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  1. Content type: Research

    FHIT is a genome caretaker/tumor suppressor that is silenced in >50% of cancers. Although it was identified more than 20 years ago, questions remain as to how FHIT loss contributes to ...

    Authors: Daniel L. Kiss, William Baez, Kay Huebner, Ralf Bundschuh and Daniel R. Schoenberg

    Citation: Molecular Cancer 2017 16:179

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  2. Content type: Research

    Heat shock protein 90 (HSP90) functions as a well-known onco-protein to regulate protein conformation, stability and degradation. Pyruvate kinase M2 (PKM2), a critical regulator of the metabolism, growth and m...

    Authors: Qiuran Xu, Jianfeng Tu, Changwei Dou, Jun Zhang, Liu Yang, Xin Liu, Kefeng Lei, Zhikui Liu, Yufeng Wang, Lijie Li, Hangxing Bao, Jiahui Wang and Kangsheng Tu

    Citation: Molecular Cancer 2017 16:178

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  3. Content type: Letter to the Editor

    Efforts to develop effective cancer therapeutics have been hindered by a lack of clinically predictive preclinical models which recapitulate this complex disease. Patient derived xenograft (PDX) models have em...

    Authors: Alexandra Borodovsky, Travis J. McQuiston, Daniel Stetson, Ambar Ahmed, David Whitston, Jingwen Zhang, Michael Grondine, Deborah Lawson, Sharon S. Challberg, Michael Zinda, Brian A. Pollok, Brian A. Dougherty and Celina M. D’Cruz

    Citation: Molecular Cancer 2017 16:177

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  4. Content type: Review

    Metastasis has intrigued researchers for more than 100 years. Despite the development of technologies and therapeutic strategies, metastasis is still the major cause of cancer-related death until today. The fa...

    Authors: Qiang Liu, Hongfei Zhang, Xiaoli Jiang, Caiyun Qian, Zhuoqi Liu and Daya Luo

    Citation: Molecular Cancer 2017 16:176

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  5. Content type: Research

    Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is belie...

    Authors: Xujun Liu, Wenzhe Si, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang and Luyang Sun

    Citation: Molecular Cancer 2017 16:175

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  6. Content type: Research

    Chemoresistance has long been recognized as a major obstacle in cancer therapy. Clarifying the underlying mechanism of chemoresistance would result in novel strategies to improve patient’s response to chemothe...

    Authors: Hu YiRen, Yu YingCong, You Sunwu, Li Keqin, Tong Xiaochun, Chen Senrui, Chen Ende, Lin XiZhou and Chen Yanfan

    Citation: Molecular Cancer 2017 16:174

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  7. Content type: Review

    Exploring gene function is critical for understanding the complexity of life. DNA sequences and the three-dimensional organization of chromatin (chromosomal interactions) are considered enigmatic factors under...

    Authors: Ruobing Jia, Peiwei Chai, He Zhang and Xianqun Fan

    Citation: Molecular Cancer 2017 16:173

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  8. Content type: Research

    Our understanding of the multiple roles exosomes play during tumor progression is still very poor and the contribution of the normal tissue derived exosomes in distant seeding and tumor outgrowth has also not ...

    Authors: Nikolina Dioufa, Amanda M. Clark, Bo Ma, Colin H. Beckwitt and Alan Wells

    Citation: Molecular Cancer 2017 16:172

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  9. Content type: Research

    Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) in the biological behaviors of glioblastoma stem cells (GSCs). Here, we elucidated the function and possible molecular...

    Authors: Rui Su, Shuo Cao, Jun Ma, Yunhui Liu, Xiaobai Liu, Jian Zheng, Jiajia Chen, Libo Liu, Heng Cai, Zhen Li, Lini Zhao, Qianru He and Yixue Xue

    Citation: Molecular Cancer 2017 16:171

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  10. Content type: Research

    Lung cancer is the leading cause of cancer death worldwide. However, the molecular mechanisms underlying lung cancer development have not been fully understood. The functions of histone deacetylases (HDACs), a...

    Authors: Yubin Lei, Lingling Liu, Shujing Zhang, Shicheng Guo, Xiaoqing Li, Jiucun Wang, Bo Su, Yuchao Fang, Xiaofeng Chen, Hengning Ke and Wufan Tao

    Citation: Molecular Cancer 2017 16:170

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  11. Content type: Research

    Pancreatic cancer, one of the top two most fatal cancers, is characterized by a desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and inducing the epithelial-to-mesenchymal transit...

