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  1. The tumour microenvironment (TME) constitutes the area surrounding the tumour during its development and has been demonstrated to play roles in cancer-related diseases through crosstalk with tumour cells. Circ...

    Authors: Qiuge Zhang, Weiwei Wang, Quanbo Zhou, Chen Chen, Weitang Yuan, Jinbo Liu, Xiaoli Li and Zhenqiang Sun

    Citation: Molecular Cancer 2020 19:14

    Content type: Review

    Published on:

  2. Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related (ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression and inhibition remains contr...

    Authors: Xiaohua Li, Shikun He and Binyun Ma

    Citation: Molecular Cancer 2020 19:12

    Content type: Review

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  3. Hypoxic tumors are refractory to DNA damage drugs. However, the underlying mechanism has yet to be elucidated. We aimed to identify lncRNAs that upregulated under hypoxia and their effects on colorectal cancer...

    Authors: Lin Huan, Tianan Guo, Yangjun Wu, Linguo Xu, Shenglin Huang, Ye Xu, Linhui Liang and Xianghuo He

    Citation: Molecular Cancer 2020 19:11

    Content type: Research

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  4. PI3K/AKT is a vital signaling pathway in humans. Recently, several PI3K/AKT inhibitors were reported to have the ability to reverse cancer multidrug resistance (MDR); however, specific targets in the PI3K/AKT ...

    Authors: Lei Zhang, Yidong Li, Qianchao Wang, Zhuo Chen, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Dan Liao, Wei Zhang and Zhe-Sheng Chen

    Citation: Molecular Cancer 2020 19:10

    Content type: Research

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  5. MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination are well established, but the involvement of long noncoding RNAs (lncRNAs) in Twist1-mediated signalin...

    Authors: Jinchang Pan, Shuai Fang, Haihua Tian, Chengwei Zhou, Xiaodong Zhao, Hui Tian, Jinxian He, Weiyu Shen, Xiaodan Meng, Xiaofeng Jin and Zhaohui Gong

    Citation: Molecular Cancer 2020 19:9

    Content type: Research

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  6. Circular RNAs (circRNAs) are a new class of endogenous non-coding RNAs (ncRNAs) widely expressed in eukaryotic cells. Mounting evidence has highlighted circRNAs as critical regulators of various tumours. More ...

    Authors: Zhonghua Ma, You Shuai, Xiangyu Gao, Xianzi Wen and Jiafu Ji

    Citation: Molecular Cancer 2020 19:8

    Content type: Review

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  7. Ovarian cancer is one of the most common and malignant cancers, partly due to its late diagnosis and high recurrence. Chemotherapy resistance has been linked to poor prognosis and is believed to be linked to t...

    Authors: Sandra Muñoz-Galván, Blanca Felipe-Abrio, Eva M. Verdugo-Sivianes, Marco Perez, Manuel P. Jiménez-García, Elisa Suarez-Martinez, Purificacion Estevez-Garcia and Amancio Carnero

    Citation: Molecular Cancer 2020 19:7

    Content type: Research

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  8. Gastric cancer (GC) is the third leading cause of cancer-related mortality globally. Long noncoding RNAs (lncRNAs) are dysregulated in obvious malignancies including GC and exploring the regulatory mechanisms ...

    Authors: You Shuai, Zhonghua Ma, Weitao Liu, Tao Yu, Changsheng Yan, Hua Jiang, Shengwang Tian, Tongpeng Xu and Yongqian Shu

    Citation: Molecular Cancer 2020 19:6

    Content type: Research

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  9. Interferon alpha (IFNα) is a well-established regulator of immunosuppression in head and neck squamous cell carcinoma (HNSCC), while the role of long noncoding RNAs (lncRNAs) in immunosuppression remains large...

    Authors: Hailong Ma, Hanyue Chang, Wenyi Yang, Yusheng Lu, Jingzhou Hu and Shufang Jin

    Citation: Molecular Cancer 2020 19:4

    Content type: Research

    Published on:

  10. Pancreatic cancer is one of the most lethal types of cancer with extremely poor diagnosis and prognosis, and chemo-resistance remains a major challenge. The dynamic and reversible N6-methyladenosine (m6A) RNA mod...

    Authors: Bo Tang, Yihua Yang, Min Kang, Yunshan Wang, Yan Wang, Yin Bi, Songqing He and Fumio Shimamoto

    Citation: Molecular Cancer 2020 19:3

    Content type: Research

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  11. The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis...

