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  1. Dominant-activating mutations in the RET proto-oncogene, a receptor tyrosine kinase, are responsible for the development of medullary thyroid carcinoma (MTC) and causative for multiple endocrine neoplasia (MEN...

    Authors: Alf Spitschak, Claudia Meier, Bhavani Kowtharapu, David Engelmann and Brigitte M. Pützer
    Citation: Molecular Cancer 2017 16:24
    Content type: Research Published on:

  2. Genetic alterations in chromatin modulators such as BRCA-1 associated protein-1 (BAP1) are the most frequent genetic alteration in intrahepatic cholangiocarcinomas (CCA). We evaluated the contribution of BAP1 ...

    Authors: Mansi Parasramka, Irene K. Yan, Xue Wang, Phuong Nguyen, Akiko Matsuda, Sayantan Maji, Catherine Foye, Yan Asmann and Tushar Patel
    Citation: Molecular Cancer 2017 16:22
    Content type: Research Published on:

  3. The development of chemoresistance and metastasis are the leading causes of death for gastric cancer (GC) patients, however, the molecular mechanisms involved remain unclear. Dysregulation of miRNAs is associa...

    Authors: Jia-Xing Zhang, Yi Xu, Ying Gao, Cui Chen, Zhou-San Zheng, Miao Yun, Hui-Wen Weng, Dan Xie and Sheng Ye
    Citation: Molecular Cancer 2017 16:18
    Content type: Research Published on:

  4. Numerous studies have shown that long non-coding RNAs (lncRNAs) behave as a novel class of transcript during multiple cancer processes, such as cell proliferation, apoptosis, migration, and invasion. LINC00152...

    Authors: Qin-nan Chen, Xin Chen, Zhen-yao Chen, Feng-qi Nie, Chen-chen Wei, Hong-wei Ma, Li Wan, Shuai Yan, Sheng-nan Ren and Zhao-xia Wang
    Citation: Molecular Cancer 2017 16:17
    Content type: Research Published on:

  5. Diffuse large B-cell lymphoma (DLBCL) is an aggressive and complex disease characterized by wide clinical, phenotypic and molecular heterogeneities. The expression pattern and clinical implication of long non-...

    Authors: Meng Zhou, Hengqiang Zhao, Wanying Xu, Siqi Bao, Liang Cheng and Jie Sun
    Citation: Molecular Cancer 2017 16:16
    Content type: Research Published on:

  6. The development of childhood solid tumours is tied to early developmental processes. These tumours may be complex and heterogeneous, and elucidating the aberrant mechanisms that alter the early embryonic envir...

    Authors: Anna L. Leichter, Michael J. Sullivan, Michael R. Eccles and Aniruddha Chatterjee
    Citation: Molecular Cancer 2017 16:15
    Content type: Review Published on:

  7. Breast cancer stem cells (CSCs) are small sub-type of the whole cancer cells that drive tumor initiation, progression and metastasis. Recent studies have demonstrated a role for the aryl hydrocarbon receptor (...

    Authors: Abdullah Al-Dhfyan, Ali Alhoshani and Hesham M. Korashy
    Citation: Molecular Cancer 2017 16:14
    Content type: Research Published on:

    The Erratum to this article has been published in Molecular Cancer 2017 16:69

  8. Despite advancements in the diagnosis and treatment of colorectal cancer (CRC), many patients die because of tumor metastasis or recurrence. Therefore, identifying new prognostic markers and elucidating the me...

    Authors: Senlin Zhao, Hongcheng Sun, Weiliang Jiang, Yushuai Mi, Dongyuan Zhang, Yugang Wen, Dantong Cheng, Huamei Tang, Shaohan Wu, Yang Yu, Xisheng Liu, Weiyingqi Cui, Meng Zhang, Xiaofeng Sun, Zongguang Zhou, Zhihai Peng…
    Citation: Molecular Cancer 2017 16:12
    Content type: Research Published on:

  9. Cancer metastasis is determined by the formation of the metastatic niche and the ability of cancer cells to adapt to microenvironmental stresses. Anoikis resistance is a fundamental feature of metastatic cance...

