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  1. Elevated expression of anti-apoptotic Bcl-2 family proteins have been linked to a poor survival rate of patients with Follicular Lymphoma (FL). This prompted us to evaluate a very potent non-peptidic Small-Mol...

    Authors: Alan A Arnold, Amro Aboukameel, Jianyong Chen, Dajun Yang, Shaomeng Wang, Ayad Al-Katib and Ramzi M Mohammad
    Citation: Molecular Cancer 2008 7:20
  2. Surplus goods, produced by a community, allow individuals to dedicate their efforts to abstract problems, while enjoying the benefits of support from the community. In return, the community benefits from the i...

    Authors: David Covarrubias, Maurice Van Emburgh, Hassan R Naqvi, Christian Schmidt and Shawn Mathur
    Citation: Molecular Cancer 2008 7:18
  3. The resistance of tumour cells to apoptosis is a major contributor to the limited effectiveness of chemotherapies. Insulin-like growth factor I (IGF-I) has potential to protect cancer cells from variety of apo...

    Authors: Shi Yu Yang, Kevin M Sales, Barry J Fuller, Alexander M Seifalian and Marc C Winslet
    Citation: Molecular Cancer 2008 7:17
  4. We have recently shown that curcumin (a diferuloylmethane, the yellow pigment in turmeric) enhances apoptosis-inducing potential of TRAIL in prostate cancer PC-3 cells, and sensitizes TRAIL-resistant LNCaP cells

    Authors: Sharmila Shankar, Suthakar Ganapathy, Qinghe Chen and Rakesh K Srivastava
    Citation: Molecular Cancer 2008 7:16
  5. DNA hypermethylation events and other epimutations occur in many neoplasms, producing gene expression changes that contribute to neoplastic transformation, tumorigenesis, and tumor behavior. Some human cancers...

    Authors: J Devon Roll, Ashley G Rivenbark, Wendell D Jones and William B Coleman
    Citation: Molecular Cancer 2008 7:15
  6. Colorectal cancer (CRC) is one of the most common causes of cancer death throughout the world. In this work our aim was to study the role of the phosphoserine aminotransferase PSAT1 in colorectal cancer develo...

    Authors: Nadia Vié, Virginie Copois, Caroline Bascoul-Mollevi, Vincent Denis, Nicole Bec, Bruno Robert, Caroline Fraslon, Emmanuel Conseiller, Franck Molina, Christian Larroque, Pierre Martineau, Maguy Del Rio and Céline Gongora
    Citation: Molecular Cancer 2008 7:14
  7. The implementation of gene therapy for the treatment of pituitary tumors emerges as a promising complement to surgery and may have distinct advantages over radiotherapy for this type of tumors. Up to now, suic...

    Authors: Gloria M Console, Claudia B Herenu, Gisela A Camihort, Georgina C Luna, Maria I Bracamonte, Gustavo R Morel and Rodolfo G Goya
    Citation: Molecular Cancer 2008 7:13
  8. CD30, a 120 kDa surface phosphorylated protein is a member of tumour necrosis/nerve growth factor receptor (TNF/NGFR) family and constitutively expressed by Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin ly...

    Authors: Minglong Zhou, Faisal M Fadlelmola, Jason B Cohn, Brian Skinnider, Randy D Gascoyne and Diponkar Banerjee
    Citation: Molecular Cancer 2008 7:12
  9. Pancreatic carcinoma usually is a fatal disease with no cure, mainly due to its invasion and metastasis prior to diagnosis. We analyzed the gene expression profiles of paired primary pancreatic tumors and meta...

    Authors: Archana Thakur, Aliccia Bollig, Jiusheng Wu and Dezhong J Liao
    Citation: Molecular Cancer 2008 7:11
  10. Metastatic osteosarcoma (OS) has a very poor prognosis. New treatments are therefore wanted. The conditionally replicative adenovirus Ad5-Δ24RGD has shown promising anti-tumor effects on local cancers, includi...

    Authors: Harm CA Graat, Victor W van Beusechem, Frederik HE Schagen, M Adhiambo Witlox, Eugenie S Kleinerman, Marco N Helder, Winald R Gerritsen, Gertjan JL Kaspers and Paul IJM Wuisman
    Citation: Molecular Cancer 2008 7:9
  11. The disturbance of zinc homeostasis featured with a significant decrease of cellular zinc level was well documented to associate with the development and progression of human prostate malignancy. We have previ...

