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  1. PIN2/TRF1-interacting telomerase inhibitor1 (PinX1) was recently suggested as a putative tumor suppressor in several types of human cancer, based on its binding to and inhibition of telomerase. Moreover, loss ...

    Authors: Jian-Ye Liu, Dong Qian, Li-Ru He, Yong-Hong Li, Yi-Ji Liao, Shi-Juan Mai, Xiao-Peng Tian, Yan-Hui Liu, Jia-Xing Zhang, Hsiang-Fu Kung, Yi-Xin Zeng, Fang-Jian Zhou and Dan Xie
    Citation: Molecular Cancer 2013 12:148
  2. VEGF receptor 2 (VEGFR2) inhibitors, as efficient antiangiogenesis agents, have been applied in the cancer treatment. However, recently, most of these anticancer drugs have some adverse effects. Discovery of n...

    Authors: Sarita Saraswati, Shakti Kumar and Abdulqader A Alhaider
    Citation: Molecular Cancer 2013 12:147
  3. The novel Akt inhibitor, API-1, induces apoptosis through undefined mechanisms. The current study focuses on revealing the mechanisms by which API-1 induces apoptosis.

    Authors: Hui Ren, Junghui Koo, Baoxiang Guan, Ping Yue, Xingming Deng, Mingwei Chen, Fadlo R Khuri and Shi-Yong Sun
    Citation: Molecular Cancer 2013 12:146
  4. Mitochondria are suggested to be important organelles for cancer initiation and promotion. This study was designed to evaluate the prognostic value of MTC02, a marker for mitochondrial content, in prostate can...

    Authors: Katharina Grupp, Karolina Jedrzejewska, Maria Christina Tsourlakis, Christina Koop, Waldemar Wilczak, Meike Adam, Alexander Quaas, Guido Sauter, Ronald Simon, Jakob Robert Izbicki, Markus Graefen, Hartwig Huland, Thorsten Schlomm, Sarah Minner and Stefan Steurer
    Citation: Molecular Cancer 2013 12:145
  5. Tumors may develop resistance to specific angiogenic inhibitors via activation of alternative pathways. Therefore, multiple angiogenic pathways should be targeted to achieve significant angiogenic blockade. In...

    Authors: Leticia Oliveira-Ferrer, Jasmin Wellbrock, Udo Bartsch, Eva Maria Murga Penas, Jessica Hauschild, Marianne Klokow, Carsten Bokemeyer, Walter Fiedler and Gunter Schuch
    Citation: Molecular Cancer 2013 12:144
  6. PAM4, an antibody that has high specificity for pancreatic ductal adenocarcinoma (PDAC), compared to normal pancreas, benign lesions of the pancreas, and cancers originating from other tissues, is being invest...

    Authors: David V Gold, Guy Newsome, Donglin Liu and David M Goldenberg
    Citation: Molecular Cancer 2013 12:143
  7. JAK-STAT signaling through the JAK2V617F mutation is central to the pathogenesis of myeloproliferative neoplasms (MPN). However, other events could precede the JAK2 mutation. The aim of this study is to analyze t...

    Authors: Miguel Gallardo, Santiago Barrio, Marisol Fernandez, Alberto Paradela, Alicia Arenas, Oscar Toldos, Rosa Ayala, Enriqueta Albizua, Ana Jimenez, Santiago Redondo, Rosa Maria Garcia-Martin, Florinda Gilsanz, Juan Pablo Albar and Joaquin Martinez-Lopez
    Citation: Molecular Cancer 2013 12:142
  8. Intronic and intergenic long noncoding RNAs (lncRNAs) are emerging gene expression regulators. The molecular pathogenesis of renal cell carcinoma (RCC) is still poorly understood, and in particular, limited st...

    Authors: Angela A Fachel, Ana C Tahira, Santiago A Vilella-Arias, Vinicius Maracaja-Coutinho, Etel RP Gimba, Giselle M Vignal, Franz S Campos, Eduardo M Reis and Sergio Verjovski-Almeida
    Citation: Molecular Cancer 2013 12:140
  9. Stem or progenitor cells from healthy tissues have the capacity to co-segregate their template DNA strands during mitosis. Here, we set out to test whether breast cancer cell lines also possess the ability to ...

