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  1. Lung cancer in nonsmokers tends to be driven by a single somatic mutation or a gene fusion. KIF5B-RET fusion is an oncogene identified in non-small cell lung cancers. In this study, we verified the oncogenic a...

    Authors: YingYing Qian, Shoujie Chai, Zuyu Liang, Yongfang Wang, You Zhou, Xia Xu, Chenchen Zhang, Min Zhang, Jingxing Si, Feiteng Huang, Zhangdan Huang, Wei Hong and Kai Wang
    Citation: Molecular Cancer 2014 13:176

    The Correction to this article has been published in Molecular Cancer 2019 18:164

  2. microRNAs (miRNAs) play both oncogenic and oncostatic roles in leukemia. However, the molecular details underlying miRNA-mediated regulation of their target genes in pediatric B- and T-cell acute lymphoblastic...

    Authors: Deepti Malik, Deepak Kaul, Nalini Chauhan and Ram Kumar Marwaha
    Citation: Molecular Cancer 2014 13:175
  3. Triple negative breast cancer (TNBC) is characterized by lack of expression of both estrogen and progesterone receptor as well as lack of overexpression or amplification of HER2. Despite an increased probabili...

    Authors: Christof Bernemann, Carolin Hülsewig, Christian Ruckert, Sarah Schäfer, Lena Blümel, Georg Hempel, Martin Götte, Burkhard Greve, Peter J Barth, Ludwig Kiesel and Cornelia Liedtke
    Citation: Molecular Cancer 2014 13:174
  4. Inhibitor of DNA binding/Differentiation 1 (ID1) is a helix loop helix transcription factor that lacks the basic DNA binding domain. Over-expression of ID1 has been correlated with a variety of human cancers; ...

    Authors: Sajitha Nair, Namrata Bora-Singhal, Deepak Perumal and Srikumar Chellappan
    Citation: Molecular Cancer 2014 13:173
  5. Head and neck squamous cell carcinoma (HNSCC) is a common cancer worldwide. Emerging evidence indicates that alteration of epigenetics might be a key event in HNSCC progression. Abnormal expression of histone ...

    Authors: Kai-Chun Li, Kuo-Tai Hua, Yi-Shen Lin, Chia-Yi Su, Jenq-Yuh Ko, Michael Hsiao, Min-Liang Kuo and Ching-Ting Tan
    Citation: Molecular Cancer 2014 13:172
  6. Long non-coding RNAs (lncRNAs) are recognized as pivotal players during developmental ontogenesis and pathogenesis of cancer. The intronic microRNA (miRNA) clusters miR-99a ~ 125b-2 and miR-100 ~ 125b-1 promote p...

    Authors: Stephan Emmrich, Alexandra Streltsov, Franziska Schmidt, Veera Raghavan Thangapandi, Dirk Reinhardt and Jan-Henning Klusmann
    Citation: Molecular Cancer 2014 13:171
  7. Recent findings indicate that exosomes released from cancer cells contain microRNAs (miRNAs) that may be delivered to cells of tumor microenvironment.

    Authors: Simona Taverna, Valeria Amodeo, Laura Saieva, Antonio Russo, Marco Giallombardo, Giacomo De Leo and Riccardo Alessandro
    Citation: Molecular Cancer 2014 13:169
  8. Recent studies emphasize the role of BRAF as a genetic marker for prediction, prognosis and risk stratification in colorectal cancer. Earlier studies have reported the incidence of BRAF mutations in the range of ...

    Authors: Abdul K Siraj, Rong Bu, Sarita Prabhakaran, Prashant Bavi, Shaham Beg, Mohsen Al Hazmi, Maha Al-Rasheed, Khadija Alobaisi, Fouad Al-Dayel, Hadeel AlManea, Nasser Al-Sanea, Shahab Uddin and Khawla S Al-Kuraya
    Citation: Molecular Cancer 2014 13:168
  9. The tight junction protein Claudin-1, a claudin family member, has been implicated in several gastro-intestinal pathologies including inflammatory bowel disease (IBD) and colorectal cancer (CRC). In this regar...

    Authors: Jillian L Pope, Rizwan Ahmad, Ajaz A Bhat, Mary K Washington, Amar B Singh and Punita Dhawan
    Citation: Molecular Cancer 2014 13:167
  10. Growing evidence indicates that miR-200c is involved in carcinogenesis and tumor progression in non-small-cell lung cancer (NSCLC). However, its precise biological role remains largely elusive.