    Authors: Hua Wei, Mohamed Mokhtar Desouki, Shufei Lin, Dakai Xiao, Renty B Franklin and Pei Feng
    Citation: Molecular Cancer 2008 7:7
  12. Clear cell renal carcinoma (RCC) is the most common and invasive adult renal cancer. For the purpose of identifying RCC biomarkers, we investigated chromosomal regions and individual genes modulated in RCC pat...

    Authors: Ingrid Cifola, Roberta Spinelli, Luca Beltrame, Clelia Peano, Ester Fasoli, Stefano Ferrero, Silvano Bosari, Stefano Signorini, Francesco Rocco, Roberto Perego, Vanessa Proserpio, Francesca Raimondo, Paolo Mocarelli and Cristina Battaglia
    Citation: Molecular Cancer 2008 7:6
  13. Pancreatic cancer is the 4th leading cause of death from cancer in the U.S. The opioid growth factor (OGF; [Met5]-enkephalin) and the OGF receptor form an inhibitory growth regulatory system involved in the patho...

    Authors: Fan Cheng, Patricia J McLaughlin, Michael F Verderame and Ian S Zagon
    Citation: Molecular Cancer 2008 7:5
  14. It is increasingly clear that complex networks of relationships between genes and/or proteins govern neoplastic processes. Our understanding of these networks is expanded by the use of functional genomic and p...

    Authors: Christopher A Maxwell, Víctor Moreno, Xavier Solé, Laia Gómez, Pilar Hernández, Ander Urruticoechea and Miguel Angel Pujana
    Citation: Molecular Cancer 2008 7:4
  15. Cervical carcinogenesis is a multistep process initiated by "high risk" human papillomaviruses (HR-HPV), most commonly HPV16. The infection per se is, however, not sufficient to induce malignant conversion. Trans...

    Authors: Jose Diaz-Chavez, Rogelio Hernandez-Pando, Paul F Lambert and Patricio Gariglio
    Citation: Molecular Cancer 2008 7:3
  16. Hodgkin lymphoma (HL) and Anaplastic Large Cell Lymphoma (ALCL), are forms of malignant lymphoma defined by unique morphologic, immunophenotypic, genotypic, and clinical characteristics, but both overexpress C...

    Authors: Faisal M Fadlelmola, Minglong Zhou, Ronald J de Leeuw, Nirpjit S Dosanjh, Karynn Harmer, David Huntsman, Wan L Lam and Diponkar Banerjee
    Citation: Molecular Cancer 2008 7:2
  17. A wide variety of animal models have been used to study human breast cancer. Murine, feline and canine mammary tumor cell lines have been studied for several decades and have been shown to have numerous aspect...

    Authors: Julie A Sharp, Sonia L Mailer, Peter C Thomson, Christophe Lefèvre and Kevin R Nicholas
    Citation: Molecular Cancer 2008 7:1
  18. Bone gamma-carboxyglutamate protein (BGLAP; osteocalcin) is a small, highly conserved molecule first identified in the mineralized matrix of bone. It has been implicated in the pathophysiology of various malig...

    Authors: Hany Kayed, Sandor Bekasi, Shereen Keleg, Christoph W Michalski, Thomas Giese, Helmut Friess and Jörg Kleeff
    Citation: Molecular Cancer 2007 6:83
  19. Retinoids are potent growth inhibitory and differentiating agents in a variety of cancer cell types. We have shown that retinoids induce growth arrest in all pancreatic cancer cell lines studied, regardless of...

    Authors: Brahmchetna Singh, Richard F Murphy, Xian-Zhong Ding, Alexandra B Roginsky, Richard H Bell Jr and Thomas E Adrian
    Citation: Molecular Cancer 2007 6:82
  20. Recently, periostin (POSTN), a gene encoding a protein with similarity to the fasciclin family and involved in cell survival and angiogenesis, has emerged as a promising marker for tumor progression in various ty...

    Authors: Gaëlle Tilman, Marina Mattiussi, Francis Brasseur, Nicolas van Baren and Anabelle Decottignies
    Citation: Molecular Cancer 2007 6:80
  21. Colorectal tumors have characteristic genome-wide expression patterns that allow their distinction from normal colon epithelia and facilitate clinical prognosis. The expression heterogeneity within a primary c...

    Authors: Eike Staub, Joern Groene, Maya Heinze, Detlev Mennerich, Stefan Roepcke, Irina Klaman, Bernd Hinzmann, Esmeralda Castanos-Velez, Christian Pilarsky, Benno Mann, Thomas Brümmendorf, Birgit Weber, Heinz-Johannes Buhr and André Rosenthal
    Citation: Molecular Cancer 2007 6:79
  22. Immunity, based on a natural and an educated system, is responsible for recognition and elimination of infectious particles, cellular waste, modified self and transformed cells. This dual system guarantees tha...

