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  1. Recent findings indicate that exosomes released from cancer cells contain microRNAs (miRNAs) that may be delivered to cells of tumor microenvironment.

    Authors: Simona Taverna, Valeria Amodeo, Laura Saieva, Antonio Russo, Marco Giallombardo, Giacomo De Leo and Riccardo Alessandro
    Citation: Molecular Cancer 2014 13:169
  2. Recent studies emphasize the role of BRAF as a genetic marker for prediction, prognosis and risk stratification in colorectal cancer. Earlier studies have reported the incidence of BRAF mutations in the range of ...

    Authors: Abdul K Siraj, Rong Bu, Sarita Prabhakaran, Prashant Bavi, Shaham Beg, Mohsen Al Hazmi, Maha Al-Rasheed, Khadija Alobaisi, Fouad Al-Dayel, Hadeel AlManea, Nasser Al-Sanea, Shahab Uddin and Khawla S Al-Kuraya
    Citation: Molecular Cancer 2014 13:168
  3. The tight junction protein Claudin-1, a claudin family member, has been implicated in several gastro-intestinal pathologies including inflammatory bowel disease (IBD) and colorectal cancer (CRC). In this regar...

    Authors: Jillian L Pope, Rizwan Ahmad, Ajaz A Bhat, Mary K Washington, Amar B Singh and Punita Dhawan
    Citation: Molecular Cancer 2014 13:167
  4. Growing evidence indicates that miR-200c is involved in carcinogenesis and tumor progression in non-small-cell lung cancer (NSCLC). However, its precise biological role remains largely elusive.

    Authors: Jing Li, Qiang Tan, Mingxia Yan, Lei Liu, Hechun Lin, Fangyu Zhao, Guoliang Bao, Hanwei Kong, Chao Ge, Fanglin Zhang, Tao Yu, Jinjun Li, Xianghuo He and Ming Yao
    Citation: Molecular Cancer 2014 13:166
  5. Docetaxel resistance remains a major obstacle in the treatment of non-small cell lung cancer (NSCLC). High-mobility group box 1 (HMGB1) has been shown to promote autophagy protection in response to antitumor t...

    Authors: Banzhou Pan, Dongqin Chen, Jiayuan Huang, Rui Wang, Bing Feng, Haizhu Song and Longbang Chen
    Citation: Molecular Cancer 2014 13:165
  6. The Wnt signaling pathway is an evolutionary conserved system, having pivotal roles during animal development. When over-activated, this signaling pathway is involved in cancer initiation and progression. The ...

    Authors: Michal Caspi, Gili Perry, Nir Skalka, Shilhav Meisel, Anastasia Firsow, Maayan Amit and Rina Rosin-Arbesfeld
    Citation: Molecular Cancer 2014 13:164
  7. Translational exploration of bacterial toxins has come to the forefront of research given their potential as a chemotherapeutic tool. Studies in select tissues have demonstrated that Clostridium perfringens iota ...

    Authors: Katerina D Fagan-Solis, Denise K Reaves, M Cristina Rangel, Michel R Popoff, Bradley G Stiles and Jodie M Fleming
    Citation: Molecular Cancer 2014 13:163
  8. The thyroid hormone, 3, 3′, 5-triiodo-L-thyronine (T3), has been shown to modulate cellular processes via interactions with thyroid hormone receptors (TRs), but the secretory proteins that are regulated to exert ...

    Authors: Cheng-Yi Chen, I-Hsiao Chung, Ming-Ming Tsai, Yi-Hsin Tseng, Hsiang-Cheng Chi, Chung-Ying Tsai, Yang-Hsiang Lin, You-Ching Wang, Chie-Pein Chen, Tzu-I Wu, Chau-Ting Yeh, Dar-In Tai and Kwang-Huei Lin
    Citation: Molecular Cancer 2014 13:162
  9. Through a transcriptome microarray analysis, we have isolated Anterior gradient protein 2 (AGR2) as a gene up-regulated in papillary thyroid carcinoma (PTC). AGR2 is a disulfide isomerase over-expressed in sev...

    Authors: Gennaro Di Maro, Paolo Salerno, Kristian Unger, Francesca Maria Orlandella, Mario Monaco, Gennaro Chiappetta, Gerry Thomas, Malgorzata Oczko-Wojciechowska, Mariorosario Masullo, Barbara Jarzab, Massimo Santoro and Giuliana Salvatore
    Citation: Molecular Cancer 2014 13:160
  10. Mantle cell lymphoma (MCL) is an aggressive type of B-cell non-Hodgkin lymphoma associated with poor prognosis. Implementation of high-dose cytarabine (araC) into induction therapy became standard-of-care for ...

