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Molecular Cancer

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  1. Content type: Research

    Gastric cancer (GC) is one of the frequent causes of cancer-related death in eastern Asian population. IGF2BP2 lists in the top rank up-regulated genes in GC, but its functional role is unclear.

    Authors: Yuhang Zhou, Tingting Huang, Ho Lam Siu, Chi Chun Wong, Yujuan Dong, Feng Wu, Bin Zhang, William K. K. Wu, Alfred S. L. Cheng, Jun Yu, Ka Fai To and Wei Kang

    Citation: Molecular Cancer 2017 16:77

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  2. Content type: Review

    Cancer cells frequently display fundamentally altered cellular metabolism, which provides the biochemical foundation and directly contributes to tumorigenicity and malignancy. Rewiring of metabolic programmes,...

    Authors: Xiangjian Luo, Can Cheng, Zheqiong Tan, Namei Li, Min Tang, Lifang Yang and Ya Cao

    Citation: Molecular Cancer 2017 16:76

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  3. Content type: Research

    The telomerase/telomere interacting protein PinX1 has been suggested as a tumor suppressor. However, the clinical and biological significance of PinX1 in human non-small cell lung cancer (NSCLC) is unclear.

    Authors: Xiao-Peng Tian, Xiao-Han Jin, Mei Li, Wei-Juan Huang, Dan Xie and Jia-Xing Zhang

    Citation: Molecular Cancer 2017 16:74

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  4. Content type: Short communication

    Early diagnosis of esophageal squamous cell carcinoma (ESCC) is an important issue to improve the prognosis. HOX transcript antisense RNA (HOTAIR), a long noncoding RNA (lncRNA) expressed from the HOXC locus, ...

    Authors: Wenjian Wang, Xiaotian He, Zehua Zheng, Xiaofan Ma, Xueting Hu, Duoguang Wu and Minghui Wang

    Citation: Molecular Cancer 2017 16:75

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  5. Content type: Research

    The role of cancer-associated fibroblasts (CAFs) during tumour progression is obscured by the inherently complex, heterotypic nature of fibroblast cells and behaviours in various subtypes of malignancies. Ther...

    Authors: Susann Busch, Daniel Andersson, Eva Bom, Claire Walsh, Anders Ståhlberg and Göran Landberg

    Citation: Molecular Cancer 2017 16:73

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  6. Content type: Research

    Vascular endothelial growth factor receptors (VEGFRs) are the major receptors involved in endothelial cell-dependent tumor angiogenesis. There are studies account for the effects of Hsp90 on angiogenesis, but ...

    Authors: Jing Meng, Yanrong Liu, Jingxia Han, Qiang Tan, Shuang Chen, Kailiang Qiao, Honggang Zhou, Tao Sun and Cheng Yang

    Citation: Molecular Cancer 2017 16:72

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  7. Content type: Research

    Metastasis is a major cause of death in human colorectal cancer patients. However, the contribution of chemokines in the tumor microenvironment to tumor metastasis is not fully understood.

    Authors: Jingkun Zhao, Baochi Ou, Dingpei Han, Puxiongzhi Wang, Yaping Zong, Congcong Zhu, Di Liu, Minhua Zheng, Jing Sun, Hao Feng and Aiguo Lu

    Citation: Molecular Cancer 2017 16:70

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  8. Content type: Research

    Although chemotherapy represents a predominant anti-cancer therapeutic modality, drug treatment efficacy is often limited due to the development of resistant tumor cells. The pregnane X receptor (PXR) affects ...

    Authors: Yan Dong, Zhe Wang, Gan-feng Xie, Chong Li, Wen-wei Zuo, Gang Meng, Cheng-ping Xu and Jian-jun Li

    Citation: Molecular Cancer 2017 16:71

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  9. Content type: Research

    Vasohibin 2 (VASH2) has previously been identified as an agiogenenic factor and a cancer related protein. Here we investigated the association of VASH2 expression and chemoresistance in pancreatic cancer.

    Authors: Min Tu, Haifeng Li, Nan Lv, Chunhua Xi, Zipeng Lu, Jishu Wei, Jianmin Chen, Feng Guo, Kuirong Jiang, Guoxin Song, Wentao Gao and Yi Miao

    Citation: Molecular Cancer 2017 16:66

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  10. Content type: Review

    Vasculogenic mimicry (VM) is a blood supply system independent of endothelial vessels in tumor cells from different origins. It reflects the plasticity of aggressive tumor cells that express vascular cell mark...

    Authors: Daniel Delgado-Bellido, Santiago Serrano-Saenz, Mónica Fernández-Cortés and F. Javier Oliver

    Citation: Molecular Cancer 2017 16:65

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  11. Content type: Research

    TRIM8 plays a key role in controlling the p53 molecular switch that sustains the transcriptional activation of cell cycle arrest genes and response to chemotherapeutic drugs. The mechanisms that regulate TRIM8...

    Authors: Francesca Mastropasqua, Flaviana Marzano, Alessio Valletti, Italia Aiello, Giuseppe Di Tullio, Annalisa Morgano, Sabino Liuni, Elena Ranieri, Luisa Guerrini, Giuseppe Gasparre, Elisabetta Sbisà, Graziano Pesole, Antonio Moschetta, Mariano Francesco Caratozzolo and Apollonia Tullo

    Citation: Molecular Cancer 2017 16:67

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  12. Content type: Review

    The cancer stem cell (CSC) model proposes that tumor development and progression are fueled and sustained by undifferentiated cancer cells, endowed with self-renewal and tumor-initiating capacity. Ovarian carc...

