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  1. Early detection can benefit cancer patients with more effective treatments and better prognosis, but existing early screening tests are limited, especially for multi-cancer detection. This study investigated t...

    Authors: Hua Bao, Zheng Wang, Xiaoji Ma, Wei Guo, Xiangyu Zhang, Wanxiangfu Tang, Xin Chen, Xinyu Wang, Yikuan Chen, Shaobo Mo, Naixin Liang, Qianli Ma, Shuyu Wu, Xiuxiu Xu, Shuang Chang, Yulin Wei…
    Citation: Molecular Cancer 2022 21:129
    Content type: Correspondence Published on:

  4. Development of resistance to targeted therapies has tempered initial optimism that precision oncology would improve poor outcomes for cancer patients. Resistance mechanisms, however, can also confer new resist...

    Authors: Mareike Berlak, Elizabeth Tucker, Mathurin Dorel, Annika Winkler, Aleixandria McGearey, Elias Rodriguez-Fos, Barbara Martins da Costa, Karen Barker, Elicia Fyle, Elizabeth Calton, Selma Eising, Kim Ober, Deborah Hughes, Eleni Koutroumanidou, Paul Carter, Reda Stankunaite…
    Citation: Molecular Cancer 2022 21:126
    Content type: Research Published on:

  5. The dynamic epigenome and proteins specialized in the interpretation of epigenetic marks critically contribute to leukemic pathogenesis but also offer alternative therapeutic avenues. Targeting newly discovere...

    Authors: Nunzio Del Gaudio, Antonella Di Costanzo, Ning Qing Liu, Lidio Conte, Carmela Dell’Aversana, Guglielmo Bove, Rosaria Benedetti, Liliana Montella, Fortunato Ciardiello, Vincenzo Carafa, Concetta Ambrosino, Valeria Tucci, Mariarosaria Conte, Joost H. A. Martens, Hendrik G. Stunnenberg, Angela Nebbioso…
    Citation: Molecular Cancer 2022 21:125
    Content type: Research Published on:

  6. Authors: Xin Xia, Xixi Li, Fanying Li, Xujia Wu, Maolei Zhang, Huangkai Zhou, Nunu Huang, Xuesong Yang, Feizhe Xiao, Dawei Liu, Lixuan Yang and Nu Zhang
    Citation: Molecular Cancer 2022 21:124
    Content type: Correction Published on:

    The original article was published in Molecular Cancer 2019 18:131

  7. Multiple lines of evidence have demonstrated that circular RNAs (circRNAs) play oncogenic or tumor-suppressive roles in various human cancers. Nevertheless, the biological functions of circRNAs in small cell l...

    Authors: Jinghan Hua, Xiaolin Wang, Liying Ma, Jingxin Li, Guozhen Cao, Shaobo Zhang and Wenchu Lin
    Citation: Molecular Cancer 2022 21:123
    Content type: Research Published on:

  9. circular RNAs (circRNAs) have been reported to play crucial roles in the biology of different cancers. However, little is known about the function of circSTX6 (hsa_circ_0007905) in pancreatic ductal adenocarci...

    Authors: Lingdong Meng, Yihan Zhang, Pengfei Wu, Danrui Li, Yichao Lu, Peng Shen, Taoyue Yang, Guodong Shi, Qun Chen, Hao Yuan, Wanli Ge, Yi Miao, Min Tu and Kuirong Jiang
    Citation: Molecular Cancer 2022 21:121
    Content type: Research Published on:

  10. AP4 (TFAP4) encodes a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor and is a direct target gene of the oncogenic transcription factor c-MYC. Here, we set out to determine the relevance of ...

    Authors: Jinjiang Chou, Markus Kaller, Stephanie Jaeckel, Matjaz Rokavec and Heiko Hermeking
    Citation: Molecular Cancer 2022 21:120
    Content type: Research Published on:

  11. Prostate cancer (PCa) is the most frequently diagnosed malignancy in men, and its mechanism remains poorly understood. Therefore, it is urgent to discover potential novel diagnostic biomarkers and therapeutic ...

