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Molecular Cancer


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  1. Content type: Letter to the Editor

    Efforts to develop effective cancer therapeutics have been hindered by a lack of clinically predictive preclinical models which recapitulate this complex disease. Patient derived xenograft (PDX) models have em...

    Authors: Alexandra Borodovsky, Travis J. McQuiston, Daniel Stetson, Ambar Ahmed, David Whitston, Jingwen Zhang, Michael Grondine, Deborah Lawson, Sharon S. Challberg, Michael Zinda, Brian A. Pollok, Brian A. Dougherty and Celina M. D’Cruz

    Citation: Molecular Cancer 2017 16:177

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  2. Content type: Review

    Metastasis has intrigued researchers for more than 100 years. Despite the development of technologies and therapeutic strategies, metastasis is still the major cause of cancer-related death until today. The fa...

    Authors: Qiang Liu, Hongfei Zhang, Xiaoli Jiang, Caiyun Qian, Zhuoqi Liu and Daya Luo

    Citation: Molecular Cancer 2017 16:176

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  3. Content type: Research

    Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is belie...

    Authors: Xujun Liu, Wenzhe Si, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang and Luyang Sun

    Citation: Molecular Cancer 2017 16:175

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  4. Content type: Research

    Chemoresistance has long been recognized as a major obstacle in cancer therapy. Clarifying the underlying mechanism of chemoresistance would result in novel strategies to improve patient’s response to chemothe...

    Authors: Hu YiRen, Yu YingCong, You Sunwu, Li Keqin, Tong Xiaochun, Chen Senrui, Chen Ende, Lin XiZhou and Chen Yanfan

    Citation: Molecular Cancer 2017 16:174

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  5. Content type: Review

    Exploring gene function is critical for understanding the complexity of life. DNA sequences and the three-dimensional organization of chromatin (chromosomal interactions) are considered enigmatic factors under...

    Authors: Ruobing Jia, Peiwei Chai, He Zhang and Xianqun Fan

    Citation: Molecular Cancer 2017 16:173

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  6. Content type: Research

    Our understanding of the multiple roles exosomes play during tumor progression is still very poor and the contribution of the normal tissue derived exosomes in distant seeding and tumor outgrowth has also not ...

    Authors: Nikolina Dioufa, Amanda M. Clark, Bo Ma, Colin H. Beckwitt and Alan Wells

    Citation: Molecular Cancer 2017 16:172

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  7. Content type: Research

    Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) in the biological behaviors of glioblastoma stem cells (GSCs). Here, we elucidated the function and possible molecular...

    Authors: Rui Su, Shuo Cao, Jun Ma, Yunhui Liu, Xiaobai Liu, Jian Zheng, Jiajia Chen, Libo Liu, Heng Cai, Zhen Li, Lini Zhao, Qianru He and Yixue Xue

    Citation: Molecular Cancer 2017 16:171

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  8. Content type: Research

    Lung cancer is the leading cause of cancer death worldwide. However, the molecular mechanisms underlying lung cancer development have not been fully understood. The functions of histone deacetylases (HDACs), a...

    Authors: Yubin Lei, Lingling Liu, Shujing Zhang, Shicheng Guo, Xiaoqing Li, Jiucun Wang, Bo Su, Yuchao Fang, Xiaofeng Chen, Hengning Ke and Wufan Tao

    Citation: Molecular Cancer 2017 16:170

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  9. Content type: Research

    Pancreatic cancer, one of the top two most fatal cancers, is characterized by a desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and inducing the epithelial-to-mesenchymal transit...

    Authors: Hongzhe Li, Xinjing Wang, Chenlei Wen, Zhen Huo, Weishen Wang, Qian Zhan, Dongfeng Cheng, Hao Chen, Xiaxing Deng, Chenghong Peng and Baiyong Shen

    Citation: Molecular Cancer 2017 16:169

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  10. Content type: Letter to the Editor

    Four molecular classifications of pancreatic ductal adenocarcinoma (PDAC), biologically and clinically relevant and based on gene expression profiles, were established in the recent years, including the Collis...

    Authors: David J. Birnbaum, Pascal Finetti, Daniel Birnbaum, Emilie Mamessier and François Bertucci

    Citation: Molecular Cancer 2017 16:168

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  11. Content type: Research

    MicroRNAs (miRNAs) can act as oncogenes or tumor suppressors by controlling cell proliferation, differentiation, metastasis and apoptosis, and miRNA dysregulation is involved in the development of pancreatic c...

    Authors: Manmei Long, Ming Zhan, Sunwang Xu, Ruimeng Yang, Wei Chen, Shilei Zhang, Yongheng Shi, Qiao He, Man Mohan, Qiang Liu and Jian Wang

    Citation: Molecular Cancer 2017 16:167

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  12. Content type: Research

    Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in tumorigenesis. Here, we report a novel lncRNA, RP11-436H11.5, that regulates renal cell carcinoma (RCC) cell prolifera...

    Authors: Kefeng Wang, Wei Jin, Yan Song and Xiang Fei

    Citation: Molecular Cancer 2017 16:166

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  13. Content type: Review

    Hepatocellular carcinoma (HCC) is one of the most common malignant tumours with a poor prognosis worldwide. While early stage tumours can be treated with curative approaches such as liver transplantation or su...

    Authors: Xiaoqi Huo, Shuanglin Han, Guang Wu, Olivier Latchoumanin, Gang Zhou, Lionel Hebbard, Jacob George and Liang Qiao

    Citation: Molecular Cancer 2017 16:165

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  14. Content type: Letter to the Editor

    Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive malignancies worldwide. Studies seeking to advance the overall understanding of lncRNA profiling in HCC remain rare.