    Authors: Hongzhe Li, Xinjing Wang, Chenlei Wen, Zhen Huo, Weishen Wang, Qian Zhan, Dongfeng Cheng, Hao Chen, Xiaxing Deng, Chenghong Peng and Baiyong Shen

    Citation: Molecular Cancer 2017 16:169

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  12. Content type: Letter to the Editor

    Four molecular classifications of pancreatic ductal adenocarcinoma (PDAC), biologically and clinically relevant and based on gene expression profiles, were established in the recent years, including the Collis...

    Authors: David J. Birnbaum, Pascal Finetti, Daniel Birnbaum, Emilie Mamessier and François Bertucci

    Citation: Molecular Cancer 2017 16:168

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  13. Content type: Research

    MicroRNAs (miRNAs) can act as oncogenes or tumor suppressors by controlling cell proliferation, differentiation, metastasis and apoptosis, and miRNA dysregulation is involved in the development of pancreatic c...

    Authors: Manmei Long, Ming Zhan, Sunwang Xu, Ruimeng Yang, Wei Chen, Shilei Zhang, Yongheng Shi, Qiao He, Man Mohan, Qiang Liu and Jian Wang

    Citation: Molecular Cancer 2017 16:167

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  14. Content type: Research

    Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in tumorigenesis. Here, we report a novel lncRNA, RP11-436H11.5, that regulates renal cell carcinoma (RCC) cell prolifera...

    Authors: Kefeng Wang, Wei Jin, Yan Song and Xiang Fei

    Citation: Molecular Cancer 2017 16:166

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  15. Content type: Review

    Hepatocellular carcinoma (HCC) is one of the most common malignant tumours with a poor prognosis worldwide. While early stage tumours can be treated with curative approaches such as liver transplantation or su...

    Authors: Xiaoqi Huo, Shuanglin Han, Guang Wu, Olivier Latchoumanin, Gang Zhou, Lionel Hebbard, Jacob George and Liang Qiao

    Citation: Molecular Cancer 2017 16:165

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  16. Content type: Letter to the Editor

    Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive malignancies worldwide. Studies seeking to advance the overall understanding of lncRNA profiling in HCC remain rare.

    Authors: Jian Yao, Lingjiao Wu, Xiaohua Meng, Huanxia Yang, Shujun Ni, Qiangfeng Wang, Jiawei Zhou, Qiong Zhang, Kunkai Su, Li Shao, Qingyi Cao, Mingding Li, Fusheng Wu and Lanjuan Li

    Citation: Molecular Cancer 2017 16:164

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  17. Content type: Research

    Molecular profiling in ovarian cancer (OC) revealed that the desmoplasia subtype presented the poorest prognosis, highlighting the contribution of stromal fibroblasts in tumor progression. This study aimed to ...

    Authors: Zongyuan Yang, Xin Yang, Sen Xu, Ping Jin, Xiaoting Li, Xiao Wei, Dan Liu, Kecheng Huang, Sixiang Long, Ya Wang, Chaoyang Sun, Gang Chen, Junbo Hu, Li Meng, Ding Ma and Qinglei Gao

    Citation: Molecular Cancer 2017 16:163

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  18. Content type: Research

    The conversion from estrogen-dependent to estrogen-independent state of ER+ breast cancer cells is the key step to promote resistance to endocrine therapies. Although the crucial role of MAPK/ERK signaling pat...

    Authors: Wan-xin Peng, Jian-guo Huang, Liu Yang, Ai-hua Gong and Yin-Yuan Mo

    Citation: Molecular Cancer 2017 16:161

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  19. Content type: Research

    Despite progress in treatment of small cell lung cancer (SCLC), the biology of the tumor still remains poorly understood. Recently, we globally investigated the contributions of lncRNA in SCLC with a special f...

    Authors: Yanqin Sun, Yuanyuan Zhou, Yifeng Bai, Qiongyao Wang, Jiarong Bao, Yingshan Luo, Ying Guo and Linlang Guo

    Citation: Molecular Cancer 2017 16:162

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  20. Content type: Letter to the Editor

    A growing number of evidence has indicated that long non-coding RNAs (lncRNA) may have many functions in the development and progression of cancer, and cloud serve as good diagnostic and prognostic biomarkers ...

