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  1. Cancer-testis (CT) antigen genes might promote the progression of multiple myeloma (MM). CT antigens may act as diagnostic and prognostic markers in MM, but their expression levels and clinical implications in...

    Authors: Yao Zhang, Li Bao, Jin Lu, Kai-Yan Liu, Jin-Lan Li, Ya-Zhen Qin, Huan Chen, Ling-Di Li, Yuan Kong, Hong-Xia Shi, Yue-Yun Lai, Yan-Rong Liu, Bin Jiang, Shan-Shan Chen, Xiao-Jun Huang and Guo-Rui Ruan
    Citation: Molecular Cancer 2014 13:25
    Content type: Research Published on:

  2. ADAM17 is one of the main sheddases of the cells and it is responsible for the cleavage and the release of ectodomains of important signaling molecules, such as EGFR ligands. Despite the known crosstalk betwee...

    Authors: Fernando Moreira Simabuco, Rebeca Kawahara, Sami Yokoo, Daniela C Granato, Lucas Miguel, Michelle Agostini, Annelize ZB Aragão, Romênia R Domingues, Isadora L Flores, Carolina CS Macedo, Ricardo Della Coletta, Edgard Graner and Adriana Franco Paes Leme
    Citation: Molecular Cancer 2014 13:24
    Content type: Research Published on:

  3. Recent studies demonstrated that engagement of sodium glucose transporter 1 (SGLT-1) by orally administered D-glucose protects the intestinal mucosa from lipopolysaccharide (LPS)-induced injury. We tested whet...

    Authors: Diego Cardani, Claudia Sardi, Barbara La Ferla, Giuseppe D’Orazio, Michele Sommariva, Fabrizio Marcucci, Daniela Olivero, Elda Tagliabue, Hermann Koepsell, Francesco Nicotra, Andrea Balsari and Cristiano Rumio
    Citation: Molecular Cancer 2014 13:23
    Content type: Research Published on:

  4. The main cause of death of breast cancer patients is not the primary tumor itself but the metastatic disease. Identifying breast cancer-specific signatures for metastasis and learning more about the nature of ...

    Authors: Irem Gurbuz, Jacqueline Ferralli, Tim Roloff, Ruth Chiquet-Ehrismann and Maria B Asparuhova
    Citation: Molecular Cancer 2014 13:22
    Content type: Research Published on:

  5. Cancer is the result of a multistep process of genomic alterations, including mutations in key regulatory proteins that result in loss of balanced gene expression and subsequent malignant transformation. Throu...

    Authors: Shikha Gaur, Linling Chen, Vincent Ann, Wei-Chen Lin, Yafan Wang, Vincent HS Chang, Nan Yong Hsu, Her-Shuyong Shia and Yun Yen
    Citation: Molecular Cancer 2014 13:21
    Content type: Research Published on:

  6. The transcription factor Nrf2 is a key regulator of the cellular antioxidant response, and its activation by chemoprotective agents has been proposed as a potential strategy to prevent cancer. However, activat...

    Authors: Juan M Funes, Stephen Henderson, Rachel Kaufman, James M Flanagan, Mathew Robson, Barbara Pedley, Salvador Moncada and Chris Boshoff
    Citation: Molecular Cancer 2014 13:20
    Content type: Research Published on:

  8. Interleukin-1β (IL-1β) has been implicated in the progression of gastric adenocarcinoma (GA); however, the molecular mechanisms of action of IL-1β in GA are poorly characterized. P38 and JNK are the major MAPK...

    Authors: Qiaojia Huang, Fenghua Lan, Xiaoting Wang, Yinghao Yu, Xuenong Ouyang, Feng Zheng, Junyong Han, Youdong Lin, Yanchuan Xie, Feilai Xie, Wei Liu, Xiaoli Yang, Han Wang, Lihong Dong, Lie Wang and Jianming Tan
    Citation: Molecular Cancer 2014 13:18
    Content type: Research Published on:

  9. T674I FIP1L1-PDGFRα in a subset of chronic eosinophilic leukemia (CEL) is a gatekeeper mutation that is resistant to many tyrosine kinase inhibitors (TKIs) (e.g., imatinib, nilotinib and dasatinib), similar to...

    Authors: Yanli Jin, Ke Ding, Honglin Li, Mengzhu Xue, Xiaoke Shi, Chengyan Wang and Jingxuan Pan
    Citation: Molecular Cancer 2014 13:17
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2021 20:137

  10. Tumor spreading is the major threat for cancer patients. The recently published anti-cancer drug salinomycin raised hope for an improved treatment by targeting therapy-refractory cancer stem cells. However, an...

