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Molecular Cancer

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  1. Content type: Research

    Most melanoma patients with BRAFV600E positive tumors respond well to a combination of BRAF kinase and MEK inhibitors. However, some patients are intrinsically resistant while the majority of patients eventually ...

    Authors: Giulia Cesi, Geoffroy Walbrecq, Andreas Zimmer, Stephanie Kreis and Claude Haan

    Citation: Molecular Cancer 2017 16:102

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  2. Content type: Review

    Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary tumor in the central nervous system. One of the most widely used chemotherapeutic drugs for GBM is temozolomide, which is a DNA...

    Authors: Hua-fu Zhao, Jing Wang, Wei Shao, Chang-peng Wu, Zhong-ping Chen, Shing-shun Tony To and Wei-ping Li

    Citation: Molecular Cancer 2017 16:100

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  3. Content type: Letter to the Editor

    Uterine smooth muscle tumors range from benign leiomyomas to malignant leiomyosarcomas. Based on numerous molecular studies, leiomyomas and leiomyosarcomas mostly lack shared mutations and the majority of tumo...

    Authors: Netta Mäkinen, Kati Kämpjärvi, Norma Frizzell, Ralf Bützow and Pia Vahteristo

    Citation: Molecular Cancer 2017 16:101

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  4. Content type: Research

    Cancer immunotherapy offers a promising approach in cancer treatment. The adenosine A2A receptor (A2AR) could protect cancerous tissues from immune clearance via inhibiting T cells response. To date, the role ...

    Authors: Si-Rui Ma, Wei-Wei Deng, Jian-Feng Liu, Liang Mao, Guang-Tao Yu, Lin-Lin Bu, Ashok B. Kulkarni, Wen-Feng Zhang and Zhi-Jun Sun

    Citation: Molecular Cancer 2017 16:99

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  5. Content type: Research

    Deregulations of long non-coding RNAs (lncRNAs) have been implicated in cancer initiation and progression. Current methods can only capture differential expression of lncRNAs at the population level and ignore...

    Authors: Fuduan Peng, Ruiping Wang, Yuanyuan Zhang, Zhangxiang Zhao, Wenbin Zhou, Zhiqiang Chang, Haihai Liang, Wenyuan Zhao, Lishuang Qi, Zheng Guo and Yunyan Gu

    Citation: Molecular Cancer 2017 16:98

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  6. Content type: Letter to the Editor

    Advanced ovarian cancer is very responsive to first line platinum therapy, however almost invariably it relapses with a resistant disease. We have reported that patient derived ovarian xenografts (PDXs), indep...

    Authors: Francesca Ricci, Federica Guffanti, Giovanna Damia and Massimo Broggini

    Citation: Molecular Cancer 2017 16:97

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  7. Content type: Research

    Current evidence indicates that miR-608 is widely down-regulated in various malignant tumors including liver cancer, colon cancer, lung cancer and glioma, and acts as a tumor suppressor by inhibiting cell prol...

    Authors: Zhen Liang, Xiao Wang, Xin Xu, Bo Xie, Alin Ji, Shuai Meng, Shiqi Li, Yi Zhu, Jian Wu, Zhenghui Hu, Yiwei Lin, Xiangyi Zheng, Liping Xie and Ben Liu

    Citation: Molecular Cancer 2017 16:96

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  8. Content type: Research

    Neuroblastoma is the most common solid tumor in childhood and develops from undifferentiated progenitor cells of the sympathetic nervous system. In neuronal tumor cells DNA-damaging chemotherapeutic agents act...

    Authors: S. Salcher, M. Hermann, U. Kiechl-Kohlendorfer, M. J. Ausserlechner and P. Obexer

    Citation: Molecular Cancer 2017 16:95

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  9. Content type: Review

    Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5′ cap or a 3′ Poly A tail. Although the mechanisms of circular RNAs’ generatio...

    Authors: Shujuan Meng, Hecheng Zhou, Ziyang Feng, Zihao Xu, Ying Tang, Peiyao Li and Minghua Wu

    Citation: Molecular Cancer 2017 16:94

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  10. Content type: Research

    The MET receptor tyrosine kinase represents a promising target in cancer. PIK3CA activating mutations are common in several tumor types and can potentially confer resistance to anti-receptor tyrosine kinase th...

    Authors: Lluís Nisa, Pascal Häfliger, Michaela Poliaková, Roland Giger, Paola Francica, Daniel Matthias Aebersold, Roch-Philippe Charles, Yitzhak Zimmer and Michaela Medová

    Citation: Molecular Cancer 2017 16:93

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  11. Content type: Research

    Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response (UPR). Extensive and acute ER stress directs the U...

    Authors: Iris C. Salaroglio, Elisa Panada, Enrico Moiso, Ilaria Buondonno, Paolo Provero, Menachem Rubinstein, Joanna Kopecka and Chiara Riganti

    Citation: Molecular Cancer 2017 16:91

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  12. Content type: Research

    Thymoma and thymic carcinoma are the most frequent subtypes of thymic epithelial tumors (TETs). A relevant advance in TET management could derive from a deeper molecular characterization of these neoplasms. We...

    Authors: Teresa Bellissimo, Federica Ganci, Enzo Gallo, Andrea Sacconi, Claudia Tito, Luciana De Angelis, Claudio Pulito, Silvia Masciarelli, Daniele Diso, Marco Anile, Vincenzo Petrozza, Felice Giangaspero, Edoardo Pescarmona, Francesco Facciolo, Federico Venuta, Mirella Marino…

    Citation: Molecular Cancer 2017 16:88

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  13. Content type: Research

    The inhibitor of growth (ING) gene family of tumor suppressors is involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling. ING5 is a new member of the ING fam...

