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  1. Content type: Review

    Intratumor heterogeneity of tumor clones and an immunosuppressive microenvironment in cancer ecosystems contribute to inherent difficulties for tumor treatment. Recently, chimeric antigen receptor (CAR) T-cell...

    Authors: Baixin Ye, Creed M. Stary, Xuejun Li, Qingping Gao, Chunsheng Kang and Xiaoxing Xiong

    Citation: Molecular Cancer 2018 17:32

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  2. Content type: Review

    The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. The structure of V-ATPase has been highly conserved among all eukaryotic cells and i...

    Authors: Sahithi Pamarthy, Arpita Kulshrestha, Gajendra K. Katara and Kenneth D. Beaman

    Citation: Molecular Cancer 2018 17:41

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  3. Content type: Research

    Circ-ITCH is a circRNA generated from several exons of itchy E3 ubiquitin protein ligase (ITCH) and tumor suppressor served as a sponge for certain miRNAs targeting their parental transcripts of ITCH. However,...

    Authors: Chengdi Yang, Wenbo Yuan, Xiao Yang, Peng Li, Jingzi Wang, Jie Han, Jun Tao, Pengchao Li, Haiwei Yang, Qiang Lv and Wei Zhang

    Citation: Molecular Cancer 2018 17:19

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  4. Content type: Review

    Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent...

    Authors: Guiling Wu, Zhiqiang Ma, Yicheng Cheng, Wei Hu, Chao Deng, Shuai Jiang, Tian Li, Fulin Chen and Yang Yang

    Citation: Molecular Cancer 2018 17:20

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  5. Content type: Research

    Long non-coding RNAs (lncRNAs) play an important role in the development and progression of various tumors, including pancreatic cancer (PC). Recent studies have shown that lncRNAs can ‘act in cis’ to regulate...

    Authors: Hao Hu, Yandong Wang, Xiangya Ding, Yuan He, Zipeng Lu, Pengfei Wu, Lei Tian, Hao Yuan, Dongfang Liu, Guodong Shi, Tianfang Xia, Jie Yin, Baobao Cai, Yi Miao and Kuirong Jiang

    Citation: Molecular Cancer 2018 17:18

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  6. Content type: Letter to the Editor

    Up to 20% of colorectal cancer (CRC) node-negative patients develop loco-regional or distant recurrences within 5 years from surgery. No predictive biomarker able to identify the node-negative subjects at high...

    Authors: Angela Grassi, Lisa Perilli, Laura Albertoni, Sofia Tessarollo, Claudia Mescoli, Emanuele D. L. Urso, Matteo Fassan, Massimo Rugge and Paola Zanovello

    Citation: Molecular Cancer 2018 17:17

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  7. Content type: Research

    Emerging evidence suggests that PIWI-interacting RNAs (piRNAs) may be important epigenetic regulators of gene expression in human cancers; however, their functional and clinical significance in colorectal canc...

    Authors: Wenhao Weng, Na Liu, Yuji Toiyama, Masato Kusunoki, Takeshi Nagasaka, Toshiyoshi Fujiwara, Qing Wei, Huanlong Qin, Haifan Lin, Yanlei Ma and Ajay Goel

    Citation: Molecular Cancer 2018 17:16

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  8. Content type: Letter to the Editor

    Tumor cells shed an abundance of extracellular vesicles (EVs) to body fluids containing bioactive molecules including DNA, RNA, and protein. Investigations in the field of tumor-derived EVs open a new horizon ...

    Authors: Jae Young Hur, Hee Joung Kim, Jong Sik Lee, Chang-Min Choi, Jae Cheol Lee, Min Kyo Jung, Chan Gi Pack and Kye Young Lee

    Citation: Molecular Cancer 2018 17:15

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  9. Content type: Research

    Protein kinase N2 (PKN2) is a PKC-related serine/threonine-protein kinase. PKN2 is required for tumor cell migration, invasion and apoptosis. However, the functional role of PKN2 in regulating tumor associated...

    Authors: Yang Cheng, Yun Zhu, Jiajia Xu, Min Yang, Peiyu Chen, Wanfu Xu, Junhong Zhao, Lanlan Geng and Sitang Gong

    Citation: Molecular Cancer 2018 17:13

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  10. Content type: Review

    Head and neck cancer (HNC) ranks as the 6th most common malignancy across the world. Metastasis is a hallmark of cancer, primarily contributing to the relapse and poor prognosis of HNC. Recently, long noncodin...

