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  1. Content type: Review

    Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant diseases worldwide. It is refractory to conventional treatments, and consequently has a documented 5-year survival rate as low as 7%....

    Authors: Yaojie Fu, Shanshan Liu, Shan Zeng and Hong Shen

    Citation: Molecular Cancer 2018 17:62

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  2. Content type: Review

    Glioma is one of the most prevalent types of primary intracranial carcinoma with varying malignancy grades I–IV and histological subtypes, including astrocytomas, glioblastoma multiform (GBM), oligodendrogliom...

    Authors: Zixuan Peng, Changhong Liu and Minghua Wu

    Citation: Molecular Cancer 2018 17:61

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  3. Content type: Review

    Bruton’s tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B cell malignancies. BTK was i...

    Authors: Simar Pal Singh, Floris Dammeijer and Rudi W. Hendriks

    Citation: Molecular Cancer 2018 17:57

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  4. Content type: Review

    The introduction of ABL Tyrosine Kinase Inhibitors (TKIs) has significantly improved the outcome of Chronic Myeloid Leukemia (CML) patients that, in large part, achieve satisfactory hematological, cytogenetic ...

    Authors: Michele Massimino, Stefania Stella, Elena Tirrò, Chiara Romano, Maria Stella Pennisi, Adriana Puma, Livia Manzella, Antonino Zanghì, Fabio Stagno, Francesco Di Raimondo and Paolo Vigneri

    Citation: Molecular Cancer 2018 17:56

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  5. Content type: Review

    Searching for targets that allow pharmacological inhibition of cell proliferation in over-proliferative states, such as cancer, leads us to finely understand the complex mechanisms orchestrating the perfect co...

    Authors: Wagner Ricardo Montor, Andrei Ronaldo Oliveira Silva Escartin Salas and Fabiana Henriques Machado de Melo

    Citation: Molecular Cancer 2018 17:55

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  6. Content type: Review

    Tyrosine kinase inhibitors (TKIs)-treatments bring significant benefit for patients harboring epidermal growth factor receptor (EGFR) mutations, especially for those with lung cancer. Unfortunately, the majori...

    Authors: Qian Liu, Shengnan Yu, Weiheng Zhao, Shuang Qin, Qian Chu and Kongming Wu

    Citation: Molecular Cancer 2018 17:53

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  7. Content type: Review

    Lung cancer is the leading cause of death by cancer in North America. A decade ago, genomic rearrangements in the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase were identified in a subset of non-sm...

    Authors: Brandon Golding, Anita Luu, Robert Jones and Alicia M. Viloria-Petit

    Citation: Molecular Cancer 2018 17:52

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  8. Content type: Review

    Deregulated activity of BCR-ABL1, a nonreceptor tyrosine kinase encoded by the fusion gene resulting from the t(9;22)(q34;q11) chromosomal translocation, is thought to be the driver event responsible for initi...

    Authors: Simona Soverini, Manuela Mancini, Luana Bavaro, Michele Cavo and Giovanni Martinelli

    Citation: Molecular Cancer 2018 17:49

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  9. Content type: Review

    The human genome encodes 538 protein kinases that transfer a γ-phosphate group from ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with human cancer initiation and progres...

    Authors: Khushwant S. Bhullar, Naiara Orrego Lagarón, Eileen M. McGowan, Indu Parmar, Amitabh Jha, Basil P. Hubbard and H. P. Vasantha Rupasinghe

    Citation: Molecular Cancer 2018 17:48

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  10. Content type: Research

    Minimal residual disease is the main issue of advanced ovarian cancer treatment. According to the literature and previous results, we hypothesized that Mesenchymal Stromal Cells (MSC) could support this minima...

    Authors: Jennifer Pasquier, Marie Gosset, Caroline Geyl, Jessica Hoarau-Véchot, Audrey Chevrot, Marc Pocard, Massoud Mirshahi, Raphael Lis, Arash Rafii and Cyril Touboul

    Citation: Molecular Cancer 2018 17:47

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  11. Content type: Research

    Epidermal growth factor receptor (EGFR) mutations enable constitutive active downstream signaling of PI3K/AKT, KRAS/ERK and JAK/STAT pathways, and promote tumor progression by inducing uncontrolled proliferation,...

    Authors: Ulrich Baumgartner, Fabienne Berger, Ali Hashemi Gheinani, Sabrina Sofia Burgener, Katia Monastyrskaya and Erik Vassella

    Citation: Molecular Cancer 2018 17:44

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  12. Content type: Review

    Tumour microenvironment (TME) is a key determinant of tumour growth and metastasis. TME could be very different for each type and location of tumour and TME may change constantly during tumour growth. Multiple...