    Authors: Florian Kopp, Adam Hermawan, Prajakta Shirish Oak, Annika Herrmann, Ernst Wagner and Andreas Roidl
    Citation: Molecular Cancer 2014 13:16
    Content type: Short communication Published on:

  11. Pancreatic cancer is a lethal disease due to the high incidence of metastasis at the time of detection. CD133 expression in clinical pancreatic cancer correlates with poor prognosis and metastasis. However, th...

    Authors: Qiang Ding, Yumi Miyazaki, Koichiro Tsukasa, Shyuichiro Matsubara, Makoto Yoshimitsu and Sonshin Takao
    Citation: Molecular Cancer 2014 13:15
    Content type: Research Published on:

  12. Deregulated energetics is a property of most cancer cells. This phenomenon, known as the Warburg Effect or aerobic glycolysis, is characterized by increased glucose uptake, lactate export and extracellular aci...

    Authors: Roger A Vaughan, Nicholas P Gannon, Randi Garcia-Smith, Yamhilette Licon-Munoz, Miguel A Barberena, Marco Bisoffi and Kristina A Trujillo
    Citation: Molecular Cancer 2014 13:14
    Content type: Research Published on:

  13. The advent of effective targeted therapeutics has led to increasing emphasis on precise biomarkers for accurate patient stratification. Here, we describe the role of ACK1, a non-receptor tyrosine kinase in abr...

    Authors: Daniel SW Tan, Benjamin Haaland, Jia Min Gan, Su Chin Tham, Indrajit Sinha, Eng Huat Tan, Kiat Hon Lim, Angela Takano, Sai Sakktee Krisna, Minn Minn Myint Thu, Hoe Peng Liew, Axel Ullrich, Wan-Teck Lim and Boon Tin Chua
    Citation: Molecular Cancer 2014 13:13
    Content type: Research Published on:

  14. Although tumor hypoxia poses challenges against conventional cancer treatments, it provides a therapeutic target for hypoxia-activated drugs. Here, we studied the effect of the hypoxia-activated synthetic quin...

    Authors: Khaled Ghattass, Sally El-Sitt, Kazem Zibara, Saide Rayes, Makhluf J Haddadin, Marwan El-Sabban and Hala Gali-Muhtasib
    Citation: Molecular Cancer 2014 13:12
    Content type: Research Published on:

  15. Defects in the DNA mismatch repair (MMR) protein MLH1 are frequently observed in sporadic and hereditary colorectal cancers (CRC). Affected tumors generate much less metastatic potential than the MLH1 proficie...

    Authors: Inga Hinrichsen, Benjamin Philipp Ernst, Franziska Nuber, Sandra Passmann, Dieter Schäfer, Verena Steinke, Nicolaus Friedrichs, Guido Plotz, Stefan Zeuzem and Angela Brieger
    Citation: Molecular Cancer 2014 13:11
    Content type: Research Published on:

  16. Tumor cell migration and metastasis require dynamic rearrangements of the actin cytoskeleton. Interestingly, the F-actin cross-linking and stabilizing protein L-plastin, originally described as a leukocyte spe...

    Authors: Selina M Riplinger, Guido H Wabnitz, Henning Kirchgessner, Beate Jahraus, Felix Lasitschka, Bianca Schulte, Gabri van der Pluijm, Geertje van der Horst, Günter J Hämmerling, Inaam Nakchbandi and Yvonne Samstag
    Citation: Molecular Cancer 2014 13:10
    Content type: Research Published on:

  17. Alternative pre-mRNA splicing (AS) widely expands proteome diversity through the combinatorial assembly of exons. The analysis of AS on a large scale, by using splice-sensitive microarrays, is a highly efficie...

    Authors: Marine Pesson, Béatrice Eymin, Pierre De La Grange, Brigitte Simon and Laurent Corcos
    Citation: Molecular Cancer 2014 13:9
    Content type: Research Published on:

  18. Accumulating evidence suggests a tumor suppressive role for miR-34a in human carcinogenesis. However, its precise biological role remains largely elusive. This study aimed to reveal the association of the miR-...