    Authors: Bing Yao, Sha Zhu, Xiyi Wei, Ming-Kun Chen, Yangkun Feng, Zhimin Li, Xinyu Xu, Yuwei Zhang, Yang Wang, Jingwan Zhou, Ningyuan Tang, Chengjian Ji, Peng Jiang, Shan-Chao Zhao, Chao Qin and Ninghan Feng
    Citation: Molecular Cancer 2022 21:119
    Content type: Research Published on:

  12. PIK3CA mutation and PTEN suppression lead to tumorigenesis and drug resistance in colorectal cancer (CRC). There is no research on the role of circular RNAs (circRNAs) in regulating PIK3CA mutation and MEK inh...

    Authors: Xiaodan Chong, Jingde Chen, Nanxin Zheng, Zhuqing Zhou, Yanan Hai, Shiqing Chen, Yu Zhang, Qingzhuo Yu, Shijun Yu, Zhiqin Chen, Wenfang Bao, Ming Quan, Zhe-Sheng Chen, Yangyang Zhan and Yong Gao
    Citation: Molecular Cancer 2022 21:118
    Content type: Research Published on:

  15. Cancer is a type of malignant affliction threatening human health worldwide; however, the molecular mechanism of cancer pathogenesis remains to be elusive. The oncogenic hedgehog (Hh) pathway is a highly evolu...

    Authors: Jia Song, Yuexin Ge, Xiaoyu Sun, Qiutong Guan, Shiqiang Gong, Minjie Wei, Jumin Niu and Lin Zhao
    Citation: Molecular Cancer 2022 21:115
    Content type: Review Published on:

  16. Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. One of the main challenges in the management of OC is the late clinical presentation of disease that results in poor survival. Conventio...

    Authors: Jie Wei Zhu, Parsa Charkhchi and Mohammad R. Akbari
    Citation: Molecular Cancer 2022 21:114
    Content type: Review Published on:

  17. Brain metastasis (BrM) is a major problem associated with cancer-related mortality, and currently, no specific biomarkers are available in clinical settings for early detection. Liquid biopsy is widely accepte...

    Authors: Asad Ur Rehman, Parvez Khan, Shailendra Kumar Maurya, Jawed A. Siddiqui, Juan A. Santamaria-Barria, Surinder K. Batra and Mohd Wasim Nasser
    Citation: Molecular Cancer 2022 21:113
    Content type: Review Published on:

  18. Although gemcitabine has been considered as the first-line drug for advanced pancreatic cancer (PC), development of resistance to gemcitabine severely limits the effectiveness of this chemotherapy, and the und...

    Authors: Jianyou Gu, Wenjie Huang, Xianxing Wang, Junfeng Zhang, Tian Tao, Yao Zheng, Songsong Liu, Jiali Yang, Zhe-Sheng Chen, Chao-Yun Cai, Jinsui Li, Huaizhi Wang and Yingfang Fan
    Citation: Molecular Cancer 2022 21:112
    Content type: Research Published on:

  19. Sunitinib resistance can be classified into primary and secondary resistance. While accumulating research has indicated several underlying factors contributing to sunitinib resistance, the precise mechanisms i...

    Authors: Yuanlei Chen, Zeyi Lu, Chao Qi, Chenhao Yu, Yang Li, Wang Huan, Ruyue Wang, Wenqin Luo, Danyang Shen, Lifeng Ding, Liangliang Ren, Haiyun Xie, Dingwei Xue, Mingchao Wang, Kangxin Ni, Liqun Xia…
    Citation: Molecular Cancer 2022 21:111
    Content type: Research Published on:

  20. Previous studies have confirmed the oncogenic role of HMGB2 in various cancers, but the biological functions of HMGB2-derived circRNAs remain unknown. Thus, we intended to investigate the potential role of HMG...