    Authors: Xiaobo Luo, Yan Qiu, Yuchen Jiang, Fangman Chen, Lu Jiang, Yu Zhou, Hongxia Dan, Xin Zeng, Yu L. Lei and Qianming Chen

    Citation: Molecular Cancer 2018 17:14

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  11. Content type: Letter to the Editor

    Immunoevasion is a hallmark of cancer progression, and immune checkpoint blockade has emerged as a promising strategy for cancer treatment. microRNAs (miRNAs) are important negative regulators of gene expressi...

    Authors: Wei Huang, Wen-Tao Wang, Ke Fang, Zhen-Hua Chen, Yu-Meng Sun, Cai Han, Lin-Yu Sun, Xue-Qun Luo and Yue-Qin Chen

    Citation: Molecular Cancer 2018 17:12

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  12. Content type: Research

    Colorectal cancer (CRC) is a severe health problem worldwide. Clarifying the mechanisms for the deregulation of oncogenes and tumour suppressors in CRC is vital for its diagnosis, treatment, prognosis and prev...

    Authors: Yanqing Liu, Xiaorui Chen, Rongjie Cheng, Fei Yang, Mengchao Yu, Chen Wang, Shufang Cui, Yeting Hong, Hongwei Liang, Minghui Liu, Chihao Zhao, Meng Ding, Wu Sun, Zhijian Liu, Feng Sun, Chenyu Zhang…

    Citation: Molecular Cancer 2018 17:11

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  13. Content type: Research

    Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role in cancer progression via tumor-promoting signals. This study aims to explore the microRNA (miRNA) profile of CCA-associa...

    Authors: Penkhae Utaijaratrasmi, Kulthida Vaeteewoottacharn, Takaaki Tsunematsu, Pranisa Jamjantra, Sopit Wongkham, Chawalit Pairojkul, Narong Khuntikeo, Naozumi Ishimaru, Yongyut Sirivatanauksorn, Ananya Pongpaibul, Peti Thuwajit, Chanitra Thuwajit and Yasusei Kudo

    Citation: Molecular Cancer 2018 17:10

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  14. Content type: Review

    A vast array of tumor-derived genetic, proteomic and cellular components are constantly released into the circulation of cancer patients. These molecules including circulating tumor DNA and RNA, proteins, tumo...

    Authors: Su Yin Lim, Jenny H. Lee, Russell J. Diefenbach, Richard F. Kefford and Helen Rizos

    Citation: Molecular Cancer 2018 17:8

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  15. Content type: Research

    Most patients with breast cancer in advanced stages of the disease suffer from bone metastases which lead to fractures and nerve compression syndromes. microRNA dysregulation is an important event in the metas...

    Authors: Wei-Luo Cai, Wen-Ding Huang, Bo Li, Tian-Rui Chen, Zhen-Xi Li, Cheng-Long Zhao, Heng-Yu Li, Yan-Mei Wu, Wang-Jun Yan and Jian-Ru Xiao

    Citation: Molecular Cancer 2018 17:9

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  16. Content type: Research

    Long noncoding RNAs (lncRNAs) are an important class of functional regulators involved in human cancers development, including gastric cancer (GC). Studying aberrantly expressed lncRNAs may provide us with new...

    Authors: Jin-Fei Chen, Peng Wu, Rui Xia, Jian Yang, Xin-Ying Huo, Dong-Ying Gu, Cui-Ju Tang, Wei De and Fen Yang

    Citation: Molecular Cancer 2018 17:6

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  17. Content type: Research

    The communication between carcinoma associated fibroblasts (CAFs) and cancer cells facilitate tumor metastasis. In this study, we further underlying the epigenetic mechanisms of CAFs feed the cancer cells and ...

    Authors: Yu Ren, Huan-huan Jia, Yi-qi Xu, Xuan Zhou, Xiao-hui Zhao, Yun-fei Wang, Xin Song, Zhi-yan Zhu, Ting Sun, Yan Dou, Wei-ping Tian, Xiu-lan Zhao, Chun-sheng Kang and Mei Mei

    Citation: Molecular Cancer 2018 17:5

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  18. Content type: Research

    Long non-coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) is oriented in an antisense direction to the protein-coding gene AFAP1 in the opposite strand. Previous studies showed t...

