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  1. Content type: Review

    Originally identified as a metabolic enzyme that catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP in the glycolytic pathway, pyruvate kinase M2-type (PKM2) has been shown to ex...

    Authors: Ming-Chuan Hsu and Wen-Chun Hung

    Citation: Molecular Cancer 2018 17:35

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  2. Content type: Review

    Lung neoplasms are the leading cause of death by cancer worldwide. Non-small cell lung cancer (NSCLC) constitutes more than 80% of all lung malignancies and the majority of patients present advanced disease at...

    Authors: Marta Román, Iosune Baraibar, Inés López, Ernest Nadal, Christian Rolfo, Silvestre Vicent and Ignacio Gil-Bazo

    Citation: Molecular Cancer 2018 17:33

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  3. Content type: Review

    The human genome encodes 538 protein kinases that transfer a γ-phosphate group from ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with human cancer initiation and progres...

    Authors: Khushwant S. Bhullar, Naiara Orrego Lagarón, Eileen M. McGowan, Indu Parmar, Amitabh Jha, Basil P. Hubbard and H. P. Vasantha Rupasinghe

    Citation: Molecular Cancer 2018 17:48

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  4. Content type: Research

    EGFR-dependent cell migration plays an important role in lung cancer progression. Our previous study observed that the HECT E3 ubiquitin ligase NEDD4 is significantly correlated with tumor metastasis and requi...

    Authors: Genbao Shao, Ranran Wang, Aiqin Sun, Jing Wei, Ke Peng, Qian Dai, Wannian Yang and Qiong Lin

    Citation: Molecular Cancer 2018 17:24

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  5. Content type: Research

    Epidermal growth factor receptor (EGFR) mutations enable constitutive active downstream signaling of PI3K/AKT, KRAS/ERK and JAK/STAT pathways, and promote tumor progression by inducing uncontrolled proliferation,...

    Authors: Ulrich Baumgartner, Fabienne Berger, Ali Hashemi Gheinani, Sabrina Sofia Burgener, Katia Monastyrskaya and Erik Vassella

    Citation: Molecular Cancer 2018 17:44

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  6. Content type: Review

    Bruton’s tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B cell malignancies. BTK was i...

    Authors: Simar Pal Singh, Floris Dammeijer and Rudi W. Hendriks

    Citation: Molecular Cancer 2018 17:57

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  7. Content type: Review

    Tyrosine kinase inhibitors (TKIs)-treatments bring significant benefit for patients harboring epidermal growth factor receptor (EGFR) mutations, especially for those with lung cancer. Unfortunately, the majori...

    Authors: Qian Liu, Shengnan Yu, Weiheng Zhao, Shuang Qin, Qian Chu and Kongming Wu

    Citation: Molecular Cancer 2018 17:53

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  8. Content type: Review

    Atypical Chronic Myeloid Leukemia (aCML) is a myeloproliferative neoplasm characterized by neutrophilic leukocytosis and dysgranulopoiesis. From a genetic point of view, aCML shows a heterogeneous mutational l...

    Authors: Stefania Rocca, Giovanna Carrà, Pietro Poggio, Alessandro Morotti and Mara Brancaccio

    Citation: Molecular Cancer 2018 17:40

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  9. Content type: Review

    Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant diseases worldwide. It is refractory to conventional treatments, and consequently has a documented 5-year survival rate as low as 7%....

    Authors: Yaojie Fu, Shanshan Liu, Shan Zeng and Hong Shen

    Citation: Molecular Cancer 2018 17:62

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  10. Content type: Review

    Lung cancer is the leading cause of death by cancer in North America. A decade ago, genomic rearrangements in the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase were identified in a subset of non-sm...

    Authors: Brandon Golding, Anita Luu, Robert Jones and Alicia M. Viloria-Petit

    Citation: Molecular Cancer 2018 17:52

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  11. Content type: Review

    Tyrosine kinases belong to a family of enzymes that mediate the movement of the phosphate group to tyrosine residues of target protein, thus transmitting signals from the cell surface to cytoplasmic proteins a...

    Authors: Kodappully S. Siveen, Kirti S. Prabhu, Iman W. Achkar, Shilpa Kuttikrishnan, Sunitha Shyam, Abdul Q. Khan, Maysaloun Merhi, Said Dermime and Shahab Uddin

    Citation: Molecular Cancer 2018 17:31

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  12. Content type: Review

    Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and dysregulation of this ...

    Authors: Nahal Haddadi, Yiguang Lin, Glena Travis, Ann M. Simpson, Najah T. Nassif and Eileen M. McGowan

    Citation: Molecular Cancer 2018 17:37

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  13. Content type: Review

    Anaplastic lymphoma kinase (ALK) gene activation is involved in the carcinogenesis process of several human cancers such as anaplastic large cell lymphoma, lung cancer, inflammatory myofibroblastic tumors and ...

    Authors: Carminia Maria Della Corte, Giuseppe Viscardi, Raimondo Di Liello, Morena Fasano, Erika Martinelli, Teresa Troiani, Fortunato Ciardiello and Floriana Morgillo

    Citation: Molecular Cancer 2018 17:30

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  14. Content type: Review

    Tumour microenvironment (TME) is a key determinant of tumour growth and metastasis. TME could be very different for each type and location of tumour and TME may change constantly during tumour growth. Multiple...

    Authors: Hor-Yue Tan, Ning Wang, Wing Lam, Wei Guo, Yibin Feng and Yung-Chi Cheng

    Citation: Molecular Cancer 2018 17:43

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  15. Content type: Review

    Deregulated activity of BCR-ABL1, a nonreceptor tyrosine kinase encoded by the fusion gene resulting from the t(9;22)(q34;q11) chromosomal translocation, is thought to be the driver event responsible for initi...

    Authors: Simona Soverini, Manuela Mancini, Luana Bavaro, Michele Cavo and Giovanni Martinelli

    Citation: Molecular Cancer 2018 17:49

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  16. Content type: Review

    Breast cancer is a multifactorial disease and driven by aberrant regulation of cell signaling pathways due to the acquisition of genetic and epigenetic changes. An array of growth factors and their receptors i...

    Authors: Ramesh Butti, Sumit Das, Vinoth Prasanna Gunasekaran, Amit Singh Yadav, Dhiraj Kumar and Gopal C. Kundu

    Citation: Molecular Cancer 2018 17:34

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  17. Content type: Review

    Glioma is one of the most prevalent types of primary intracranial carcinoma with varying malignancy grades I–IV and histological subtypes, including astrocytomas, glioblastoma multiform (GBM), oligodendrogliom...

    Authors: Zixuan Peng, Changhong Liu and Minghua Wu

    Citation: Molecular Cancer 2018 17:61

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  18. Content type: Research

    During embryonic development Wnt family members and bone morphogenetic proteins (BMPs) cooperatively induce epithelial-mesenchymal transition (EMT) in the neural crest. Wnt and BMPs are reactivated during mali...

    Authors: Tobias Sinnberg, Mitchell P. Levesque, Jelena Krochmann, Phil F. Cheng, Kristian Ikenberg, Francisco Meraz-Torres, Heike Niessner, Claus Garbe and Christian Busch

    Citation: Molecular Cancer 2018 17:59

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