Cerniglia GJ, Dey S, Gallagher-Colombo SM, Daurio NA, Tuttle S, Busch TM, Lin A, Sun R, Esipova TV, Vinogradov SA, et al. The PI3K/Akt pathway regulates oxygen metabolism via pyruvate dehydrogenase (PDH)-E1alpha phosphorylation. Mol Cancer Ther. 2015;14(8):1928–38.
Article
CAS
PubMed
PubMed Central
Google Scholar
Courtnay R, Ngo DC, Malik N, Ververis K, Tortorella SM, Karagiannis TC. Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K. Mol Biol Rep. 2015;42(4):841–51.
Article
CAS
PubMed
Google Scholar
Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, et al. The Dlk1-Gtl2 locus preserves LT-HSC function by inhibiting the PI3K-mTOR pathway to restrict mitochondrial metabolism. Cell Stem Cell. 2016;18(2):214–28.
Article
CAS
PubMed
Google Scholar
Liu X. Overstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activity. Springerplus. 2014;3:356.
Article
PubMed
PubMed Central
CAS
Google Scholar
McKnight NC, Zhenyu Y. Beclin 1, an essential component and master regulator of PI3K-III in health and disease. Curr Pathobiol Rep. 2013;1(4):231–8.
Article
PubMed
PubMed Central
Google Scholar
Shanware NP, Bray K, Abraham RT. The PI3K, metabolic, and autophagy networks: interactive partners in cellular health and disease. Annu Rev Pharmacol Toxicol. 2013;53:89–106.
Article
CAS
PubMed
Google Scholar
Sanchez-Alegria K, Flores-Leon M, Avila-Munoz E, Rodriguez-Corona N, Arias C. PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions. Int J Mol Sci. 2018;19(12):3725.
Article
PubMed Central
CAS
Google Scholar
Kloo B, Nagel D, Pfeifer M, Grau M, Duwel M, Vincendeau M, Dorken B, Lenz P, Lenz G, Krappmann D. Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells. Proc Natl Acad Sci U S A. 2011;108(1):272–7.
Article
CAS
PubMed
Google Scholar
Xie D, Gore C, Zhou J, Pong RC, Zhang H, Yu L, Vessella RL, Min W, Hsieh JT. DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis. Proc Natl Acad Sci U S A. 2009;106(47):19878–83.
Article
CAS
PubMed
PubMed Central
Google Scholar
Foukas LC, Berenjeno IM, Gray A, Khwaja A, Vanhaesebroeck B. Activity of any class IA PI3K isoform can sustain cell proliferation and survival. Proc Natl Acad Sci U S A. 2010;107(25):11381–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Leevers SJ, Vanhaesebroeck B, Waterfield MD. Signalling through phosphoinositide 3-kinases: the lipids take Centre stage. Curr Opin Cell Biol. 1999;11(2):219–5.
Article
CAS
PubMed
Google Scholar
Holand K, Boller D, Hagel C, Dolski S, Treszl A, Pardo OE, Cwiek P, Salm F, Leni Z, Shepherd PR, et al. Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma. PLoS One. 2014;9(4):e94132.
Article
PubMed
PubMed Central
CAS
Google Scholar
Bleeker FE, Lamba S, Zanon C, Molenaar RJ, Hulsebos TJM, Troost D, van Tilborg AA, Vandertop WP, Leenstra S, van Noorden CJF, et al. Mutational profiling of kinases in glioblastoma. BMC Cancer. 2014;14:718.
Article
PubMed
PubMed Central
CAS
Google Scholar
Ojeda L, Gao JL, Hooten KG, Wang EY, Thonhoff JR, Dunn TJ, Gao TY, Wu P. Critical Role of PI3K/Akt/GSK3 beta in Motoneuron Specification from Human Neural Stem Cells in Response to FGF2 and EGF. Plos One. 2011;6(8):e23414.
Article
CAS
PubMed
PubMed Central
Google Scholar
Peltier J, O'Neill A, Schaffer DV. PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation. Dev Neurobiol. 2007;67(10):1348–61.
Article
CAS
PubMed
Google Scholar
Rafalski VA, Brunet A. Energy metabolism in adult neural stem cell fate. Prog Neurobiol. 2011;93(2):182–203.
Article
CAS
PubMed
Google Scholar
King D, Yeomanson D, Bryant HE. PI3King the lock: targeting the PI3K/Akt/mTOR pathway as a novel therapeutic strategy in neuroblastoma. J Pediat Hematol Onc. 2015;37(4):245–51.