    Authors: Celia S. L. Mak, Mingo M. H. Yung, Lynn M. N. Hui, Leanne L. Leung, Rui Liang, Kangmei Chen, Stephanie S. Liu, Yiming Qin, Thomas H. Y. Leung, Kai-Fai Lee, Karen K. L. Chan, Hextan Y. S. Ngan and David W. Chan
    Citation: Molecular Cancer 2017 16:11
    Content type: Research Published on:

  10. With more than 600,000 mortalities each year, colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide. Recently, mechanisms involving noncoding RNAs have been implicated in the de...

    Authors: Peng Han, Jing-wen Li, Bo-miao Zhang, Jia-chen Lv, Yong-min Li, Xin-yue Gu, Zhi-wei Yu, Yun-he Jia, Xue-feng Bai, Li Li, Yan-long Liu and Bin-bin Cui
    Citation: Molecular Cancer 2017 16:9
    Content type: Research Published on:

  11. Taurine upregulated gene1 (TUG1) as a 7.1-kb lncRNA, has been shown to play an oncogenic role in various cancers. However, the biological functions of lncRNA TUG1 in small cell lung cancer (SCLC) remain unknow...

    Authors: Yuchun Niu, Feng Ma, Weimei Huang, Shun Fang, Man Li, Ting Wei and Linlang Guo
    Citation: Molecular Cancer 2017 16:5
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2024 23:112

  12. DNA methylation regulates together with other epigenetic mechanisms the transcriptional activity of genes and is involved in the pathogenesis of malignant diseases including lung cancer. In non-small cell lung...

    Authors: Corinna Altenberger, Gerwin Heller, Barbara Ziegler, Erwin Tomasich, Maximilian Marhold, Thais Topakian, Leonhard Müllauer, Petra Heffeter, György Lang, Adelheid End-Pfützenreuter, Balazs Döme, Britt-Madeleine Arns, Walter Klepetko, Christoph C. Zielinski and Sabine Zöchbauer-Müller
    Citation: Molecular Cancer 2017 16:1
    Content type: Research Published on:

  13. Cell lines are still a tool of choice for many fields of biomedical research, including oncology. Although cancer is a very complex disease, many discoveries have been made using monocultures of established ce...

    Authors: Klaudia K. Brodaczewska, Cezary Szczylik, Michal Fiedorowicz, Camillo Porta and Anna M. Czarnecka
    Citation: Molecular Cancer 2016 15:83
    Content type: Review Published on:

  14. Survivin (encoded by the gene BIRC5) plays an important role in the carcinogenesis of bladder cancer. Identifying miRNAs that target Survivin in the setting of bladder cancer will help to develop Survivin-base...

    Authors: Rong Yang, Minghui Liu, Hongwei Liang, Suhan Guo, Xu Guo, Min Yuan, Huibo Lian, Xiang Yan, Shiwei Zhang, Xi Chen, Feng Fang, Hongqian Guo and Chenyu Zhang
    Citation: Molecular Cancer 2016 15:82
    Content type: Research Published on:

  15. SAG (Sensitive to Apoptosis Gene), also known as RBX2, ROC2 or RNF7, is a RING component of CRL (Cullin-RING ligase), required for its activity. Our recent study showed that SAG/RBX2 co-operated with Kras to p...

    Authors: Mingjia Tan, Jie Xu, Javed Siddiqui, Felix Feng and Yi Sun
    Citation: Molecular Cancer 2016 15:81
    Content type: Research Published on:

  16. Gastric cancer (GC) ranks the most common cancer types and is one of the leading causes of cancer-related death. Due to delayed diagnosis and high metastatic frequency, 5-year survival rate of GC is rather low...

