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  1. Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) – a highly aggress...

    Authors: A. Katharina Ceranski, Martha J. Carreño-Gonzalez, Anna C. Ehlers, Maria Vittoria Colombo, Florencia Cidre-Aranaz and Thomas G. P. Grünewald
    Citation: Molecular Cancer 2023 22:49
  2. The malignant tumor is a multi-etiological, systemic and complex disease characterized by uncontrolled cell proliferation and distant metastasis. Anticancer treatments including adjuvant therapies and targeted...

    Authors: Zhennan Yuan, Yingpu Li, Sifan Zhang, Xueying Wang, He Dou, Xi Yu, Zhiren Zhang, Shanshan Yang and Min Xiao
    Citation: Molecular Cancer 2023 22:48
  3. Cuproptosis was a copper-dependent and unique kind of cell death that was separate from existing other forms of cell death. The last decade has witnessed a considerable increase in investigations of programmed...

    Authors: Jiaming Xie, Yannan Yang, Yibo Gao and Jie He
    Citation: Molecular Cancer 2023 22:46
  4. PIWI proteins have a strong correlation with PIWI-interacting RNAs (piRNAs), which are significant in development and reproduction of organisms. Recently, emerging evidences have indicated that apart from the ...

    Authors: Qun Zhang, Yazhi Zhu, Xinyu Cao, Wenhui Tan, Jianglong Yu, Yaqiong Lu, Ran Kang, Xiaolan Wang and Ermao Li
    Citation: Molecular Cancer 2023 22:45
  5. Cancer development is closely associated with immunosuppressive tumor microenvironment (TME) that attenuates antitumor immune responses and promotes tumor cell immunologic escape. The sequential conversion of ...

    Authors: Chenglai Xia, Shuanghong Yin, Kenneth K. W. To and Liwu Fu
    Citation: Molecular Cancer 2023 22:44
  6. N6-methyladenosine (m6A) methylation is the most universal internal modification in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and readers, m6A modulation is involved in myriad ph...

    Authors: Xiaoxue Cao, Qishun Geng, Danping Fan, Qiong Wang, Xing Wang, Mengxiao Zhang, Lu Zhao, Yi Jiao, Tingting Deng, Honglin Liu, Jing Zhou, Liqun Jia and Cheng Xiao
    Citation: Molecular Cancer 2023 22:42
  7. Breast cancer is the most common malignant tumor that threatens women's health. Attention has been paid on the study of long- non-coding RNA (lncRNA) in breast cancer. However, the specific mechanism remains n...

    Authors: Yunxiang Zhang, Xiaotong Dong, Xiangyu Guo, Chunsen Li, Yanping Fan, Pengju Liu, Dawei Yuan, Xialin Ma, Jingru Wang, Jie Zheng, Hongli Li and Peng Gao
    Citation: Molecular Cancer 2023 22:41
  8. Lung cancer is the primary cause of mortality in the United States and around the globe. Therapeutic options for lung cancer treatment include surgery, radiation therapy, chemotherapy, and targeted drug therap...

    Authors: Aritraa Lahiri, Avik Maji, Pravin D. Potdar, Navneet Singh, Purvish Parikh, Bharti Bisht, Anubhab Mukherjee and Manash K. Paul
    Citation: Molecular Cancer 2023 22:40
  9. Hematological malignancies are a highly heterogeneous group of diseases with varied molecular and phenotypical characteristics. SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling complexes play sign...

    Authors: Alvaro Andrades, Paola Peinado, Juan Carlos Alvarez-Perez, Juan Sanjuan-Hidalgo, Daniel J. García, Alberto M. Arenas, Ana M. Matia-González and Pedro P. Medina
    Citation: Molecular Cancer 2023 22:39
  10. Ongoing research has revealed that the existence of cancer stem cells (CSCs) is one of the biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor progression, recurrence an...

    Authors: Bo Wu, Xiang Shi, Meixi Jiang and Hongxu Liu
    Citation: Molecular Cancer 2023 22:38
  11. Renal cell carcinoma (RCC) is a major pathological type of kidney cancer and is one of the most common malignancies worldwide. The unremarkable symptoms of early stages, proneness to postoperative metastasis o...

    Authors: Mingyang Li, Lei Li, Jianyi Zheng, Zeyu Li, Shijie Li, Kefeng Wang and Xiaonan Chen
    Citation: Molecular Cancer 2023 22:37
  12. The incidence and mortality of cancer are the major health issue worldwide. Apart from the treatments developed to date, the unsatisfactory therapeutic effects of cancers have not been addressed by broadening ...

