Skip to main content

Articles

Page 42 of 66

  1. The human genome encodes thousands of unique long non-coding RNAs (lncRNAs), and these transcripts are emerging as critical regulators of gene expression and cell fate. However, the transcriptional regulation ...

    Authors: Orit Feldstein, Tal Nizri, Tirza Doniger, Jasmine Jacob, Gideon Rechavi and Doron Ginsberg
    Citation: Molecular Cancer 2013 12:131
  2. The microRNA 125b is a double-faced gene expression regulator described both as a tumor suppressor gene (in solid tumors) and an oncogene (in hematologic malignancies). In human breast cancer, it is one of the...

    Authors: Manuela Ferracin, Cristian Bassi, Massimo Pedriali, Sara Pagotto, Lucilla D’Abundo, Barbara Zagatti, Fabio Corrà, Gentian Musa, Elisa Callegari, Laura Lupini, Stefano Volpato, Patrizia Querzoli and Massimo Negrini
    Citation: Molecular Cancer 2013 12:130
  3. Bone morphogenetic proteins (BMP) are embryonic morphogens that are aberrantly expressed in lung cancer. BMPs mediate cell fate decisions and self-renewal of stem cells, through transcription regulation of inh...

    Authors: Elaine Langenfeld, Malik Deen, Emmanuel Zachariah and John Langenfeld
    Citation: Molecular Cancer 2013 12:129
  4. Nasopharyngeal carcinoma (NPC) is an epithelial malignancy strongly associated with Epstein-Barr virus (EBV). AT13387 is a novel heat shock protein 90 (Hsp90) inhibitor, which inhibits the chaperone function o...

    Authors: King Chi Chan, Choi Man Ting, Pui Shan Chan, Ming Chu Lo, Kwok Wai Lo, Jayne E Curry, Tomoko Smyth, Anne Wing Mui Lee, Wai Tong Ng, George Sai Wah Tsao, Ricky Ngok Shun Wong, Maria Li Lung and Nai Ki Mak
    Citation: Molecular Cancer 2013 12:128
  5. Malignant tumors of the central nervous system (CNS) are the 10th most frequent cause of cancer mortality. Despite the strong malignancy of some such tumors, oncogenic mutations are rarely found in classic member...

    Authors: Sylvia Gutierrez-Erlandsson, Pedro Herrero-Vidal, Marcos Fernandez-Alfara, Susana Hernandez-Garcia, Sandra Gonzalo-Flores, Alberto Mudarra-Rubio, Manuel Fresno and Beatriz Cubelos
    Citation: Molecular Cancer 2013 12:127
  6. Colon cancer stem cells are shown to be the self-renewing cells within a tumor that give rise to all lineages of more differentiated tumor cells. In this respect they are remarkably similar to their non-malign...

    Authors: Pramudita Ramadhina Prasetyanti, Cheryl Doreen Zimberlin, Michael Bots, Louis Vermeulen, Felipe De Sousa E Melo and Jan Paul Medema
    Citation: Molecular Cancer 2013 12:126
  7. The lung squamous cell carcinoma survival rate is very poor despite multimodal treatment. It is urgent to discover novel candidate biomarkers for prognostic assessment and therapeutic targets to lung squamous ...

    Authors: Fengming Gong, Xingchen Peng, Can Luo, Guobo Shen, Chengjian Zhao, Liqun Zou, Longhao Li, Yaxiong Sang, Yuwei Zhao and Xia Zhao
    Citation: Molecular Cancer 2013 12:125
  8. Reactive oxygen species contribute to normal thyroid function. The NRF2 oxidative response pathway is frequently and constitutively activated in multiple tumor types, including papillary thyroid carcinoma (PTC...

    Authors: Victor D Martinez, Emily A Vucic, Larissa A Pikor, Kelsie L Thu, Roland Hubaux and Wan L Lam
    Citation: Molecular Cancer 2013 12:124
  9. MiRNAs play important roles in diverse biological processes including tumorigenesis. However, little is known about the function and mechanism of miR-451 in nasopharyngeal carcinoma (NPC).