    Authors: H Peter Vollmers and Stephanie Brändlein
    Citation: Molecular Cancer 2007 6:78
  23. Neoplastic cells increase glycolysis in order to produce anabolic precursors and energy within the hypoxic environment of a tumor. Ras signaling is activated in several cancers and has been found to regulate m...

    Authors: Sucheta Telang, Andrew N Lane, Kristin K Nelson, Sengodagounder Arumugam and Jason Chesney
    Citation: Molecular Cancer 2007 6:77
  24. Although a high level of functional voltage-gated sodium channel (VGSC) expression has been found in strongly metastatic human and rat prostate cancer (PCa) cells, the mechanism(s) responsible for the upregula...

    Authors: Pinar Uysal-Onganer and Mustafa BA Djamgoz
    Citation: Molecular Cancer 2007 6:76
  25. The studies on cancer-stem-cells (CSCs) have attracted so much attention in recent years as possible therapeutic implications. This study was carried out to investigate the gene expression profile of CSCs in h...

    Authors: Dong-Cheol Seo, Ji-Min Sung, Hee-Jung Cho, Hee Yi, Kun-Ho Seo, In-Soo Choi, Dong-Ku Kim, Jin-Suk Kim, Abd El-Aty AM and Ho-Chul Shin
    Citation: Molecular Cancer 2007 6:75
  26. GPI anchor attachment is catalyzed by the GPI transamidase (GPIT) complex. GAA1, PIG-T and PIG-U are the three of five GPIT subunits. Previous studies demonstrated amplification and overexpression of GPIT subunit...

    Authors: Wei-Wen Jiang, Marianna Zahurak, Zeng-Tong Zhou, Hannah Lui Park, Zhong-Min Guo, Guo-Jun Wu, David Sidransky, Barry Trink and Joseph A Califano
    Citation: Molecular Cancer 2007 6:74
  27. Bortezomib is a novel anti-cancer agent which has shown promising activity in non-small lung cancer (NSCLC) patients. However, only a subset of patients respond to this treatment. We show that NSCLC cell lines...

    Authors: Jens Voortman, Agnieszka Chęcińska and Giuseppe Giaccone
    Citation: Molecular Cancer 2007 6:73
  28. Enhanced osteoblast-dependent osteoclastogenesis due to inhibition of Wnt/β-catenin signaling in bone morphogenic protein (BMP)-driven osteoprogenitors has been repeatedly implicated in the natural history of ...

    Authors: Ken-ichi Fujita and Siegfried Janz
    Citation: Molecular Cancer 2007 6:71
  29. Lung cancer is the number one cancer killer of both men and women in the United States. Three quarters of lung cancer patients are diagnosed with regionally or distantly disseminated disease; their 5-year surv...

    Authors: Jeffrey A Tsou, Janice S Galler, Kimberly D Siegmund, Peter W Laird, Sally Turla, Wendy Cozen, Jeffrey A Hagen, Michael N Koss and Ite A Laird-Offringa
    Citation: Molecular Cancer 2007 6:70
  30. Histone deacetylase inhibitors (HDACIs) have many effects on cancer cells, such as growth inhibition, induction of cell death, differentiation, and anti-angiogenesis, all with a wide therapeutic index. However...

    Authors: Selena Kuljaca, Tao Liu, Andrew EL Tee, Michelle Haber, Murray D Norris, Tanya Dwarte and Glenn M Marshall
    Citation: Molecular Cancer 2007 6:68
  31. Ph-positive leukemias are caused by the aberrant fusion of the BCR and ABL genes. Nilotinib is a selective Bcr/Abl tyrosine kinase inhibitor related to imatinib, which is widely used to treat chronic myelogenous ...

    Authors: Pavinder Kaur, Niklas Feldhahn, Bin Zhang, Daniel Trageser, Markus Müschen, Veerle Pertz, John Groffen and Nora Heisterkamp
    Citation: Molecular Cancer 2007 6:67
  32. The incidence of malignant pleural mesothelioma (MPM) is associated with exposure to asbestos, and projections suggest that the yearly number of deaths in Western Europe due to MPM will increase until 2020. De...