    Authors: Yizuo Song, Yichi Xu, Chunyu Pan, Linzhi Yan, Zhi-wei Wang and Xueqiong Zhu

    Citation: Molecular Cancer 2020 19:2

    Content type: Review

    Published on:

  12. Hepatocellular carcinoma (HCC) is the most commonmalignancy. Exsome plays a significant role in the elucidation of signal transduction pathways between hepatoma cells, angiogenesis and early diagnosis of HCC. ...

    Authors: Xin Li, Chuanyun Li, Liping Zhang, Min Wu, Ke Cao, Feifei Jiang, Dexi Chen, Ning Li and Weihua Li

    Citation: Molecular Cancer 2020 19:1

    Content type: Review

    Published on:

  13. N6-Methyladenosine (m6A) modification has been implicated in many biological processes. It is important for the regulation of messenger RNA (mRNA) stability, splicing, and translation. However, its role in cancer...

    Authors: Li Liu, Jing Wang, Guifeng Sun, Qiong Wu, Ji Ma, Xin Zhang, Nan Huang, Zhixuan Bian, Song Gu, Min Xu, Minzhi Yin, Fenyong Sun and Qiuhui Pan

    Citation: Molecular Cancer 2019 18:188

    Content type: Research

    Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:24

  14. The majority of breast cancer patients die of metastasis rather than primary tumors, whereas the molecular mechanisms orchestrating cancer metastasis remains poorly understood. Long noncoding RNAs (lncRNA) hav...

    Authors: Bingqiu Xiu, Yayun Chi, Lei Liu, Weiru Chi, Qi Zhang, Jiajian Chen, Rong Guo, Jing Si, Lun Li, Jingyan Xue, Zhi-Ming Shao, Zhao-Hui Wu, Shenglin Huang and Jiong Wu

    Citation: Molecular Cancer 2019 18:187

    Content type: Research

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  15. N6-methyladenosine (m6A) modification, the most abundant internal methylation of eukaryotic RNA transcripts, is critically implicated in RNA processing. As the largest known component in the m6A methyltransfer...

    Authors: Tian Lan, Hui Li, Delin Zhang, Lin Xu, Hailing Liu, Xiangyong Hao, Xiaokai Yan, Haotian Liao, Xiangzheng Chen, Kunlin Xie, Jiaxin Li, Mingheng Liao, Jiwei Huang, Kefei Yuan, Yong Zeng and Hong Wu

    Citation: Molecular Cancer 2019 18:186

    Content type: Research

    Published on:

  16. Colon cancer (CC) cells can exhibit stemness and expansion capabilities, which contribute to resistance to conventional chemotherapies. Aberrant expression of CBX8 has been identified in many types of cancer, ...

    Authors: Yi Zhang, Min Kang, Bin Zhang, Fanchao Meng, Jun Song, Hiroshi Kaneko, Fumio Shimamoto and Bo Tang

    Citation: Molecular Cancer 2019 18:185

    Content type: Research

    Published on:

  17. Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death and is one of the most difficult-to-treat cancers. Surgical resection and adjuvant therapy have limited effects on th...

    Authors: Xiaomeng Liu, Jin Xu, Bo Zhang, Jiang Liu, Chen Liang, Qingcai Meng, Jie Hua, Xianjun Yu and Si Shi

    Citation: Molecular Cancer 2019 18:184

    Content type: Review

    Published on:

  18. Chemotherapy is a widely used treatment for cancer. However, the development of acquired multidrug resistance (MDR) is a serious issue. Emerging evidence has shown that the extracellular vesicles (EVs) mediate...

    Authors: Xiaokun Wang, Dongjuan Qiao, Likun Chen, Meng Xu, Shupeng Chen, Liyan Huang, Fang Wang, Zhen Chen, Jiye Cai and Liwu Fu

    Citation: Molecular Cancer 2019 18:182

    Content type: Research

    Published on:

  19. Brain metastasis (BM) is one of the principal causes of mortality for lung cancer patients. While the molecular events that govern BM of lung cancer remain frustrating cloudy.

    Authors: Hongsheng Wang, Qianqian Deng, Ziyan Lv, Yuyi Ling, Xue Hou, Zhuojia Chen, Xiaoxiao Dinglin, Shuxiang Ma, Delan Li, Yingmin Wu, Yanxi Peng, Hongbing Huang and Likun Chen

    Citation: Molecular Cancer 2019 18:181

    Content type: Research

    Published on:

  20. Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOX...