    Authors: Na Liu, Ning Jiang, Rui Guo, Wei Jiang, Qing-Mei He, Ya-Fei Xu, Ying-Qin Li, Ling-Long Tang, Yan-Ping Mao, Ying Sun and Jun Ma
    Citation: Molecular Cancer 2013 12:123
  10. The hypoxic environment of tumor region stimulated the up regulation of growth factors responsible for angiogenesis and tumor proliferation. Thus, targeting the tumor vasculature along with the proliferation b...

    Authors: Siddik Sarkar, Shashi Rajput, Amit Kumar Tripathi and Mahitosh Mandal
    Citation: Molecular Cancer 2013 12:122
  11. Rectal cancer is one of the most prevalent tumor types. Understanding the metabolic profile of rectal cancer is important for developing therapeutic approaches and molecular diagnosis.

    Authors: Huijuan Wang, Liang Wang, Hailong Zhang, Pengchi Deng, Jie Chen, Bin Zhou, Jing Hu, Jun Zou, Wenjie Lu, Pu Xiang, Tianming Wu, Xiaoni Shao, Yuan Li, Zongguang Zhou and Ying-Lan Zhao
    Citation: Molecular Cancer 2013 12:121
  12. Overexpression of Decoy Receptor 3 (DcR3), a soluble member of the tumor necrosis factor receptor superfamily, is a common event in several types of cancer. In renal cell carcinoma (RCC), DcR3 overexpression i...

    Authors: Daniel Weissinger, Katrin E Tagscherer, Stephan Macher-Göppinger, Axel Haferkamp, Nina Wagener and Wilfried Roth
    Citation: Molecular Cancer 2013 12:120
  13. microRNAs have been shown to regulate the chemosensitivity of cancer cells. The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP...

    Authors: Ning Wang, Meifen Zhu, Sai-Wah Tsao, Kwan Man, Zhangjin Zhang and Yibin Feng
    Citation: Molecular Cancer 2013 12:119
  14. Extracellular vesicle (EV) trafficking is a fundamental cellular process that occurs in cells and is required for different aspects of pathophysiology. EV trafficking leads to changes in cellular function incl...

    Authors: Kiriaki Panagopoulos, Sam Cross-Knorr, Christen Dillard, Dionysios Pantazatos, Michael Del Tatto, David Mills, Lisa Goldstein, Joseph Renzulli, Peter Quesenberry and Devasis Chatterjee
    Citation: Molecular Cancer 2013 12:118
  15. Wnt/β-catenin signaling is a highly conserved pathway in organism evolution and is important in many biological processes. Overactivation of Wnt/β-catenin signaling is closely related to tumor development and ...

    Authors: Zhao Yan, Zhongling Zhu, Jinghui Wang, Jian Sun, Yihui Chen, Guang Yang, Wenting Chen and Yuheng Deng
    Citation: Molecular Cancer 2013 12:116
  16. CD164 (endolyn), a sialomucin, has been reported to play a role in the proliferation, adhesion, and differentiation of hematopoietic stem cells. The potential association of CD164 with tumorigenicity remains u...

    Authors: Ai-Fang Huang, Min-Wei Chen, Shih-Ming Huang, Chu-Lien Kao, Hung-Cheng Lai and James Yi-Hsin Chan
    Citation: Molecular Cancer 2013 12:115
  17. Gankyrin has shown to be overexpressed in human liver cancers and plays a complex role in hepatocarcinogenesis. Panobinostat (LBH589), a new hydroxamic acid-derived histone deacetylase inhibitor has shown prom...

    Authors: Xuan Song, Jiabei Wang, Tongsen Zheng, Ruipeng Song, Yingjian Liang, Nishant Bhatta, Dalong Yin, Shangha Pan, Jiaren Liu, Hongchi Jiang and Lianxin Liu
    Citation: Molecular Cancer 2013 12:114
  18. The members of MRE11/RAD50/NBN (MRN) protein complex participates in DNA double-strand break repair and DNA-damage checkpoint activation. We have previously shown that the p.I171V NBN gene mutation may contribute...

