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  1. Lung cancer and pleural mesothelioma are two of the most deadly forms of cancer. The prognosis of lung cancer and mesothelioma is extremely poor due to limited treatment modalities and lack of understanding of...

    Authors: Xiaoqing He, Liying Wang, Heimo Riedel, Kai Wang, Yong Yang, Cerasela Zoica Dinu and Yon Rojanasakul
    Citation: Molecular Cancer 2017 16:63
    Content type: Research Published on:

  2. High levels of SOX2 protein are correlated with increased dissemination of breast cancer. However, the underlying molecular mechanisms are not fully understood.

    Authors: Kuancan Liu, Fuan Xie, Anding Gao, Rui Zhang, Long Zhang, Zhangwu Xiao, Qiong Hu, Weifeng Huang, Qiaojia Huang, Baoshun Lin, Jian Zhu, Haikun Wang, Jianwen Que and Xiaopeng Lan
    Citation: Molecular Cancer 2017 16:62
    Content type: Research Published on:

  3. As an atypical member of cyclin dependent kinase family, Cyclin dependent kinase 5 (Cdk5) is considered as a neuron-specific kinase in the past decade due to the abundant existence of its activator p35 in post...

    Authors: Wan Liu, Jun Li, Yu-Shu Song, Yue Li, Yu-Hong Jia and Hai-Dong Zhao
    Citation: Molecular Cancer 2017 16:60
    Content type: Review Published on:

  4. Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs significantly associated with out...

    Authors: Hua Zhao, Jie Shen, Tiffany R. Hodges, Renduo Song, Gregory N. Fuller and Amy B. Heimberger
    Citation: Molecular Cancer 2017 16:59
    Content type: Letter to the Editor Published on:

  5. A new type of RNAs was identified from genes traditionally thought to express messenger or linear ncRNA (noncoding RNA) only. They were subsequently named as circRNAs (circular RNAs) due to the covalently clos...

    Authors: Jing Liu, Tian Liu, Xiaman Wang and Aili He
    Citation: Molecular Cancer 2017 16:58
    Content type: Review Published on:

  6. Inflammatory breast cancer (IBC), a particularly aggressive form of breast cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted therapies, the identification of molecular mar...

    Authors: Sherif Abdelaziz Ibrahim, Ramy Gadalla, Eslam A. El-Ghonaimy, Omnia Samir, Hossam Taha Mohamed, Hebatallah Hassan, Burkhard Greve, Mohamed El-Shinawi, Mona Mostafa Mohamed and Martin Götte
    Citation: Molecular Cancer 2017 16:57
    Content type: Research Published on:

  7. The polycomb group protein, BMI1 plays important roles in chromatin modification, stem cell function, DNA damage repair and mitochondrial bioenergetics. Such diverse cellular functions of BMI1 could be, in par...

    Authors: Soumyajit Banerjee Mustafi, Prabir Kumar Chakraborty, Shailendra Kumar Dhar Dwivedi, Kai Ding, Katherine M. Moxley, Priyabrata Mukherjee and Resham Bhattacharya
    Citation: Molecular Cancer 2017 16:56
    Content type: Research Published on:

  8. Many tumor-related factors have shown the ability to affect metabolic pathways by paving the way for cancer-specific metabolic features. Here, we investigate the regulation of mTORC1 by MDM4, a p53-inhibitor w...

    Authors: Francesca Mancini, Emanuela Teveroni, Giusy Di Conza, Valentina Monteleone, Ivan Arisi, Marsha Pellegrino, Marianna Buttarelli, Luisa Pieroni, Mara D’Onofrio, Andrea Urbani, Alfredo Pontecorvi, Massimiliano Mazzone and Fabiola Moretti
    Citation: Molecular Cancer 2017 16:55
    Content type: Research Published on:

  9. Gastric cancer (GC) is a common disease with few effective treatment choices and poor prognosis, and has the second-highest mortality rates among all cancers worldwide. Dysregulation and/or malfunction of ion ...

    Authors: Jianling Xia, Hongqiang Wang, Shi Li, Qinghui Wu, Li Sun, Hongxiang Huang and Ming Zeng
    Citation: Molecular Cancer 2017 16:54
    Content type: Review Published on:

  10. Colorectal cancer (CRC) is a major worldwide health problem due to its high prevalence and mortality rate. T-cell intracellular antigen 1 (TIA1) is an important tumor suppressor involved in many aspects of car...