    Authors: Tingting Huang, Yuhang Zhou, Alfred S. L. Cheng, Jun Yu, Ka Fai To and Wei Kang
    Citation: Molecular Cancer 2016 15:80
    Content type: Review Published on:

  17. STAT3 signaling plays the pivotal role in tumorigenesis through EZH2 epigenetic modification, which enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3. Here, another possible feedback mecha...

    Authors: Yuan-Ming Pan, Cheng-Gang Wang, Min Zhu, Rui Xing, Jian-Tao Cui, Wen-Mei Li, De-Dong Yu, Shu-Bin Wang, Wei Zhu, Ying-Jiang Ye, Yun Wu, Shan Wang and You-Yong Lu
    Citation: Molecular Cancer 2016 15:79
    Content type: Research Published on:

  18. Blocking the mechanistic target of rapamycin complex-1 (mTORC1) with chemical inhibitors such as rapamycin has shown limited clinical efficacy in cancer. The tumor microenvironment is characterized by an acidi...

    Authors: Seraina Faes, Adrian P. Duval, Anne Planche, Emilie Uldry, Tania Santoro, Catherine Pythoud, Jean-Christophe Stehle, Janine Horlbeck, Igor Letovanec, Nicolo Riggi, Nicolas Demartines and Olivier Dormond
    Citation: Molecular Cancer 2016 15:78
    Content type: Research Published on:

  19. Lipocalin2 (LCN2) is a secretory protein that is aberrantly expressed in several types of cancer and has been involved in metastatic progression. However, neither mechanisms nor the role that LCN2 plays in the...

    Authors: Meibao Feng, Jieqiong Feng, Wuzhen Chen, Wubin Wang, Xuesong Wu, Jing Zhang, Fangying Xu and Maode Lai
    Citation: Molecular Cancer 2016 15:77
    Content type: Research Published on:

  21. Triple-negative breast cancer (TNBC) has a high risk of relapse and there are few chemotherapy options. Although 5-hydroxytryptamine (5-HT, serotonin) signaling pathways have been suggested as potential target...

    Authors: Jaya Gautam, Suhrid Banskota, Sushil Chandra Regmi, Subi Ahn, Yong Hyun Jeon, Hyunyoung Jeong, Seung Joo Kim, Tae-gyu Nam, Byeong-Seon Jeong and Jung-Ae Kim
    Citation: Molecular Cancer 2016 15:75
    Content type: Research Published on:

  22. Glioblastomas (GBM) continue to remain one of the most dreaded tumours that are highly infiltrative in nature and easily preclude comprehensive surgical resection. GBMs pose an intricate etiology as they are b...

    Authors: Zahid Nawaz, Vikas Patil, Yashna Paul, Alangar S. Hegde, Arimappamagan Arivazhagan, Vani Santosh and Kumaravel Somasundaram
    Citation: Molecular Cancer 2016 15:74
    Content type: Research Published on:

  23. It is still controversial whether comprehensive genome screening of target molecules by next generation sequencing (NGS) is needed to increase clinical efficacy of investigational drugs or accelerate drug deve...

    Authors: Yuko Tanabe, Hitoshi Ichikawa, Takashi Kohno, Hiroshi Yoshida, Takashi Kubo, Mamoru Kato, Satoru Iwasa, Atsushi Ochiai, Noboru Yamamoto, Yasuhiro Fujiwara and Kenji Tamura
    Citation: Molecular Cancer 2016 15:73
    Content type: Letter to the Editor Published on:

  24. In many cancers, microRNAs (miRs) contribute to metastatic progression by modulating phenotypic reprogramming processes such as epithelial-mesenchymal plasticity. This can be driven by miRs targeting multiple ...

    Authors: Miles C. Andrews, Joseph Cursons, Daniel G. Hurley, Matthew Anaka, Jonathan S. Cebon, Andreas Behren and Edmund J. Crampin
    Citation: Molecular Cancer 2016 15:72
    Content type: Research Published on:

  25. Caveolin-1 (CAV1) is an oncogenic membrane protein associated with endocytosis, extracellular matrix organisation, cholesterol distribution, cell migration and signaling. Recent studies reveal that CAV1 is inv...