    Authors: Xiaoli Chen, Meiyu Dai, Hongzhen Zhu, Jinwan Li, Zhizhuo Huang, Xuexiang Liu, Yujie Huang, Jingfan Chen and Shengming Dai

    Citation: Molecular Cancer 2017 16:160

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  21. Content type: Research

    Tumor-derived exosomes (TDEs) play a pivotal role in tumor establishment and progression, and are emerging biomarkers for tumor diagnosis in personalized medicine. To date, there is a lack of efficient technol...

    Authors: Enrico Iaccino, Selena Mimmi, Vincenzo Dattilo, Fabiola Marino, Patrizio Candeloro, Antonio Di Loria, Danilo Marimpietri, Antonio Pisano, Francesco Albano, Eleonora Vecchio, Simona Ceglia, Gaetanina Golino, Antonio Lupia, Giuseppe Fiume, Ileana Quinto and Giuseppe Scala

    Citation: Molecular Cancer 2017 16:159

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  22. Content type: Research

    N-myc (and STAT) interactor (NMI) plays vital roles in tumor growth, progression, and metastasis. In this study, we identified NMI as a potential tumor suppressor in lung cancer and explored its molecular mech...

    Authors: Jingshu Wang, Kun Zou, Xu Feng, Miao Chen, Cong Li, Ranran Tang, Yang Xuan, Meihua Luo, Wangbing Chen, Huijuan Qiu, Ge Qin, Yixin Li, Changlin Zhang, Binyi Xiao, Lan Kang, Tiebang Kang…

    Citation: Molecular Cancer 2017 16:158

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  23. Content type: Research

    MicroRNAs (miRNAs) are important regulators involved in diverse physiological and pathological processes including cancer. SUMO (small ubiquitin-like modifier) is a reversible protein modifier. We recently fou...

    Authors: Haihua Yuan, Rong Deng, Xian Zhao, Ran Chen, Guofang Hou, Hailong Zhang, Yanli Wang, Ming Xu, Bin Jiang and Jianxiu Yu

    Citation: Molecular Cancer 2017 16:157

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  24. Content type: Letter to the Editor

    The aim of this study was to identify microRNAs in urinary exosomes that are differently expressed in prostate cancer patients and healthy donors. For this purpose, RNA was extracted from urinary exosomes from...

    Authors: Marta Rodríguez, Cristina Bajo-Santos, Nina P. Hessvik, Susanne Lorenz, Bastian Fromm, Viktor Berge, Kirsten Sandvig, Aija Linē and Alicia Llorente

    Citation: Molecular Cancer 2017 16:156

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  25. Content type: Research

    Although both long and micro RNAs are emerging as important functional components in colorectal cancer (CRC) progression and metastasis, the mechanism of their interaction remains poorly understood. CCAT2 (Col...

    Authors: Yingjie Yu, Pratima Nangia-Makker, Lulu Farhana and Adhip P. N. Majumdar

    Citation: Molecular Cancer 2017 16:155

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  26. Content type: Research

    Reprogrammed energy metabolism as an emerging hallmark of cancer has recently drawn special attention since it facilitate cell growth and proliferation. Recently, long noncoding RNAs (lncRNAs) have been served...

    Authors: Binyao Yang, Lisha Zhang, Yi Cao, Shuai Chen, Jun Cao, Di Wu, Jiansong Chen, Huali Xiong, Zihua Pan, Fuman Qiu, Jinbin Chen, Xiaoxuan Ling, Maosheng Yan, Suli Huang, Shiyu Zhou, Tiegang Li…

    Citation: Molecular Cancer 2017 16:154

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  27. Content type: Research

    Non-coding RNAs (ncRNAs) have been shown to regulate gene expression involved in tumor progression of multiple malignancies. Our previous studies indicated that large tumor suppressor kinase 1 (LATS1), a core ...

    Authors: Jing Zhang, Hui Liu, Lidan Hou, Ge Wang, Rui Zhang, Yanxia Huang, Xiaoyu Chen and Jinshui Zhu

    Citation: Molecular Cancer 2017 16:151

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  28. Content type: Research

    Abnormal expression of numerous long non-coding RNAs (lncRNAs) has been reported in esophageal squamous cell carcinoma (ESCC) recently, but the great majority of their roles and mechanisms remain largely uncle...