    Authors: Zaoqu Liu, Meixin Shi, Yuqing Ren, Hui Xu, Siyuan Weng, Wenjing Ning, Xiaoyong Ge, Long Liu, Chunguang Guo, Mengjie Duo, Lifeng Li, Jing Li and Xinwei Han
    Citation: Molecular Cancer 2023 22:35
  13. Current clinical tools for breast cancer (BC) diagnosis are insufficient but liquid biopsy of different bodily fluids has recently emerged as a minimally invasive strategy that provides a real-time snapshot of...

    Authors: Yujin Lee, Jie Ni, Julia Beretov, Valerie C. Wasinger, Peter Graham and Yong Li
    Citation: Molecular Cancer 2023 22:33
  14. Transfer RNAs (tRNAs) are a class of non-coding RNAs responsible for amino acid translocation during protein synthesis and are ubiquitously found in organisms. With certain modifications and under specific con...

    Authors: Mei Yang, Yongzhen Mo, Daixi Ren, Shun Liu, Zhaoyang Zeng and Wei Xiong
    Citation: Molecular Cancer 2023 22:32
  15. As a nontraditional T-cell subgroup, γδT cells have gained popularity in the field of immunotherapy in recent years. They have extraordinary antitumor potential and prospects for clinical application. Immune c...

    Authors: Zhifei Gao, Yifeng Bai, Anqi Lin, Aimin Jiang, Chaozheng Zhou, Quan Cheng, Zaoqu Liu, Xin Chen, Jian Zhang and Peng Luo
    Citation: Molecular Cancer 2023 22:31
  16. tRNA-derived fragments (tRFs) are an emerging category of small non-coding RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance in high-throughput sequencing has contributed to...

    Authors: Min Fu, Jianmei Gu, Maoye Wang, Jiahui Zhang, Yanke Chen, Pengcheng Jiang, Taofeng Zhu and Xu Zhang
    Citation: Molecular Cancer 2023 22:30
  17. In recent years, breakthroughs have been made in tumor immunotherapy. However, tumor immunotherapy, particularly anti-PD-1/PD-L1 immune checkpoint inhibitors, is effective in only a small percentage of patient...

    Authors: Liping Pei, Yang Liu, Lin Liu, Shuochen Gao, Xueyan Gao, Yudi Feng, Zhenqiang Sun, Yan Zhang and Chengzeng Wang
    Citation: Molecular Cancer 2023 22:29
  18. In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-T) therapy are two milestone achievements in clinical immunotherapy. However, both show limited efficacies in most solid ...

    Authors: Qiaofei Liu, Jiayi Li, Huaijin Zheng, Sen Yang, Yuze Hua, Nan Huang, Jorg Kleeff, Quan Liao and Wenming Wu
    Citation: Molecular Cancer 2023 22:28
  19. Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate into proteins or execute gene regulatory functions. Many RNAs associate with chromatin directly or indirectly and are calle...

    Authors: Jun Tang, Xiang Wang, Desheng Xiao, Shuang Liu and Yongguang Tao
    Citation: Molecular Cancer 2023 22:27
  20. Several mechanisms and cell types are involved in the regulation of the immune response. These include mostly regulatory T cells (Tregs), regulatory macrophages (Mregs), myeloid suppressor cells (MDSCs) and ot...

    Authors: María Iglesias-Escudero, Noelia Arias-González and Eva Martínez-Cáceres
    Citation: Molecular Cancer 2023 22:26
  21. Current methods for the early detection and minimal residual disease (MRD) monitoring of urothelial carcinoma (UC) are invasive and/or possess suboptimal sensitivity. We developed an efficient workflow named u...

    Authors: Kaiwei Yang, Hailong Hu, Junlong Wu, Huina Wang, Zhaoxia Guo, Wei Yu, Lin Yao, Feng Ding, Tao Zhou, Wang Wang, Yunkai Wang, Lei Liu, Jing Guo, Shuaipeng Zhu, Xinhao Zhang, Shanbo Cao…
    Citation: Molecular Cancer 2023 22:25
  22. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-018-0899-5.

    Authors: Qi Wu, Si Sun, Zhiyu Li, Qian Yang, Bei Li, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Changhua Yang, Juanjuan Li and Shengrong Sun
    Citation: Molecular Cancer 2023 22:24
  23. Cancer remains a leading cause of death worldwide, placing a significant burden on healthcare systems as well as the global economy. Rare cancers comprise a group of about 200 cancers that individually occur a...

    Authors: Sneha Vivekanandhan, Deborah Bahr, Ashish Kothari, Mohammed Ali Ashary, Mizba Baksh and Emmanuel Gabriel
    Citation: Molecular Cancer 2023 22:23
  24. Malignant brain tumors rank among the most challenging type of malignancies to manage. The current treatment protocol commonly entails surgery followed by radiotherapy and/or chemotherapy, however, the median ...