    Authors: Iwona Ziółkowska-Suchanek, Maria Mosor, Małgorzata Wierzbicka, Małgorzata Rydzanicz, Marta Baranowska and Jerzy Nowak
    Citation: Molecular Cancer 2013 12:113
  19. The cellular and molecular mechanisms that mediate interactions between tumour cells and the surrounding bone stroma are to date largely undetermined in prostate cancer (PCa) progression. The purpose of this s...

    Authors: Louisa CE Windus, Tristan T Glover and Vicky M Avery
    Citation: Molecular Cancer 2013 12:112

    The Erratum to this article has been published in Molecular Cancer 2014 13:188

  20. Alterations in lipid metabolism are inherent to the metabolic transformations that support tumorigenesis. The relationship between the synthesis, storage and use of lipids and their importance in cancer is poo...

    Authors: Anja Pucer, Vesna Brglez, Christine Payré, Jože Pungerčar, Gérard Lambeau and Toni Petan
    Citation: Molecular Cancer 2013 12:111
  21. Increasing evidence suggests that cancer is a metabolic disease. Here, we investigated the potential role of fructose-1,6-bisphosphatase-2 (FBP2), the enzyme that catalyses the hydrolysis of fructose-1,6-bisph...

    Authors: He Li, Juan Wang, Huiyu Xu, Rui Xing, Yuanming Pan, Wenmei Li, Jiantao Cui, Hongbing Zhang and Youyong Lu
    Citation: Molecular Cancer 2013 12:110
  22. The survival rate of head and neck squamous cell carcinoma (HNSCC) at advanced stage is poor, despite contemporary advances in treatment modalities. Recent studies have indicated that astrocyte elevated gene-1...

    Authors: Yi-Ping Wang, I-Ju Liu, Chiung-Pin Chiang and Han-Chung Wu
    Citation: Molecular Cancer 2013 12:109
  23. One of the striking characteristics of cancer cells is their phenotypic diversity and ability to switch phenotypes in response to environmental fluctuations. Such phenotypic changes (e.g. from drug-sensitive t...

    Authors: Prakash Kulkarni, Takumi Shiraishi and Rahul V Kulkarni
    Citation: Molecular Cancer 2013 12:108
  24. Epithelial-mesenchymal transition (EMT) is a key process in embryonic development and metastases formation during malignant progression. This review focuses on transcriptional regulation, non-coding RNAs, alte...

    Authors: Timur R Samatov, Alexander G Tonevitsky and Udo Schumacher
    Citation: Molecular Cancer 2013 12:107
  25. Pancreatic cancer is one of the most lethal human malignancies, with an all-stage 5-year survival of <5%, mainly due to lack of effective available therapies. Cancer cell survival is dependent upon up-regulati...

    Authors: Zhiyu Chen, Veena Sangwan, Sulagna Banerjee, Tiffany Mackenzie, Vikas Dudeja, Xiaowu Li, Huaizhi Wang, Selwyn M Vickers and Ashok K Saluja
    Citation: Molecular Cancer 2013 12:105
  26. Among the solid tumors, human pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis. Gemcitabine is the standard first line of therapy for pancreatic cancer but has limited efficacy due to inherent o...

    Authors: Kolaparthi Venkatasubbarao, Lindsay Peterson, Shujie Zhao, Ping Hill, Lin Cao, Qing Zhou, Steffan T Nawrocki and James W Freeman
    Citation: Molecular Cancer 2013 12:104
  27. Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells via tumor vasculature targ...

    Authors: David L Bartlett, Zuqiang Liu, Magesh Sathaiah, Roshni Ravindranathan, Zongbi Guo, Yukai He and Zong Sheng Guo
    Citation: Molecular Cancer 2013 12:103
  28. MTA2 gene belongs to metastasis associated family, and is highly expressed in some solid tumors, including gastric cancer. Its biological function in gastric cancer is currently undefined.

    Authors: Chenfei Zhou, Jun Ji, Qu Cai, Min Shi, Xuehua Chen, Yingyan Yu, Bingya Liu, Zhenggang Zhu and Jun Zhang
    Citation: Molecular Cancer 2013 12:102
  29. DNA topoisomerases are key enzymes that modulate the topological state of DNA through the breaking and rejoining of DNA strands. Human topoisomerase IB can be inhibited by several compounds that act through di...

