR) antagonists and androgen withdrawal ini...

    Authors: Richard Ottman, Camha Nguyen, Robert Lorch and Ratna Chakrabarti
    Citation: Molecular Cancer 2014 13:1
    Content type: Research Published on:

  48. The miR-9 family microRNAs have been identified as a tumor suppressor miRNA in cancers. We postulated that miR-9-1, miR-9-2 and miR-9-3 might be inactivated by DNA hypermethylation in chronic lymphocytic leukemia...

    Authors: Lu Qian Wang, Yok Lam Kwong, Chi Shan Bonnie Kho, Kit Fai Wong, Kwan Yeung Wong, Manuela Ferracin, George A Calin and Chor Sang Chim
    Citation: Molecular Cancer 2013 12:173
    Content type: Research Published on:

  49. The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads to Akt phosphorylation at Ser-473, which is important for the carcinogenic effects of excessive sun exposure. The present study investig...

    Authors: Ying Tu, Chao Ji, Bo Yang, Zhi Yang, Hua Gu, Chun-Cheng Lu, Rong Wang, Zhong-Lan Su, Bin Chen, Wei-Ling Sun, Ji-Ping Xia, Zhi-Gang Bi and Li He
    Citation: Molecular Cancer 2013 12:172
    Content type: Research Published on:
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Molecular Cancer

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