    Authors: Jing Li, Qiang Tan, Mingxia Yan, Lei Liu, Hechun Lin, Fangyu Zhao, Guoliang Bao, Hanwei Kong, Chao Ge, Fanglin Zhang, Tao Yu, Jinjun Li, Xianghuo He and Ming Yao
    Citation: Molecular Cancer 2014 13:166
  11. Docetaxel resistance remains a major obstacle in the treatment of non-small cell lung cancer (NSCLC). High-mobility group box 1 (HMGB1) has been shown to promote autophagy protection in response to antitumor t...

    Authors: Banzhou Pan, Dongqin Chen, Jiayuan Huang, Rui Wang, Bing Feng, Haizhu Song and Longbang Chen
    Citation: Molecular Cancer 2014 13:165
  12. The Wnt signaling pathway is an evolutionary conserved system, having pivotal roles during animal development. When over-activated, this signaling pathway is involved in cancer initiation and progression. The ...

    Authors: Michal Caspi, Gili Perry, Nir Skalka, Shilhav Meisel, Anastasia Firsow, Maayan Amit and Rina Rosin-Arbesfeld
    Citation: Molecular Cancer 2014 13:164
  13. Translational exploration of bacterial toxins has come to the forefront of research given their potential as a chemotherapeutic tool. Studies in select tissues have demonstrated that Clostridium perfringens iota ...

    Authors: Katerina D Fagan-Solis, Denise K Reaves, M Cristina Rangel, Michel R Popoff, Bradley G Stiles and Jodie M Fleming
    Citation: Molecular Cancer 2014 13:163
  14. The thyroid hormone, 3, 3′, 5-triiodo-L-thyronine (T3), has been shown to modulate cellular processes via interactions with thyroid hormone receptors (TRs), but the secretory proteins that are regulated to exert ...

    Authors: Cheng-Yi Chen, I-Hsiao Chung, Ming-Ming Tsai, Yi-Hsin Tseng, Hsiang-Cheng Chi, Chung-Ying Tsai, Yang-Hsiang Lin, You-Ching Wang, Chie-Pein Chen, Tzu-I Wu, Chau-Ting Yeh, Dar-In Tai and Kwang-Huei Lin
    Citation: Molecular Cancer 2014 13:162
  15. Through a transcriptome microarray analysis, we have isolated Anterior gradient protein 2 (AGR2) as a gene up-regulated in papillary thyroid carcinoma (PTC). AGR2 is a disulfide isomerase over-expressed in sev...

    Authors: Gennaro Di Maro, Paolo Salerno, Kristian Unger, Francesca Maria Orlandella, Mario Monaco, Gennaro Chiappetta, Gerry Thomas, Malgorzata Oczko-Wojciechowska, Mariorosario Masullo, Barbara Jarzab, Massimo Santoro and Giuliana Salvatore
    Citation: Molecular Cancer 2014 13:160
  16. Mantle cell lymphoma (MCL) is an aggressive type of B-cell non-Hodgkin lymphoma associated with poor prognosis. Implementation of high-dose cytarabine (araC) into induction therapy became standard-of-care for ...

    Authors: Magdalena Klanova, Lucie Lorkova, Ondrej Vit, Bokang Maswabi, Jan Molinsky, Jana Pospisilova, Petra Vockova, Cory Mavis, Lucie Lateckova, Vojtech Kulvait, Dana Vejmelkova, Radek Jaksa, Francisco Hernandez, Marek Trneny, Martin Vokurka, Jiri Petrak…
    Citation: Molecular Cancer 2014 13:159
  17. Metronomic cyclophosphamide given on an intermittent, 6-day repeating schedule, but not on an exposure dose-equivalent daily schedule, activates an anti-tumor innate immune response that leads to major regress...

    Authors: Joshua C Doloff, Chong-Sheng Chen and David J Waxman
    Citation: Molecular Cancer 2014 13:158
  18. HER2 targeted therapies including trastuzumab and more recently lapatinib have significantly improved the prognosis for HER2 positive breast cancer patients. However, resistance to these agents is a significan...

    Authors: Martina S J McDermott, Brigid C Browne, Neil T Conlon, Neil A O’Brien, Dennis J Slamon, Michael Henry, Paula Meleady, Martin Clynes, Paul Dowling, John Crown and Norma O’Donovan
    Citation: Molecular Cancer 2014 13:157

    The Correction to this article has been published in Molecular Cancer 2023 22:175

  19. Protein coding genes account for only about 2% of the human genome, whereas the vast majority of transcripts are non-coding RNAs including long non-coding RNAs. A growing volume of literature has proposed that...