    Authors: Hor-Yue Tan, Ning Wang, Wing Lam, Wei Guo, Yibin Feng and Yung-Chi Cheng

    Citation: Molecular Cancer 2018 17:43

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  13. Content type: Research

    ETS variant gene 6 (ETV6) is a putative tumor suppressor and repressed by epidermal growth factor receptor (EGFR) signaling in prostate cancer. Since EGFR antagonists seem ineffective in castration-resistant p...

    Authors: Yuan-Chin Tsai, Tao Zeng, Wassim Abou-Kheir, Hsiu-Lien Yeh, Juan Juan Yin, Yi-Chao Lee, Wei-Yu Chen and Yen-Nien Liu

    Citation: Molecular Cancer 2018 17:42

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  14. Content type: Review

    Atypical Chronic Myeloid Leukemia (aCML) is a myeloproliferative neoplasm characterized by neutrophilic leukocytosis and dysgranulopoiesis. From a genetic point of view, aCML shows a heterogeneous mutational l...

    Authors: Stefania Rocca, Giovanna Carrà, Pietro Poggio, Alessandro Morotti and Mara Brancaccio

    Citation: Molecular Cancer 2018 17:40

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  15. Content type: Review

    Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and dysregulation of this ...

    Authors: Nahal Haddadi, Yiguang Lin, Glena Travis, Ann M. Simpson, Najah T. Nassif and Eileen M. McGowan

    Citation: Molecular Cancer 2018 17:37

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  16. Content type: Review

    Originally identified as a metabolic enzyme that catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP in the glycolytic pathway, pyruvate kinase M2-type (PKM2) has been shown to ex...

    Authors: Ming-Chuan Hsu and Wen-Chun Hung

    Citation: Molecular Cancer 2018 17:35

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  17. Content type: Review

    Breast cancer is a multifactorial disease and driven by aberrant regulation of cell signaling pathways due to the acquisition of genetic and epigenetic changes. An array of growth factors and their receptors i...

    Authors: Ramesh Butti, Sumit Das, Vinoth Prasanna Gunasekaran, Amit Singh Yadav, Dhiraj Kumar and Gopal C. Kundu

    Citation: Molecular Cancer 2018 17:34

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  18. Content type: Review

    Lung neoplasms are the leading cause of death by cancer worldwide. Non-small cell lung cancer (NSCLC) constitutes more than 80% of all lung malignancies and the majority of patients present advanced disease at...

    Authors: Marta Román, Iosune Baraibar, Inés López, Ernest Nadal, Christian Rolfo, Silvestre Vicent and Ignacio Gil-Bazo

    Citation: Molecular Cancer 2018 17:33

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  19. Content type: Review

    Tyrosine kinases belong to a family of enzymes that mediate the movement of the phosphate group to tyrosine residues of target protein, thus transmitting signals from the cell surface to cytoplasmic proteins a...

    Authors: Kodappully S. Siveen, Kirti S. Prabhu, Iman W. Achkar, Shilpa Kuttikrishnan, Sunitha Shyam, Abdul Q. Khan, Maysaloun Merhi, Said Dermime and Shahab Uddin

    Citation: Molecular Cancer 2018 17:31

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  20. Content type: Review

    Anaplastic lymphoma kinase (ALK) gene activation is involved in the carcinogenesis process of several human cancers such as anaplastic large cell lymphoma, lung cancer, inflammatory myofibroblastic tumors and ...

    Authors: Carminia Maria Della Corte, Giuseppe Viscardi, Raimondo Di Liello, Morena Fasano, Erika Martinelli, Teresa Troiani, Fortunato Ciardiello and Floriana Morgillo

    Citation: Molecular Cancer 2018 17:30

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  21. Content type: Review

    Acquired T790 M mutation is the commonest cause of resistance for advanced non-small cell lung cancer (NSCLC) epidermal growth factor receptor (EGFR) mutant patients who had progressed after first line EGFR TKI (...

    Authors: Chee-Seng Tan, Nesaretnam Barr Kumarakulasinghe, Yi-Qing Huang, Yvonne Li En Ang, Joan Rou-En Choo, Boon-Cher Goh and Ross A. Soo

    Citation: Molecular Cancer 2018 17:29

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  22. Content type: Research

    EGFR-dependent cell migration plays an important role in lung cancer progression. Our previous study observed that the HECT E3 ubiquitin ligase NEDD4 is significantly correlated with tumor metastasis and requi...

