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  1. Content type: Review

    Intratumor heterogeneity of tumor clones and an immunosuppressive microenvironment in cancer ecosystems contribute to inherent difficulties for tumor treatment. Recently, chimeric antigen receptor (CAR) T-cell...

    Authors: Baixin Ye, Creed M. Stary, Xuejun Li, Qingping Gao, Chunsheng Kang and Xiaoxing Xiong

    Citation: Molecular Cancer 2018 17:32

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  2. Content type: Review

    The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. The structure of V-ATPase has been highly conserved among all eukaryotic cells and i...

    Authors: Sahithi Pamarthy, Arpita Kulshrestha, Gajendra K. Katara and Kenneth D. Beaman

    Citation: Molecular Cancer 2018 17:41

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  3. Content type: Letter to the Editor

    Germline mutations in BUB1 and BUB3 have been reported to increase the risk of developing colorectal cancer (CRC) at young age, in presence of variegated aneuploidy and reminiscent dysmorphic traits of mosaic var...

    Authors: Pilar Mur, Richarda M. De Voer, Rubén Olivera-Salguero, Sandra Rodríguez-Perales, Tirso Pons, Fernando Setién, Gemma Aiza, Rafael Valdés-Mas, Angelo Bertini, Marta Pineda, Lilian Vreede, Matilde Navarro, Silvia Iglesias, Sara González, Joan Brunet, Alfonso Valencia…

    Citation: Molecular Cancer 2018 17:23

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  4. Content type: Research

    Circ-ITCH is a circRNA generated from several exons of itchy E3 ubiquitin protein ligase (ITCH) and tumor suppressor served as a sponge for certain miRNAs targeting their parental transcripts of ITCH. However,...

    Authors: Chengdi Yang, Wenbo Yuan, Xiao Yang, Peng Li, Jingzi Wang, Jie Han, Jun Tao, Pengchao Li, Haiwei Yang, Qiang Lv and Wei Zhang

    Citation: Molecular Cancer 2018 17:19

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  5. Content type: Review

    Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent...

    Authors: Guiling Wu, Zhiqiang Ma, Yicheng Cheng, Wei Hu, Chao Deng, Shuai Jiang, Tian Li, Fulin Chen and Yang Yang

    Citation: Molecular Cancer 2018 17:20

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  6. Content type: Research

    Long non-coding RNAs (lncRNAs) play an important role in the development and progression of various tumors, including pancreatic cancer (PC). Recent studies have shown that lncRNAs can ‘act in cis’ to regulate...

    Authors: Hao Hu, Yandong Wang, Xiangya Ding, Yuan He, Zipeng Lu, Pengfei Wu, Lei Tian, Hao Yuan, Dongfang Liu, Guodong Shi, Tianfang Xia, Jie Yin, Baobao Cai, Yi Miao and Kuirong Jiang

    Citation: Molecular Cancer 2018 17:18

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  7. Content type: Letter to the Editor

    Up to 20% of colorectal cancer (CRC) node-negative patients develop loco-regional or distant recurrences within 5 years from surgery. No predictive biomarker able to identify the node-negative subjects at high...

    Authors: Angela Grassi, Lisa Perilli, Laura Albertoni, Sofia Tessarollo, Claudia Mescoli, Emanuele D. L. Urso, Matteo Fassan, Massimo Rugge and Paola Zanovello

    Citation: Molecular Cancer 2018 17:17

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  8. Content type: Research

    Emerging evidence suggests that PIWI-interacting RNAs (piRNAs) may be important epigenetic regulators of gene expression in human cancers; however, their functional and clinical significance in colorectal canc...

    Authors: Wenhao Weng, Na Liu, Yuji Toiyama, Masato Kusunoki, Takeshi Nagasaka, Toshiyoshi Fujiwara, Qing Wei, Huanlong Qin, Haifan Lin, Yanlei Ma and Ajay Goel

    Citation: Molecular Cancer 2018 17:16

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  9. Content type: Letter to the Editor

    Tumor cells shed an abundance of extracellular vesicles (EVs) to body fluids containing bioactive molecules including DNA, RNA, and protein. Investigations in the field of tumor-derived EVs open a new horizon ...

    Authors: Jae Young Hur, Hee Joung Kim, Jong Sik Lee, Chang-Min Choi, Jae Cheol Lee, Min Kyo Jung, Chan Gi Pack and Kye Young Lee

    Citation: Molecular Cancer 2018 17:15

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  10. Content type: Research

    Protein kinase N2 (PKN2) is a PKC-related serine/threonine-protein kinase. PKN2 is required for tumor cell migration, invasion and apoptosis. However, the functional role of PKN2 in regulating tumor associated...

    Authors: Yang Cheng, Yun Zhu, Jiajia Xu, Min Yang, Peiyu Chen, Wanfu Xu, Junhong Zhao, Lanlan Geng and Sitang Gong

    Citation: Molecular Cancer 2018 17:13

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  11. Content type: Review

    Head and neck cancer (HNC) ranks as the 6th most common malignancy across the world. Metastasis is a hallmark of cancer, primarily contributing to the relapse and poor prognosis of HNC. Recently, long noncodin...