    Authors: Ze-you Wang, Min Hu, Min-hui Dai, Jing Xiong, Shuai Zhang, Han-jiang Wu, Shan-shan Zhang and Zhao-jian Gong

    Citation: Molecular Cancer 2018 17:3

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  19. Content type: Research

    Aberrant activation of the Wnt/β-catenin signaling pathway is frequently observed in colorectal cancer (CRC). β-catenin is the major Wnt signaling pathway effector and inactivation of adenomatous polyposis col...

    Authors: Ying Zhang, Lu Guo, Yuhuan Li, Gui-Hai Feng, Fei Teng, Wei Li and Qi Zhou

    Citation: Molecular Cancer 2018 17:1

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  20. Content type: Review

    Pancreatic cancer is one of the most lethal cancers worldwide due to its insidious symptoms, early metastasis, and chemoresistance. Hence, the underlying mechanisms contributing to pancreatic cancer progressio...

    Authors: Jiangdong Qiu, Gang Yang, Mengyu Feng, Suli Zheng, Zhe Cao, Lei You, Lianfang Zheng, Taiping Zhang and Yupei Zhao

    Citation: Molecular Cancer 2018 17:2

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  21. Content type: Research

    FHIT is a genome caretaker/tumor suppressor that is silenced in >50% of cancers. Although it was identified more than 20 years ago, questions remain as to how FHIT loss contributes to ...

    Authors: Daniel L. Kiss, William Baez, Kay Huebner, Ralf Bundschuh and Daniel R. Schoenberg

    Citation: Molecular Cancer 2017 16:179

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  22. Content type: Research

    Heat shock protein 90 (HSP90) functions as a well-known onco-protein to regulate protein conformation, stability and degradation. Pyruvate kinase M2 (PKM2), a critical regulator of the metabolism, growth and m...

    Authors: Qiuran Xu, Jianfeng Tu, Changwei Dou, Jun Zhang, Liu Yang, Xin Liu, Kefeng Lei, Zhikui Liu, Yufeng Wang, Lijie Li, Hangxing Bao, Jiahui Wang and Kangsheng Tu

    Citation: Molecular Cancer 2017 16:178

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  23. Content type: Letter to the Editor

    Efforts to develop effective cancer therapeutics have been hindered by a lack of clinically predictive preclinical models which recapitulate this complex disease. Patient derived xenograft (PDX) models have em...

    Authors: Alexandra Borodovsky, Travis J. McQuiston, Daniel Stetson, Ambar Ahmed, David Whitston, Jingwen Zhang, Michael Grondine, Deborah Lawson, Sharon S. Challberg, Michael Zinda, Brian A. Pollok, Brian A. Dougherty and Celina M. D’Cruz

    Citation: Molecular Cancer 2017 16:177

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  24. Content type: Review

    Metastasis has intrigued researchers for more than 100 years. Despite the development of technologies and therapeutic strategies, metastasis is still the major cause of cancer-related death until today. The fa...

    Authors: Qiang Liu, Hongfei Zhang, Xiaoli Jiang, Caiyun Qian, Zhuoqi Liu and Daya Luo

    Citation: Molecular Cancer 2017 16:176

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  25. Content type: Research

    Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is belie...

    Authors: Xujun Liu, Wenzhe Si, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang and Luyang Sun

    Citation: Molecular Cancer 2017 16:175

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  26. Content type: Research

    Chemoresistance has long been recognized as a major obstacle in cancer therapy. Clarifying the underlying mechanism of chemoresistance would result in novel strategies to improve patient’s response to chemothe...

    Authors: Hu YiRen, Yu YingCong, You Sunwu, Li Keqin, Tong Xiaochun, Chen Senrui, Chen Ende, Lin XiZhou and Chen Yanfan

    Citation: Molecular Cancer 2017 16:174

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  27. Content type: Review

    Exploring gene function is critical for understanding the complexity of life. DNA sequences and the three-dimensional organization of chromatin (chromosomal interactions) are considered enigmatic factors under...

    Authors: Ruobing Jia, Peiwei Chai, He Zhang and Xianqun Fan

    Citation: Molecular Cancer 2017 16:173

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  28. Content type: Research

    Our understanding of the multiple roles exosomes play during tumor progression is still very poor and the contribution of the normal tissue derived exosomes in distant seeding and tumor outgrowth has also not ...

    Authors: Nikolina Dioufa, Amanda M. Clark, Bo Ma, Colin H. Beckwitt and Alan Wells

    Citation: Molecular Cancer 2017 16:172

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  29. Content type: Research

    Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) in the biological behaviors of glioblastoma stem cells (GSCs). Here, we elucidated the function and possible molecular...