    Authors: Heng Li, Gan Yu, Runlin Shi, Bin Lang, Xianguo Chen, Ding Xia, Haibing Xiao, Xiaolin Guo, Wei Guan, Zhangqun Ye, Wei Xiao and Hua Xu
    Citation: Molecular Cancer 2014 13:8
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2022 21:155

    The Erratum to this article has been published in Molecular Cancer 2014 13:183

  19. Traditional systemic chemotherapy does not provide survival benefits in patients with hepatocellular carcinoma (HCC). Molecular targeted therapy shows promise for HCC treatment, however, the duration of effect...

    Authors: Jian Kong, Fandong Kong, Jun Gao, Qiangbo Zhang, Shuying Dong, Fang Gu, Shan Ke, Bing Pan, Qiang Shen, Huichuan Sun, Lemin Zheng and Wenbing Sun
    Citation: Molecular Cancer 2014 13:7
    Content type: Research Published on:

  20. MicroRNAs (miRNAs), small noncoding RNA molecules can function as oncogenes or tumor suppressors in tumorigenesis. Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers worldwide with a 5-ye...

    Authors: Yi-Chen Yen, Shine-Gwo Shiah, Hsiao-Chien Chu, Yuan-Ming Hsu, Jenn-Ren Hsiao, Jang-Yang Chang, Wen-Chun Hung, Chun-Ta Liao, Ann-Joy Cheng, Ya-Ching Lu and Ya-Wen Chen
    Citation: Molecular Cancer 2014 13:6
    Content type: Research Published on:

  21. Acute lymphoblastic leukemia (ALL) is the most frequently occurring malignant neoplasm in children. Despite advances in treatment and outcomes for ALL patients, the pathogenesis of the disease remains unclear....

    Authors: Han Zhang, Lin Zhu, Huacheng He, Shanshan Zhu, Wei Zhang, Xiao Liu, Xiaoxi Zhao, Chao Gao, Mei Mei, Shilai Bao and Huyong Zheng
    Citation: Molecular Cancer 2014 13:5
    Content type: Research Published on:

  23. We previously identified that the CpG island-associated promoter of the novel lincRNA ZNF300P1 (also known as LOC134466) is frequently hypermethylated and silenced in ovarian cancer tissues. However, the function...

    Authors: Brian Gloss, Kim Moran-Jones, Vita Lin, Maria Gonzalez, James Scurry, Neville F Hacker, Robert L Sutherland, Susan J Clark and Goli Samimi
    Citation: Molecular Cancer 2014 13:3
    Content type: Research Published on:

  24. To explore whether combining inhibitors that target the insulin-like growth factor receptor (IGFR)/PI3K/Akt/mTOR signaling pathway (vertical blockade) can improve treatment efficacy for hepatocellular carcinom...

    Authors: Da-Liang Ou, Bin-Shyun Lee, Liang-In Lin, Jun-Yang Liou, Sheng-Chieh Liao, Chiun Hsu and Ann-Lii Cheng
    Citation: Molecular Cancer 2014 13:2
    Content type: Research Published on:

  25. Development of resistance to androgen deprivation therapy (ADT) is a major obstacle for the management of advanced prostate cancer. Therapies with androgen receptor (AR) antagonists and androgen withdrawal ini...

    Authors: Richard Ottman, Camha Nguyen, Robert Lorch and Ratna Chakrabarti
    Citation: Molecular Cancer 2014 13:1
    Content type: Research Published on:

  26. The miR-9 family microRNAs have been identified as a tumor suppressor miRNA in cancers. We postulated that miR-9-1, miR-9-2 and miR-9-3 might be inactivated by DNA hypermethylation in chronic lymphocytic leukemia...

    Authors: Lu Qian Wang, Yok Lam Kwong, Chi Shan Bonnie Kho, Kit Fai Wong, Kwan Yeung Wong, Manuela Ferracin, George A Calin and Chor Sang Chim
    Citation: Molecular Cancer 2013 12:173
    Content type: Research Published on:

  27. The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads to Akt phosphorylation at Ser-473, which is important for the carcinogenic effects of excessive sun exposure. The present study investig...

    Authors: Ying Tu, Chao Ji, Bo Yang, Zhi Yang, Hua Gu, Chun-Cheng Lu, Rong Wang, Zhong-Lan Su, Bin Chen, Wei-Ling Sun, Ji-Ping Xia, Zhi-Gang Bi and Li He
    Citation: Molecular Cancer 2013 12:172
    Content type: Research Published on:

  29. Comprehensive sequencing efforts have revealed the genomic landscapes of common forms of human cancer and ~ 140 driver genes have been identified, but not all of them have been extensively investigated. CHD1L (ch...