    Authors: Zeribe Chike Nwosu, Matthias Philip Ebert, Steven Dooley and Christoph Meyer
    Citation: Molecular Cancer 2016 15:71
    Content type: Review Published on:

  26. Treatment options for metastatic castrate-resistant prostate cancer (mCRPC) are limited and typically are centered on docetaxel-based chemotherapy. We previously reported that elevated miR-375 levels were sign...

    Authors: Yuan Wang, Rachel Lieberman, Jing Pan, Qi Zhang, Meijun Du, Peng Zhang, Marja Nevalainen, Manish Kohli, Niraj K. Shenoy, Hui Meng, Ming You and Liang Wang
    Citation: Molecular Cancer 2016 15:70
    Content type: Research Published on:

  27. Cancer Stem cells (CSCs) are a unipotent cell population present within the tumour cell mass. CSCs are known to be highly chemo-resistant, and in recent years, they have gained intense interest as key tumour i...

    Authors: Abhijeet Deshmukh, Kedar Deshpande, Frank Arfuso, Philip Newsholme and Arun Dharmarajan
    Citation: Molecular Cancer 2016 15:69
    Content type: Review Published on:

  28. The CXCL12/CXCR4 axis transactivates HER2 and promotes intraosseous tumor growth. To further explore the transactivation of HER2 by CXCL12, we investigated the role of small GTP protein Gαi2 in Src and HER2 phosp...

    Authors: M. Katie Conley-LaComb, Louie Semaan, Rajareddy Singareddy, Yanfeng Li, Elisabeth I. Heath, Seongho Kim, Michael L. Cher and Sreenivasa R. Chinni
    Citation: Molecular Cancer 2016 15:68
    Content type: Research Published on:

  29. Lung cancer is a leading cause of cancer-related deaths worldwide. Lung cancer risk factors, including smoking and exposure to environmental carcinogens, have been linked to chronic inflammation. An integral f...

    Authors: Erin A. Marshall, Kevin W. Ng, Sonia H. Y. Kung, Emma M. Conway, Victor D. Martinez, Elizabeth C. Halvorsen, David A. Rowbotham, Emily A. Vucic, Adam W. Plumb, Daiana D. Becker-Santos, Katey S. S. Enfield, Jennifer Y. Kennett, Kevin L. Bennewith, William W. Lockwood, Stephen Lam, John C. English…
    Citation: Molecular Cancer 2016 15:67
    Content type: Review Published on:

  30. Nearly one-third of serous ovarian cancer (OVCA) patients will not respond to initial treatment with surgery and chemotherapy and die within one year of diagnosis. If patients who are unlikely to respond to cu...

    Authors: Jesus Gonzalez Bosquet, Andreea M. Newtson, Rebecca K. Chung, Kristina W. Thiel, Timothy Ginader, Michael J. Goodheart, Kimberly K. Leslie and Brian J. Smith
    Citation: Molecular Cancer 2016 15:66
    Content type: Research Published on:

  31. Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) is a multifunctional protease implicated in metastatic progression ostensibly due to its ability to degrade extracellular matrix (ECM) components and allow mi...

    Authors: Mario A. Cepeda, Jacob J. H. Pelling, Caitlin L. Evered, Karla C. Williams, Zoey Freedman, Ioana Stan, Jessica A. Willson, Hon S. Leong and Sashko Damjanovski
    Citation: Molecular Cancer 2016 15:65
    Content type: Research Published on:

  32. A handful of studies have exploited antitumor potential of esculetin, a dihydroxy coumarine derivative; the targets to which it binds and the possible downstream mechanism for its cytotoxicity in cancer cells ...

    Authors: Rashi Arora, Sharad Sawney, Vikas Saini, Chris Steffi, Manisha Tiwari and Daman Saluja
    Citation: Molecular Cancer 2016 15:64
    Content type: Research Published on:

  33. Targeted next generation sequencing (tNGS) has become part of molecular pathology diagnostics for determining RAS mutation status in colorectal cancer (CRC) patients as predictive tool for decision on EGFR-tar...