    Authors: Xiaobo Luo, Yan Qiu, Yuchen Jiang, Fangman Chen, Lu Jiang, Yu Zhou, Hongxia Dan, Xin Zeng, Yu L. Lei and Qianming Chen

    Citation: Molecular Cancer 2018 17:14

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  12. Content type: Letter to the Editor

    Immunoevasion is a hallmark of cancer progression, and immune checkpoint blockade has emerged as a promising strategy for cancer treatment. microRNAs (miRNAs) are important negative regulators of gene expressi...

    Authors: Wei Huang, Wen-Tao Wang, Ke Fang, Zhen-Hua Chen, Yu-Meng Sun, Cai Han, Lin-Yu Sun, Xue-Qun Luo and Yue-Qin Chen

    Citation: Molecular Cancer 2018 17:12

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  13. Content type: Research

    Colorectal cancer (CRC) is a severe health problem worldwide. Clarifying the mechanisms for the deregulation of oncogenes and tumour suppressors in CRC is vital for its diagnosis, treatment, prognosis and prev...

    Authors: Yanqing Liu, Xiaorui Chen, Rongjie Cheng, Fei Yang, Mengchao Yu, Chen Wang, Shufang Cui, Yeting Hong, Hongwei Liang, Minghui Liu, Chihao Zhao, Meng Ding, Wu Sun, Zhijian Liu, Feng Sun, Chenyu Zhang…

    Citation: Molecular Cancer 2018 17:11

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  14. Content type: Research

    Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role in cancer progression via tumor-promoting signals. This study aims to explore the microRNA (miRNA) profile of CCA-associa...

    Authors: Penkhae Utaijaratrasmi, Kulthida Vaeteewoottacharn, Takaaki Tsunematsu, Pranisa Jamjantra, Sopit Wongkham, Chawalit Pairojkul, Narong Khuntikeo, Naozumi Ishimaru, Yongyut Sirivatanauksorn, Ananya Pongpaibul, Peti Thuwajit, Chanitra Thuwajit and Yasusei Kudo

    Citation: Molecular Cancer 2018 17:10

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  15. Content type: Review

    A vast array of tumor-derived genetic, proteomic and cellular components are constantly released into the circulation of cancer patients. These molecules including circulating tumor DNA and RNA, proteins, tumo...

    Authors: Su Yin Lim, Jenny H. Lee, Russell J. Diefenbach, Richard F. Kefford and Helen Rizos

    Citation: Molecular Cancer 2018 17:8

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  16. Content type: Research

    Most patients with breast cancer in advanced stages of the disease suffer from bone metastases which lead to fractures and nerve compression syndromes. microRNA dysregulation is an important event in the metas...

    Authors: Wei-Luo Cai, Wen-Ding Huang, Bo Li, Tian-Rui Chen, Zhen-Xi Li, Cheng-Long Zhao, Heng-Yu Li, Yan-Mei Wu, Wang-Jun Yan and Jian-Ru Xiao

    Citation: Molecular Cancer 2018 17:9

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  17. Content type: Research

    Long noncoding RNAs (lncRNAs) are an important class of functional regulators involved in human cancers development, including gastric cancer (GC). Studying aberrantly expressed lncRNAs may provide us with new...

    Authors: Jin-Fei Chen, Peng Wu, Rui Xia, Jian Yang, Xin-Ying Huo, Dong-Ying Gu, Cui-Ju Tang, Wei De and Fen Yang

    Citation: Molecular Cancer 2018 17:6

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  18. Content type: Research

    The communication between carcinoma associated fibroblasts (CAFs) and cancer cells facilitate tumor metastasis. In this study, we further underlying the epigenetic mechanisms of CAFs feed the cancer cells and ...

    Authors: Yu Ren, Huan-huan Jia, Yi-qi Xu, Xuan Zhou, Xiao-hui Zhao, Yun-fei Wang, Xin Song, Zhi-yan Zhu, Ting Sun, Yan Dou, Wei-ping Tian, Xiu-lan Zhao, Chun-sheng Kang and Mei Mei

    Citation: Molecular Cancer 2018 17:5

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  19. Content type: Research

    Long non-coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) is oriented in an antisense direction to the protein-coding gene AFAP1 in the opposite strand. Previous studies showed t...

    Authors: Ze-you Wang, Min Hu, Min-hui Dai, Jing Xiong, Shuai Zhang, Han-jiang Wu, Shan-shan Zhang and Zhao-jian Gong

    Citation: Molecular Cancer 2018 17:3

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  20. Content type: Research

    Aberrant activation of the Wnt/β-catenin signaling pathway is frequently observed in colorectal cancer (CRC). β-catenin is the major Wnt signaling pathway effector and inactivation of adenomatous polyposis col...

    Authors: Ying Zhang, Lu Guo, Yuhuan Li, Gui-Hai Feng, Fei Teng, Wei Li and Qi Zhou

    Citation: Molecular Cancer 2018 17:1

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  21. Content type: Review

    Pancreatic cancer is one of the most lethal cancers worldwide due to its insidious symptoms, early metastasis, and chemoresistance. Hence, the underlying mechanisms contributing to pancreatic cancer progressio...

    Authors: Jiangdong Qiu, Gang Yang, Mengyu Feng, Suli Zheng, Zhe Cao, Lei You, Lianfang Zheng, Taiping Zhang and Yupei Zhao

    Citation: Molecular Cancer 2018 17:2

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Page 4 of 84

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