    Authors: Wen Cheng, Yun Su and Feng Xu
    Citation: Molecular Cancer 2013 12:170
    Content type: Review Published on:

  30. Overexpression of CD98hc (SLC3A2) occurs in a variety of cancers and is suspected to contribute to tumor growth. CD98, a heterodimeric transmembrane protein, physically associates with certain integrin β subun...

    Authors: Marina Poettler, Matthias Unseld, Kira Braemswig, Andrea Haitel, Christoph C Zielinski and Gerald W Prager
    Citation: Molecular Cancer 2013 12:169
    Content type: Research Published on:

  31. Interactions between cancer cells and surrounding cancer-associated fibroblasts (CAFs) play an important role in cancer progression. Invasive ductal carcinoma (IDC) of the pancreas is characterized by abundant...

    Authors: Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Kenji Fujiwara, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Kazuhiro Mizumoto, Masao Tanaka and Yoshinao Oda
    Citation: Molecular Cancer 2013 12:168
    Content type: Research Published on:

  32. The expression of annexin A6 (AnxA6) in AnxA6-deficient non-invasive tumor cells has been shown to terminate epidermal growth factor receptor (EGFR) activation and downstream signaling. However, as a scaffoldi...

    Authors: Rainelli B Koumangoye, Gladys N Nangami, Pamela D Thompson, Vincent K Agboto, Josiah Ochieng and Amos M Sakwe
    Citation: Molecular Cancer 2013 12:167
    Content type: Research Published on:

  33. Cancer is both a systemic and a genetic disease. The pathogenesis of cancer might be related to dampened immunity. Host immunity recognizes nascent malignant cells – a process referred to as immune surveillanc...

    Authors: Mingrong Cheng, Kangkang Zhi, Xiaoyan Gao, Bing He, Yingchun Li, Jiang Han, Zhiping Zhang and Yan Wu
    Citation: Molecular Cancer 2013 12:166
    Content type: Research Published on:

  34. Beyond its possible correlation with stemness of tumor cells, CD133/prominin1 is considered an important marker in breast cancer, since it correlates with tumor size, metastasis and clinical stage of triple-ne...

    Authors: Federica Brugnoli, Silvia Grassilli, Manuela Piazzi, Maria Palomba, Ervin Nika, Alberto Bavelloni, Silvano Capitani and Valeria Bertagnolo
    Citation: Molecular Cancer 2013 12:165
    Content type: Research Published on:

  35. MicroRNA-133b (miR-133b), which is a muscle-specific microRNA, has been reported to be downregulated in human colorectal carcinoma (CRC) when compared to adjacent non-tumor tissue. However, its diagnostic valu...

    Authors: Fang-Ting Duan, Feng Qian, Ke Fang, Kang-Yu Lin, Wen-Tao Wang and Yue-Qin Chen
    Citation: Molecular Cancer 2013 12:164
    Content type: Research Published on:

  36. MicroRNAs (miRNAs) have been documented as playing important roles in cancer development. In this study, we investigated the role of miR-124 in breast cancer and clarified the regulation of flotillin-1 (FLOT1) by...

    Authors: Laisheng Li, Jinmei Luo, Bo Wang, Dong Wang, Xinhua Xie, Linjing Yuan, Jiaoli Guo, Shaoyan Xi, Jie Gao, Xiaoti Lin, Yanan Kong, Xiangdong Xu, Hailing Tang, Xiaoming Xie and Min Liu
    Citation: Molecular Cancer 2013 12:163
    Content type: Research Published on:

  37. Hepatocellular carcinoma (HCC) is a challenging malignancy of global importance, it is the third most common cause of cancer-related mortality worldwide. In the last years the multikinase inhibitor sorafenib h...

    Authors: Alessandro Salvi, Isabel Conde, Edoardo Abeni, Bruna Arici, Ilaria Grossi, Claudia Specchia, Nazario Portolani, Sergio Barlati and Giuseppina De Petro
    Citation: Molecular Cancer 2013 12:162
    Content type: Research Published on:

  38. The mechanisms that can restore biological activity of mutant p53 are an area of high interest given that mutant p53 expression is observed in one third of prostate cancer. Here we demonstrate that Id4, an HLH...

    Authors: Ashley E Knowell, Divya Patel, Derrick J Morton, Pankaj Sharma, Shanora Glymph and Jaideep Chaudhary
    Citation: Molecular Cancer 2013 12:161
    Content type: Research Published on:

  39. The NF-kB family of transcription factors is up-regulated in inflammation and different cancers. Recent data described heterozygous deletions of the NF-kB Inhibitor alpha gene (NFKBIA) in about 20% of glioblastom...