    Authors: Genbao Shao, Ranran Wang, Aiqin Sun, Jing Wei, Ke Peng, Qian Dai, Wannian Yang and Qiong Lin

    Citation: Molecular Cancer 2018 17:24

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  23. Content type: Research

    During embryonic development Wnt family members and bone morphogenetic proteins (BMPs) cooperatively induce epithelial-mesenchymal transition (EMT) in the neural crest. Wnt and BMPs are reactivated during mali...

    Authors: Tobias Sinnberg, Mitchell P. Levesque, Jelena Krochmann, Phil F. Cheng, Kristian Ikenberg, Francisco Meraz-Torres, Heike Niessner, Claus Garbe and Christian Busch

    Citation: Molecular Cancer 2018 17:59

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  24. Content type: Review

    The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. The structure of V-ATPase has been highly conserved among all eukaryotic cells and i...

    Authors: Sahithi Pamarthy, Arpita Kulshrestha, Gajendra K. Katara and Kenneth D. Beaman

    Citation: Molecular Cancer 2018 17:41

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  25. Content type: Review

    Intratumor heterogeneity of tumor clones and an immunosuppressive microenvironment in cancer ecosystems contribute to inherent difficulties for tumor treatment. Recently, chimeric antigen receptor (CAR) T-cell...

    Authors: Baixin Ye, Creed M. Stary, Xuejun Li, Qingping Gao, Chunsheng Kang and Xiaoxing Xiong

    Citation: Molecular Cancer 2018 17:32

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  26. Content type: Letter to the Editor

    Germline mutations in BUB1 and BUB3 have been reported to increase the risk of developing colorectal cancer (CRC) at young age, in presence of variegated aneuploidy and reminiscent dysmorphic traits of mosaic var...

    Authors: Pilar Mur, Richarda M. De Voer, Rubén Olivera-Salguero, Sandra Rodríguez-Perales, Tirso Pons, Fernando Setién, Gemma Aiza, Rafael Valdés-Mas, Angelo Bertini, Marta Pineda, Lilian Vreede, Matilde Navarro, Silvia Iglesias, Sara González, Joan Brunet, Alfonso Valencia…

    Citation: Molecular Cancer 2018 17:23

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  27. Content type: Review

    Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent...

    Authors: Guiling Wu, Zhiqiang Ma, Yicheng Cheng, Wei Hu, Chao Deng, Shuai Jiang, Tian Li, Fulin Chen and Yang Yang

    Citation: Molecular Cancer 2018 17:20

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  28. Content type: Research

    Circ-ITCH is a circRNA generated from several exons of itchy E3 ubiquitin protein ligase (ITCH) and tumor suppressor served as a sponge for certain miRNAs targeting their parental transcripts of ITCH. However,...

    Authors: Chengdi Yang, Wenbo Yuan, Xiao Yang, Peng Li, Jingzi Wang, Jie Han, Jun Tao, Pengchao Li, Haiwei Yang, Qiang Lv and Wei Zhang

    Citation: Molecular Cancer 2018 17:19

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  29. Content type: Research

    Long non-coding RNAs (lncRNAs) play an important role in the development and progression of various tumors, including pancreatic cancer (PC). Recent studies have shown that lncRNAs can ‘act in cis’ to regulate...

    Authors: Hao Hu, Yandong Wang, Xiangya Ding, Yuan He, Zipeng Lu, Pengfei Wu, Lei Tian, Hao Yuan, Dongfang Liu, Guodong Shi, Tianfang Xia, Jie Yin, Baobao Cai, Yi Miao and Kuirong Jiang

    Citation: Molecular Cancer 2018 17:18

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  30. Content type: Letter to the Editor

    Up to 20% of colorectal cancer (CRC) node-negative patients develop loco-regional or distant recurrences within 5 years from surgery. No predictive biomarker able to identify the node-negative subjects at high...

    Authors: Angela Grassi, Lisa Perilli, Laura Albertoni, Sofia Tessarollo, Claudia Mescoli, Emanuele D. L. Urso, Matteo Fassan, Massimo Rugge and Paola Zanovello

    Citation: Molecular Cancer 2018 17:17

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  31. Content type: Research

    Emerging evidence suggests that PIWI-interacting RNAs (piRNAs) may be important epigenetic regulators of gene expression in human cancers; however, their functional and clinical significance in colorectal canc...