    Authors: Yanqing Liu, Rui Liu, Fei Yang, Rongjie Cheng, Xiaorui Chen, Shufang Cui, Yuanyuan Gu, Wu Sun, Chaoying You, Zhijian Liu, Feng Sun, Yanbo Wang, Zheng Fu, Chao Ye, Chenyu Zhang, Jing Li…
    Citation: Molecular Cancer 2017 16:53
    Content type: Research Published on:

  11. The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective o...

    Authors: Pingting Zhou, Bo Li, Furao Liu, Meichao Zhang, Qian Wang, Yuanhua Liu, Yuan Yao and Dong Li
    Citation: Molecular Cancer 2017 16:52
    Content type: Review Published on:

  12. Cancer stem cells (CSCs) are thought to play an important role in tumor recurrence and drug resistance, and present a major challenge in cancer therapy. The tumor microenvironment such as growth factors, nutri...

    Authors: Jianwei Liao, Pan-Pan Liu, Guoxin Hou, Jiajia Shao, Jing Yang, Kaiyan Liu, Wenhua Lu, Shijun Wen, Yumin Hu and Peng Huang
    Citation: Molecular Cancer 2017 16:51
    Content type: Research Published on:

  13. Lung adenocarcinoma (LAD) is considered to be a highly aggressive disease with heterogeneous prognosis and the molecular mechanisms underlying tumor progression remain elusive. Growing evidence demonstrates th...

    Authors: Lipin Liu, Nan Bi, Lihong Wu, Xiao Ding, Yu Men, Wei Zhou, Lin Li, Weimin Zhang, Susheng Shi, Yongmei Song and Luhua Wang
    Citation: Molecular Cancer 2017 16:50
    Content type: Research Published on:

  14. Matrix metalloproteinases (MMPs) play a critical role in cancer pathogenesis, including tumor growth and osteolysis within the bone marrow microenvironment. However, the anti-tumor effects of MMPs are poorly u...

    Authors: S. T. Lwin, J. A. Fowler, M. T. Drake, J. R. Edwards, C. C. Lynch and C. M. Edwards
    Citation: Molecular Cancer 2017 16:49
    Content type: Short communication Published on:

  15. Even though aberrant expression of microRNA (miR)-30d has been reported in prostate cancer (PCa), its associations with cancer progression remain contradictory. The aim of this study was to investigate clinica...

    Authors: Zhuo-yuan Lin, Guo Chen, Yan-qiong Zhang, Hui-chan He, Yu-xiang Liang, Jian-heng Ye, Ying-ke Liang, Ru-jun Mo, Jian-ming Lu, Yang-jia Zhuo, Yu Zheng, Fu-neng Jiang, Zhao-dong Han, Shu-lin Wu, Wei-de Zhong and Chin-Lee Wu
    Citation: Molecular Cancer 2017 16:48
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2019 18:122

  16. Borderline ovarian tumors are rare low malignant potential neoplasms characterized by the absence of stromal invasion, whose main prognostic factors are stage and type of peritoneal implants. The latter are de...

    Authors: Giulia Girolimetti, Pierandrea De Iaco, Martina Procaccini, Riccardo Panzacchi, Ivana Kurelac, Laura Benedetta Amato, Giulia Dondi, Giacomo Caprara, Claudio Ceccarelli, Donatella Santini, Anna Maria Porcelli, Anna Myriam Perrone and Giuseppe Gasparre
    Citation: Molecular Cancer 2017 16:47
    Content type: Letter to the Editor Published on:

  17. Inactivation of tumor suppressor genes by promoter hypermethylation plays a key role in the tumorgenesis. It is necessary to uncover the detailed pattern of whole genome-wide abnormal DNA methylation during th...

    Authors: Gaoxiang Ma, Hanting Liu, Qiuhan Hua, Meilin Wang, Mulong Du, Yadi Lin, Yuqiu Ge, Weida Gong, Qinghong Zhao, Fulin Qiang, Guoquan Tao, Zhengdong Zhang and Haiyan Chu
    Citation: Molecular Cancer 2017 16:46
    Content type: Research Published on:

  18. Cisplatin is a potent antitumor agent. However, toxicity and primary and secondary resistance are major limitations of cisplatin-based chemotherapy, leading to therapeutic failure. We have previously reported ...