Article
CAS
Google Scholar
Wyatt LA, Filbin MT, Keirstead HS. PTEN inhibition enhances Neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells. J Comp Neurol. 2014;522(12):2741–55.
Article
CAS
PubMed
Google Scholar
Kathawala RJ, Gupta P, Ashby CR, Chen ZS. The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade. Drug Resist Update. 2015;18:1–17.
Article
Google Scholar
Zou ZY, Zhang J, Zhang HY, Liu HG, Li ZG, Cheng D, Chen J, Liu L, Ni MJ, Zhang Y, et al. 3-Methyladenine can depress drug efflux transporters via blocking the PI3K-AKT-mTOR pathway thus sensitizing MDR cancer to chemotherapy. J Drug Target. 2014;22(9):839–48.
Article
CAS
PubMed
Google Scholar
Wu CP, Murakami M, Hsiao SH, Chou AW, Li YQ, Huang YH, Hung TH, Ambudkar SV. Overexpression of ATP-binding cassette subfamily G member 2 confers resistance to phosphatidylinositol 3-kinase inhibitor PF-4989216 in Cancer cells. Mol Pharm. 2017;14(7):2368–77.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang K, Shan YT, Ma L, Yang KY, Hua BJ, Yin W, Yin FZ, Chen Y. Natural product toosendanin reverses the resistance of human breast cancer cells to adriamycin as a novel PI3K inhibitor. Biochem Pharmacol. 2018;152:153–64.
Article
CAS
Google Scholar
Ambudkar SV. Drug-stimulatable ATPase activity in crude membranes of human MDR1-transfected mammalian cells. Methods Enzymol. 1998;292:504–14.
Article
CAS
PubMed
Google Scholar
Gupta P, Zhang YK, Zhang XY, Wang YJ, Lu KW, Hall T, Peng R, Yang DH, Xie N, Chen ZS. Voruciclib, a potent CDK4/6 inhibitor, antagonizes ABCB1 and ABCG2-mediated multi-drug resistance in Cancer cells. Cell Physiol Biochem. 2018;45(4):1515–28.
Article
CAS
PubMed
Google Scholar
Smiley ST, Reers M, Mottolahartshorn C, Lin M, Chen A, Smith TW, Steele GD, Chen LB. Intracellular heterogeneity in mitochondrial-membrane potentials revealed by a J-aggregate-forming lipophilic Cation Jc-1. P Natl Acad Sci USA. 1991;88(9):3671–5.
Article
CAS
Google Scholar
Kim Y, Chen J. Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation. Science. 2018;359(6378):915–9.
Article
CAS
PubMed
Google Scholar
Wang SQ, Liu ST, Zhao BX, Yang FH, Wang YT, Liang QY, Sun YB, Liu Y, Song ZH, Cai Y, et al. Afatinib reverses multidrug resistance in ovarian cancer via dually inhibiting ATP binding cassette subfamily B member 1. Oncotarget. 2015;6(28):26142–60.
PubMed
PubMed Central
Google Scholar
Wu CP, Hsieh YJ, Hsiao SH, Su CY, Li YQ, Huang YH, Huang CW, Hsieh CH, Yu JS, Wu YS. Human ATP-binding cassette transporter ABCG2 confers resistance to CUDC-907, a dual inhibitor of histone Deacetylase and phosphatidylinositol 3-kinase. Mol Pharm. 2016;13(3):784–94.
Article
CAS
PubMed
Google Scholar
Baba Y, Nosho K, Shima K, Hayashi M, Meyerhardt JA, Chan AT, Giovannucci E, Fuchs CS, Ogino S. Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers. Cancer-Am Cancer Soc. 2011;117(7):1399–408.
CAS
Google Scholar
Li SL, Huang CH, Lin CC, Huang ZN, Chern JH, Lien HY, Wu YY, Cheng CH, Chang CY, Chuu JJ. Antitumor effect of BPR-DC-2, a novel synthetic cyclic cyanoguanidine derivative, involving the inhibition of MDR-1 expression and down-regulation of p-AKT and PARP-1 in lung cancer. Investig New Drugs. 2011;29(2):195–206.
Article
CAS
Google Scholar
Wang L, Chen B, Lin M, Cao Y, Chen Y, Chen X, Liu T, Hu J. Decreased expression of nucleophosmin/B23 increases drug sensitivity of adriamycin-resistant Molt-4 leukemia cells through mdr-1 regulation and Akt/mTOR signaling. Immunobiology. 2015;220(3):331–40.