    Authors: Yuanyuan Wu, Liwen Hu, Yan Liang, Juan Li, Kai Wang, Xuedan Chen, Hui Meng, Xingying Guan, Kang Yang and Yun Bai

    Citation: Molecular Cancer 2017 16:150

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  29. Content type: Research

    The Ghrelin-system is a complex, pleiotropic family composed of several peptides, including native-ghrelin and its In1-ghrelin splicing variant, and receptors (GHSR 1a/b), which are dysregulated in various end...

    Authors: Daniel Hormaechea-Agulla, Manuel D. Gahete, Juan M. Jiménez-Vacas, Enrique Gómez-Gómez, Alejandro Ibáñez-Costa, Fernando L-López, Esther Rivero-Cortés, André Sarmento-Cabral, José Valero-Rosa, Julia Carrasco-Valiente, Rafael Sánchez-Sánchez, Rosa Ortega-Salas, María M. Moreno, Natia Tsomaia, Steve M. Swanson, Michael D. Culler…

    Citation: Molecular Cancer 2017 16:146

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  30. Content type: Review

    Exosomes are emerging as a new type of cancer biomarkers. Exosome is a bilayered nano-sized vesicle secreted by various living cells in all body fluids. Based on the expanding albeit incomplete knowledge of th...

    Authors: Weihua Li, Chuanyun Li, Tong Zhou, Xiuhong Liu, Xiaoni Liu, Xiuhui Li and Dexi Chen

    Citation: Molecular Cancer 2017 16:145

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  31. Content type: Review

    The present review aimed to assess the role of exosomal miRNAs in cancer-associated fibroblasts (CAFs), normal fibroblasts (NFs), and cancer cells. The roles of exosomal miRNAs and miRNA dysregulation in CAF f...

    Authors: Fengming Yang, Zhiqiang Ning, Ling Ma, Weitao Liu, Chuchu Shao, Yongqian Shu and Hua Shen

    Citation: Molecular Cancer 2017 16:148

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  32. Content type: Research

    Phospholipid phosphatase 4 (PPAPDC1A or PLPP4) has been demonstrated to be involved in the malignant process of many cancers. The purpose of this study was to investigate the clinical significance and biologic...

    Authors: Xin Zhang, Lan Zhang, Bihua Lin, Xingxing Chai, Ronggang Li, Yuehua Liao, Xinghui Deng, Qiongru Liu, Wenli Yang, Yubo Cai, Wei Zhou, Zhichao Lin, Wenhai Huang, Meigong Zhong, Fangyong Lei, Jinhua Wu…

    Citation: Molecular Cancer 2017 16:147

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  33. Content type: Erratum

    Authors: Wei Lu, Honghe Zhang, Yuequn Niu, Yongfeng Wu, Wenjie Sun, Hongyi Li, Jianlu Kong, Kefeng Ding, Han-Ming Shen, Han Wu, Dajing Xia and Yihua Wu

    Citation: Molecular Cancer 2017 16:144

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    The original article was published in Molecular Cancer 2017 16:118

  34. Content type: Research

    To overcome the hostile hypoxic microenvironment of solid tumors, tumor cells secrete a large number of non-coding RNA-containing exosomes that facilitate tumor development and metastasis. However, the precise...

    Authors: Mei Xue, Wei Chen, An Xiang, Ruiqi Wang, He Chen, Jingjing Pan, Huan Pang, Hongli An, Xiang Wang, Huilian Hou and Xu Li

    Citation: Molecular Cancer 2017 16:143

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  35. Content type: Research

    Emerging studies show that long noncoding RNAs (lncRNAs) play important roles in carcinogenesis and cancer progression. The lncRNA ZEB1 antisense 1 (ZEB1-AS1) derives from the promoter region of ZEB1 and we st...

    Authors: Wenjing Su, Miao Xu, Xueqin Chen, Ni Chen, Jing Gong, Ling Nie, Ling Li, Xinglan Li, Mengni Zhang and Qiao Zhou

    Citation: Molecular Cancer 2017 16:142

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  36. Content type: Research

    Aberrant expression of microRNAs in different human cancer types has been widely reported. MiR-218 acts as a tumor suppressor in diverse human cancer types impacting regulation of multiple genes in oncogenic p...