    Authors: Ming-zhe Ma, Chun-xiao Li, Yan Zhang, Ming-zhe Weng, Ming-di Zhang, Yi-yu Qin, Wei Gong and Zhi-wei Quan
    Citation: Molecular Cancer 2014 13:156
  20. With increased long-term survivors of childhood cancer patients, therapy-associated infertility has become one of the most common late side-effects and significantly affects their life-quality. Therefore, eval...

    Authors: Mi Hou, Emma Eriksson, Konstantin Svechnikov, Kirsi Jahnukainen, Olle Söder, Andreas Meinhardt and Lars Sävendahl
    Citation: Molecular Cancer 2014 13:155
  21. The importance of the genetic background of cancer cells for the individual susceptibility to cancer treatments is increasingly apparent. In melanoma, the existence of a BRAF mutation is a main predictor for succ...

    Authors: Imanol Arozarena, Ibai Goicoechea, Oihane Erice, Jennnifer Ferguson, Geoffrey P Margison and Claudia Wellbrock
    Citation: Molecular Cancer 2014 13:154
  22. The influence of natural regulatory T cells (nTregs) on the patients with colon cancer is unclear. Demethylated status of the Treg-specific demethylated region (TSDR) of the FOXP3 gene was reported to be a potent...

    Authors: Changhua Zhuo, Zhiyuan Li, Ye Xu, Yuwei Wang, Qingguo Li, Junjie Peng, Hongtu Zheng, Peng Wu, Bin Li and Sanjun Cai
    Citation: Molecular Cancer 2014 13:153
  23. Targeted therapies have improved therapeutic options of treating renal cell carcinoma (RCC). However, drug response is temporary due to resistance development.

    Authors: Eva Juengel, Snigdha Nowaz, Jasmina Makarevi, Iyad Natsheh, Isabella Werner, Karen Nelson, Michael Reiter, Igor Tsaur, Jens Mani, Sebastian Harder, Georg Bartsch, Axel Haferkamp and Roman A Blaheta
    Citation: Molecular Cancer 2014 13:152
  24. Epidemiological data show that the incidence of carcinomas in humans is highly dependent on age. However, the initial steps of the age-related molecular oncogenic processes by which the switch towards the neop...

    Authors: Nathalie Martin, Clara Salazar-Cardozo, Chantal Vercamer, Louise Ott, Guillemette Marot, Predrag Slijepcevic, Corinne Abbadie and Olivier Pluquet
    Citation: Molecular Cancer 2014 13:151
  25. Heat shock protein 90 (Hsp90) is a promising therapeutic target and inhibition of Hsp90 will presumably result in suppression of multiple signaling pathways. FW-04-806, a bis-oxazolyl macrolide compound extrac...

    Authors: Wei Huang, Min Ye, Lian-ru Zhang, Qun-dan Wu, Min Zhang, Jian-hua Xu and Wei Zheng
    Citation: Molecular Cancer 2014 13:150
  26. Peroxisome proliferator-activated receptors gamma (PPARγ) ligands have been shown to inhibit the growth of non-small cell lung cancer (NSCLC) cells. However, the mechanisms underlying this effect remain incomp...

    Authors: SWei Sunny Hann, Qing Tang, Fang Zheng, Shunyu Zhao, Jianping Chen and ZhiYu Wang
    Citation: Molecular Cancer 2014 13:149
  27. Resistance to cell death in the presence of stressful stimuli is one of the hallmarks of cancer cells acquired during multistep tumorigenesis, and knowledge of the molecular mechanism of stress adaptation can ...

    Authors: Hye-Kyung Park, Ji-Eun Lee, Jaehwa Lim and Byoung Heon Kang
    Citation: Molecular Cancer 2014 13:148
  28. Chk1 forms a core component of the DNA damage response and small molecule inhibitors are currently being investigated in the clinic as cytotoxic chemotherapy potentiators. Recent evidence suggests that Chk1 in...

    Authors: Christopher Bryant, Kirsten Scriven and Andrew J Massey
    Citation: Molecular Cancer 2014 13:147
  29. High androgen receptor (AR) level in primary tumour predicts increased prostate cancer (PCa)-specific mortality. Furthermore, activations of the AR, PI3K, mTOR, NFκB and Hedgehog (Hh) signaling pathways are in...

    Authors: Andrea Köhler, Ümmühan Demir, Eva Kickstein, Sybille Krauss, Johanna Aigner, Beatriz Aranda-Orgillés, Antonios I Karagiannidis, Clemens Achmüller, Huajie Bu, Andrea Wunderlich, Michal-Ruth Schweiger, Georg Schaefer, Susann Schweiger, Helmut Klocker and Rainer Schneider
    Citation: Molecular Cancer 2014 13:146
  30. The Abelson tyrosine kinase (c-Abl) inhibitor STI571 (Glivec®) has been shown to effectively inhibit colorectal cancer cell migration and invasion. The c-Abl substrate abelson interactor 1 (Abi1) is a key regu...