    Authors: Ling-Xian Zhang, Jian Gao, Xiang Long, Peng-Fei Zhang, Xin Yang, Shu-Qiang Zhu, Xu Pei, Bai-Quan Qiu, Shi-Wei Chen, Feng Lu, Kun Lin, Jian Jun Xu and Yong-Bing Wu
    Citation: Molecular Cancer 2022 21:110
    Content type: Research Published on:

  21. Emerging evidence suggest the critical role of circular RNAs (circRNAs) in disease development especially in various cancers. However, the oncogenic role of circRNAs in hepatocellular carcinoma (HCC) is still ...

    Authors: Ashuai Du, Shiqin Li, Yuzheng Zhou, Cyrollah Disoma, Yujie Liao, Yongxing Zhang, Zongpeng Chen, Qinglong Yang, Pinjia Liu, Sixu Liu, Zijun Dong, Aroona Razzaq, Siyi Tao, Xuan Chen, Yuxin Liu, Lunan Xu…
    Citation: Molecular Cancer 2022 21:109
    Content type: Research Published on:

  22. CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation...

    Authors: Chen Xue, Ganglei Li, Qiuxian Zheng, Xinyu Gu, Zhengyi Bao, Juan Lu and Lanjuan Li
    Citation: Molecular Cancer 2022 21:108
    Content type: Review Published on:

  24. Lung cancer is a kind of malignancy with high morbidity and mortality worldwide. Paclitaxel (PTX) is the main treatment for non-small cell lung cancer (NSCLC), and resistance to PTX seriously affects the survi...

    Authors: Wenjing Wang, Jianmin Wang, Shuai Liu, Yong Ren, Jingyu Wang, Sen Liu, Wei Cui, Lina Jia, Xing Tang, Jingyu Yang, Chunfu Wu and Lihui Wang
    Citation: Molecular Cancer 2022 21:106
    Content type: Research Published on:

  25. Long non-coding RNAs (lncRNAs) have been demonstrated to play vital roles in cancer development and progression. However, their biological roles and function mechanisms in liver cancer remain largely unknown.

    Authors: Kefei Yuan, Jiang Lan, Lin Xu, Xuping Feng, Haotian Liao, Kunlin Xie, Hong Wu and Yong Zeng
    Citation: Molecular Cancer 2022 21:105
    Content type: Research Published on:

  27. Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1/P-gp) is a major cause of cancer chemotherapy failure, but the regulation mechanisms are largely unknown.

    Authors: Lei Zhang, Yidong Li, Chaohua Hu, Yangmin Chen, Zhuo Chen, Zhe-Sheng Chen, Jian-Ye Zhang and Shuo Fang
    Citation: Molecular Cancer 2022 21:103
    Content type: Research Published on:

  28. Redirecting pre-existing virus-specific cytotoxic CD8+ T lymphocytes (CTLs) to tumors by simulating a viral infection of the tumor cells has great potential for cancer immunotherapy. However, this strategy is lim...

    Authors: Keunok Jung, Min-Jeong Son, Se-Young Lee, Jeong-Ah Kim, Deok-Han Ko, Sojung Yoo, Chul-Ho Kim and Yong-Sung Kim
    Citation: Molecular Cancer 2022 21:102
    Content type: Research Published on:

  29. Authors: Changwei Lin, Min Ma, Yi Zhang, Liang Li, Fei Long, Canbin Xie, Hua Xiao, Teng Liu, Buning Tian, Kaiyan Yang, Yihang Guo, Miao Chen, Jin Chou, Ni Gong, Xiaorong Li and Gui Hu
    Citation: Molecular Cancer 2022 21:101
    Content type: Correction Published on:

    The original article was published in Molecular Cancer 2022 21:80

  31. Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein degradation. A bifunctional PROTAC molecule with two covalently-linked ligands recruits target protein and E3 ubiquitin l...