    Authors: Yan Yang, Lili Ding, Qun Hu, Jia Xia, Junjie Sun, Xudong Wang, Hua Xiong, Deepak Gurbani, Lianbo Li, Yan Liu and Aiguo Liu

    Citation: Molecular Cancer 2017 16:141

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  37. Content type: Research

    Glioma stem cells (GSCs) are a major cause of the frequent relapse observed in glioma, due to their high drug resistance and their differentiation potential. Therefore, understanding the molecular mechanisms g...

    Authors: Soo-Jung Kwon, Ok-Seon Kwon, Keun-Tae Kim, Young-Hyun Go, Si-in Yu, Byeong-ha Lee, Hiroyuki Miyoshi, Eunsel Oh, Seung-Ju Cho and Hyuk-Jin Cha

    Citation: Molecular Cancer 2017 16:140

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  38. Content type: Research

    The aberrant expression of microRNA-140-5p (miR-140-5p) has been described in gastric cancer (GC). However, the role of miR-140-5p in GC remains unclear. In this study, the prognostic relevance of miR-140-5p i...

    Authors: Zheng Fang, Shuai Yin, Ruochuan Sun, Shangxin Zhang, Min Fu, Youliang Wu, Tao Zhang, Junaid Khaliq and Yongxiang Li

    Citation: Molecular Cancer 2017 16:139

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  39. Content type: Review

    Expression of high levels of immune cells including neutrophils has been associated with detrimental outcome in several solid tumors and new strategies to decrease their presence and activity are currently und...

    Authors: Alberto Ocana, Cristina Nieto-Jiménez, Atanasio Pandiella and Arnoud J Templeton

    Citation: Molecular Cancer 2017 16:137

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  40. Content type: Research

    Several of the thousands of human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in hepatocellular carcinoma (HCC) remains poorly understood.

    Authors: Hui Wang, Xisong Huo, Xin-Rong Yang, Jia He, Lijun Cheng, Na Wang, Xuan Deng, Haojie Jin, Ning Wang, Cun Wang, Fangyu Zhao, Jingyuan Fang, Ming Yao, Jia Fan and Wenxin Qin

    Citation: Molecular Cancer 2017 16:136

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  41. Content type: Research

    RAB GTPases are important in the regulation of membrane trafficking and cell movement. Recently, exocytic RABs have received increasing attention in cancer research. However, the functional roles of exocytic R...

    Authors: Yu-Chan Chang, Chia-Yi Su, Ming-Huang Chen, Wei-Shone Chen, Chi-Long Chen and Michael Hsiao

    Citation: Molecular Cancer 2017 16:135

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  42. Content type: Review

    RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention. In the development of RNAi-based therapies, nanoparticle...

    Authors: Yong Xin, Min Huang, Wen Wen Guo, Qian Huang, Long zhen Zhang and Guan Jiang

    Citation: Molecular Cancer 2017 16:134

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  43. Content type: Research

    Protein-tyrosine phosphatase MEG2 (MEG2) is a classic tyrosine-specific protein tyrosine phosphatase (PTP). It has been reported that MEG2 participates in the carcinogenesis of the breast and liver. However, f...

    Authors: Zhijian Liu, Feng Sun, Yeting Hong, Yanqing Liu, Min Fen, Kai Yin, Xiaolong Ge, Feng Wang, Xi Chen and Wenxian Guan

    Citation: Molecular Cancer 2017 16:133

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  44. Content type: Research

    Although gemcitabine-based chemotherapy has been established as a core multimodal therapy for non-small cell lung cancer (NSCLC) treatment, its clinical efficacy remains limited by the development of acquired ...

    Authors: Feng Wei, Chengyuan Ma, Tong Zhou, Xuechao Dong, Qinghua Luo, Li Geng, Lijuan Ding, Yandong Zhang, Li Zhang, Nan Li, Yang Li and Yan Liu

    Citation: Molecular Cancer 2017 16:132

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  45. Content type: Review

    Long-noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides and do not code for proteins. However, this class of RNAs plays pivotal regulatory roles. The mechanism of their ac...

    Authors: Chunmei Fan, Yanyan Tang, Jinpeng Wang, Fang Xiong, Can Guo, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Fang Wei, Liting Yang, Yi He, Ming Zhou, Xiaoling Li, Guiyuan Li, Wei Xiong and Zhaoyang Zeng

    Citation: Molecular Cancer 2017 16:130

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