    Authors: Larisa L Belyanskaya, Thomas M Marti, Sally Hopkins-Donaldson, Stefanie Kurtz, Emanuela Felley-Bosco and Rolf A Stahel
    Citation: Molecular Cancer 2007 6:66
  33. PP2Cα is the representative member of the type 2C family of protein phosphatases, and it has recently been implicated in the regulation of p53-, TGFβ-, cyclin-dependent kinase- and apoptosis-signaling. To inve...

    Authors: Twan Lammers, Peter Peschke, Volker Ehemann, Jürgen Debus, Boris Slobodin, Sara Lavi and Peter Huber
    Citation: Molecular Cancer 2007 6:65
  34. Meningiomas are common brain tumors that are classified into three World Health Organization grades (benign, atypical and malignant) and are molecularly ill-defined tumors. The purpose of this study was identi...

    Authors: Lucia Helena Carvalho, Ivan Smirnov, Gilson S Baia, Zora Modrusan, Justin S Smith, Peter Jun, Joseph F Costello, Michael W McDermott, Scott R VandenBerg and Anita Lal
    Citation: Molecular Cancer 2007 6:64
  35. Searching for novel molecular markers that dependably predict or indicate responses of human cancer cells to epidermal growth factor receptor (EGFR)-targeted therapy is strongly warranted. The purpose of the c...

    Authors: Yang Lu, Ke Liang, Xinqun Li and Zhen Fan
    Citation: Molecular Cancer 2007 6:63
  36. Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expres...

    Authors: Kosei Ishida, Satoshi Ito, Naoyuki Wada, Hiroyo Deguchi, Tsuyoshi Hata, Masaru Hosoda and Tsutomu Nohno
    Citation: Molecular Cancer 2007 6:62
  37. It is more and more recognized that hypoxia plays a role in the resistance of cancer cells to chemotherapy. However, the mechanisms underlying this resistance still need deeper understanding. The aim of this s...

    Authors: Jean-Philippe Cosse, Audrey Sermeus, Kayleen Vannuvel, Noelle Ninane, Martine Raes and Carine Michiels
    Citation: Molecular Cancer 2007 6:61
  38. Multiple myeloma (MM) is a common hematological malignancy which remains incurable due to both intrinsic and acquired resistance to conventional or more novel drugs. Estrogenic and antiestrogenic compounds are...

    Authors: Brigitte Sola and Jack-Michel Renoir
    Citation: Molecular Cancer 2007 6:59
  39. Drug resistance is a major problem in cancer chemotherapy. Acquisition of chemo-resistance not only reduces the effectiveness of drugs, but also promotes side effects and markedly reduces the patient's quality...

    Authors: Jun Hamaguchi, Hiroaki Nakagawa, Masato Takahashi, Takeaki Kudo, Naoya Kamiyama, Bailong Sun, Takahiro Oshima, Yuji Sato, Kisaburo Deguchi, Satoru Todo and Shin-Ichiro Nishimura
    Citation: Molecular Cancer 2007 6:58
  40. The use of retinoids as anti-cancer agents has been limited due to resistance and low efficacy. The dynamics of nuclear receptor coregulation are incompletely understood. Cell-and context-specific activities o...

    Authors: Kelly C Heim, Kristina A White, Dexin Deng, Craig R Tomlinson, Jason H Moore, Sarah J Freemantle and Michael J Spinella
    Citation: Molecular Cancer 2007 6:57
  41. The presence of EGFR kinase domain mutations in a subset of NSCLC patients correlates with the response to treatment with the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. Although most EGFR mutatio...

    Authors: Matheus M de Gunst, Marielle I Gallegos-Ruiz, Giuseppe Giaccone and Jose Antonio Rodriguez
    Citation: Molecular Cancer 2007 6:56
  42. Neuroblastoma (NB) is an extra-cranial solid tumour of childhood. In spite of the good clinical response to first-line therapy, complete eradication of NB cells is rarely achieved. Thus, new therapeutic strate...

    Authors: Roberta Carosio, Guendalina Zuccari, Isabella Orienti, Salvatore Mangraviti and Paolo G Montaldo
    Citation: Molecular Cancer 2007 6:55
  43. Colorectal cancer develops through two main genetic instability pathways characterized by distinct pathologic features and clinical outcome.

    Authors: Giovanni Lanza, Manuela Ferracin, Roberta Gafà, Angelo Veronese, Riccardo Spizzo, Flavia Pichiorri, Chang-gong Liu, George A Calin, Carlo M Croce and Massimo Negrini
    Citation: Molecular Cancer 2007 6:54

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