    Authors: Zoufang Huang, Saikat Dewanjee, Pratik Chakraborty, Niraj Kumar Jha, Abhijit Dey, Moumita Gangopadhyay, Xuan-Yu Chen, Jian Wang and Saurabh Kumar Jha
    Citation: Molecular Cancer 2023 22:22
  25. Excessive extracellular matrix deposition and increased stiffness are typical features of solid tumors such as hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC). These conditions creat...

    Authors: Zihan Yang, Li Zhou, Tongxu Si, Siyuan Chen, Chengxi Liu, Kelvin Kaki Ng, Zesheng Wang, Zhiji Chen, Chan Qiu, Guopan Liu, Qingliang Wang, Xiaoyu Zhou, Liang Zhang, Zhongping Yao, Song He, Mengsu Yang…
    Citation: Molecular Cancer 2023 22:21
  26. In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a promising immunotherapeutic approach to fight cancers. This approach consists of genetically engineered immune cells expressi...

    Authors: Karama Makni Maalej, Maysaloun Merhi, Varghese P. Inchakalody, Sarra Mestiri, Majid Alam, Cristina Maccalli, Honar Cherif, Shahab Uddin, Martin Steinhoff, Francesco M. Marincola and Said Dermime
    Citation: Molecular Cancer 2023 22:20
  27. Colorectal cancer liver metastases (CRCLM) are associated with a poor prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti-VEGF antibody administration is one of the l...

    Authors: Johannes Robert Fleischer, Alexandra Maria Schmitt, Gwendolyn Haas, Xingbo Xu, Elisabeth Maria Zeisberg, Hanibal Bohnenberger, Stefan Küffer, Laure-Anne Teuwen, Philipp Johannes Karras, Tim Beißbarth, Annalen Bleckmann, Mélanie Planque, Sarah-Maria Fendt, Peter Vermeulen, Michael Ghadimi, Joanna Kalucka…
    Citation: Molecular Cancer 2023 22:17
  28. hsa_circ_0001727 (circZKSCAN1) has been reported to be a tumor-associated circRNA by sponging microRNAs. Intriguingly, we found that circZKSCAN1 encoded a secretory peptide (circZKSaa) in the liver. The presen...

    Authors: Runjie Song, Shuoqian Ma, Jiajia Xu, Xin Ren, Peilan Guo, Huijiao Liu, Peng Li, Fan Yin, Mei Liu, Qiang Wang, Lei Yu, Jiali Liu, Binwei Duan, Nafis A. Rahman, Sławomir Wołczyński, Guangming Li…
    Citation: Molecular Cancer 2023 22:16
  29. Despite advances in early detection and therapies, cancer is still one of the most common causes of death worldwide. Since each tumor is unique, there is a need to implement personalized care and develop robus...

    Authors: Pavel Stejskal, Hani Goodarzi, Josef Srovnal, Marián Hajdúch, Laura J. van ’t Veer and Mark Jesus M. Magbanua
    Citation: Molecular Cancer 2023 22:15
  30. The acquisition of genetic abnormalities engendering oncogene dysregulation underpins cancer development. Certain proto-oncogenes possess several dysregulation mechanisms, yet how each mechanism impacts clinic...

    Authors: Charlotte Smith, Aurore Touzart, Mathieu Simonin, Christine Tran-Quang, Guillaume Hypolite, Mehdi Latiri, Guillaume P. Andrieu, Estelle Balducci, Marie-Émilie Dourthe, Ashish Goyal, Françoise Huguet, Arnaud Petit, Norbert Ifrah, André Baruchel, Hervé Dombret, Elizabeth Macintyre…
    Citation: Molecular Cancer 2023 22:12
  31. Skin cancer has emerged as the fifth most commonly reported cancer in the world, causing a burden on global health and the economy. The enormously rising environmental changes, industrialization, and genetic m...

    Authors: Leli Zeng, B. H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Mohammed A. S. Abourehab, Zhe-Sheng Chen, Changhua Zhang, Jia Li and Prashant Kesharwani
    Citation: Molecular Cancer 2023 22:10
  32. Pancreatic cancer (PC) is a fatal disease that has a poor 5-year survival rate. The poor prognosis can be attributed to both troublesome detections at the initial stage, which makes the majority of the treatme...