    Authors: Konrad Steinestel, Silke Brüderlein, Jochen K Lennerz, Julie Steinestel, Klaus Kraft, Christian Pröpper, Viktor Meineke and Peter Möller
    Citation: Molecular Cancer 2014 13:145
  31. HER-2 represents a relatively new therapeutic target for non small cell lung cancer (NSCLC) patients. The incidence for reported HER-2 overexpression/amplification/mutations ranges from 2 to 20% in NSCLC. More...

    Authors: Daniele Cretella, Francesca Saccani, Federico Quaini, Caterina Frati, Costanza Lagrasta, Mara Bonelli, Cristina Caffarra, Andrea Cavazzoni, Claudia Fumarola, Maricla Galetti, Silvia La Monica, Luca Ampollini, Marcello Tiseo, Andrea Ardizzoni, Pier Giorgio Petronini and Roberta R Alfieri
    Citation: Molecular Cancer 2014 13:143
  32. MicroRNA-10b (miR-10b) has a prominent role in regulating tumor invasion and metastasis by targeting the HOXD10 transcriptional repressor and has been found up-regulated in several tumor types.

    Authors: Paola Parrella, Raffaela Barbano, Barbara Pasculli, Andrea Fontana, Massimiliano Copetti, Vanna Maria Valori, Maria Luana Poeta, Giuseppe Perrone, Daniela Righi, Marina Castelvetere, Michelina Coco, Teresa Balsamo, Maria Morritti, Fabio Pellegrini, Andrea Onetti-Muda, Evaristo Maiello…
    Citation: Molecular Cancer 2014 13:142
  33. Inhibition of the activated epidermal growth factor receptor (EGFR) with either enzymatic kinase inhibitors or anti-EGFR antibodies such as cetuximab, is an effective modality of treatment for multiple human c...

    Authors: Jeonghee Cho, Adam J Bass, Michael S Lawrence, Kristian Cibulskis, Ahye Cho, Shi-Nai Lee, Mai Yamauchi, Nikhil Wagle, Panisa Pochanard, Nayoung Kim, Angela K J Park, Jonghwa Won, Hyung-Suk Hur, Heidi Greulich, Shuji Ogino, Carrie Sougnez…
    Citation: Molecular Cancer 2014 13:141
  34. Authors: Takashi Mitamura, Hidemichi Watari, Lei Wang, Hiromi Kanno, Masaya Miyazaki, Makiko Kitagawa, Mohamed Kamel Hassan, Peixin Dong, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Shinya Tanaka and Noriaki Sakuragi
    Citation: Molecular Cancer 2014 13:140

    The original article was published in Molecular Cancer 2014 13:97

  35. The introduction of cisplatin has improved the long-term survival rate in osteosarcoma patients. However, some patients are intrinsically resistant to cisplatin. This study reported that the activation of Notc...

    Authors: Lei Wang, Fangchun Jin, An Qin, Yongqiang Hao, Yufeng Dong, Shengfang Ge and Kerong Dai
    Citation: Molecular Cancer 2014 13:139
  36. Although long-term estrogen (E2) exposure is associated with increased breast cancer (BC) risk, and E2 appears to sustain growth of BC cells that express functional estrogen receptors (ERs), its role in promot...

    Authors: Ying Sun, Yunshan Wang, Cong Fan, Peng Gao, Xiuwen Wang, Guangwei Wei and Junmin Wei
    Citation: Molecular Cancer 2014 13:137
  37. Insulin-like growth factor I (IGF-I) can induce epithelial mesenchymal transition (EMT) in many epithelial tumors; however, the molecular mechanism by which this occurs is not clearly understood. Additionally,...

    Authors: Heming Li, Ling Xu, Ce Li, Lei Zhao, Yanju Ma, Huachuan Zheng, Zhi Li, Ye Zhang, Ruoyu Wang, Yunpeng Liu and Xiujuan Qu
    Citation: Molecular Cancer 2014 13:136
  38. KRAS mutations in codons 12 and 13 are established predictive biomarkers for anti-EGFR therapy in colorectal cancer. Previous studies suggest that KRAS codon 61 and 146 mutations may also predict resistance to an...