    Authors: Shufang Cui, Xin Liao, Chao Ye, Xin Yin, Minghui Liu, Yeting Hong, Mengchao Yu, Yanqing Liu, Hongwei Liang, Chen-Yu Zhang and Xi Chen

    Citation: Molecular Cancer 2017 16:89

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  14. Content type: Research

    Estrogenic signals are suggested to have protection roles in the development of colorectal cancer (CRC). The G protein-coupled estrogen receptor (GPER) has been reported to mediate non-genomic effects of estro...

    Authors: Qiao Liu, Zhuojia Chen, Guanmin Jiang, Yan Zhou, Xiangling Yang, Hongbin Huang, Huanliang Liu, Jun Du and Hongsheng Wang

    Citation: Molecular Cancer 2017 16:87

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  15. Content type: Research

    Enhancing the antitumor activity of the DNA-damaging drugs is an attractive strategy to improve current treatment options. Trabectedin is an isoquinoline alkylating agent with a peculiar mechanism of action. I...

    Authors: Ymera Pignochino, Federica Capozzi, Lorenzo D’Ambrosio, Carmine Dell’Aglio, Marco Basiricò, Marta Canta, Annalisa Lorenzato, Francesca Vignolo Lutati, Sandra Aliberti, Erica Palesandro, Paola Boccone, Danilo Galizia, Sara Miano, Giulia Chiabotto, Lucia Napione, Loretta Gammaitoni…

    Citation: Molecular Cancer 2017 16:86

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  16. Content type: Research

    The BRAF protein kinase is widely studied as a cancer driver and therapeutic target. However, the regulation of its expression is not completely understood.

    Authors: Andrea Marranci, Zhijie Jiang, Marianna Vitiello, Elena Guzzolino, Laura Comelli, Samanta Sarti, Simone Lubrano, Cinzia Franchin, Ileabett Echevarría-Vargas, Andrea Tuccoli, Alberto Mercatanti, Monica Evangelista, Paolo Sportoletti, Giorgio Cozza, Ettore Luzi, Enrico Capobianco…

    Citation: Molecular Cancer 2017 16:85

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  17. Content type: Research

    Both mTOR and Skp2 play critical roles in gastric cancer (GC) tumorigenesis. However, potential mechanisms for the association between these two proteins remains unidentified.

    Authors: Qirong Geng, Jianjun Liu, Zhaohui Gong, Shangxiang Chen, Shuai Chen, Xiaoxing Li, Yue Lu, Xiaofeng Zhu, Hui-kuan Lin and Dazhi Xu

    Citation: Molecular Cancer 2017 16:83

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  18. Content type: Research

    Cancer/testis (CT) genes have expression normally restricted to the testis, but become activated during oncogenesis, so they have excellent potential as cancer-specific biomarkers. Evidence is starting to emer...

    Authors: Vicente Planells-Palop, Ali Hazazi, Julia Feichtinger, Jana Jezkova, Gerhard Thallinger, Naif O. Alsiwiehri, Mikhlid Almutairi, Lee Parry, Jane A. Wakeman and Ramsay J. McFarlane

    Citation: Molecular Cancer 2017 16:84

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  19. Content type: Research

    Long noncoding RNAs (lncRNAs) have emerged as critical regulators in a variety of human cancers, including gastric cancer (GC). However, the function and mechanisms responsible for these molecules in GC are no...

    Authors: Zhili Liu, Zhenyao Chen, Ruihua Fan, Bin Jiang, Xin Chen, Qinnan Chen, Fengqi Nie, Kaihua Lu and Ming Sun

    Citation: Molecular Cancer 2017 16:82

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  20. Content type: Research

    Esophageal squamous cell carcinoma (ESCC) is highly malignant with highly invasive and metastatic capabilities and poor prognosis. It is believed that the ESCC cancer stem-like cells (ECSLCs) are critical for ...

    Authors: Qiang Liu, Xiang Cui, Xi Yu, Bai-Shi-Jiao Bian, Feng Qian, Xu-gang Hu, Cheng-dong Ji, Lang Yang, Yong Ren, Wei Cui, Xia Zhang, Peng Zhang, Ji Ming Wang, You-hong Cui and Xiu-wu Bian

    Citation: Molecular Cancer 2017 16:81

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  21. Content type: Review

    There is a growing trend towards exploring the use of a minimally invasive “liquid biopsy” to identify biomarkers in a number of cancers, including urologic malignancies. Multiple aspects can be assessed in ci...

    Authors: Ashley Di Meo, Jenni Bartlett, Yufeng Cheng, Maria D. Pasic and George M. Yousef

    Citation: Molecular Cancer 2017 16:80

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  22. Content type: Research

    Profiling evidences of selectin demonstrate that they play an crucial role in cancer progression and metastasis. However, DC-SIGNR as a family member of selectin participates in gastric cancer liver metastasis...

    Authors: Yu Zhang, Qianshi Zhang, Mengyang Zhang, Menglang Yuan, Zhaohui Wang, Jingbo Zhang, Xu Zhou, Yinan Zhang, Fang Lin, Heya NA, Shuangyi Ren and Yunfei Zuo

    Citation: Molecular Cancer 2017 16:78

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  23. Content type: Review

    Cancer cells are frequently confronted with metabolic stress in tumor microenvironments due to their rapid growth and limited nutrient supply. Metabolic stress induces cell death through ROS-induced apoptosis....

    Authors: Yang Zhao, Xingbin Hu, Yajing Liu, Shumin Dong, Zhaowei Wen, Wanming He, Shuyi Zhang, Qiong Huang and Min Shi

    Citation: Molecular Cancer 2017 16:79

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