    Authors: Michela Lupia and Ugo Cavallaro

    Citation: Molecular Cancer 2017 16:64

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  13. Content type: Review

    As an atypical member of cyclin dependent kinase family, Cyclin dependent kinase 5 (Cdk5) is considered as a neuron-specific kinase in the past decade due to the abundant existence of its activator p35 in post...

    Authors: Wan Liu, Jun Li, Yu-Shu Song, Yue Li, Yu-Hong Jia and Hai-Dong Zhao

    Citation: Molecular Cancer 2017 16:60

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  14. Content type: Research

    Lung cancer and pleural mesothelioma are two of the most deadly forms of cancer. The prognosis of lung cancer and mesothelioma is extremely poor due to limited treatment modalities and lack of understanding of...

    Authors: Xiaoqing He, Liying Wang, Heimo Riedel, Kai Wang, Yong Yang, Cerasela Zoica Dinu and Yon Rojanasakul

    Citation: Molecular Cancer 2017 16:63

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  15. Content type: Research

    High levels of SOX2 protein are correlated with increased dissemination of breast cancer. However, the underlying molecular mechanisms are not fully understood.

    Authors: Kuancan Liu, Fuan Xie, Anding Gao, Rui Zhang, Long Zhang, Zhangwu Xiao, Qiong Hu, Weifeng Huang, Qiaojia Huang, Baoshun Lin, Jian Zhu, Haikun Wang, Jianwen Que and Xiaopeng Lan

    Citation: Molecular Cancer 2017 16:62

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  16. Content type: Research

    Pancreatic cancer is a highly lethal disease and has the worst prognosis of any major malignancy. G protein-coupled receptor GPR87 is reported to be overexpressed in multiple cancers. The clinical significance...

    Authors: Li Wang, Wei Zhou, Yunfeng Zhong, Yongbao Huo, Ping Fan, Sudong Zhan, Jun Xiao, Xin Jin, Shanmiao Gou, Tao Yin, Heshui Wu and Tao Liu

    Citation: Molecular Cancer 2017 16:61

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  17. Content type: Letter to the Editor

    Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs significantly associated with out...

    Authors: Hua Zhao, Jie Shen, Tiffany R. Hodges, Renduo Song, Gregory N. Fuller and Amy B. Heimberger

    Citation: Molecular Cancer 2017 16:59

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  18. Content type: Review

    A new type of RNAs was identified from genes traditionally thought to express messenger or linear ncRNA (noncoding RNA) only. They were subsequently named as circRNAs (circular RNAs) due to the covalently clos...

    Authors: Jing Liu, Tian Liu, Xiaman Wang and Aili He

    Citation: Molecular Cancer 2017 16:58

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  19. Content type: Research

    The polycomb group protein, BMI1 plays important roles in chromatin modification, stem cell function, DNA damage repair and mitochondrial bioenergetics. Such diverse cellular functions of BMI1 could be, in par...

    Authors: Soumyajit Banerjee Mustafi, Prabir Kumar Chakraborty, Shailendra Kumar Dhar Dwivedi, Kai Ding, Katherine M. Moxley, Priyabrata Mukherjee and Resham Bhattacharya

    Citation: Molecular Cancer 2017 16:56

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  20. Content type: Research

    Many tumor-related factors have shown the ability to affect metabolic pathways by paving the way for cancer-specific metabolic features. Here, we investigate the regulation of mTORC1 by MDM4, a p53-inhibitor w...

    Authors: Francesca Mancini, Emanuela Teveroni, Giusy Di Conza, Valentina Monteleone, Ivan Arisi, Marsha Pellegrino, Marianna Buttarelli, Luisa Pieroni, Mara D’Onofrio, Andrea Urbani, Alfredo Pontecorvi, Massimiliano Mazzone and Fabiola Moretti

    Citation: Molecular Cancer 2017 16:55

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  21. Content type: Research

    Inflammatory breast cancer (IBC), a particularly aggressive form of breast cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted therapies, the identification of molecular mar...

    Authors: Sherif Abdelaziz Ibrahim, Ramy Gadalla, Eslam A. El-Ghonaimy, Omnia Samir, Hossam Taha Mohamed, Hebatallah Hassan, Burkhard Greve, Mohamed El-Shinawi, Mona Mostafa Mohamed and Martin Götte

    Citation: Molecular Cancer 2017 16:57

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  22. Content type: Review

    Gastric cancer (GC) is a common disease with few effective treatment choices and poor prognosis, and has the second-highest mortality rates among all cancers worldwide. Dysregulation and/or malfunction of ion ...

    Authors: Jianling Xia, Hongqiang Wang, Shi Li, Qinghui Wu, Li Sun, Hongxiang Huang and Ming Zeng

    Citation: Molecular Cancer 2017 16:54

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  23. Content type: Research

    Colorectal cancer (CRC) is a major worldwide health problem due to its high prevalence and mortality rate. T-cell intracellular antigen 1 (TIA1) is an important tumor suppressor involved in many aspects of car...

    Authors: Yanqing Liu, Rui Liu, Fei Yang, Rongjie Cheng, Xiaorui Chen, Shufang Cui, Yuanyuan Gu, Wu Sun, Chaoying You, Zhijian Liu, Feng Sun, Yanbo Wang, Zheng Fu, Chao Ye, Chenyu Zhang, Jing Li…

    Citation: Molecular Cancer 2017 16:53

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