    Authors: Cinzia Tesauro, Blasco Morozzo della Rocca, Alessio Ottaviani, Andrea Coletta, Laura Zuccaro, Barbara Arnò, Ilda D'Annessa, Paola Fiorani and Alessandro Desideri
    Citation: Molecular Cancer 2013 12:100
  30. Hypermethylation of the promoter of the tumor suppressor gene RASSF1A silences its expression and has been found to be associated with advanced grade prostatic tumors. The DNA methyltransferase (DNMT) family of e...

    Authors: Soumik Agarwal, Karishma S Amin, Shankar Jagadeesh, Gokul Baishay, Paruchuri G Rao, Nabin C Barua, Samir Bhattacharya and Partha P Banerjee
    Citation: Molecular Cancer 2013 12:99
  31. Inflammation and cancer have a profound yet ambiguous relationship. Inflammation - especially chronic inflammation - has protumorigenic effects, but inflammatory cells also mediate an immune response against t...

    Authors: Rudi Beyaert, Laurent Beaugerie, Gert Van Assche, Lieve Brochez, Jean-Christophe Renauld, Manuelle Viguier, Veronique Cocquyt, Guy Jerusalem, Jean-Pascal Machiels, Hans Prenen, Pierre Masson, Edouard Louis and Filip De Keyser
    Citation: Molecular Cancer 2013 12:98
  32. Glycolysis in presence of oxygen with high glucose consumption is known to be the metabolism of choice in many tumors. In lung cancer this phenomenon is routinely exploited in diagnostic PET imaging of fluorod...

    Authors: Roberto Puzone, Graziana Savarino, Sandra Salvi, Maria Giovanna Dal Bello, Giulia Barletta, Carlo Genova, Erika Rijavec, Claudio Sini, Alessia Isabella Esposito, Giovanni Battista Ratto, Mauro Truini, Francesco Grossi and Ulrich Pfeffer
    Citation: Molecular Cancer 2013 12:97
  33. PCAF is an important intrinsic histone acetyltransferases. This study tried to establish the effect of PCAF on HCC cell apoptosis.

    Authors: Xin Zheng, Xiaohong Gai, Feihu Ding, Zhongtang Lu, Kangsheng Tu, Yingmin Yao and Qingguang Liu
    Citation: Molecular Cancer 2013 12:96

    The Correction to this article has been published in Molecular Cancer 2022 21:187

  34. Centromere protein-F (CENP-F) is a large nuclear protein of 367 kDa, which is involved in multiple mitosis-related events such as proper assembly of the kinetochores, stabilization of heterochromatin, chromoso...

    Authors: Simon Welner, Nicole Hartwig Trier, Morten Frisch, Henning Locht, Paul Robert Hansen and Gunnar Houen
    Citation: Molecular Cancer 2013 12:95
  35. Ionizing radiation (IR) is used for patients diagnosed with unresectable non small cell lung cancer (NSCLC), however radiotherapy remains largely palliative due to radioresistance. Cancer stem cells (CSCs), as...

    Authors: Roberto Gomez-Casal, Chitralekha Bhattacharya, Nandita Ganesh, Lisa Bailey, Per Basse, Michael Gibson, Michael Epperly and Vera Levina
    Citation: Molecular Cancer 2013 12:94
  36. Abnormal rates of growth together with metastatic potential and lack of susceptibility to cellular signals leading to apoptosis are widely investigated characteristics of tumors that develop via genetic or epi...

    Authors: Joanna Obacz, Silvia Pastorekova, Borek Vojtesek and Roman Hrstka
    Citation: Molecular Cancer 2013 12:93
  37. In eukaryotes, miR-16 is an important microRNA (miRNA) that is involved in numerous biological processes. However, it is not fully understood how miR-16 executes its physiological functions. In the present stu...