    Authors: Magdalena Klanova, Lucie Lorkova, Ondrej Vit, Bokang Maswabi, Jan Molinsky, Jana Pospisilova, Petra Vockova, Cory Mavis, Lucie Lateckova, Vojtech Kulvait, Dana Vejmelkova, Radek Jaksa, Francisco Hernandez, Marek Trneny, Martin Vokurka, Jiri Petrak…
    Citation: Molecular Cancer 2014 13:159
  11. Metronomic cyclophosphamide given on an intermittent, 6-day repeating schedule, but not on an exposure dose-equivalent daily schedule, activates an anti-tumor innate immune response that leads to major regress...

    Authors: Joshua C Doloff, Chong-Sheng Chen and David J Waxman
    Citation: Molecular Cancer 2014 13:158
  12. HER2 targeted therapies including trastuzumab and more recently lapatinib have significantly improved the prognosis for HER2 positive breast cancer patients. However, resistance to these agents is a significan...

    Authors: Martina S J McDermott, Brigid C Browne, Neil T Conlon, Neil A O’Brien, Dennis J Slamon, Michael Henry, Paula Meleady, Martin Clynes, Paul Dowling, John Crown and Norma O’Donovan
    Citation: Molecular Cancer 2014 13:157

    The Correction to this article has been published in Molecular Cancer 2023 22:175

  13. Protein coding genes account for only about 2% of the human genome, whereas the vast majority of transcripts are non-coding RNAs including long non-coding RNAs. A growing volume of literature has proposed that...

    Authors: Ming-zhe Ma, Chun-xiao Li, Yan Zhang, Ming-zhe Weng, Ming-di Zhang, Yi-yu Qin, Wei Gong and Zhi-wei Quan
    Citation: Molecular Cancer 2014 13:156
  14. With increased long-term survivors of childhood cancer patients, therapy-associated infertility has become one of the most common late side-effects and significantly affects their life-quality. Therefore, eval...

    Authors: Mi Hou, Emma Eriksson, Konstantin Svechnikov, Kirsi Jahnukainen, Olle Söder, Andreas Meinhardt and Lars Sävendahl
    Citation: Molecular Cancer 2014 13:155
  15. The importance of the genetic background of cancer cells for the individual susceptibility to cancer treatments is increasingly apparent. In melanoma, the existence of a BRAF mutation is a main predictor for succ...

    Authors: Imanol Arozarena, Ibai Goicoechea, Oihane Erice, Jennnifer Ferguson, Geoffrey P Margison and Claudia Wellbrock
    Citation: Molecular Cancer 2014 13:154
  16. The influence of natural regulatory T cells (nTregs) on the patients with colon cancer is unclear. Demethylated status of the Treg-specific demethylated region (TSDR) of the FOXP3 gene was reported to be a potent...

    Authors: Changhua Zhuo, Zhiyuan Li, Ye Xu, Yuwei Wang, Qingguo Li, Junjie Peng, Hongtu Zheng, Peng Wu, Bin Li and Sanjun Cai
    Citation: Molecular Cancer 2014 13:153
  17. Targeted therapies have improved therapeutic options of treating renal cell carcinoma (RCC). However, drug response is temporary due to resistance development.

    Authors: Eva Juengel, Snigdha Nowaz, Jasmina Makarevi, Iyad Natsheh, Isabella Werner, Karen Nelson, Michael Reiter, Igor Tsaur, Jens Mani, Sebastian Harder, Georg Bartsch, Axel Haferkamp and Roman A Blaheta
    Citation: Molecular Cancer 2014 13:152
  18. Epidemiological data show that the incidence of carcinomas in humans is highly dependent on age. However, the initial steps of the age-related molecular oncogenic processes by which the switch towards the neop...

    Authors: Nathalie Martin, Clara Salazar-Cardozo, Chantal Vercamer, Louise Ott, Guillemette Marot, Predrag Slijepcevic, Corinne Abbadie and Olivier Pluquet
    Citation: Molecular Cancer 2014 13:151
  19. Heat shock protein 90 (Hsp90) is a promising therapeutic target and inhibition of Hsp90 will presumably result in suppression of multiple signaling pathways. FW-04-806, a bis-oxazolyl macrolide compound extrac...

    Authors: Wei Huang, Min Ye, Lian-ru Zhang, Qun-dan Wu, Min Zhang, Jian-hua Xu and Wei Zheng
    Citation: Molecular Cancer 2014 13:150
  20. Peroxisome proliferator-activated receptors gamma (PPARγ) ligands have been shown to inhibit the growth of non-small cell lung cancer (NSCLC) cells. However, the mechanisms underlying this effect remain incomp...