    Authors: Wenyu Liu, Gajan Jeganathan, Sohrab Amiri, Katherine M Morgan, Bríd M Ryan and Sharon R Pine
    Citation: Molecular Cancer 2013 12:139
  10. The activity of P-glycoprotein (Pgp) and multidrug resistance related protein 1 (MRP1), two membrane transporters involved in multidrug resistance of colon cancer, is increased by high amounts of cholesterol i...

    Authors: Giada Gelsomino, Paola A Corsetto, Ivana Campia, Gigliola Montorfano, Joanna Kopecka, Barbara Castella, Elena Gazzano, Dario Ghigo, Angela M Rizzo and Chiara Riganti
    Citation: Molecular Cancer 2013 12:137
  11. 6-Shogaol is a promising antitumor agent isolated from dietary ginger (Zingiber officinale). However, little is known about the efficacy of 6-shogaol on leukemia cells. Here we investigated the underlying mechani...

    Authors: Qun Liu, Yong-Bo Peng, Ping Zhou, Lian-Wen Qi, Mu Zhang, Ning Gao, E-Hu Liu and Ping Li
    Citation: Molecular Cancer 2013 12:135
  12. Elevated expression of erbB3 receptor has been reported to induce resistance to therapeutic agents, including trastuzumab in erbB2-overexpressing breast cancer. Our recent studies indicate that erbB3 interacts...

    Authors: Jingcao Huang, Shuiliang Wang, Hui Lyu, Bo Cai, XiaoHe Yang, Jianxiang Wang and Bolin Liu
    Citation: Molecular Cancer 2013 12:134
  13. Kinases downstream of growth factor receptors have been implicated in radioresistance and are, therefore, attractive targets to improve radiotherapy outcome in head and neck squamous cell carcinoma (HNSCC) pat...

    Authors: Hanneke Stegeman, Johannes HAM Kaanders, Marieke MG Verheijen, Wenny JM Peeters, Deric L Wheeler, Mari Iida, Reidar Grénman, Albert J van der Kogel, Paul N Span and Johan Bussink
    Citation: Molecular Cancer 2013 12:133
  14. Basal-like breast cancer is a heterogeneous disease characterized by the expression of basal cell markers, no estrogen or progesterone receptor expression and a lack of HER2 ov erexpression. Recent studies hav...

    Authors: Mejdi Moumen, Aurélie Chiche, Charles Decraene, Valérie Petit, Alberto Gandarillas, Marie-Ange Deugnier, Marina A Glukhova and Marisa M Faraldo
    Citation: Molecular Cancer 2013 12:132
  15. The human genome encodes thousands of unique long non-coding RNAs (lncRNAs), and these transcripts are emerging as critical regulators of gene expression and cell fate. However, the transcriptional regulation ...

    Authors: Orit Feldstein, Tal Nizri, Tirza Doniger, Jasmine Jacob, Gideon Rechavi and Doron Ginsberg
    Citation: Molecular Cancer 2013 12:131
  16. The microRNA 125b is a double-faced gene expression regulator described both as a tumor suppressor gene (in solid tumors) and an oncogene (in hematologic malignancies). In human breast cancer, it is one of the...

    Authors: Manuela Ferracin, Cristian Bassi, Massimo Pedriali, Sara Pagotto, Lucilla D’Abundo, Barbara Zagatti, Fabio Corrà, Gentian Musa, Elisa Callegari, Laura Lupini, Stefano Volpato, Patrizia Querzoli and Massimo Negrini
    Citation: Molecular Cancer 2013 12:130
  17. Bone morphogenetic proteins (BMP) are embryonic morphogens that are aberrantly expressed in lung cancer. BMPs mediate cell fate decisions and self-renewal of stem cells, through transcription regulation of inh...