Article
CAS
PubMed
Google Scholar
Xie Y, Shi X, Sheng K, Han G, Li W, Zhao Q, Jiang B, Feng J, Li J, Gu Y. PI3K/Akt signaling transduction pathway, erythropoiesis and glycolysis in hypoxia (review). Mol Med Rep. 2019;19(2):783–91.
CAS
PubMed
Google Scholar
Naderali E, Khaki AA, Rad JS, Ali-Hemmati A, Rahmati M, Charoudeh HN. Regulation and modulation of PTEN activity. Mol Biol Rep. 2018;45(6):2869–81.
Article
CAS
PubMed
Google Scholar
Zhang SL, Ma L, Zhao J, You SP, Ma XT, Ye XY, Liu T. The Phenylethanol glycoside liposome inhibits PDGF-induced HSC activation via regulation of the FAK/PI3K/Akt signaling pathway. Molecules. 2019;24(18):3282.
Article
PubMed Central
CAS
Google Scholar
Chang LC, Sun HL, Tsai CH, Kuo CW, Liu KL, Lii CK, Huang CS, Li CC. 1,25(OH)2 D3 attenuates indoxyl sulfate-induced epithelial-to-mesenchymal cell transition via inactivation of PI3K/Akt/beta-catenin signaling in renal tubular epithelial cells. Nutrition. 2019;69:110554.
Article
PubMed
CAS
Google Scholar
Shi G, Zhang H, Yu Q, Hu C, Ji Y. GATA1 gene silencing inhibits invasion, proliferation and migration of cholangiocarcinoma stem cells via disrupting the PI3K/AKT pathway. Onco Targets Ther. 2019;12:5335–54.
Article
PubMed
PubMed Central
Google Scholar
Kim JY, Ohn J, Yoon JS, Kang BM, Park M, Kim S, Lee W, Hwang S, Kim JI, Kim KH, et al. Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy. Nat Commun. 2019;10(1):3694.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhang YZ, Xia MF, Jin K, Wang SF, Wei H, Fan CM, Wu YF, Li XL, Li XY, Li GY, et al. Function of the c-met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities. Mol Cancer. 2018;17:45.
Article
PubMed
PubMed Central
CAS
Google Scholar
Yang WB, Wu ZJ, Yang K, Han YX, Chen YJ, Zhao WL, Huang FY, Jin Y, Jin W. BMI1 promotes cardiac fibrosis in ischemia-induced heart failure via the PTEN-PI3K/Akt-mTOR signaling pathway. Am J Physiol-Heart C. 2019;316(1):H61–9.
Article
CAS
Google Scholar
Yang X, Zhao T, Feng L, Shi Y, Jiang J, Liang S, Sun B, Xu Q, Duan J, Sun Z. PM2.5-induced ADRB2 hypermethylation contributed to cardiac dysfunction through cardiomyocytes apoptosis via PI3K/Akt pathway. Environ Int. 2019;127:601–14.
Article
CAS
PubMed
Google Scholar
Zhuo MQ, Pan YX, Wu K, Xu YH, Luo Z. Characterization and mechanism of phosphoinositide 3-kinases (PI3Ks) members in insulin-induced changes of protein metabolism in yellow catfish Pelteobagrus fulvidraco. Gen Comp Endocr. 2017;247:34–45.
Article
CAS
PubMed
Google Scholar
Yan X, Hui Y, Hua Y, Huang L, Wang L, Peng F, Tang C, Liu D, Song J, Wang F. EG-VEGF silencing inhibits cell proliferation and promotes cell apoptosis in pancreatic carcinoma via PI3K/AKT/mTOR signaling pathway. Biomed Pharmacother. 2019;109:762–9.
Article
CAS
PubMed
Google Scholar
Wu Y, Hu Y, Yu X, Zhang Y, Huang X, Chen S, Li Y, Zeng C. TAL1 mediates imatinib-induced CML cell apoptosis via the PTEN/PI3K/AKT pathway. Biochem Biophys Res Commun. 2019;519(2):234–9.
Article
CAS
PubMed
Google Scholar
Zhou S, Sakamoto K. Pyruvic acid/ethyl pyruvate inhibits melanogenesis in B16F10 melanoma cells through PI3K/AKT, GSK3beta, and ROS-ERK signaling pathways. Genes Cells. 2019;24(1):60–9.