    Authors: SWei Sunny Hann, Qing Tang, Fang Zheng, Shunyu Zhao, Jianping Chen and ZhiYu Wang
    Citation: Molecular Cancer 2014 13:149
  21. Resistance to cell death in the presence of stressful stimuli is one of the hallmarks of cancer cells acquired during multistep tumorigenesis, and knowledge of the molecular mechanism of stress adaptation can ...

    Authors: Hye-Kyung Park, Ji-Eun Lee, Jaehwa Lim and Byoung Heon Kang
    Citation: Molecular Cancer 2014 13:148
  22. Chk1 forms a core component of the DNA damage response and small molecule inhibitors are currently being investigated in the clinic as cytotoxic chemotherapy potentiators. Recent evidence suggests that Chk1 in...

    Authors: Christopher Bryant, Kirsten Scriven and Andrew J Massey
    Citation: Molecular Cancer 2014 13:147
  23. High androgen receptor (AR) level in primary tumour predicts increased prostate cancer (PCa)-specific mortality. Furthermore, activations of the AR, PI3K, mTOR, NFκB and Hedgehog (Hh) signaling pathways are in...

    Authors: Andrea Köhler, Ümmühan Demir, Eva Kickstein, Sybille Krauss, Johanna Aigner, Beatriz Aranda-Orgillés, Antonios I Karagiannidis, Clemens Achmüller, Huajie Bu, Andrea Wunderlich, Michal-Ruth Schweiger, Georg Schaefer, Susann Schweiger, Helmut Klocker and Rainer Schneider
    Citation: Molecular Cancer 2014 13:146
  24. The Abelson tyrosine kinase (c-Abl) inhibitor STI571 (Glivec®) has been shown to effectively inhibit colorectal cancer cell migration and invasion. The c-Abl substrate abelson interactor 1 (Abi1) is a key regu...

    Authors: Konrad Steinestel, Silke Brüderlein, Jochen K Lennerz, Julie Steinestel, Klaus Kraft, Christian Pröpper, Viktor Meineke and Peter Möller
    Citation: Molecular Cancer 2014 13:145
  25. HER-2 represents a relatively new therapeutic target for non small cell lung cancer (NSCLC) patients. The incidence for reported HER-2 overexpression/amplification/mutations ranges from 2 to 20% in NSCLC. More...

    Authors: Daniele Cretella, Francesca Saccani, Federico Quaini, Caterina Frati, Costanza Lagrasta, Mara Bonelli, Cristina Caffarra, Andrea Cavazzoni, Claudia Fumarola, Maricla Galetti, Silvia La Monica, Luca Ampollini, Marcello Tiseo, Andrea Ardizzoni, Pier Giorgio Petronini and Roberta R Alfieri
    Citation: Molecular Cancer 2014 13:143
  26. MicroRNA-10b (miR-10b) has a prominent role in regulating tumor invasion and metastasis by targeting the HOXD10 transcriptional repressor and has been found up-regulated in several tumor types.

    Authors: Paola Parrella, Raffaela Barbano, Barbara Pasculli, Andrea Fontana, Massimiliano Copetti, Vanna Maria Valori, Maria Luana Poeta, Giuseppe Perrone, Daniela Righi, Marina Castelvetere, Michelina Coco, Teresa Balsamo, Maria Morritti, Fabio Pellegrini, Andrea Onetti-Muda, Evaristo Maiello…
    Citation: Molecular Cancer 2014 13:142
  27. Inhibition of the activated epidermal growth factor receptor (EGFR) with either enzymatic kinase inhibitors or anti-EGFR antibodies such as cetuximab, is an effective modality of treatment for multiple human c...

    Authors: Jeonghee Cho, Adam J Bass, Michael S Lawrence, Kristian Cibulskis, Ahye Cho, Shi-Nai Lee, Mai Yamauchi, Nikhil Wagle, Panisa Pochanard, Nayoung Kim, Angela K J Park, Jonghwa Won, Hyung-Suk Hur, Heidi Greulich, Shuji Ogino, Carrie Sougnez…
    Citation: Molecular Cancer 2014 13:141
  28. Authors: Takashi Mitamura, Hidemichi Watari, Lei Wang, Hiromi Kanno, Masaya Miyazaki, Makiko Kitagawa, Mohamed Kamel Hassan, Peixin Dong, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Shinya Tanaka and Noriaki Sakuragi
    Citation: Molecular Cancer 2014 13:140

    The original article was published in Molecular Cancer 2014 13:97

  29. The introduction of cisplatin has improved the long-term survival rate in osteosarcoma patients. However, some patients are intrinsically resistant to cisplatin. This study reported that the activation of Notc...

