Legler JM, Ries LA, Smith MA, Warren JL, Heineman EF, Kaplan RS, Linet MS: Cancer surveillance series [corrected]: brain and other central nervous system cancers: recent trends in incidence and mortality. J Natl Cancer Inst. 1999, 91: 1382-1390.
Article
CAS
PubMed
Google Scholar
Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005, 352: 987-996.
Article
CAS
PubMed
Google Scholar
Goldbrunner RH, Bendszus M, Wood J, Kiderlen M, Sasaki M, Tonn JC: PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization. Neurosurgery. 2004, 55: 426-432.
Article
PubMed
Google Scholar
Szentirmai O, Baker CH, Bullain SS, Lin N, Takahashi M, Folkman J, Mulligan RC, Carter BS: Successful inhibition of intracranial human glioblastoma multiforme xenograft growth via systemic adenoviral delivery of soluble endostatin and soluble vascular endothelial growth factor receptor-2: laboratory investigation. J Neurosurg. 2008, 108: 979-988.
Article
PubMed Central
CAS
PubMed
Google Scholar
Anderson JC, McFarland BC, Gladson CL: New molecular targets in angiogenic vessels of glioblastoma tumours. Expert Rev Mol Med. 2008, 10: e23-
Article
PubMed Central
PubMed
Google Scholar
Stupack DG: The biology of integrins. Oncology (Williston Park). 2007, 21: 6-12.
Google Scholar
Hood JD, Cheresh DA: Role of integrins in cell invasion and migration. Nat Rev Cancer. 2002, 2: 91-100.
Article
PubMed
Google Scholar
Kumar CC: Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis. Curr Drug Targets. 2003, 4: 123-131.
Article
CAS
PubMed
Google Scholar
Gingras MC, Roussel E, Bruner JM, Branch CD, Moser RP: Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue. J Neuroimmunol. 1995, 57: 143-153.
Article
CAS
PubMed
Google Scholar
Gladson CL: Expression of integrin alpha v beta 3 in small blood vessels of glioblastoma tumors. J Neuropathol Exp Neurol. 1996, 55: 1143-1149.
Article
CAS
PubMed
Google Scholar
Dechantsreiter MA, Planker E, Matha B, Lohof E, Holzemann G, Jonczyk A, Goodman SL, Kessler H: N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem. 1999, 42: 3033-3040.
Article
CAS
PubMed
Google Scholar
Burke PA, DeNardo SJ, Miers LA, Lamborn KR, Matzku S, DeNardo GL: Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts. Cancer Res. 2002, 62: 4263-4272.
CAS
PubMed
Google Scholar
MacDonald TJ, Taga T, Shimada H, Tabrizi P, Zlokovic BV, Cheresh DA, Laug WE: Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist. Neurosurgery. 2001, 48: 151-157.
CAS
PubMed
Google Scholar
Bello L, Francolini M, Marthyn P, Zhang J, Carroll RS, Nikas DC, Strasser JF, Villani R, Cheresh DA, Black PM: Alpha(v)beta3 and alpha(v)beta5 integrin expression in glioma periphery. Neurosurgery. 2001, 49: 380-389.
CAS
PubMed
Google Scholar
Paulus W, Baur I, Schuppan D, Roggendorf W: Characterization of integrin receptors in normal and neoplastic human brain. Am J Pathol. 1993, 143: 154-163.
PubMed Central
CAS
PubMed
Google Scholar
Lim M, Guccione S, Haddix T, Sims L, Cheshier S, Chu P, Vogel H, Harsh G: alpha(v)beta(3) Integrin in central nervous system tumors. Hum Pathol. 2005, 36: 665-669.
Article
CAS
PubMed
Google Scholar
Oliveira-Ferrer L, Hauschild J, Fiedler W, Bokemeyer C, Nippgen J, Celik I, Schuch G: Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway. J Exp Clin Cancer Res. 2008, 27: 86-
Article
PubMed Central
PubMed
Google Scholar
Jain RK, Di TE, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT: Angiogenesis in brain tumours. Nat Rev Neurosci. 2007, 8: 610-622.
Article
CAS
PubMed
Google Scholar
Batchelor TT, Sorensen AG, Di TE, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M: AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell. 2007, 11: 83-95.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sudhakar A, Sugimoto H, Yang C, Lively J, Zeisberg M, Kalluri R: Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. Proc Natl Acad Sci U S A. 2003, 100: 4766-4771.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kim YM, Hwang S, Kim YM, Pyun BJ, Kim TY, Lee ST, Gho YS, Kwon YG: Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1. J Biol Chem. 2002, 277: 27872-27879.