    Authors: Rui Su, Shuo Cao, Jun Ma, Yunhui Liu, Xiaobai Liu, Jian Zheng, Jiajia Chen, Libo Liu, Heng Cai, Zhen Li, Lini Zhao, Qianru He and Yixue Xue

    Citation: Molecular Cancer 2017 16:171

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  30. Content type: Research

    Lung cancer is the leading cause of cancer death worldwide. However, the molecular mechanisms underlying lung cancer development have not been fully understood. The functions of histone deacetylases (HDACs), a...

    Authors: Yubin Lei, Lingling Liu, Shujing Zhang, Shicheng Guo, Xiaoqing Li, Jiucun Wang, Bo Su, Yuchao Fang, Xiaofeng Chen, Hengning Ke and Wufan Tao

    Citation: Molecular Cancer 2017 16:170

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  31. Content type: Research

    Pancreatic cancer, one of the top two most fatal cancers, is characterized by a desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and inducing the epithelial-to-mesenchymal transit...

    Authors: Hongzhe Li, Xinjing Wang, Chenlei Wen, Zhen Huo, Weishen Wang, Qian Zhan, Dongfeng Cheng, Hao Chen, Xiaxing Deng, Chenghong Peng and Baiyong Shen

    Citation: Molecular Cancer 2017 16:169

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  32. Content type: Letter to the Editor

    Four molecular classifications of pancreatic ductal adenocarcinoma (PDAC), biologically and clinically relevant and based on gene expression profiles, were established in the recent years, including the Collis...

    Authors: David J. Birnbaum, Pascal Finetti, Daniel Birnbaum, Emilie Mamessier and François Bertucci

    Citation: Molecular Cancer 2017 16:168

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  33. Content type: Research

    MicroRNAs (miRNAs) can act as oncogenes or tumor suppressors by controlling cell proliferation, differentiation, metastasis and apoptosis, and miRNA dysregulation is involved in the development of pancreatic c...

    Authors: Manmei Long, Ming Zhan, Sunwang Xu, Ruimeng Yang, Wei Chen, Shilei Zhang, Yongheng Shi, Qiao He, Man Mohan, Qiang Liu and Jian Wang

    Citation: Molecular Cancer 2017 16:167

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  34. Content type: Research

    Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in tumorigenesis. Here, we report a novel lncRNA, RP11-436H11.5, that regulates renal cell carcinoma (RCC) cell prolifera...

    Authors: Kefeng Wang, Wei Jin, Yan Song and Xiang Fei

    Citation: Molecular Cancer 2017 16:166

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  35. Content type: Review

    Hepatocellular carcinoma (HCC) is one of the most common malignant tumours with a poor prognosis worldwide. While early stage tumours can be treated with curative approaches such as liver transplantation or su...

    Authors: Xiaoqi Huo, Shuanglin Han, Guang Wu, Olivier Latchoumanin, Gang Zhou, Lionel Hebbard, Jacob George and Liang Qiao

    Citation: Molecular Cancer 2017 16:165

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  36. Content type: Letter to the Editor

    Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive malignancies worldwide. Studies seeking to advance the overall understanding of lncRNA profiling in HCC remain rare.

    Authors: Jian Yao, Lingjiao Wu, Xiaohua Meng, Huanxia Yang, Shujun Ni, Qiangfeng Wang, Jiawei Zhou, Qiong Zhang, Kunkai Su, Li Shao, Qingyi Cao, Mingding Li, Fusheng Wu and Lanjuan Li

    Citation: Molecular Cancer 2017 16:164

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  37. Content type: Research

    Molecular profiling in ovarian cancer (OC) revealed that the desmoplasia subtype presented the poorest prognosis, highlighting the contribution of stromal fibroblasts in tumor progression. This study aimed to ...

    Authors: Zongyuan Yang, Xin Yang, Sen Xu, Ping Jin, Xiaoting Li, Xiao Wei, Dan Liu, Kecheng Huang, Sixiang Long, Ya Wang, Chaoyang Sun, Gang Chen, Junbo Hu, Li Meng, Ding Ma and Qinglei Gao

    Citation: Molecular Cancer 2017 16:163

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  38. Content type: Research

    The conversion from estrogen-dependent to estrogen-independent state of ER+ breast cancer cells is the key step to promote resistance to endocrine therapies. Although the crucial role of MAPK/ERK signaling pat...