    Authors: Xin Yan, Hongwei Liang, Ting Deng, Kegan Zhu, Suyang Zhang, Nan Wang, Xueyuan Jiang, Xueliang Wang, Rui Liu, Ke Zen, Chen-Yu Zhang, Yi Ba and Xi Chen
    Citation: Molecular Cancer 2013 12:92
  38. Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis, and the enzymes that participate in this process, in particular E3 ubiquitin ligases and deubiquitinases (DUBs),...

    Authors: Iraia García-Santisteban, Godefridus J Peters, Elisa Giovannetti and Jose Antonio Rodríguez
    Citation: Molecular Cancer 2013 12:91
  39. Recent epidemiological studies demonstrate that both active and involuntary exposure to tobacco smoke increase the risk of breast cancer. Little is known, however, about the molecular mechanisms by which conti...

    Authors: Francescopaolo Di Cello, V Lynn Flowers, Huili Li, Briana Vecchio-Pagán, Brent Gordon, Kirsten Harbom, James Shin, Robert Beaty, Wei Wang, Cory Brayton, Stephen B Baylin and Cynthia A Zahnow
    Citation: Molecular Cancer 2013 12:90
  40. Farnesyltransferase inhibitors (FTIs) are anticancer agents with a spectrum of activity in Ras-dependent and independent tumor cellular and xenograph models. How inhibition of protein farnesylation by FTIs res...

    Authors: Giampiero Porcu, Ainslie B Parsons, Daniele Di Giandomenico, Giuseppe Lucisano, Maria Giovanna Mosca, Charles Boone and Antonella Ragnini-Wilson
    Citation: Molecular Cancer 2013 12:88
  41. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with high mutational heterogeneity and a generally poor clinical outcome. Despite implicated roles of deregulated TP53, IGF-2 and Wnt signaling pat...

    Authors: Reju Korah, James M Healy, John W Kunstman, Annabelle L Fonseca, Amir H Ameri, Manju L Prasad and Tobias Carling
    Citation: Molecular Cancer 2013 12:87
  42. The NF-κB family of transcription factors has an essential role in inflammation and innate immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of cancer initiation and pro...

    Authors: Bastian Hoesel and Johannes A Schmid
    Citation: Molecular Cancer 2013 12:86
  43. The chemokine CXCL12, also known as SDF-1, and its receptor, CXCR4, are overexpressed in prostate cancers and in animal models of prostate-specific PTEN deletion, but their regulation is poorly understood. Los...

    Authors: M Katie Conley-LaComb, Allen Saliganan, Pridvi Kandagatla, Yong Q Chen, Michael L Cher and Sreenivasa R Chinni
    Citation: Molecular Cancer 2013 12:85
  44. Due to frequent mutations in certain cancers, FGFR3 gene is considered as an oncogene. However, in some normal tissues, FGFR3 can limit cell growth and promote cell differentiation. Thus, FGFR3 action appears par...

    Authors: Marie Lafitte, Isabelle Moranvillier, Stéphane Garcia, Evelyne Peuchant, Juan Iovanna, Benoit Rousseau, Pierre Dubus, Véronique Guyonnet-Dupérat, Geneviève Belleannée, Jeanne Ramos, Aurélie Bedel, Hubert de Verneuil, François Moreau-Gaudry and Sandrine Dabernat
    Citation: Molecular Cancer 2013 12:83
  45. Anti-angiogenesis targeting VEGFR2 has been considered as an important strategy for cancer therapy. Tylophorine is known to possess anti-inflammatory and antitumor activity, but its roles in tumor angiogenesis...

    Authors: Sarita Saraswati, Pawan K Kanaujia, Shakti Kumar, Ranjeet Kumar and Abdulqader A Alhaider
    Citation: Molecular Cancer 2013 12:82

Annual Journal Metrics

  • 2022 Citation Impact
    37.3 - 2-year Impact Factor
    33.1 - 5-year Impact Factor
    5.740 - SNIP (Source Normalized Impact per Paper)
    8.703 - SJR (SCImago Journal Rank)

    2023 Speed
    5 days submission to first editorial decision for all manuscripts (Median)
    91 days submission to accept (Median)

    2023 Usage 
    3,569,666 downloads
    2,070 Altmetric mentions