    Authors: Lei Wang, Fangchun Jin, An Qin, Yongqiang Hao, Yufeng Dong, Shengfang Ge and Kerong Dai
    Citation: Molecular Cancer 2014 13:139
  30. Although long-term estrogen (E2) exposure is associated with increased breast cancer (BC) risk, and E2 appears to sustain growth of BC cells that express functional estrogen receptors (ERs), its role in promot...

    Authors: Ying Sun, Yunshan Wang, Cong Fan, Peng Gao, Xiuwen Wang, Guangwei Wei and Junmin Wei
    Citation: Molecular Cancer 2014 13:137
  31. Insulin-like growth factor I (IGF-I) can induce epithelial mesenchymal transition (EMT) in many epithelial tumors; however, the molecular mechanism by which this occurs is not clearly understood. Additionally,...

    Authors: Heming Li, Ling Xu, Ce Li, Lei Zhao, Yanju Ma, Huachuan Zheng, Zhi Li, Ye Zhang, Ruoyu Wang, Yunpeng Liu and Xiujuan Qu
    Citation: Molecular Cancer 2014 13:136
  32. KRAS mutations in codons 12 and 13 are established predictive biomarkers for anti-EGFR therapy in colorectal cancer. Previous studies suggest that KRAS codon 61 and 146 mutations may also predict resistance to an...

    Authors: Yu Imamura, Paul Lochhead, Mai Yamauchi, Aya Kuchiba, Zhi Rong Qian, Xiaoyun Liao, Reiko Nishihara, Seungyoun Jung, Kana Wu, Katsuhiko Nosho, Yaoyu E Wang, Shouyong Peng, Adam J Bass, Kevin M Haigis, Jeffrey A Meyerhardt, Andrew T Chan…
    Citation: Molecular Cancer 2014 13:135
  33. The tetraspanin CD63 is a highly N-glycosylated protein that is known to regulate cancer malignancy. However, the contribution of glycosylation of CD63 to cancer malignancy remains unclear. Previously, we repo...

    Authors: Naoomi Tominaga, Keitaro Hagiwara, Nobuyoshi Kosaka, Kimi Honma, Hitoshi Nakagama and Takahiro Ochiya
    Citation: Molecular Cancer 2014 13:134
  34. Arsenic trioxide has been demonstrated as an effective anti-cancer drug against leukemia and solid tumors both in vitro and in vivo. However, recent phase II trials demonstrated that single agent arsenic trioxide...

    Authors: Tongsen Zheng, Dalong Yin, Zhaoyang Lu, Jiabei Wang, Yuejin Li, Xi Chen, Yingjian Liang, Xuan Song, Shuyi Qi, Boshi Sun, Changming Xie, Xianzhi Meng, Shangha Pan, Jiaren Liu, Hongchi Jiang and Lianxin Liu
    Citation: Molecular Cancer 2014 13:133
  35. Interferon (IFN)-γ-mediated immune response plays an important role in tumor immunosurveillance. However, the regulation of IFN-γ-mediated tumorigenesis and immune response remains elusive. USP18, an interfero...

    Authors: Bangxing Hong, Haiyan Li, Yong Lu, Mingjun Zhang, Yuhuan Zheng, Jianfei Qian and Qing Yi
    Citation: Molecular Cancer 2014 13:132
  36. Metastasis accounts for the majority of deaths from cancer. Although tumor microenvironment has been shown to have a significant impact on the initiation and/or promotion of metastasis, the mechanism remains e...

    Authors: Xin Tang, Theresa B Kuhlenschmidt, Qian Li, Shahjahan Ali, Stephane Lezmi, Hong Chen, Melissa Pires-Alves, William W Laegreid, Taher A Saif and Mark S Kuhlenschmidt
    Citation: Molecular Cancer 2014 13:131
  37. Increasing evidence indicates an important role of transcription factor Yin Yang-1 (YY1) in human tumorigenesis. However, its function in cancer remains controversial and the relevance of YY1 to pancreatic duc...

    Authors: Jing-Jing Zhang, Yi Zhu, Kun-Ling Xie, Yun-Peng Peng, Jin-Qiu Tao, Jie Tang, Zheng Li, Ze-Kuan Xu, Cun-Cai Dai, Zhu-Yin Qian, Kui-Rong Jiang, Jun-Li Wu, Wen-Tao Gao, Qing Du and Yi Miao
    Citation: Molecular Cancer 2014 13:130
  38. Over three decades have passed since the first report on the expression of CA125 by ovarian tumors. Since that time our understanding of ovarian cancer biology has changed significantly to the point that these...

