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  1. Long noncoding RNAs (lncRNAs) have emerged as critical players in cancer progression, but their functions in colorectal cancer (CRC) metastasis have not been systematically clarified.

    Authors: Yingmin Wu, Xiangling Yang, Zhuojia Chen, Lin Tian, Guanmin Jiang, Feng Chen, Jiexin Li, Panpan An, Linlin Lu, Nan Luo, Jun Du, Hong Shan, Huanliang Liu and Hongsheng Wang

    Citation: Molecular Cancer 2019 18:87

    Content type: Research

    Published on:

  2. Clear cell renal cell carcinoma (CCRCC) is characterized by a highly metastatic potential. The stromal communication between stem cells and cancer cells critically influences metastatic dissemination of cancer...

    Authors: Lu Wang, Guang Yang, Danfeng Zhao, Jiaqi Wang, Yang Bai, Qiang Peng, Hongzhi Wang, Ruizhe Fang, Guang Chen, Zhichao Wang, Keliang Wang, Guangbin Li, Yinhui Yang, Ziqi Wang, Pengyu Guo, Li Peng…

    Citation: Molecular Cancer 2019 18:86

    Content type: Research

    Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:144

  3. Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic interventions. Development of a new class of anticancer agents t...

    Authors: Ke Xu, Dongkyoo Park, Andrew T. Magis, Jun Zhang, Wei Zhou, Gabriel L. Sica, Suresh S. Ramalingam, Walter J. Curran and Xingming Deng

    Citation: Molecular Cancer 2019 18:85

    Content type: Research

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    The Correction to this article has been published in Molecular Cancer 2020 19:93

  4. Long noncoding RNAs (lncRNAs), defined as the transcripts longer than 200 nt without protein-coding capacity, have been found to be aberrantly expressed in diverse human diseases including cancer. A reciprocal...

    Authors: Xuefei Wang, Jianling Yang, Guijie Guo, Riyue Feng, Ke Chen, Yuan Liao, Lianfeng Zhang, Liping Sun, Shile Huang and Ji-Long Chen

    Citation: Molecular Cancer 2019 18:84

    Content type: Research

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  5. The proliferation and metastasis ability of tumors are mediate by the "mutual dialogue" between cells in the tumor microenvironment (TME). Extracellular vesicles (EVs), mainly exosomes and microvesicles, play ...

    Authors: Changqing Xie, Ning Ji, Zhangui Tang, Jing Li and Qianming Chen

    Citation: Molecular Cancer 2019 18:83

    Content type: Review

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  6. Gallbladder cancer is the most common biliary tract malignancy and not sensitive to chemotherapy. Autophagy is an important factor prolonging the survival of cancer cells under chemotherapeutic stress. We aime...

    Authors: Qiang Cai, Shouhua Wang, Longyang Jin, Mingzhe Weng, Di Zhou, Jiandong Wang, Zhaohui Tang and Zhiwei Quan

    Citation: Molecular Cancer 2019 18:82

    Content type: Research

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  7. The aberrant expression of long noncoding RNAs (lncRNAs) has recently emerged as key molecules in human cancers; however, whether lncRNAs are implicated in the progression of clear cell renal cell carcinoma (c...

    Authors: Wei Zhai, Rujian Zhu, Junjie Ma, Dongkui Gong, Haimin Zhang, Jin Zhang, Yonghui Chen, Yiran Huang, Junhua Zheng and Wei Xue

    Citation: Molecular Cancer 2019 18:81

    Content type: Research

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  8. Accumulating evidence shows that, the dysregulation of circular RNAs (circRNAs) is associated with the progression of multiple malignancies. But, the underlying mechanisms by which has_circ_0032627 (circDLST) ...

    Authors: Jing Zhang, Lidan Hou, Rui Liang, Xiaoyu Chen, Rui Zhang, Wei Chen and Jinshui Zhu

    Citation: Molecular Cancer 2019 18:80

    Content type: Research

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    The Correction to this article has been published in Molecular Cancer 2020 19:125

  9. Emerging evidence indicates that tumor cells release a large amount of exosomes loaded with cargos during tumorigenesis. Exosome secretion is a multi-step process regulated by certain related molecules. Long n...

    Authors: Liang Yang, Xueqiang Peng, Yan Li, Xiaodong Zhang, Yingbo Ma, Chunli Wu, Qing Fan, Shibo Wei, Hangyu Li and Jingang Liu

    Citation: Molecular Cancer 2019 18:78

    Content type: Research

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  10. Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to substrate proteins, modulates many important biological processes, including tumorigenesis. The process of protein ne...

    Authors: Lisha Zhou, Yanyu Jiang, Qin Luo, Lihui Li and Lijun Jia

    Citation: Molecular Cancer 2019 18:77

    Content type: Review

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  11. Cervical cancer screening through detection and treatment of high-grade cervical intraepithelial neoplasia (CIN) is most successful in cancer prevention. However, the accuracy of the current cervical cancer sc...