    Authors: Elaine Langenfeld, Malik Deen, Emmanuel Zachariah and John Langenfeld
    Citation: Molecular Cancer 2013 12:129
  18. Nasopharyngeal carcinoma (NPC) is an epithelial malignancy strongly associated with Epstein-Barr virus (EBV). AT13387 is a novel heat shock protein 90 (Hsp90) inhibitor, which inhibits the chaperone function o...

    Authors: King Chi Chan, Choi Man Ting, Pui Shan Chan, Ming Chu Lo, Kwok Wai Lo, Jayne E Curry, Tomoko Smyth, Anne Wing Mui Lee, Wai Tong Ng, George Sai Wah Tsao, Ricky Ngok Shun Wong, Maria Li Lung and Nai Ki Mak
    Citation: Molecular Cancer 2013 12:128
  19. Malignant tumors of the central nervous system (CNS) are the 10th most frequent cause of cancer mortality. Despite the strong malignancy of some such tumors, oncogenic mutations are rarely found in classic member...

    Authors: Sylvia Gutierrez-Erlandsson, Pedro Herrero-Vidal, Marcos Fernandez-Alfara, Susana Hernandez-Garcia, Sandra Gonzalo-Flores, Alberto Mudarra-Rubio, Manuel Fresno and Beatriz Cubelos
    Citation: Molecular Cancer 2013 12:127
  20. Colon cancer stem cells are shown to be the self-renewing cells within a tumor that give rise to all lineages of more differentiated tumor cells. In this respect they are remarkably similar to their non-malign...

    Authors: Pramudita Ramadhina Prasetyanti, Cheryl Doreen Zimberlin, Michael Bots, Louis Vermeulen, Felipe De Sousa E Melo and Jan Paul Medema
    Citation: Molecular Cancer 2013 12:126
  21. The lung squamous cell carcinoma survival rate is very poor despite multimodal treatment. It is urgent to discover novel candidate biomarkers for prognostic assessment and therapeutic targets to lung squamous ...

    Authors: Fengming Gong, Xingchen Peng, Can Luo, Guobo Shen, Chengjian Zhao, Liqun Zou, Longhao Li, Yaxiong Sang, Yuwei Zhao and Xia Zhao
    Citation: Molecular Cancer 2013 12:125
  22. Reactive oxygen species contribute to normal thyroid function. The NRF2 oxidative response pathway is frequently and constitutively activated in multiple tumor types, including papillary thyroid carcinoma (PTC...

    Authors: Victor D Martinez, Emily A Vucic, Larissa A Pikor, Kelsie L Thu, Roland Hubaux and Wan L Lam
    Citation: Molecular Cancer 2013 12:124
  23. MiRNAs play important roles in diverse biological processes including tumorigenesis. However, little is known about the function and mechanism of miR-451 in nasopharyngeal carcinoma (NPC).

    Authors: Na Liu, Ning Jiang, Rui Guo, Wei Jiang, Qing-Mei He, Ya-Fei Xu, Ying-Qin Li, Ling-Long Tang, Yan-Ping Mao, Ying Sun and Jun Ma
    Citation: Molecular Cancer 2013 12:123
  24. The hypoxic environment of tumor region stimulated the up regulation of growth factors responsible for angiogenesis and tumor proliferation. Thus, targeting the tumor vasculature along with the proliferation b...

    Authors: Siddik Sarkar, Shashi Rajput, Amit Kumar Tripathi and Mahitosh Mandal
    Citation: Molecular Cancer 2013 12:122
  25. Rectal cancer is one of the most prevalent tumor types. Understanding the metabolic profile of rectal cancer is important for developing therapeutic approaches and molecular diagnosis.

    Authors: Huijuan Wang, Liang Wang, Hailong Zhang, Pengchi Deng, Jie Chen, Bin Zhou, Jing Hu, Jun Zou, Wenjie Lu, Pu Xiang, Tianming Wu, Xiaoni Shao, Yuan Li, Zongguang Zhou and Ying-Lan Zhao
    Citation: Molecular Cancer 2013 12:121
  26. Overexpression of Decoy Receptor 3 (DcR3), a soluble member of the tumor necrosis factor receptor superfamily, is a common event in several types of cancer. In renal cell carcinoma (RCC), DcR3 overexpression i...