    Authors: Alba Agudo-López, Elena Prieto-García, José Alemán, Carlos Pérez, C. Vanesa Díaz-García, Lucía Parrilla-Rubio, Silvia Cabrera, Carmen Navarro-Ranninger, Hernán Cortés-Funes, José A. López-Martín and M. Teresa Agulló-Ortuño
    Citation: Molecular Cancer 2017 16:45
    Content type: Research Published on:

  19. Extracellular matrix (ECM) is known to maintain epithelial integrity. In carcinogenesis ECM degradation triggers metastasis by controlling migration and differentiation including cancer stem cell (CSC) charact...

    Authors: Michael Rose, Vera Kloten, Erik Noetzel, Lukas Gola, Josef Ehling, Timon Heide, Steffen K. Meurer, Aljona Gaiko-Shcherbak, Antonio S. Sechi, Sebastian Huth, Ralf Weiskirchen, Oliver Klaas, Wiebke Antonopoulos, Qiong Lin, Wolfgang Wagner, Jürgen Veeck…
    Citation: Molecular Cancer 2017 16:44
    Content type: Research Published on:

  20. It is widely believed that targeting the tumour-initiating cancer stem cell (CSC) component of malignancy has great therapeutic potential, particularly in therapy-resistant disease. However, despite concerted ...

    Authors: Claudia Gasch, Brendan Ffrench, John J. O’Leary and Michael F. Gallagher
    Citation: Molecular Cancer 2017 16:43
    Content type: Review Published on:

  21. Chromatin remodeling controls gene expression and signaling pathway activation, and aberrant chromatin structure and gene dysregulation are primary characteristics of human cancer progression. Recent reports h...

    Authors: Yanyan Tang, Jinpeng Wang, Yu Lian, Chunmei Fan, Ping Zhang, Yingfen Wu, Xiayu Li, Fang Xiong, Xiaoling Li, Guiyuan Li, Wei Xiong and Zhaoyang Zeng
    Citation: Molecular Cancer 2017 16:42
    Content type: Review Published on:

  22. Tumor heterogeneity represents an ongoing challenge in the field of cancer therapy. Heterogeneity is evident between cancers from different patients (inter-tumor heterogeneity) and within a single tumor (intra...

    Authors: Pramudita R. Prasetyanti and Jan Paul Medema
    Citation: Molecular Cancer 2017 16:41
    Content type: Review Published on:

  23. Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-rene...

    Authors: Komal Qureshi-Baig, Pit Ullmann, Serge Haan and Elisabeth Letellier
    Citation: Molecular Cancer 2017 16:40
    Content type: Review Published on:

  24. Although the prognosis of gastric cancer patients have a favorable progression, there are some patients with unusual patterns of locoregional and systemic recurrence. Therefore, a better understanding of early...

    Authors: Yan-wen Liu, Rui Xia, Kai Lu, Min Xie, Fen Yang, Ming Sun, Wei De, Cailian Wang and Guozhong Ji
    Citation: Molecular Cancer 2017 16:39
    Content type: Research Published on:

  25. Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain...

    Authors: Mansi Shah, Ryan Cardenas, Belinda Wang, Jenny Persson, Nigel P. Mongan, Anna Grabowska and Cinzia Allegrucci
    Citation: Molecular Cancer 2017 16:38
    Content type: Research Published on:

  26. Anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase, is essentially and transiently expressed in the developing nervous system. Recently, the deregulated expression of full-length ALK has bee...

    Authors: H Inoue, M Hashimura, M Akiya, R Chiba and M Saegusa
    Citation: Molecular Cancer 2017 16:37
    Content type: Research Published on:

  27. We previously discovered that tetracyclines increase the expression of lipid phosphate phosphatases at the surface of cells. These enzymes degrade circulating lysophosphatidate and therefore doxycycline increa...

    Authors: Xiaoyun Tang, Xianyan Wang, Yuan Y. Zhao, Jonathan M. Curtis and David N. Brindley
    Citation: Molecular Cancer 2017 16:36
    Content type: Research Published on:

  28. Hypoxia plays an important role in the development of various cancers. MicroRNAs (miRNAs) act as post-transcriptional regulators of gene expression and modulate the tumorigenesis, including gastric cancer. How...