    Authors: Jian Yao, Lingjiao Wu, Xiaohua Meng, Huanxia Yang, Shujun Ni, Qiangfeng Wang, Jiawei Zhou, Qiong Zhang, Kunkai Su, Li Shao, Qingyi Cao, Mingding Li, Fusheng Wu and Lanjuan Li

    Citation: Molecular Cancer 2017 16:164

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  15. Content type: Research

    Molecular profiling in ovarian cancer (OC) revealed that the desmoplasia subtype presented the poorest prognosis, highlighting the contribution of stromal fibroblasts in tumor progression. This study aimed to ...

    Authors: Zongyuan Yang, Xin Yang, Sen Xu, Ping Jin, Xiaoting Li, Xiao Wei, Dan Liu, Kecheng Huang, Sixiang Long, Ya Wang, Chaoyang Sun, Gang Chen, Junbo Hu, Li Meng, Ding Ma and Qinglei Gao

    Citation: Molecular Cancer 2017 16:163

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  16. Content type: Research

    The conversion from estrogen-dependent to estrogen-independent state of ER+ breast cancer cells is the key step to promote resistance to endocrine therapies. Although the crucial role of MAPK/ERK signaling pat...

    Authors: Wan-xin Peng, Jian-guo Huang, Liu Yang, Ai-hua Gong and Yin-Yuan Mo

    Citation: Molecular Cancer 2017 16:161

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  17. Content type: Research

    Despite progress in treatment of small cell lung cancer (SCLC), the biology of the tumor still remains poorly understood. Recently, we globally investigated the contributions of lncRNA in SCLC with a special f...

    Authors: Yanqin Sun, Yuanyuan Zhou, Yifeng Bai, Qiongyao Wang, Jiarong Bao, Yingshan Luo, Ying Guo and Linlang Guo

    Citation: Molecular Cancer 2017 16:162

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  18. Content type: Letter to the Editor

    A growing number of evidence has indicated that long non-coding RNAs (lncRNA) may have many functions in the development and progression of cancer, and cloud serve as good diagnostic and prognostic biomarkers ...

    Authors: Xiaoli Chen, Meiyu Dai, Hongzhen Zhu, Jinwan Li, Zhizhuo Huang, Xuexiang Liu, Yujie Huang, Jingfan Chen and Shengming Dai

    Citation: Molecular Cancer 2017 16:160

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  19. Content type: Research

    Tumor-derived exosomes (TDEs) play a pivotal role in tumor establishment and progression, and are emerging biomarkers for tumor diagnosis in personalized medicine. To date, there is a lack of efficient technol...

    Authors: Enrico Iaccino, Selena Mimmi, Vincenzo Dattilo, Fabiola Marino, Patrizio Candeloro, Antonio Di Loria, Danilo Marimpietri, Antonio Pisano, Francesco Albano, Eleonora Vecchio, Simona Ceglia, Gaetanina Golino, Antonio Lupia, Giuseppe Fiume, Ileana Quinto and Giuseppe Scala

    Citation: Molecular Cancer 2017 16:159

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  20. Content type: Research

    N-myc (and STAT) interactor (NMI) plays vital roles in tumor growth, progression, and metastasis. In this study, we identified NMI as a potential tumor suppressor in lung cancer and explored its molecular mech...

    Authors: Jingshu Wang, Kun Zou, Xu Feng, Miao Chen, Cong Li, Ranran Tang, Yang Xuan, Meihua Luo, Wangbing Chen, Huijuan Qiu, Ge Qin, Yixin Li, Changlin Zhang, Binyi Xiao, Lan Kang, Tiebang Kang…

    Citation: Molecular Cancer 2017 16:158

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  21. Content type: Research

    MicroRNAs (miRNAs) are important regulators involved in diverse physiological and pathological processes including cancer. SUMO (small ubiquitin-like modifier) is a reversible protein modifier. We recently fou...

    Authors: Haihua Yuan, Rong Deng, Xian Zhao, Ran Chen, Guofang Hou, Hailong Zhang, Yanli Wang, Ming Xu, Bin Jiang and Jianxiu Yu

    Citation: Molecular Cancer 2017 16:157

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  22. Content type: Letter to the Editor

    The aim of this study was to identify microRNAs in urinary exosomes that are differently expressed in prostate cancer patients and healthy donors. For this purpose, RNA was extracted from urinary exosomes from...

    Authors: Marta Rodríguez, Cristina Bajo-Santos, Nina P. Hessvik, Susanne Lorenz, Bastian Fromm, Viktor Berge, Kirsten Sandvig, Aija Linē and Alicia Llorente

    Citation: Molecular Cancer 2017 16:156

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  23. Content type: Research

    Although both long and micro RNAs are emerging as important functional components in colorectal cancer (CRC) progression and metastasis, the mechanism of their interaction remains poorly understood. CCAT2 (Col...

    Authors: Yingjie Yu, Pratima Nangia-Makker, Lulu Farhana and Adhip P. N. Majumdar

    Citation: Molecular Cancer 2017 16:155

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  24. Content type: Research

    Reprogrammed energy metabolism as an emerging hallmark of cancer has recently drawn special attention since it facilitate cell growth and proliferation. Recently, long noncoding RNAs (lncRNAs) have been served...

    Authors: Binyao Yang, Lisha Zhang, Yi Cao, Shuai Chen, Jun Cao, Di Wu, Jiansong Chen, Huali Xiong, Zihua Pan, Fuman Qiu, Jinbin Chen, Xiaoxuan Ling, Maosheng Yan, Suli Huang, Shiyu Zhou, Tiegang Li…

    Citation: Molecular Cancer 2017 16:154

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