    Authors: Mengyue Zheng, Ling Hou, Yu Ma, Lanyun Zhou, Fenfen Wang, Bei Cheng, Wei Wang, Bingjian Lu, Pengyuan Liu, Weiguo Lu and Yan Lu

    Citation: Molecular Cancer 2019 18:76

    Content type: Letter to the Editor

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  12. Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion, metastasis and drug-resistance. ...

    Authors: Ladan Mashouri, Hassan Yousefi, Amir Reza Aref, Ali mohammad Ahadi, Fatemeh Molaei and Suresh K. Alahari

    Citation: Molecular Cancer 2019 18:75

    Content type: Review

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  13. tRNA-derived small RNA (tsRNA) is a novel regulatory small non-coding RNA and participates in diverse physiological and pathological processes. However, the presence of tsRNAs in exosome and their diagnostic p...

    Authors: Lei Zhu, Jiao Li, Youling Gong, Qingbin Wu, Shuangyan Tan, Dan Sun, Xiaomin Xu, Yuanli Zuo, Yun Zhao, Yu-Quan Wei, Xia-Wei Wei and Yong Peng

    Citation: Molecular Cancer 2019 18:74

    Content type: Letter to the Editor

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  14. As a subclass of noncoding RNAs, circular RNAs (circRNAs) have been demonstrated to play a critical role in regulating gene expression in eukaryotes. Recent studies have revealed the pivotal functions of circR...

    Authors: Yizheng Wu, Ziang Xie, Junxin Chen, Jiaxin Chen, Weiyu Ni, Yan Ma, Kangmao Huang, Gangliang Wang, Jiying Wang, Jianjun Ma, Shuying Shen and Shunwu Fan

    Citation: Molecular Cancer 2019 18:73

    Content type: Research

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  15. Following publication of the original article [1], the authors reported an error in affiliation 5.

    Authors: Yu-Shui Ma, Tao Huang, Xiao-Ming Zhong, Hong-Wei Zhang, Xian-Ling Cong, Hong Xu, Gai-Xia Lu, Fei Yu, Shao-Bo Xue, Zhong-Wei Lv and Da Fu

    Citation: Molecular Cancer 2019 18:72

    Content type: Correction

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    The original article was published in Molecular Cancer 2018 17:139

  16. Cisplatin (CDDP) treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). A better understanding of the mechanisms of CDDP resistance can greatly improve ther...

    Authors: Xiaoxu Huang, Zheng Li, Qiang Zhang, Weizhi Wang, Bowen Li, Lu Wang, Zhipeng Xu, Ailiang Zeng, Xing Zhang, Xuan Zhang, Zhongyuan He, Qiang Li, Guangli Sun, Sen Wang, Qing Li, Linjun Wang…

    Citation: Molecular Cancer 2019 18:71

    Content type: Research

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  17. In the last decades, the role of the microenvironment in tumor progression and therapeutic outcome has gained increasing attention. Cancer-associated fibroblasts (CAFs) have emerged as key players among stroma...

    Authors: Micol Eleonora Fiori, Simone Di Franco, Lidia Villanova, Paola Bianca, Giorgio Stassi and Ruggero De Maria

    Citation: Molecular Cancer 2019 18:70

    Content type: Review

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  18. Although the tumor stroma in solid tumors like gastric cancer (GC) plays a crucial role in chemo-resistance, specific targets to inhibit the interaction between the stromal and cancer cells have not yet been u...

    Authors: In-Hye Ham, Hye Jeong Oh, Hyejin Jin, Cheong A Bae, Sang-Min Jeon, Kyeong Sook Choi, Sang-Yong Son, Sang-Uk Han, Rolf A. Brekken, Dakeun Lee and Hoon Hur

    Citation: Molecular Cancer 2019 18:68

    Content type: Research

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  19. Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endotheli...

    Authors: Jana Plava, Marina Cihova, Monika Burikova, Miroslava Matuskova, Lucia Kucerova and Svetlana Miklikova

    Citation: Molecular Cancer 2019 18:67

    Content type: Review

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  20. The intestinal epithelial lining is one of the most rapidly renewing cell populations in the body. As a result, the gut has been an attractive model to resolve key mechanisms in epithelial homeostasis. In part...

    Authors: Maartje van der Heijden and Louis Vermeulen

    Citation: Molecular Cancer 2019 18:66

    Content type: Review

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  21. Tumor-associated macrophages (TAMs) are major components of tumor microenvironment that frequently associated with tumor metastasis in human cancers. Circulating tumor cell (CTC), originating from primary tumo...