    Authors: Valentina Kovaleva, Anna-Lena Geissler, Lisa Lutz, Ralph Fritsch, Frank Makowiec, Sebastian Wiesemann, Ulrich T. Hopt, Bernward Passlick, Martin Werner and Silke Lassmann
    Citation: Molecular Cancer 2016 15:63
    Content type: Research Published on:

  36. Increasing evidence suggests long non-coding RNAs (lncRNAs) are frequently aberrantly expressed in cancers, however, few related lncRNA signatures have been established for prediction of cancer prognosis. We a...

    Authors: Xiaoqiang Zhu, Xianglong Tian, Chenyang Yu, Chaoqin Shen, Tingting Yan, Jie Hong, Zheng Wang, Jing-Yuan Fang and Haoyan Chen
    Citation: Molecular Cancer 2016 15:60
    Content type: Research Published on:

  37. The mechanisms involved in lung cancer (LC) progression are poorly understood making discovery of successful therapies difficult. Adaptor proteins play a crucial role in cancer as they link cell surface recept...

    Authors: Niranjan Jeganathan, Dan Predescu, Jin Zhang, Fei Sha, Cristina Bardita, Monal Patel, Stephen Wood, Jeffrey A. Borgia, Robert A. Balk and Sanda Predescu
    Citation: Molecular Cancer 2016 15:59
    Content type: Research Published on:

  38. Ovarian cancer (OC) ascites consist in a proinflammatory tumor environment that is characterized by the presence of various cytokines, chemokines and growth factors. The presence of these inflammatory-related ...

    Authors: Denis Lane, Isabelle Matte, Claude Laplante, Perrine Garde-Granger, Alex Carignan, Paul Bessette, Claudine Rancourt and Alain Piché
    Citation: Molecular Cancer 2016 15:58
    Content type: Research Published on:

  39. Liver cancer is one of the main causes of cancer-related death in human. HOXA7 has been proved to be related with several cancers.

    Authors: Bo Tang, Guangying Qi, Xiaoyu Sun, Fang Tang, Shengguang Yuan, Zhenran Wang, Xingsi Liang, Bo Li, Shuiping Yu, Jie Liu, Qi Huang, Yangchao Wei, Run Zhai, Biao Lei, Xinjin Guo and Songqing He
    Citation: Molecular Cancer 2016 15:57
    Content type: Research Published on:

  40. Over the past few years, microRNAs (miRNAs) have not only emerged as integral regulators of gene expression at the post-transcriptional level but also respond to signalling molecules to affect cell function(s)...

    Authors: Emenike K. Onyido, Eloise Sweeney and Abdolrahman Shams Nateri
    Citation: Molecular Cancer 2016 15:56
    Content type: Review Published on:

  41. Colorectal cancer (CRC) is 3rd most commonly diagnosed cancer in males and the second in females. PD-1/PD-L1 axis, as an immune checkpoint, is up-regulated in many tumors and their microenvironment. However, t...

    Authors: Yaqi Li, Lei Liang, Weixing Dai, Guoxiang Cai, Ye Xu, Xinxiang Li, Qingguo Li and Sanjun Cai
    Citation: Molecular Cancer 2016 15:55
    Content type: Research Published on:

  42. Previous studies have established that proteinase-activated receptor 2 (PAR2) promotes migration and invasion of hepatocellular carcinoma (HCC) cells, suggesting a role in HCC progression. Here, we assessed the i...

    Authors: Franziska Mußbach, Hendrik Ungefroren, Bernd Günther, Kathrin Katenkamp, Petra Henklein, Martin Westermann, Utz Settmacher, Lennart Lenk, Susanne Sebens, Jörg P. Müller, Frank-Dietmar Böhmer and Roland Kaufmann
    Citation: Molecular Cancer 2016 15:54
    Content type: Research Published on:

  43. Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and frequently progresses from an actinic keratosis (AK), a sun-induced keratinocyte intraepithelial neoplasia (KIN). Epigenetic m...