    Authors: Zhe Liu, Neha Parveen, Urushi Rehman, Aisha Aziz, Afsana Sheikh, Mohammed A. S. Abourehab, Wei Guo, Junhao Huang, Zhenning Wang and Prashant Kesharwani
    Citation: Molecular Cancer 2023 22:8
  33. Gastric cancer (GC) is one of the most common tumors worldwide and the leading cause of tumor-related mortality. Endoscopy and serological tumor marker testing are currently the main methods of GC screening, a...

    Authors: Shuo Ma, Meiling Zhou, Yanhua Xu, Xinliang Gu, Mingyuan Zou, Gulinaizhaer Abudushalamu, Yuming Yao, Xiaobo Fan and Guoqiu Wu
    Citation: Molecular Cancer 2023 22:7
  34. Human epidermal growth factor receptor 2-positive (HER2+) breast cancer is characterized by invasive growth, rapid metastasis and chemoresistance. Trastuzumab is an effective treatment for HER2+ breast cancer;...

    Authors: Fei Xing, Hongli Gao, Guanglei Chen, Lisha Sun, Jiayi Sun, Xinbo Qiao, Jinqi Xue and Caigang Liu
    Citation: Molecular Cancer 2023 22:6
  35. Accumulated evidence highlights the significance of the crosstalk between epigenetic and epitranscriptomic mechanisms, notably 5-methylcytosine (5mC) and N6-methyladenosine (m6A). Herein, we conducted a widesprea...

    Authors: Yu Tian, Haijuan Xiao, Yanhui Yang, Pingping Zhang, Jiahui Yuan, Wei Zhang, Lijie Chen, Yibao Fan, Jinze Zhang, Huan Cheng, Tingwei Deng, Lin Yang, Weiwei Wang, Guoyong Chen, Peiqin Wang, Peng Gong…
    Citation: Molecular Cancer 2023 22:5
  36. Metastatic colonization is one of the critical steps in tumor metastasis. A pre-metastatic niche is required for metastatic colonization and is determined by tumor-stroma interactions, yet the mechanistic unde...

    Authors: Yulan Mo, Leanne L. Leung, Celia S. L. Mak, Xueyu Wang, Wai-Sun Chan, Lynn M. N. Hui, Hermit W. M. Tang, Michelle K. Y. Siu, Rakesh Sharma, Dakang Xu, Stephen K. W. Tsui, Hextan Y. S. Ngan, Mingo M. H. Yung, Karen K. L. Chan and David W. Chan
    Citation: Molecular Cancer 2023 22:4
  37. This study aimed to validate whether infusion of GD2-specific fourth-generation safety-designed chimeric antigen receptor (4SCAR)-T cells is safe and whether CAR-T cells exert anti-glioblastoma (GBM) activity.

    Authors: Zhuohao Liu, Jiayi Zhou, Xinzhi Yang, Yuchen Liu, Chang Zou, Wen Lv, Cheng Chen, Kenneth King-yip Cheng, Tao Chen, Lung-Ji Chang, Dinglan Wu and Jie Mao
    Citation: Molecular Cancer 2023 22:3
  38. According to current guidelines, more than 70% of patients with invasive submucosal colorectal cancer (T1 CRC) undergo a radical operation with lymph node dissection, even though only ~ 10% have lymph node met...

    Authors: Katsuki Miyazaki, Yuma Wada, Keisuke Okuno, Tatsuro Murano, Yuji Morine, Tetsuya Ikemoto, Yu Saito, Hiroaki Ikematsu, Yusuke Kinugasa, Mitsuo Shimada and Ajay Goel
    Citation: Molecular Cancer 2023 22:2
  39. Small cell lung cancer (SCLC) is an aggressive lung cancer subtype that is associated with high recurrence and poor prognosis. Due to lack of potential drug targets, SCLC patients have few therapeutic options....

    Authors: Parvez Khan, Jawed Akhtar Siddiqui, Prakash G. Kshirsagar, Ramakanth Chirravuri Venkata, Shailendra Kumar Maurya, Tamara Mirzapoiazova, Naveenkumar Perumal, Sanjib Chaudhary, Ranjana Kumari Kanchan, Mahek Fatima, Md Arafat Khan, Asad Ur Rehman, Imayavaramban Lakshmanan, Sidharth Mahapatra, Geoffrey A. Talmon, Prakash Kulkarni…
    Citation: Molecular Cancer 2023 22:1
  40. Lung cancer is the most prevalent form of cancer and has a high mortality rate, making it a global public health concern. The N6-methyladenosine (m6A) modification is a highly dynamic and reversible process that ...

    Authors: Jin Wang, Lirong Tan, Xueting Yu, Xiyuan Cao, Beibei Jia, Rui Chen and Jianxiang Li
    Citation: Molecular Cancer 2022 21:229

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