    Authors: Chen Wei, Chaogang Yang, Shuyi Wang, Dongdong Shi, Chunxiao Zhang, Xiaobin Lin, Qing Liu, Rongzhang Dou and Bin Xiong

    Citation: Molecular Cancer 2019 18:64

    Content type: Research

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  22. The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. T...

    Authors: Barbora Peltanova, Martina Raudenska and Michal Masarik

    Citation: Molecular Cancer 2019 18:63

    Content type: Review

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  23. Gastric cancer (GC) is one of the leading causes of cancer-related death in both men and women due to delayed diagnosis and high metastatic frequency. Extracellular vesicles (EVs) are membrane-bound nanovesicl...

    Authors: Tingting Huang, Chunli Song, Lei Zheng, Ligang Xia, Yang Li and Yiwen Zhou

    Citation: Molecular Cancer 2019 18:62

    Content type: Review

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  24. Myeloid-derived suppressor cells (MDSCs) participate in tumor-elicited immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby influencing the effectiveness of cancer immunothera...

    Authors: Yu Zheng, Xinyu Tian, Tingting Wang, Xueli Xia, Fenghua Cao, Jie Tian, Ping Xu, Jie Ma, Huaxi Xu and Shengjun Wang

    Citation: Molecular Cancer 2019 18:61

    Content type: Research

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  25. Therapy resistance can arise within tumor cells because of genetic or phenotypic changes (intrinsic resistance), or it can be the result of an interaction with the tumor microenvironment (extrinsic resistance)...

    Authors: Teresa Bernadette Steinbichler, József Dudás, Sergej Skvortsov, Ute Ganswindt, Herbert Riechelmann and Ira-Ida Skvortsova

    Citation: Molecular Cancer 2019 18:58

    Content type: Review

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  26. Hypoxic tumor microenvironment is a common feature of solid tumors and is associated with aggressiveness and poor patient outcomes. A continuous interference between cancer cells and stromal cells within the h...

    Authors: Wanrong Meng, Yaying Hao, Chuanshi He, Ling Li and Guiquan Zhu

    Citation: Molecular Cancer 2019 18:57

    Content type: Review

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  27. CircRNAs, as new members of long noncoding RNAs, have been the focus of recent investigation. CircRNAs feature a closed continuous loop structure without 5′-3′ polarity or a poly A tail. Many studies have repo...

    Authors: Hetian Bai, Kexin Lei, Fei Huang, Zhou Jiang and Xikun Zhou

    Citation: Molecular Cancer 2019 18:56

    Content type: Review

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  28. The tumor microenvironment represents a complex network, in which tumor cells not only communicate with each other but also with stromal and immune cells. Current research has demonstrated the vital role of th...

    Authors: Selma Maacha, Ajaz A. Bhat, Lizandra Jimenez, Afsheen Raza, Mohammad Haris, Shahab Uddin and Jean-Charles Grivel

    Citation: Molecular Cancer 2019 18:55

    Content type: Review

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  29. MicroRNAs (miRs) are involved in lymphoma progression by regulating tumor cell interaction with microenvironment. MiR155 is overexpressed in diffuse large B-cell lymphoma (DLBCL) and its biological effect on t...

    Authors: Zhong Zheng, Rui Sun, Hui-Jin Zhao, Di Fu, Hui-Juan Zhong, Xiang-Qin Weng, Bin Qu, Yan Zhao, Li Wang and Wei-Li Zhao

    Citation: Molecular Cancer 2019 18:54

    Content type: Research

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  30. Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intra...

    Authors: Kathleen M. McAndrews and Raghu Kalluri

    Citation: Molecular Cancer 2019 18:52

    Content type: Review

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  31. The tumor microenvironment is a complex and dynamic cellular community comprising the tumor epithelium and various tumor-supporting cells such as immune cells, fibroblasts, immunosuppressive cells, adipose cel...

    Authors: Hong Sheng Cheng, Jeannie Xue Ting Lee, Walter Wahli and Nguan Soon Tan

    Citation: Molecular Cancer 2019 18:51

    Content type: Review

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  32. Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) ...

    Authors: Xiaojie Bian, Yu-Tian Xiao, Tianqi Wu, Mengfei Yao, Leilei Du, Shancheng Ren and Jianhua Wang

    Citation: Molecular Cancer 2019 18:50

    Content type: Review

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  33. Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a p...

    Authors: Nancy T. Chee, Ines Lohse and Shaun P. Brothers

    Citation: Molecular Cancer 2019 18:49

    Content type: Review

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  34. Among all the deadly cancers, pancreatic cancer ranks seventh in mortality. The absence of any grave symptoms coupled with the unavailability of early prognostic and diagnostic markers make the disease incurab...

    Authors: Manendra Babu Lankadasari, Pramiti Mukhopadhyay, Sabira Mohammed and Kuzhuvelil B. Harikumar

    Citation: Molecular Cancer 2019 18:48

    Content type: Review

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  35. It has been well established that circular RNAs (circRNAs) play an important regulatory role during tumor progression. Recent studies have indicated that even though circRNAs generally regulate gene expression...

