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  1. Pancreatic cancer remains a challenging disease with an overall cumulative 5-year survival rate below 1%. The process of cancer initiation, progression and metastasis is still not understood well. Invasion and...

    Authors: Shereen Keleg, Peter Büchler, Roman Ludwig, Markus W Büchler and Helmut Friess
    Citation: Molecular Cancer 2003 2:14
  2. The concept of pancreatic cancer origin is controversial. Acinar, ductal or islet cells have been hypothesized as the cell of origin. The pros and cons of each of these hypotheses are discussed. Based on the w...

    Authors: Parviz M Pour, Krishan K Pandey and Surinder K Batra
    Citation: Molecular Cancer 2003 2:13
  3. The incidence and mortality of pancreatic adenocarcinoma are nearly coincident having a five-year survival of less than 5%. Enormous advances have been made in our knowledge of the molecular alterations common...

    Authors: Patrick S Moore, Stefania Beghelli, Giuseppe Zamboni and Aldo Scarpa
    Citation: Molecular Cancer 2003 2:7
  4. Pancreatic adenocarcinoma is characterized by poor prognosis, because of late diagnosis and lack of response to chemo- and/or radiation therapies. Resistance to apoptosis mainly causes this insensitivity to co...

    Authors: Sabine Westphal and Holger Kalthoff
    Citation: Molecular Cancer 2003 2:6
  5. About 80% of pancreatic cancer patients have glucose intolerance or frank diabetes. This observation has led to the following two hypotheses: i. pancreatic cancer causes the associated diabetes and ii. the condit...

    Authors: Feng Wang, Margery Herrington, Jörgen Larsson and Johan Permert
    Citation: Molecular Cancer 2003 2:4
  6. Glucocorticoids inhibit hepatocellular proliferation and modulate the expression of oncogenes and tumor suppressor genes via mechanisms involving the glucocorticoid receptor. Glucocorticoids also produce a recept...

    Authors: Jihan A Youssef and Mostafa Z Badr
    Citation: Molecular Cancer 2003 2:3
  7. Rhabdomyosarcoma is a common malignancy in children. There are two major types of rhabdomyosarcomas, the embryonal and the alveolar, differing in cytogenetic and morphologic features. The alveolar type of rhab...

    Authors: Peilin Zhang, Kunjan S Bhakta, Pier Lorenzo Puri, Robert O Newbury, James R Feramisco and Jean Y Wang
    Citation: Molecular Cancer 2003 2:2

    The Retraction Note to this article has been published in Molecular Cancer 2003 2:17

  8. Gleevec (aka STI571, Imatinib) is a recently FDA approved anti-tumor drug for chronic myelogenous leukemia. Gleevec binds specifically to BCR-ABL tyrosine kinase and inhibit the tyrosine kinase activity. It cr...

    Authors: Peilin Zhang, Wei Yi Gao, Steven Turner and Barbara S Ducatman
    Citation: Molecular Cancer 2003 2:1
  9. Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Defects in mitochondrial function have long been suspected to contribute to the development and progress...

    Authors: Jennifer S Carew and Peng Huang
    Citation: Molecular Cancer 2002 1:9
  10. Human male germ cell tumors (GCTs) arise from undifferentiated primordial germ cells (PGCs), a stage in which extensive methylation reprogramming occurs. GCTs exhibit pluripotentality and are highly sensitive ...

    Authors: Sanjay Koul, Jane Houldsworth, Mahesh M Mansukhani, Alessia Donadio, James M McKiernan, Victor E Reuter, George J Bosl, Raju S Chaganti and Vundavalli V Murty
    Citation: Molecular Cancer 2002 1:8
  11. Sex steroid hormones, estrogen, progesterone and androgen, play pivotal roles in sex differentiation and development, and in reproductive functions and sexual behavior. Studies have shown that sex steroid horm...

    Authors: Xiuhua Gao, Brian W Loggie and Zafar Nawaz
    Citation: Molecular Cancer 2002 1:7
  12. The interaction of nuclear and mitochondrial genes is an essential feature in maintenance of normal cellular function. Of 82 structural subunits that make up the oxidative phosphorylation system in the mitocho...

    Authors: Robert Delsite, Sushant Kachhap, Ramaswamy Anbazhagan, Edward Gabrielson and Keshav K Singh
    Citation: Molecular Cancer 2002 1:6
  13. PGE-2 is constitutively produced by many non-small cell lung cancers (NSCLC) and its immunosuppressive effects have been linked to altered immune responses in lung cancer. We asked whether elevated levels of p...

    Authors: Giovanna E Hidalgo, Li Zhong, Dennis E Doherty and Edward A Hirschowitz
    Citation: Molecular Cancer 2002 1:5
  14. Anaplastic thyroid carcinoma, which is one of the most aggressive, malignant tumors in humans, results in an extremely poor prognosis despite chemotherapy and radiotherapy. The present study was designed to ev...

    Authors: Ken Ohnishi, Ichiro Ota, Katsunari Yane, Akihisa Takahashi, Kazue Yuki, Mie Emoto, Hiroshi Hosoi and Takeo Ohnishi
    Citation: Molecular Cancer 2002 1:4
  15. Previous studies have shown that the short arm of chromosome 5 (5p) exhibit frequent genetic changes in invasive cervical carcinoma (CC), and that these changes arise early during the carcinogenesis, in precan...

    Authors: Hugo Arias-Pulido, Gopeshwar Narayan, Hernan Vargas, Mahesh Mansukhani and Vundavalli VVS Murty
    Citation: Molecular Cancer 2002 1:3
  16. The active copy of the imprinted gene H19 is turned off by inappropriate methylation in several pediatric tumors including Wilms' Tumour and embryonal rhabdomyosarcoma. H19 controls in cis the linked Insulin-like...

    Authors: Catherine A Lynch, Benjamin Tycko, Timothy H Bestor and Colum P Walsh
    Citation: Molecular Cancer 2002 1:2

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