    Authors: Agustí Toll, Rocío Salgado, Blanca Espinet, Angel Díaz-Lagares, Eugenia Hernández-Ruiz, Evelyn Andrades, Juan Sandoval, Manel Esteller, Ramón M Pujol and Inmaculada Hernández-Muñoz
    Citation: Molecular Cancer 2016 15:53
    Content type: Research Published on:

  44. Both epidemiological and experimental studies suggest that excessive alcohol exposure increases the risk for breast cancer and enhances metastasis/recurrence. We have previously demonstrated that alcohol enhan...

    Authors: Mei Xu, Zhenhua Ren, Xin Wang, Ashley Comer, Jacqueline A. Frank, Zun-ji Ke, Yi Huang, Zhuo Zhang, Xianglin Shi, Siying Wang and Jia Luo
    Citation: Molecular Cancer 2016 15:52
    Content type: Research Published on:

  45. Dysregulation of microRNAs (miRNAs) have been demonstrated to contribute to carcinogenesis. MiR-143-3p has been identified to function as a tumor suppressor in several tumors, but the role of miR-143-3p in eso...

    Authors: Zhenyue He, Jun Yi, Xiaolong Liu, Jing Chen, Siqi Han, Li Jin, Longbang Chen and Haizhu Song
    Citation: Molecular Cancer 2016 15:51
    Content type: Research Published on:

  46. Expression of various long noncoding RNAs (lncRNAs) may affect cancer prognosis. Here, we aim to gather and examine all evidence on the potential role of lncRNAs as novel predictors of survival in human cancer.

    Authors: Stylianos Serghiou, Aikaterini Kyriakopoulou and John P. A. Ioannidis
    Citation: Molecular Cancer 2016 15:50
    Content type: Review Published on:

  47. Pancreatic cancer is one of the most lethal malignancies. The innovative treatments are required and now the cancer stem cells (CSCs) are expected to be an effective target for novel therapies. Therefore we in...

    Authors: Yumi Miyazaki, Shyuichirou Matsubara, Qiang Ding, Koichiro Tsukasa, Makoto Yoshimitsu, Ken-ichiro Kosai and Sonshin Takao
    Citation: Molecular Cancer 2016 15:49
    Content type: Research Published on:

  48. Ovarian cancer is the leading cause of death among gynecologic malignancies. Since ovarian cancer develops asymptomatically, it is often diagnosed at an advanced and incurable stage. Despite many years of rese...

    Authors: Koji Nakamura, Kenjiro Sawada, Akihiko Yoshimura, Yasuto Kinose, Erika Nakatsuka and Tadashi Kimura
    Citation: Molecular Cancer 2016 15:48
    Content type: Review Published on:

  49. Fusion proteins have unique oncogenic properties and their identification can be useful either as diagnostic or therapeutic targets. Next generation sequencing data have previously shown a fusion gene formed b...

    Authors: Arjun Kalvala, Li Gao, Brittany Aguila, Kathleen Dotts, Mohammad Rahman, Serge P. Nana-Sinkam, Xiaoping Zhou, Qi-En Wang, Joseph Amann, Gregory A. Otterson, Miguel A. Villalona-Calero and Wenrui Duan
    Citation: Molecular Cancer 2016 15:47
    Content type: Research Published on:

  50. Triple-negative breast cancer (TNBC) is the most aggressive and invasive of the breast cancer subtypes. TNBC is a challenging disease that lacks targets for treatment. Histone deacetylase inhibitors (HDACi) ar...

    Authors: Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Sheng-Yow Ho, Pinpin Lin and Ying-Jan Wang
    Citation: Molecular Cancer 2016 15:46
    Content type: Research Published on:
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Molecular Cancer

ISSN: 1476-4598