    Authors: Chuan He, Libo Wang, Jiantao Zhang and Hong Xu
    Citation: Molecular Cancer 2017 16:35
    Content type: Research Published on:

  29. CD73 (ecto-5′-nucleotidase) is implicated in the development of many types of cancer. CD73 inhibitors are currently being tested in clinical trials for the treatment of cancer. Understanding the molecular and ...

    Authors: Jianjie Zhu, Yuanyuan Zeng, Wei Li, Hualong Qin, Zhe Lei, Dan Shen, Dongmei Gu, Jian-an Huang and Zeyi Liu
    Citation: Molecular Cancer 2017 16:34
    Content type: Research Published on:

  30. Colorectal cancer is third most common malignancy and is the second most common cause of cancer-related death. The MUC1 heterodimeric protein is aberrantly overexpressed in colorectal cancer and has been linke...

    Authors: Rehan Ahmad, Maroof Alam, Masanori Hasegawa, Yasumitsu Uchida, Omar Al-Obaid, Surender Kharbanda and Donald Kufe
    Citation: Molecular Cancer 2017 16:33
    Content type: Research Published on:

  31. ADAM12 is upregulated in human breast cancers and is a predictor of chemoresistance in estrogen receptor-negative tumors. ADAM12 is induced during epithelial-to-mesenchymal transition, a feature associated wit...

    Authors: Sara Duhachek-Muggy, Yue Qi, Randi Wise, Linda Alyahya, Hui Li, Jacob Hodge and Anna Zolkiewska
    Citation: Molecular Cancer 2017 16:32
    Content type: Research Published on:

  32. Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells,...

    Authors: Sarah M. Ridge, Francis J. Sullivan and Sharon A. Glynn
    Citation: Molecular Cancer 2017 16:31
    Content type: Review Published on:

  33. More than 80% of intestinal neoplasia is associated with the adenomatous polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is overexpressed in colorectal cancer and specifically...

    Authors: Parthasarathy Chandrakesan, Jiannan Yao, Dongfeng Qu, Randal May, Nathaniel Weygant, Yang Ge, Naushad Ali, Sripathi M. Sureban, Modhi Gude, Kenneth Vega, Eddie Bannerman-Menson, Lijun Xia, Michael Bronze, Guangyu An and Courtney W. Houchen
    Citation: Molecular Cancer 2017 16:30
    Content type: Research Published on:

  34. Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key...

    Authors: Tan Boon Toh, Jhin Jieh Lim and Edward Kai-Hua Chow
    Citation: Molecular Cancer 2017 16:29
    Content type: Review Published on:

  35. The initiation and progression of malignant tumors is driven by distinct subsets of tumor-initiating or cancer stem-like cells (CSCs) which develop therapy/apoptosis resistance and self-renewal capacity. In or...

    Authors: Catharina Melzer, Juliane von der Ohe, Hendrik Lehnert, Hendrik Ungefroren and Ralf Hass
    Citation: Molecular Cancer 2017 16:28
    Content type: Review Published on:

  36. It is widely recognized that inflammation promotes breast cancer invasion and metastasis. Given the complex nature of the breast tumor inflammatory microenvironment, much remains to be understood of the molecu...

    Authors: Stephanie Tsang Mui Chung, Dirk Geerts, Kim Roseman, Ashleigh Renaud and Linda Connelly
    Citation: Molecular Cancer 2017 16:27
    Content type: Research Published on:

  37. Contemporary challenges of prostate cancer (PCa) include overdiagnosis and overtreatment, entailing the need for novel clinical tools to improve risk stratification and therapy selection. PCa diagnosis and pro...

    Authors: Jorge Torres-Ferreira, João Ramalho-Carvalho, Antonio Gomez, Francisco Duarte Menezes, Rui Freitas, Jorge Oliveira, Luís Antunes, Maria José Bento, Manel Esteller, Rui Henrique and Carmen Jerónimo
    Citation: Molecular Cancer 2017 16:26
    Content type: Research Published on:

  38. CircRNAs are a novel type of RNAs. With the newly developed technology of next-generation sequencing (NGS), especially RNA-seq technology, over 30,000 circRNAs have already been found. Owing to their unique st...