    Authors: Yu Imamura, Paul Lochhead, Mai Yamauchi, Aya Kuchiba, Zhi Rong Qian, Xiaoyun Liao, Reiko Nishihara, Seungyoun Jung, Kana Wu, Katsuhiko Nosho, Yaoyu E Wang, Shouyong Peng, Adam J Bass, Kevin M Haigis, Jeffrey A Meyerhardt, Andrew T Chan…
    Citation: Molecular Cancer 2014 13:135
  39. The tetraspanin CD63 is a highly N-glycosylated protein that is known to regulate cancer malignancy. However, the contribution of glycosylation of CD63 to cancer malignancy remains unclear. Previously, we repo...

    Authors: Naoomi Tominaga, Keitaro Hagiwara, Nobuyoshi Kosaka, Kimi Honma, Hitoshi Nakagama and Takahiro Ochiya
    Citation: Molecular Cancer 2014 13:134
  40. Arsenic trioxide has been demonstrated as an effective anti-cancer drug against leukemia and solid tumors both in vitro and in vivo. However, recent phase II trials demonstrated that single agent arsenic trioxide...

    Authors: Tongsen Zheng, Dalong Yin, Zhaoyang Lu, Jiabei Wang, Yuejin Li, Xi Chen, Yingjian Liang, Xuan Song, Shuyi Qi, Boshi Sun, Changming Xie, Xianzhi Meng, Shangha Pan, Jiaren Liu, Hongchi Jiang and Lianxin Liu
    Citation: Molecular Cancer 2014 13:133
  41. Interferon (IFN)-γ-mediated immune response plays an important role in tumor immunosurveillance. However, the regulation of IFN-γ-mediated tumorigenesis and immune response remains elusive. USP18, an interfero...

    Authors: Bangxing Hong, Haiyan Li, Yong Lu, Mingjun Zhang, Yuhuan Zheng, Jianfei Qian and Qing Yi
    Citation: Molecular Cancer 2014 13:132
  42. Metastasis accounts for the majority of deaths from cancer. Although tumor microenvironment has been shown to have a significant impact on the initiation and/or promotion of metastasis, the mechanism remains e...

    Authors: Xin Tang, Theresa B Kuhlenschmidt, Qian Li, Shahjahan Ali, Stephane Lezmi, Hong Chen, Melissa Pires-Alves, William W Laegreid, Taher A Saif and Mark S Kuhlenschmidt
    Citation: Molecular Cancer 2014 13:131
  43. Increasing evidence indicates an important role of transcription factor Yin Yang-1 (YY1) in human tumorigenesis. However, its function in cancer remains controversial and the relevance of YY1 to pancreatic duc...

    Authors: Jing-Jing Zhang, Yi Zhu, Kun-Ling Xie, Yun-Peng Peng, Jin-Qiu Tao, Jie Tang, Zheng Li, Ze-Kuan Xu, Cun-Cai Dai, Zhu-Yin Qian, Kui-Rong Jiang, Jun-Li Wu, Wen-Tao Gao, Qing Du and Yi Miao
    Citation: Molecular Cancer 2014 13:130
  44. Over three decades have passed since the first report on the expression of CA125 by ovarian tumors. Since that time our understanding of ovarian cancer biology has changed significantly to the point that these...

    Authors: Mildred Felder, Arvinder Kapur, Jesus Gonzalez-Bosquet, Sachi Horibata, Joseph Heintz, Ralph Albrecht, Lucas Fass, Justanjyot Kaur, Kevin Hu, Hadi Shojaei, Rebecca J Whelan and Manish S Patankar
    Citation: Molecular Cancer 2014 13:129
  45. Hepatitis B virus X protein (HBx) plays crucial roles in hepatocarcinogenesis. However, the underlying mechanism remains elusive. We have reported that HBx is able to up-regulate survivin in hepatocellular car...

    Authors: Weiying Zhang, Zhanping Lu, Guangyao Kong, Yuen Gao, Tao Wang, Qi Wang, Na Cai, Honghui Wang, Fabao Liu, Lihong Ye and Xiaodong Zhang
    Citation: Molecular Cancer 2014 13:128
  46. microRNAs are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development of malignant behaviors. Accumulating evidence sugge...

    Authors: Yantao Duan, Lei Hu, Bing Liu, Beiqin Yu, Jianfang Li, Min Yan, Yingyan Yu, Chen Li, Liping Su, Zhenggang Zhu, Ming Xiang, Bingya Liu and Qiumeng Yang
    Citation: Molecular Cancer 2014 13:127
  47. Prostate cancer (PCa) is one of the leading causes of cancer-related mortality and morbidity in the aging male population and represents the most frequently diagnosed malignancy in men around the world. The De...

    Authors: Samia B Bachmann, Sandra C Frommel, Rosalba Camicia, Hans C Winkler, Raffaella Santoro and Paul O Hassa
    Citation: Molecular Cancer 2014 13:125

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