    Authors: Ju-Ha Kim, Jisung Hwang, Ji Hoon Jung, Hyo-Jung Lee, Dae Young Lee and Sung-Hoon Kim

    Citation: Molecular Cancer 2019 18:180

    Content type: Review

    Published on:

  21. Immune system evasion, distance tumor metastases, and increased cell proliferation are the main reasons for the progression of non-small cell lung cancer (NSCLC) and the death of NSCLC patients. Dysregulation ...

    Authors: Peng-Fei Zhang, Xu Pei, Ke-Sang Li, Li-Na Jin, Fei Wang, Jing Wu and Xue-Mei Zhang

    Citation: Molecular Cancer 2019 18:179

    Content type: Research

    Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:21

  22. Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modificatio...

    Authors: Bin-bin Hu, Xiao-yan Wang, Xu-Yu Gu, Chen Zou, Zhen-jun Gao, Heng Zhang and Yu Fan

    Citation: Molecular Cancer 2019 18:178

    Content type: Review

    Published on:

  23. Cancer immunotherapies that engage immune cells to fight against tumors are proving to be powerful weapons in combating cancer and are becoming increasingly utilized in the clinics. However, for the majority o...

    Authors: Xiaolei Li, Rui Liu, Xiao Su, Yongsha Pan, Xiaofeng Han, Changshun Shao and Yufang Shi

    Citation: Molecular Cancer 2019 18:177

    Content type: Review

    Published on:

  24. N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene...

    Authors: Liuer He, Huiyu Li, Anqi Wu, Yulong Peng, Guang Shu and Gang Yin

    Citation: Molecular Cancer 2019 18:176

    Content type: Review

    Published on:

  25. Carcinoma-associated fibroblasts (CAFs) have been known to promote cancer progression by modifying the primary tumor microenvironment. We aimed to elucidate the intercellular communication between CAFs and sec...

    Authors: Jing Kong, Hongzhu Tian, Fuyin Zhang, Zebing Zhang, Jiao Li, Xue Liu, Xiancheng Li, Jing Liu, Xiaojie Li, Dong Jin, Xuesong Yang, Bo Sun, Tao Guo, Yong Luo, Yao Lu, Bingcheng Lin…

    Citation: Molecular Cancer 2019 18:175

    Content type: Research

    Published on:

  26. Long noncoding RNAs (lncRNAs) play nonnegligible roles in the epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that promotes the colorectal cancer (CRC) progression and cou...

    Authors: Yun Wang, Jia-Huan Lu, Qi-Nian Wu, Ying Jin, De-Shen Wang, Yan-Xing Chen, Jia Liu, Xiao-Jing Luo, Qi Meng, Heng-Ying Pu, Ying-Nan Wang, Pei-Shan Hu, Ze-Xian Liu, Zhao-Lei Zeng, Qi Zhao, Rong Deng…

    Citation: Molecular Cancer 2019 18:174

    Content type: Research

    Published on:

  27. Pancreatic cancer is one of the most lethal malignancies. Recent studies indicated that development of pancreatic cancer may be intimately connected with the microbiome. In this review, we discuss the mechanis...

    Authors: Yicheng Wang, Gang Yang, Lei You, Jinshou Yang, Mengyu Feng, Jiangdong Qiu, Fangyu Zhao, Yueze Liu, Zhe Cao, Lianfang Zheng, Taiping Zhang and Yupei Zhao

    Citation: Molecular Cancer 2019 18:173

    Content type: Review

    Published on:

  28. Following publication of the work [1], authors reported the “flow cytometery plots” panel in Fig. 4e contained an inter-duplication in error.

    Authors: Jingjie Li, Bin Hu, Ting Wang, Wenhua Huang, Chunmin Ma, Qin Zhao, Lingang Zhuo, Tao Zhang and Yuhui Jiang

    Citation: Molecular Cancer 2019 18:172

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2018 17:174

  29. Long noncoding RNAs (lncRNAs) are emerging as key players in the development and progression of cancer. However, the biological role and clinical significance of most lncRNAs in lung carcinogenesis remain uncl...