    Authors: Mildred Felder, Arvinder Kapur, Jesus Gonzalez-Bosquet, Sachi Horibata, Joseph Heintz, Ralph Albrecht, Lucas Fass, Justanjyot Kaur, Kevin Hu, Hadi Shojaei, Rebecca J Whelan and Manish S Patankar
    Citation: Molecular Cancer 2014 13:129
  39. Hepatitis B virus X protein (HBx) plays crucial roles in hepatocarcinogenesis. However, the underlying mechanism remains elusive. We have reported that HBx is able to up-regulate survivin in hepatocellular car...

    Authors: Weiying Zhang, Zhanping Lu, Guangyao Kong, Yuen Gao, Tao Wang, Qi Wang, Na Cai, Honghui Wang, Fabao Liu, Lihong Ye and Xiaodong Zhang
    Citation: Molecular Cancer 2014 13:128
  40. microRNAs are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development of malignant behaviors. Accumulating evidence sugge...

    Authors: Yantao Duan, Lei Hu, Bing Liu, Beiqin Yu, Jianfang Li, Min Yan, Yingyan Yu, Chen Li, Liping Su, Zhenggang Zhu, Ming Xiang, Bingya Liu and Qiumeng Yang
    Citation: Molecular Cancer 2014 13:127
  41. Transforming growth factor, beta (TGFB) signal is considered to be a tumor suppressive pathway based on the frequent genomic deletion of the SMAD4 gene in pancreatic cancer (PC); however; the role of the activin ...

    Authors: Yosuke Togashi, Hiroki Sakamoto, Hidetoshi Hayashi, Masato Terashima, Marco A de Velasco, Yoshihiko Fujita, Yasuo Kodera, Kazuko Sakai, Shuta Tomida, Masayuki Kitano, Akihiko Ito, Masatoshi Kudo and Kazuto Nishio
    Citation: Molecular Cancer 2014 13:126
  42. Prostate cancer (PCa) is one of the leading causes of cancer-related mortality and morbidity in the aging male population and represents the most frequently diagnosed malignancy in men around the world. The De...

    Authors: Samia B Bachmann, Sandra C Frommel, Rosalba Camicia, Hans C Winkler, Raffaella Santoro and Paul O Hassa
    Citation: Molecular Cancer 2014 13:125
  43. miR-139-5p was identified to be significantly down-regulated in colon tumor tissues by miRNA array. We aimed to clarify its biological function, molecular mechanisms and direct target gene in colorectal cancer...

    Authors: Lijing Zhang, Yujuan Dong, Nana Zhu, Ho Tsoi, Zengren Zhao, Chung Wah Wu, Kunning Wang, Shu Zheng, Simon SM Ng, Francis KL Chan, Joseph JY Sung and Jun Yu
    Citation: Molecular Cancer 2014 13:124
  44. Acute Myeloid Leukaemia (AML) is a highly heterogeneous disease. Studies in adult AML have identified epigenetic changes, specifically DNA methylation, associated with leukaemia subtype, age of onset and patie...

    Authors: Leah Morenos, Zac Chatterton, Jane L Ng, Minhee S Halemba, Mandy Parkinson-Bates, Francoise Mechinaud, Ngaire Elwood, Richard Saffery and Nicholas C Wong
    Citation: Molecular Cancer 2014 13:123
  45. Colorectal cancers carrying the B-Raf V600E-mutation are associated with a poor prognosis. The purpose of this study was to identify B-RafV600E-mediated traits of cancer cells in a genetic in vitro model and to a...

    Authors: Benjamin Hirschi, Eike Gallmeier, Andreas Ziesch, Maximilian Marschall and Frank T Kolligs
    Citation: Molecular Cancer 2014 13:122
  46. Epithelial-to-mesenchymal transition (EMT) is a key step of the progression of tumor cell metastasis. Recent work has demonstrated some miRNAs play critical roles in EMT. In this study, we focused on the roles...

    Authors: Jingshuang Yu, Furong Xie, Xin Bao, Wantao Chen and Qin Xu
    Citation: Molecular Cancer 2014 13:121
  47. Malignant pleural mesothelioma (MPM) is an aggressive cancer with short overall survival. Long non-coding RNAs (lncRNA) are a class of RNAs more than 200 nucleotides long that do not code for protein and are p...

    Authors: Arun Renganathan, Jelena Kresoja-Rakic, Nohemy Echeverry, Gabriela Ziltener, Bart Vrugt, Isabelle Opitz, Rolf A Stahel and Emanuela Felley-Bosco
    Citation: Molecular Cancer 2014 13:119

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