    Authors: Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu and Jingting Jiang

    Citation: Molecular Cancer 2019 18:47

    Content type: Research

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  36. N6-methyladenosine (m6A) modification is the most pervasive modification in mRNA, and has been considered as a new layer of epigenetic regulation on mRNA processing, stability and translation. Despite its func...

    Authors: Yi Niu, Ziyou Lin, Arabella Wan, Honglei Chen, Heng Liang, Lei Sun, Yuan Wang, Xi Li, Xiao-feng Xiong, Bo Wei, Xiaobin Wu and Guohui Wan

    Citation: Molecular Cancer 2019 18:46

    Content type: Research

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  37. Circular RNAs (circRNAs) are a novel type of noncoding RNAs and play important roles in tumorigenesis, including gastric cancer (GC). However, the functions of most circRNAs remain poorly understood. In our st...

    Authors: Lixian Ding, Yuying Zhao, Shuwei Dang, Yue Wang, Xinglong Li, Xiaotong Yu, Zhongsheng Li, Jiufeng Wei, Ming Liu and Guodong Li

    Citation: Molecular Cancer 2019 18:45

    Content type: Research

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  38. Circular RNAs are abundant endogenous non-coding RNA with no 5′ cap and 3′ polyadenylation tail that modify liner mRNAs and have no terminal structures. Our knowledge of the biogenesis of circular RNAs has bee...

    Authors: Yang Guo, Jiechao Yang, Qiang Huang, Chiyao Hsueh, Juan Zheng, Chunping Wu, Hui Chen and Liang Zhou

    Citation: Molecular Cancer 2019 18:44

    Content type: Review

    Published on:

  39. Oxaliplatin resistance is a major challenge for treatment of advanced colorectal cancer (CRC). Both acquisition of epithelial-mesenchymal transition (EMT) and suppressed drug accumulation in cancer cells contr...

    Authors: Tong Liu, Xin Zhang, Lutao Du, Yunshan Wang, Xiaoming Liu, Hui Tian, Lili Wang, Peilong Li, Yinghui Zhao, Weili Duan, Yujiao Xie, Zhaowei Sun and Chuanxin Wang

    Citation: Molecular Cancer 2019 18:43

    Content type: Research

    Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:89

  40. Triple-negative breast cancer (TNBC) is a poor prognostic breast cancer with the highest mutations and limited therapeutic choices. Cytokine networking between cancer cells and the tumor microenvironment (TME)...

    Authors: Yueh-Shan Weng, Hong-Yu Tseng, Yen-An Chen, Pei-Chun Shen, Aushia Tanzih Al Haq, Li-Mei Chen, Yi-Chung Tung and Hsin-Ling Hsu

    Citation: Molecular Cancer 2019 18:42

    Content type: Research

    Published on:

  41. Exosomes are nanosized extracellular vesicles that can be released by almost all types of cells. Initially considered as the garbage bins acting to discard unwanted products of cells, exosomes are now recogniz...

    Authors: Min Fu, Jianmei Gu, Pengcheng Jiang, Hui Qian, Wenrong Xu and Xu Zhang

    Citation: Molecular Cancer 2019 18:41

    Content type: Review

    Published on:

  42. Metastasis is the main cause of lung cancer mortality. Bone marrow-derived mesenchymal stem cells (BMSCs) are a component of the cancer microenvironment and contribute to cancer progression. Intratumoral hypox...

    Authors: Xina Zhang, Buqing Sai, Fan Wang, Lujuan Wang, Yuhui Wang, Leliang Zheng, Guiyuan Li, Jingqun Tang and Juanjuan Xiang

    Citation: Molecular Cancer 2019 18:40

    Content type: Research

    Published on:

  43. A pre-metastatic niche is a microenvironment prepared for the colonization of circulating tumor cells in specific organs. Exosomes are extracellular vesicles with a variety of biological functions. Exosomes pl...

    Authors: Yaxin Guo, Xiang Ji, Jinbo Liu, Dandan Fan, Quanbo Zhou, Chen Chen, Weiwei Wang, Guixian Wang, Haijiang Wang, Weitang Yuan, Zhenyu Ji and Zhenqiang Sun

    Citation: Molecular Cancer 2019 18:39

    Content type: Review

    Published on:

  44. Long intergenic noncoding RNA p21 (lincRNA-p21) is considered a target of wild-type p53, but little is known about its regulation by mutant p53 and its functions during the progression of head and neck squamou...

    Authors: Shufang Jin, Xi Yang, Jiayi Li, Wenyi Yang, Hailong Ma and Zhiyuan Zhang

    Citation: Molecular Cancer 2019 18:38

    Content type: Research

    Published on:

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