Article
CAS
PubMed
Google Scholar
Joki T, Machluf M, Atala A, Zhu J, Seyfried NT, Dunn IF, Abe T, Carroll RS, Black PM: Continuous release of endostatin from microencapsulated engineered cells for tumor therapy. Nat Biotechnol. 2001, 19: 35-39.
Article
CAS
PubMed
Google Scholar
Schuch G, Machluf M, Bartsch G, Nomi M, Richard H, Atala A, Soker S: In vivo administration of vascular endothelial growth factor (VEGF) and its antagonist, soluble neuropilin-1, predicts a role of VEGF in the progression of acute myeloid leukemia in vivo. Blood. 2002, 100: 4622-4628.
Article
CAS
PubMed
Google Scholar
Bartsch G, Eggert K, Soker S, Bokemeyer C, Hautmann R, Schuch G: Combined antiangiogenic therapy is superior to single inhibitors in a model of renal cell carcinoma. J Urol. 2008, 179: 326-332.
Article
CAS
PubMed
Google Scholar
Mariani TJ, Budhraja V, Mecham BH, Gu CC, Watson MA, Sadovsky Y: A variable fold change threshold determines significance for expression microarrays. FASEB J. 2003, 17: 321-323.
CAS
PubMed
Google Scholar
Johnson MP, Thompson SA, Lubaroff DM: Differential effects of prolactin on rat dorsolateral prostate and R3327 prostatic tumor sublines. J Urol. 1985, 133: 1112-1120.
CAS
PubMed
Google Scholar
Manni A, Pontari M, Wright C: Autocrine stimulation by prolactin of hormone-responsive breast cancer growth in culture. Endocrinology. 1985, 117: 2040-2043.
Article
CAS
PubMed
Google Scholar
Brockman JL, Schroeder MD, Schuler LA: PRL activates the cyclin D1 promoter via the Jak2/Stat pathway. Mol Endocrinol. 2002, 16: 774-784.
Article
CAS
PubMed
Google Scholar
Miller KD, Sweeney CJ, Sledge GW: Can tumor angiogenesis be inhibited without resistance?. EXS. 2005, 112: 95-112.
Google Scholar
Kerbel RS, Yu J, Tran J, Man S, Viloria-Petit A, Klement G, Coomber BL, Rak J: Possible mechanisms of acquired resistance to anti-angiogenic drugs: implications for the use of combination therapy approaches. Cancer Metastasis Rev. 2001, 20: 79-86.
Article
CAS
PubMed
Google Scholar
Glade BJ, Cooney EM, Kandel JJ, Yamashiro DJ: Vascular remodeling and clinical resistance to antiangiogenic cancer therapy. Drug Resist Updat. 2004, 7: 289-300.
Article
Google Scholar
Schuch G, Oliveira-Ferrer L, Loges S, Laack E, Bokemeyer C, Hossfeld DK, Fiedler W, Ergun S: Antiangiogenic treatment with endostatin inhibits progression of AML in vivo. Leukemia. 2005, 19: 1312-1317.
Article
CAS
PubMed
Google Scholar
Read TA, Sorensen DR, Mahesparan R, Enger PO, Timpl R, Olsen BR, Hjelstuen MH, Haraldseth O, Bjerkvig R: Local endostatin treatment of gliomas administered by microencapsulated producer cells. Nat Biotechnol. 2001, 19: 29-34.
Article
CAS
PubMed
Google Scholar
Kawaguchi T, Yamashita Y, Kanamori M, Endersby R, Bankiewicz KS, Baker SJ, Bergers G, Pieper RO: The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Cancer Res. 2006, 66: 11331-11340.
Article
CAS
PubMed
Google Scholar
Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006, 444: 756-760.
Article
CAS
PubMed
Google Scholar
Bleau AM, Holland EC: [Chemotherapeutic treatment of gliomas increases the amount of cancer stem-like cells]. Med Sci (Paris). 2009, 25: 775-777.
Article
Google Scholar
Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR, Lu L, Irvin D, Black KL, Yu JS: Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer. 2006, 5: 67-
Article
PubMed Central
PubMed
Google Scholar
Clark PA, Iida M, Treisman DM, Kalluri H, Ezhilan S, Zorniak M, Wheeler DL, Kuo JS: Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibition. Neoplasia. 2012, 14: 420-428.