    Authors: Daniel Weissinger, Katrin E Tagscherer, Stephan Macher-Göppinger, Axel Haferkamp, Nina Wagener and Wilfried Roth
    Citation: Molecular Cancer 2013 12:120
  27. microRNAs have been shown to regulate the chemosensitivity of cancer cells. The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP...

    Authors: Ning Wang, Meifen Zhu, Sai-Wah Tsao, Kwan Man, Zhangjin Zhang and Yibin Feng
    Citation: Molecular Cancer 2013 12:119
  28. Extracellular vesicle (EV) trafficking is a fundamental cellular process that occurs in cells and is required for different aspects of pathophysiology. EV trafficking leads to changes in cellular function incl...

    Authors: Kiriaki Panagopoulos, Sam Cross-Knorr, Christen Dillard, Dionysios Pantazatos, Michael Del Tatto, David Mills, Lisa Goldstein, Joseph Renzulli, Peter Quesenberry and Devasis Chatterjee
    Citation: Molecular Cancer 2013 12:118
  29. Wnt/β-catenin signaling is a highly conserved pathway in organism evolution and is important in many biological processes. Overactivation of Wnt/β-catenin signaling is closely related to tumor development and ...

    Authors: Zhao Yan, Zhongling Zhu, Jinghui Wang, Jian Sun, Yihui Chen, Guang Yang, Wenting Chen and Yuheng Deng
    Citation: Molecular Cancer 2013 12:116
  30. CD164 (endolyn), a sialomucin, has been reported to play a role in the proliferation, adhesion, and differentiation of hematopoietic stem cells. The potential association of CD164 with tumorigenicity remains u...

    Authors: Ai-Fang Huang, Min-Wei Chen, Shih-Ming Huang, Chu-Lien Kao, Hung-Cheng Lai and James Yi-Hsin Chan
    Citation: Molecular Cancer 2013 12:115
  31. Gankyrin has shown to be overexpressed in human liver cancers and plays a complex role in hepatocarcinogenesis. Panobinostat (LBH589), a new hydroxamic acid-derived histone deacetylase inhibitor has shown prom...

    Authors: Xuan Song, Jiabei Wang, Tongsen Zheng, Ruipeng Song, Yingjian Liang, Nishant Bhatta, Dalong Yin, Shangha Pan, Jiaren Liu, Hongchi Jiang and Lianxin Liu
    Citation: Molecular Cancer 2013 12:114
  32. The members of MRE11/RAD50/NBN (MRN) protein complex participates in DNA double-strand break repair and DNA-damage checkpoint activation. We have previously shown that the p.I171V NBN gene mutation may contribute...

    Authors: Iwona Ziółkowska-Suchanek, Maria Mosor, Małgorzata Wierzbicka, Małgorzata Rydzanicz, Marta Baranowska and Jerzy Nowak
    Citation: Molecular Cancer 2013 12:113
  33. The cellular and molecular mechanisms that mediate interactions between tumour cells and the surrounding bone stroma are to date largely undetermined in prostate cancer (PCa) progression. The purpose of this s...

    Authors: Louisa CE Windus, Tristan T Glover and Vicky M Avery
    Citation: Molecular Cancer 2013 12:112

    The Erratum to this article has been published in Molecular Cancer 2014 13:188

  34. Alterations in lipid metabolism are inherent to the metabolic transformations that support tumorigenesis. The relationship between the synthesis, storage and use of lipids and their importance in cancer is poo...

    Authors: Anja Pucer, Vesna Brglez, Christine Payré, Jože Pungerčar, Gérard Lambeau and Toni Petan
    Citation: Molecular Cancer 2013 12:111
  35. Increasing evidence suggests that cancer is a metabolic disease. Here, we investigated the potential role of fructose-1,6-bisphosphatase-2 (FBP2), the enzyme that catalyses the hydrolysis of fructose-1,6-bisph...