Article
CAS
PubMed
Google Scholar
Wang J, Sun J, Zhang N, Yang R, Li H, Zhang Y, Chen K, Kong D. PES1 enhances proliferation and tumorigenesis in hepatocellular carcinoma via the PI3K/AKT pathway. Life Sci. 2019;219:182–9.
Article
CAS
PubMed
Google Scholar
Lu M, Hartmann D, Braren R, Gupta A, Wang B, Wang Y, Mogler C, Cheng Z, Wirth T, Friess H, et al. Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis. BMC Cancer. 2019;19(1):887.
Article
PubMed
PubMed Central
CAS
Google Scholar
Liu MH, Li GH, Peng LJ, Qu SL, Zhang Y, Peng J, Luo XY, Hu HJ, Ren Z, Liu Y, et al. PI3K/Akt/FoxO3a signaling mediates cardioprotection of FGF-2 against hydrogen peroxide-induced apoptosis in H9c2 cells. Mol Cell Biochem. 2016;414(1–2):57–66.
CAS
PubMed
Google Scholar
Ma L, Meng Y, Tu C, Cao X, Wang H, Li Y, Man S, Zhou J, Li M, Liu Z, et al. A cardiac glycoside HTF-1 isolated from Helleborus thibetanus Franch displays potent in vitro anti-cancer activity via caspase-9, MAPK and PI3K-Akt-mTOR pathways. Eur J Med Chem. 2018;158:743–52.
Article
CAS
PubMed
Google Scholar
Lee C, Kim JS, Waldman T. Activated PI3K signaling as an endogenous inducer of p53 in human cancer. Cell Cycle. 2007;6(4):394–6.
Article
CAS
PubMed
Google Scholar
Tsuji T, Ozasa H, Aoki W, Aburaya S, Funazo T, Furugaki K, Yoshimura Y, Ajimizu H, Okutani R, Yasuda Y, et al. Alectinib resistance in ALK-rearranged lung Cancer by dual salvage signaling in a clinically paired resistance model. Mol Cancer Res. 2019;17(1):212–24.
Article
CAS
PubMed
Google Scholar
Gasser JA, Inuzuka H, Lau AW, Wei W, Beroukhim R, Toker A. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Mol Cell. 2014;56(4):595–607.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene. 2008;27(41):5497–510.
Article
CAS
PubMed
PubMed Central
Google Scholar
Janku F, Yap TA, Meric-Bernstam F. Targeting the PI3K pathway in cancer: are we making headway? Nat Rev Clin Oncol. 2018;15(5):273–91.
Article
CAS
PubMed
Google Scholar
Fransson S, Uv A, Eriksson H, Andersson MK, Wettergren Y, Bergo M, Ejeskar K. p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors. Oncogene. 2012;31(27):3277–86.
Article
CAS
PubMed
Google Scholar
Naduthodi MIS, Mohanraju P, Sudfeld C, D'Adamo S, Barbosa MJ, van der Oost J. CRISPR-Cas ribonucleoprotein mediated homology-directed repair for efficient targeted genome editing in microalgae Nannochloropsis oceanica IMET1. Biotechnol Biofuels. 2019;12:66.
Article
PubMed
PubMed Central
Google Scholar
Guo T, Feng YL, Xiao JJ, Liu Q, Sun XN, Xiang JF, Kong N, Liu SC, Chen GQ, Wang Y, et al. Harnessing accurate non-homologous end joining for efficient precise deletion in CRISPR/Cas9-mediated genome editing. Genome Biol. 2018;19(1):170.
Article
PubMed
PubMed Central
CAS
Google Scholar
Momose T, De Cian A, Shiba K, Inaba K, Giovannangeli C, Concordet JP. High doses of CRISPR/Cas9 ribonucleoprotein efficiently induce gene knockout with low mosaicism in the hydrozoan Clytia hemisphaerica through microhomology-mediated deletion. Sci Rep. 2018;8(1):11734.
Article
PubMed
PubMed Central
CAS
Google Scholar
Cheng C, Liu ZG, Zhang H, Xie JD, Chen XG, Zhao XQ, Wang F, Liang YJ, Chen LK, Singh S, et al. Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an Aurora kinase inhibitor CCT129202. Mol Pharm. 2012;9(7):1971–82.
Article
CAS
PubMed
Google Scholar
Zeng L, Gupta P, Chen Y, Wang E, Ji L, Chao H, Chen ZS. The development of anticancer ruthenium (ii) complexes: from single molecule compounds to nanomaterials. Chem Soc Rev. 2017;46(19):5771–804.
Article
CAS
PubMed
PubMed Central
Google Scholar