    Authors: Juze Yang, Qiongzi Qiu, Xinyi Qian, Jiani Yi, Yiling Jiao, Mengqian Yu, Xufan Li, Jia Li, Chunyi Mi, Jisong Zhang, Bingjian Lu, Enguo Chen, Pengyuan Liu and Yan Lu

    Citation: Molecular Cancer 2019 18:171

    Content type: Research

    Published on:

  30. The gene encoding the E3 ubiquitin ligase substrate-binding adaptor SPOP is frequently mutated in primary prostate cancer, but how SPOP mutations contribute to prostate cancer pathogenesis remains poorly under...

    Authors: Qing Shi, Yasheng Zhu, Jian Ma, Kun Chang, Dongling Ding, Yang Bai, Kun Gao, Pingzhao Zhang, Ren Mo, Kai Feng, Xiaying Zhao, Liang Zhang, Huiru Sun, Dongyue Jiao, Yingji Chen, Yinghao Sun…

    Citation: Molecular Cancer 2019 18:170

    Content type: Research

    Published on:

  31. N6-methyladenosine (m6A) emerges as one of the most important modification of RNA. Bladder cancer is a common cancer type in developed countries, and hundreds of thousands of bladder cancer patients die every yea...

    Authors: Chaohui Gu, Zhiyu Wang, Naichun Zhou, Guanru Li, Yiping Kou, Yang Luo, Yidi Wang, Jinjian Yang and Fengyan Tian

    Citation: Molecular Cancer 2019 18:168

    Content type: Research

    Published on:

  32. Long non-coding RNAs (lncRNAs) are essential factors that regulate tumor development and metastasis via diverse molecular mechanisms in a broad type of cancers. However, the pathological roles of lncRNAs in ga...

    Authors: Yun-ping Hu, Yun-peng Jin, Xiang-song Wu, Yang Yang, Yong-sheng Li, Huai-feng Li, Shan-shan Xiang, Xiao-ling Song, Lin Jiang, Yi-jian Zhang, Wen Huang, Shi-li Chen, Fa-tao Liu, Chen Chen, Qin Zhu, Hong-zhuan Chen…

    Citation: Molecular Cancer 2019 18:167

    Content type: Research

    Published on:

  33. CircRNAs are found to affect initiation and progression of several cancer types. However, whether circRNAs are implicated in gallbladder cancer (GBC) progression remains obscure.

    Authors: Xince Huang, Ming He, Shuai Huang, Ruirong Lin, Ming Zhan, Dong Yang, Hui Shen, Sunwang Xu, Wei Cheng, Jianxiu Yu, Zilong Qiu and Jian Wang

    Citation: Molecular Cancer 2019 18:166

    Content type: Research

    Published on:

  34. The ATLANTIC trial reported that higher PD-L1 expression in tumors was involved in a higher objective response in patients with EGFR+/ALK+ non-small cell lung cancer (NSCLC), indicating the possibility of anti-PD...

    Authors: Shunli Peng, Rong Wang, Xiaojuan Zhang, Yueyun Ma, Longhui Zhong, Ke Li, Akihiro Nishiyama, Sachiko Arai, Seiji Yano and Wei Wang

    Citation: Molecular Cancer 2019 18:165

    Content type: Research

    Published on:

  35. After the publication of this work [1],

    Authors: Yingying Qian, Shoujie Chai, Zuyu Liang, Yongfang Wang, You Zhou, Xia Xu, Chenchen Zhang, Min Zhang, Jingxing Si, Feiteng Huang, Zhangdan Huang, Wei Hong and Kai Wang

    Citation: Molecular Cancer 2019 18:164

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2014 13:176

  36. Dynamic N6-methyladenosine (m6A) modification was previously identified as a ubiquitous post-transcriptional regulation that affected mRNA homeostasis. However, the m6A-related epitranscriptomic alterations and f...

    Authors: Jiajie Hou, He Zhang, Jun Liu, Zhenjun Zhao, Jianye Wang, Zhike Lu, Bian Hu, Jiankui Zhou, Zhicong Zhao, Mingxuan Feng, Haiyan Zhang, Bin Shen, Xingxu Huang, Beicheng Sun, Chuan He and Qiang Xia

    Citation: Molecular Cancer 2019 18:163

    Content type: Research

    Published on:

  37. As a novel class of non-coding RNAs, circular RNAs (circRNAs) are key regulators of the development and progression of different cancers. However, little is known about the function and biological mechanism of...