    Authors: Wan-xin Peng, Jian-guo Huang, Liu Yang, Ai-hua Gong and Yin-Yuan Mo

    Citation: Molecular Cancer 2017 16:161

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  39. Content type: Research

    Despite progress in treatment of small cell lung cancer (SCLC), the biology of the tumor still remains poorly understood. Recently, we globally investigated the contributions of lncRNA in SCLC with a special f...

    Authors: Yanqin Sun, Yuanyuan Zhou, Yifeng Bai, Qiongyao Wang, Jiarong Bao, Yingshan Luo, Ying Guo and Linlang Guo

    Citation: Molecular Cancer 2017 16:162

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  40. Content type: Letter to the Editor

    A growing number of evidence has indicated that long non-coding RNAs (lncRNA) may have many functions in the development and progression of cancer, and cloud serve as good diagnostic and prognostic biomarkers ...

    Authors: Xiaoli Chen, Meiyu Dai, Hongzhen Zhu, Jinwan Li, Zhizhuo Huang, Xuexiang Liu, Yujie Huang, Jingfan Chen and Shengming Dai

    Citation: Molecular Cancer 2017 16:160

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  41. Content type: Research

    Tumor-derived exosomes (TDEs) play a pivotal role in tumor establishment and progression, and are emerging biomarkers for tumor diagnosis in personalized medicine. To date, there is a lack of efficient technol...

    Authors: Enrico Iaccino, Selena Mimmi, Vincenzo Dattilo, Fabiola Marino, Patrizio Candeloro, Antonio Di Loria, Danilo Marimpietri, Antonio Pisano, Francesco Albano, Eleonora Vecchio, Simona Ceglia, Gaetanina Golino, Antonio Lupia, Giuseppe Fiume, Ileana Quinto and Giuseppe Scala

    Citation: Molecular Cancer 2017 16:159

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  42. Content type: Research

    N-myc (and STAT) interactor (NMI) plays vital roles in tumor growth, progression, and metastasis. In this study, we identified NMI as a potential tumor suppressor in lung cancer and explored its molecular mech...

    Authors: Jingshu Wang, Kun Zou, Xu Feng, Miao Chen, Cong Li, Ranran Tang, Yang Xuan, Meihua Luo, Wangbing Chen, Huijuan Qiu, Ge Qin, Yixin Li, Changlin Zhang, Binyi Xiao, Lan Kang, Tiebang Kang…

    Citation: Molecular Cancer 2017 16:158

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  43. Content type: Research

    MicroRNAs (miRNAs) are important regulators involved in diverse physiological and pathological processes including cancer. SUMO (small ubiquitin-like modifier) is a reversible protein modifier. We recently fou...

    Authors: Haihua Yuan, Rong Deng, Xian Zhao, Ran Chen, Guofang Hou, Hailong Zhang, Yanli Wang, Ming Xu, Bin Jiang and Jianxiu Yu

    Citation: Molecular Cancer 2017 16:157

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  44. Content type: Letter to the Editor

    The aim of this study was to identify microRNAs in urinary exosomes that are differently expressed in prostate cancer patients and healthy donors. For this purpose, RNA was extracted from urinary exosomes from...

    Authors: Marta Rodríguez, Cristina Bajo-Santos, Nina P. Hessvik, Susanne Lorenz, Bastian Fromm, Viktor Berge, Kirsten Sandvig, Aija Linē and Alicia Llorente

    Citation: Molecular Cancer 2017 16:156

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  45. Content type: Research

    Although both long and micro RNAs are emerging as important functional components in colorectal cancer (CRC) progression and metastasis, the mechanism of their interaction remains poorly understood. CCAT2 (Col...

    Authors: Yingjie Yu, Pratima Nangia-Makker, Lulu Farhana and Adhip P. N. Majumdar

    Citation: Molecular Cancer 2017 16:155

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  46. Content type: Research

    Reprogrammed energy metabolism as an emerging hallmark of cancer has recently drawn special attention since it facilitate cell growth and proliferation. Recently, long noncoding RNAs (lncRNAs) have been served...

    Authors: Binyao Yang, Lisha Zhang, Yi Cao, Shuai Chen, Jun Cao, Di Wu, Jiansong Chen, Huali Xiong, Zihua Pan, Fuman Qiu, Jinbin Chen, Xiaoxuan Ling, Maosheng Yan, Suli Huang, Shiyu Zhou, Tiegang Li…

    Citation: Molecular Cancer 2017 16:154

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