Article
PubMed Central
CAS
PubMed
Google Scholar
Oakes SR, Robertson FG, Kench JG, Gardiner-Garden M, Wand MP, Green JE, Ormandy CJ: Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions. Oncogene. 2007, 26: 543-553.
Article
CAS
PubMed
Google Scholar
Buckley AR, Putnam CW, Russell DH: Prolactin is a tumor promoter in rat liver. Life Sci. 1985, 37: 2569-2575.
Article
CAS
PubMed
Google Scholar
Janssen T, Darro F, Petein M, Raviv G, Pasteels JL, Kiss R, Schulman CC: In vitro characterization of prolactin-induced effects on proliferation in the neoplastic LNCaP, DU145, and PC3 models of the human prostate. Cancer. 1996, 7: 144-149.
Article
Google Scholar
Beck MT, Chen NY, Franek KJ, Chen WY: Prolactin antagonist-endostatin fusion protein as a targeted dual-functional therapeutic agent for breast cancer. Cancer Res. 2003, 63: 3598-3604.
CAS
PubMed
Google Scholar
DeVito WJ, Stone S, Mori K, Shamgochian M: Ethanol inhibits prolactin- and tumor necrosis factor-alpha-, but not gamma interferon-induced expression of intercellular adhesion molecule-1 in human astrocytoma cells. J Cell Biochem. 2000, 77: 455-464.
Article
CAS
PubMed
Google Scholar
Ciccarelli E, Razzore P, Gaia D, Todaro C, Longo A, Forni M, Ghe C, Camanni F, Muccioli G, Faccani G: Hyperprolactinaemia and prolactin binding in benign intracranial tumours. J Neurosurg Sci. 2001, 45: 70-74.
CAS
PubMed
Google Scholar
Ducret T, Boudina S, Sorin B, Vacher AM, Gourdou I, Liguoro D, Guerin J, Bresson-Bepoldin L, Vacher P: Effects of prolactin on intracellular calcium concentration and cell proliferation in human glioma cells. Glia. 2002, 38: 200-214.
Article
PubMed
Google Scholar
Galbaugh T, Feeney YB, Clevenger CV: Prolactin receptor-integrin cross-talk mediated by SIRPalpha in breast cancer cells. Mol Cancer Res. 2010, 8: 1413-1424.
Article
PubMed Central
CAS
PubMed
Google Scholar
Struman I, Bentzien F, Lee H, Mainfroid V, D'Angelo G, Goffin V, Weiner RI, Martial JA: Opposing actions of intact and N-terminal fragments of the human prolactin/growth hormone family members on angiogenesis: an efficient mechanism for the regulation of angiogenesis. Proc Natl Acad Sci U S A. 1999, 96: 1246-1251.
Article
PubMed Central
CAS
PubMed
Google Scholar
LaPensee EW, Schwemberger SJ, LaPensee CR, Bahassi EM, Afton SE, Ben Jonathan N: Prolactin confers resistance against cisplatin in breast cancer cells by activating glutathione-S-transferase. Carcinogenesis. 2009, 30: 1298-1304.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sai Sato M, Nagashima Y, Miyagi E, Sato K, Ohta I, Vonderhaar BK, Hirahara F: Prolactin inhibits apoptosis of ovarian carcinoma cells induced by serum starvation or cisplatin treatment. Int J Cancer. 2005, 115: 539-544.
Article
Google Scholar
Hansen K, Wagner B, Hamel W, Schweizer M, Haag F, Westphal M, Lamszus K: Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells. J Neurochem. 2007, 103: 259-275.
CAS
PubMed
Google Scholar
Workman P, Aboagye EO, Balkwill F, Balmain A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DA, Glennie MJ, Kelland LR, Robinson V, Stratford IJ, Tozer GM, Watson S, Wedge SR, Eccles SA: Guidelines for the welfare and use of animals in cancer research. Br J Cancer. 2010, 102: 1555-1577.
Article
PubMed Central
CAS
PubMed
Google Scholar
Oliveira Ferrer L, Wellbrock J, Braig M, Klokow M, Hauschild J, Bokemeyer C, Fiedler W, Erguen S, Schuch G: The metabolite 3-hydroxiglutaric acid effectively reduces glioblastoma growth in vivo by affecting the structural integrity of tumor vasculature. Cancer Lett. 2012, 326 (2): 161-167.
Article
CAS
PubMed
Google Scholar