    Authors: Monica Patanè, Paola Porrati, Elisa Bottega, Sara Morosini, Gabriele Cantini, Vita Girgenti, Ambra Rizzo, Marica Eoli, Bianca Pollo, Francesca L Sciacca, Serena Pellegatta and Gaetano Finocchiaro
    Citation: Molecular Cancer 2013 12:160
    Content type: Research Published on:

  40. Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognoses among all cancers. Over the past several decades, investigators have made great advances in the research of PDAC pathogenesis. Important...

    Authors: Ming Quan, Peipei Wang, Jiujie Cui, Yong Gao and Keping Xie
    Citation: Molecular Cancer 2013 12:159
    Content type: Review Published on:

  41. Insights into the mechanisms associated with chemotherapy-resistance are important for implementation of therapeutic strategies and for unraveling the mode of action of chemotherapeutics. Although cidofovir (C...

    Authors: Tim De Schutter, Graciela Andrei, Dimitri Topalis, Sophie Duraffour, Tania Mitera, Joost van den Oord, Patrick Matthys and Robert Snoeck
    Citation: Molecular Cancer 2013 12:158
    Content type: Research Published on:

  42. Recently several reports have indicated that elevated expression of DKK1 is tightly associated with the progression of hepatocellular carcinoma (HCC). However, the biological function of DKK1 in HCC has not ye...

    Authors: Liang Chen, Ming Li, Qian Li, Chao-jie Wang and Song-qiang Xie
    Citation: Molecular Cancer 2013 12:157
    Content type: Research Published on:

  44. We previously identified TrkB as an oncogene involved in promoting metastasis in endometrial carcinoma (EC). Here, we sought to delineate the effect of changes in TrkB expression on the global profile of micro...

    Authors: Wei Bao, Hui-Hui Wang, Fu-Ju Tian, Xiao-Ying He, Mei-Ting Qiu, Jing-Yun Wang, Hui-Juan Zhang, Li-Hua Wang and Xiao-Ping Wan
    Citation: Molecular Cancer 2013 12:155
    Content type: Research Published on:

  45. Tumor cells produce various cytokines and chemokines that attract leukocytes. Leukocytes can amplify parenchymal innate immune responses, and have been shown to contribute to tumor promotion. Neutrophils are a...

    Authors: Lei Gong, Amber M Cumpian, Mauricio S Caetano, Cesar E Ochoa, Maria Miguelina De la Garza, Daniel J Lapid, Seyedeh Golsar Mirabolfathinejad, Burton F Dickey, Qinghua Zhou and Seyed Javad Moghaddam
    Citation: Molecular Cancer 2013 12:154
    Content type: Research Published on:

  46. Secondary lymphoid tissue chemokine (SLC) is a key CC chemokine for chemotaxis of immune cells and has been an attractive candidate for anti-tumor treatments. However, among the immune cells recruited by SLC t...

    Authors: Long Chen, Shuang Zhou, Jie Qin, Heng Hu, Huiying Ma, Binbin Liu, Xuan Wang, Jiaqi Ma, Shenglong Ye, Cuiping Zhong, Guomin Zhou and Chunmin Liang
    Citation: Molecular Cancer 2013 12:153
    Content type: Research Published on:

  48. In our previous study using oligonucleotide microarrays, we revealed that transglutaminase 3 (TGM3) was remarkably down-regulated in head and neck cancer (HNC). However, the potential of TGM3 as a useful bioma...

    Authors: Xiangbing Wu, Wei Cao, Xu Wang, Jianjun Zhang, Zhongjing Lv, Xing Qin, Yadi Wu and Wantao Chen
    Citation: Molecular Cancer 2013 12:151
    Content type: Research Published on:

  50. Tumor invasion and metastasis are the major reasons for leading death of patients with hepatocellular carcinoma (HCC). Therefore, to identify molecules that can suppress invasion and metastasis of tumor will p...

    Authors: Xuelei Cao, Li Zhang, Yongyu Shi, Yue Sun, Shen Dai, Chun Guo, Faliang Zhu, Qun wang, Jianing Wang, Xiaoyan Wang, Youhai H Chen and Lining Zhang
    Citation: Molecular Cancer 2013 12:149
    Content type: Research Published on:
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Molecular Cancer

ISSN: 1476-4598