    Authors: Wenhao Weng, Na Liu, Yuji Toiyama, Masato Kusunoki, Takeshi Nagasaka, Toshiyoshi Fujiwara, Qing Wei, Huanlong Qin, Haifan Lin, Yanlei Ma and Ajay Goel

    Citation: Molecular Cancer 2018 17:16

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  32. Content type: Letter to the Editor

    Tumor cells shed an abundance of extracellular vesicles (EVs) to body fluids containing bioactive molecules including DNA, RNA, and protein. Investigations in the field of tumor-derived EVs open a new horizon ...

    Authors: Jae Young Hur, Hee Joung Kim, Jong Sik Lee, Chang-Min Choi, Jae Cheol Lee, Min Kyo Jung, Chan Gi Pack and Kye Young Lee

    Citation: Molecular Cancer 2018 17:15

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  33. Content type: Review

    Head and neck cancer (HNC) ranks as the 6th most common malignancy across the world. Metastasis is a hallmark of cancer, primarily contributing to the relapse and poor prognosis of HNC. Recently, long noncodin...

    Authors: Xiaobo Luo, Yan Qiu, Yuchen Jiang, Fangman Chen, Lu Jiang, Yu Zhou, Hongxia Dan, Xin Zeng, Yu L. Lei and Qianming Chen

    Citation: Molecular Cancer 2018 17:14

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  34. Content type: Research

    Protein kinase N2 (PKN2) is a PKC-related serine/threonine-protein kinase. PKN2 is required for tumor cell migration, invasion and apoptosis. However, the functional role of PKN2 in regulating tumor associated...

    Authors: Yang Cheng, Yun Zhu, Jiajia Xu, Min Yang, Peiyu Chen, Wanfu Xu, Junhong Zhao, Lanlan Geng and Sitang Gong

    Citation: Molecular Cancer 2018 17:13

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  35. Content type: Letter to the Editor

    Immunoevasion is a hallmark of cancer progression, and immune checkpoint blockade has emerged as a promising strategy for cancer treatment. microRNAs (miRNAs) are important negative regulators of gene expressi...

    Authors: Wei Huang, Wen-Tao Wang, Ke Fang, Zhen-Hua Chen, Yu-Meng Sun, Cai Han, Lin-Yu Sun, Xue-Qun Luo and Yue-Qin Chen

    Citation: Molecular Cancer 2018 17:12

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  36. Content type: Research

    Colorectal cancer (CRC) is a severe health problem worldwide. Clarifying the mechanisms for the deregulation of oncogenes and tumour suppressors in CRC is vital for its diagnosis, treatment, prognosis and prev...

    Authors: Yanqing Liu, Xiaorui Chen, Rongjie Cheng, Fei Yang, Mengchao Yu, Chen Wang, Shufang Cui, Yeting Hong, Hongwei Liang, Minghui Liu, Chihao Zhao, Meng Ding, Wu Sun, Zhijian Liu, Feng Sun, Chenyu Zhang…

    Citation: Molecular Cancer 2018 17:11

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  37. Content type: Research

    Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role in cancer progression via tumor-promoting signals. This study aims to explore the microRNA (miRNA) profile of CCA-associa...

    Authors: Penkhae Utaijaratrasmi, Kulthida Vaeteewoottacharn, Takaaki Tsunematsu, Pranisa Jamjantra, Sopit Wongkham, Chawalit Pairojkul, Narong Khuntikeo, Naozumi Ishimaru, Yongyut Sirivatanauksorn, Ananya Pongpaibul, Peti Thuwajit, Chanitra Thuwajit and Yasusei Kudo

    Citation: Molecular Cancer 2018 17:10

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  38. Content type: Research

    Most patients with breast cancer in advanced stages of the disease suffer from bone metastases which lead to fractures and nerve compression syndromes. microRNA dysregulation is an important event in the metas...

    Authors: Wei-Luo Cai, Wen-Ding Huang, Bo Li, Tian-Rui Chen, Zhen-Xi Li, Cheng-Long Zhao, Heng-Yu Li, Yan-Mei Wu, Wang-Jun Yan and Jian-Ru Xiao

    Citation: Molecular Cancer 2018 17:9

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  39. Content type: Review

    A vast array of tumor-derived genetic, proteomic and cellular components are constantly released into the circulation of cancer patients. These molecules including circulating tumor DNA and RNA, proteins, tumo...

    Authors: Su Yin Lim, Jenny H. Lee, Russell J. Diefenbach, Richard F. Kefford and Helen Rizos

    Citation: Molecular Cancer 2018 17:8

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