    Authors: Sen Wang, Dong Tang, Wei Wang, Yining Yang, Xiaoqing Wu, Liuhua Wang and Daorong Wang

    Citation: Molecular Cancer 2019 18:162

    Content type: Research

    Published on:

  38. Dynamic N6-methyladenosine (m6A) RNA modification generated and erased by N6-methyltransferases and demethylases regulates gene expression, alternative splicing and cell fate. Ocular melanoma, comprising uveal me...

    Authors: Ruobing Jia, Peiwei Chai, Shanzheng Wang, Baofa Sun, Yangfan Xu, Ying Yang, Shengfang Ge, Renbing Jia, Yun-Gui Yang and Xianqun Fan

    Citation: Molecular Cancer 2019 18:161

    Content type: Research

    Published on:

  39. Circular RNAs (circRNAs), a novel class of noncoding RNAs, have recently drawn much attention in the pathogenesis of human cancers. However, the role of circRNAs in esophageal squamous cell carcinoma (ESCC) re...

    Authors: Xueting Hu, Duoguang Wu, Xiaotian He, Huiying Zhao, Zhanghai He, Jiatong Lin, Kefeng Wang, Wenjian Wang, Zihao Pan, Huayue Lin and Minghui Wang

    Citation: Molecular Cancer 2019 18:160

    Content type: Research

    Published on:

  40. Uveal melanoma (UM) is the most common primary intraocular tumor. Hepatic metastasis is the major and direct death-related reason in UM patients. Given that cancer stem-like cells (CSCs) are roots of metastasi...

    Authors: Jingfeng Zhou, Shenglan Liu, Yun Wang, Wei Dai, Hailin Zou, Shubo Wang, Jing Zhang and Jingxuan Pan

    Citation: Molecular Cancer 2019 18:159

    Content type: Research

    Published on:

  41. Circular RNAs (circRNAs), a subclass of non-coding RNAs, play essential roles in tumorigenesis and aggressiveness. Our previous study has identified that circAGO2 drives gastric cancer progression through activat...

    Authors: Feng Yang, Anpei Hu, Dan Li, Jianqun Wang, Yanhua Guo, Yang Liu, Hongjun Li, Yajun Chen, Xiaojing Wang, Kai Huang, Liduan Zheng and Qiangsong Tong

    Citation: Molecular Cancer 2019 18:158

    Content type: Research

    Published on:

  42. Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy ...

    Authors: Xinming Jing, Fengming Yang, Chuchu Shao, Ke Wei, Mengyan Xie, Hua Shen and Yongqian Shu

    Citation: Molecular Cancer 2019 18:157

    Content type: Review

    Published on:

  43. Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable proo...

    Authors: Qiushi Lin, Xuesong Chen, Fanzheng Meng, Kosuke Ogawa, Min Li, Ruipeng Song, Shugeng Zhang, Ziran Zhang, Xianglu Kong, Qinggang Xu, Fuliang He, Xuewei Bai, Bei Sun, Mien-Chie Hung, Lianxin Liu, Jack Wands…

    Citation: Molecular Cancer 2019 18:156

    Content type: Research

    Published on:

  44. The emergence of immune checkpoint inhibitors (ICIs), mainly including anti-programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) and anti-cytotoxic T lymphocyte-associated antigen-4 (CTL...

    Authors: Shuang Qin, Linping Xu, Ming Yi, Shengnan Yu, Kongming Wu and Suxia Luo

    Citation: Molecular Cancer 2019 18:155

    Content type: Review

    Published on:

  45. Proteasome inhibitors, immunomodulatory agents and monoclonal antibodies have dramatically changed the natural history of multiple myeloma (MM). However, most patients eventually suffer a relapse and succumb t...

    Authors: Quande Lin, Juanjuan Zhao, Yongping Song and Delong Liu

    Citation: Molecular Cancer 2019 18:154

    Content type: Review

    Published on:

  46. Molecular targeted therapy for cancer has been a research hotspot for decades. AXL is a member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 (GAS6). The Gas6/AXL signalling p...

    Authors: Chenjing Zhu, Yuquan Wei and Xiawei Wei

    Citation: Molecular Cancer 2019 18:153

    Content type: Review

    Published on:

  47. The aberrant appearance of DNA in the cytoplasm triggers the activation of cGAS-cGAMP-STING signaling and induces the production of type I interferons, which play critical roles in activating both innate and a...

    Authors: Yuanyuan Zhu, Xiang An, Xiao Zhang, Yu Qiao, Tongsen Zheng and Xiaobo Li

    Citation: Molecular Cancer 2019 18:152

    Content type: Review

    Published on:

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