    Authors: Yumin Wang, Yongzhen Mo, Zhaojian Gong, Xiang Yang, Mo Yang, Shanshan Zhang, Fang Xiong, Bo Xiang, Ming Zhou, Qianjin Liao, Wenling Zhang, Xiayu Li, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng…
    Citation: Molecular Cancer 2017 16:25
    Content type: Review Published on:

  39. Cancer stem cells are suggested to contribute to the extremely poor prognosis of pancreatic ductal adenocarcinoma and dysregulation of symmetric and asymmetric stem cell division may be involved. Anticancer be...

    Authors: Clifford C. Nwaeburu, Alia Abukiwan, Zhefu Zhao and Ingrid Herr
    Citation: Molecular Cancer 2017 16:23
    Content type: Research Published on:

  40. Pilocytic astrocytomas (PAs) are the most common pediatric central nervous system neoplasms. In the majority of cases these tumors are benign and receive favorable prognosis following gross total surgical rese...

    Authors: Guifa Xi, Yuping Derek Li, Gordan Grahovac, Veena Rajaram, Nitin Wadhwani, Tatiana Pundy, Barbara Mania-Farnell, Charles David James and Tadanori Tomita
    Citation: Molecular Cancer 2017 16:21
    Content type: Research Published on:

  41. Colorectal cancer remains one of the most common malignant tumors worldwide. Colorectal cancer initiating cells (CCICs) are a small subpopulation responsible for malignant behaviors of colorectal cancer. Aberr...

    Authors: Zhenzhen Wen, Tianhui Pan, Saisai Yang, Jingwen Liu, Haiying Tao, Yiming Zhao, Dingting Xu, Wei Shao, Jia Wu, Xiyong Liu, Yongjiang Wang, Jianshan Mao and Yongliang Zhu
    Citation: Molecular Cancer 2017 16:20
    Content type: Research Published on:

  42. Breast cancer is the major cause of cancer-related mortality in women. It is thought that quiescent stem-like cells within solid tumors are responsible for cancer maintenance, progression and eventual metastas...

    Authors: Sarah T. Boyle, Krystyna A. Gieniec, Carly E. Gregor, Jessica W. Faulkner, Shaun R. McColl and Marina Kochetkova
    Citation: Molecular Cancer 2017 16:19
    Content type: Short communication Published on:

  44. Radiation therapy is one of the major tools of cancer treatment, and is widely used for a variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or indirectly via the generation of...

    Authors: Su Yeon Lee, Eui Kyong Jeong, Min Kyung Ju, Hyun Min Jeon, Min Young Kim, Cho Hee Kim, Hye Gyeong Park, Song Iy Han and Ho Sung Kang
    Citation: Molecular Cancer 2017 16:10
    Content type: Review Published on:

  45. Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well as with generation and maintenance of cancer stem cells. In this way, EMT contributes to tumor invasion, heterogeneity...

    Authors: Davide Pradella, Chiara Naro, Claudio Sette and Claudia Ghigna
    Citation: Molecular Cancer 2017 16:8
    Content type: Review Published on:

  47. The insulin-like growth factor-I (IGF-I) signaling induces epithelial to mesenchymal transition (EMT) program and contributes to metastasis and drug resistance in several subtypes of tumors. In preclinical stu...

    Authors: Heming Li, Izhar Singh Batth, Xiujuan Qu, Ling Xu, Na Song, Ruoyu Wang and Yunpeng Liu
    Citation: Molecular Cancer 2017 16:6
    Content type: Review Published on:

  48. Liver cancer is an often fatal malignant tumor with a high recurrence rate and chemoresistance. The major malignant phenotypes of cancer, including recurrence, metastasis, and chemoresistance, are related to t...

    Authors: Kouki Nio, Taro Yamashita and Shuichi Kaneko
    Citation: Molecular Cancer 2017 16:4
    Content type: Review Published on:

  49. Epithelial-mesenchymal transition (EMT) and cancer stem-like cells (CSC) are becoming highly relevant targets in anticancer drug discovery. A large body of evidence suggests that epithelial-mesenchymal transit...

    Authors: Fabrizio Marcucci, Pietro Ghezzi and Cristiano Rumio
    Citation: Molecular Cancer 2017 16:3
    Content type: Review Published on:
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    Journal Impact Factor: 27.7
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Molecular Cancer

ISSN: 1476-4598