    Authors: He Li, Juan Wang, Huiyu Xu, Rui Xing, Yuanming Pan, Wenmei Li, Jiantao Cui, Hongbing Zhang and Youyong Lu
    Citation: Molecular Cancer 2013 12:110
  36. The survival rate of head and neck squamous cell carcinoma (HNSCC) at advanced stage is poor, despite contemporary advances in treatment modalities. Recent studies have indicated that astrocyte elevated gene-1...

    Authors: Yi-Ping Wang, I-Ju Liu, Chiung-Pin Chiang and Han-Chung Wu
    Citation: Molecular Cancer 2013 12:109
  37. One of the striking characteristics of cancer cells is their phenotypic diversity and ability to switch phenotypes in response to environmental fluctuations. Such phenotypic changes (e.g. from drug-sensitive t...

    Authors: Prakash Kulkarni, Takumi Shiraishi and Rahul V Kulkarni
    Citation: Molecular Cancer 2013 12:108
  38. Epithelial-mesenchymal transition (EMT) is a key process in embryonic development and metastases formation during malignant progression. This review focuses on transcriptional regulation, non-coding RNAs, alte...

    Authors: Timur R Samatov, Alexander G Tonevitsky and Udo Schumacher
    Citation: Molecular Cancer 2013 12:107
  39. Pancreatic cancer is one of the most lethal human malignancies, with an all-stage 5-year survival of <5%, mainly due to lack of effective available therapies. Cancer cell survival is dependent upon up-regulati...

    Authors: Zhiyu Chen, Veena Sangwan, Sulagna Banerjee, Tiffany Mackenzie, Vikas Dudeja, Xiaowu Li, Huaizhi Wang, Selwyn M Vickers and Ashok K Saluja
    Citation: Molecular Cancer 2013 12:105
  40. Among the solid tumors, human pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis. Gemcitabine is the standard first line of therapy for pancreatic cancer but has limited efficacy due to inherent o...

    Authors: Kolaparthi Venkatasubbarao, Lindsay Peterson, Shujie Zhao, Ping Hill, Lin Cao, Qing Zhou, Steffan T Nawrocki and James W Freeman
    Citation: Molecular Cancer 2013 12:104
  41. Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells via tumor vasculature targ...

    Authors: David L Bartlett, Zuqiang Liu, Magesh Sathaiah, Roshni Ravindranathan, Zongbi Guo, Yukai He and Zong Sheng Guo
    Citation: Molecular Cancer 2013 12:103
  42. MTA2 gene belongs to metastasis associated family, and is highly expressed in some solid tumors, including gastric cancer. Its biological function in gastric cancer is currently undefined.

    Authors: Chenfei Zhou, Jun Ji, Qu Cai, Min Shi, Xuehua Chen, Yingyan Yu, Bingya Liu, Zhenggang Zhu and Jun Zhang
    Citation: Molecular Cancer 2013 12:102
  43. DNA topoisomerases are key enzymes that modulate the topological state of DNA through the breaking and rejoining of DNA strands. Human topoisomerase IB can be inhibited by several compounds that act through di...

    Authors: Cinzia Tesauro, Blasco Morozzo della Rocca, Alessio Ottaviani, Andrea Coletta, Laura Zuccaro, Barbara Arnò, Ilda D'Annessa, Paola Fiorani and Alessandro Desideri
    Citation: Molecular Cancer 2013 12:100
  44. Hypermethylation of the promoter of the tumor suppressor gene RASSF1A silences its expression and has been found to be associated with advanced grade prostatic tumors. The DNA methyltransferase (DNMT) family of e...

    Authors: Soumik Agarwal, Karishma S Amin, Shankar Jagadeesh, Gokul Baishay, Paruchuri G Rao, Nabin C Barua, Samir Bhattacharya and Partha P Banerjee
    Citation: Molecular Cancer 2013 12:99

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