    Authors: Xinyi Li, Wenchen Pu, Qingquan Zheng, Min Ai, Song Chen and Yong Peng
    Citation: Molecular Cancer 2022 21:99
    Content type: Review Published on:

  32. The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays essential roles in tumor development and metastasis. The clinical outcomes of tumors are often closely related to indivi...

    Authors: Ke Liu, Jia-Jia Cui, Yan Zhan, Qian-Ying Ouyang, Qi-Si Lu, Dong-Hua Yang, Xiang-Ping Li and Ji-Ye Yin
    Citation: Molecular Cancer 2022 21:98
    Content type: Review Published on:

  33. N6-methyladenosine (m6A) RNA modification plays a critical role in various physiological and pathological conditions. However, the role of m6A modification in head and neck squamous cell carcinoma (HNSCC) rema...

    Authors: Shufang Jin, Mingyu Li, Hanyue Chang, Ruijie Wang, Zhiyuan Zhang, Jianjun Zhang, Yue He and Hailong Ma
    Citation: Molecular Cancer 2022 21:97
    Content type: Research Published on:

  35. Breast cancer continues to be a major global problem with significant mortality associated with advanced stage and metastases at clinical presentation. However, several findings suggest that metastasis is inde...

    Authors: Vinitha Richard, Matthew G. Davey, Heidi Annuk, Nicola Miller and Michael J. Kerin
    Citation: Molecular Cancer 2022 21:95
    Content type: Review Published on:

  36. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-015-0465-3.

    Authors: Peng Yang, Fang Ni, Rui-qing Deng, Guo Qiang, Hua Zhao, Ming-zhen Yang, Xin-yi Wang, You-zhi Xu, Li Chen, Dan-lei Chen, Zhi-jun Chen, Li-xin Kan and Si-Ying Wang
    Citation: Molecular Cancer 2022 21:94
    Content type: Retraction Note Published on:

  37. Circular RNAs (circRNAs) regulate various biological activities and have been shown to play crucial roles in hepatocellular carcinoma (HCC) progression. However, only a few coding circRNAs have been identified...

    Authors: Jin-Ling Duan, Wei Chen, Juan-Juan Xie, Mao-Lei Zhang, Run-Cong Nie, Hu Liang, Jie Mei, Kai Han, Zhi-Cheng Xiang, Feng-Wei Wang, Kai Teng, Ri-Xin Chen, Min-Hua Deng, Yi-Xin Yin, Nu Zhang, Dan Xie…
    Citation: Molecular Cancer 2022 21:93
    Content type: Research Published on:

  38. Circular RNAs (circRNAs) are involved in regulatory processes of ubiquitination and deubiquitination in various tumors at post-transcriptional epigenetic modification level. However, the underlying mechanism a...

    Authors: Zheng Wang, Anqi Sun, Aihui Yan, Jian Yao, Haibo Huang, Ziming Gao, Tao Han, Jia Gu, Ni Li, Huizhe Wu and Kai Li
    Citation: Molecular Cancer 2022 21:92
    Content type: Research Published on:

  39. Authors: Kuailu Lin, Franziska Baenke, Xixi Lai, Martin Schneider, Dominic Helm, Heike Polster, Venkatesh S. Rao, Nicole Ganig, Fang Cheng Wong, Lena Seifert, Adrian M. Seifert, Beatrix Jahnke, Nicole Kretschmann, Tjalf Ziemssen, Fee Klupp, Thomas Schmidt…
    Citation: Molecular Cancer 2022 21:91
    Content type: Letter to the Editor Published on:

  40. Authors: Chunling Ma, Fang Wang, Bing Han, Xiaoli Zhong, Fusheng Si, Jian Ye, Eddy C. Hsueh, Lynn Robbins, Susan M. Kiefer, Yanping Zhang, Pamela Hunborg, Mark A. Varvares, Michael Rauchman and Guangyong Peng
    Citation: Molecular Cancer 2022 21:90
    Content type: Correction Published on:

    The original article was published in Molecular Cancer 2018 17:78

  41. Frequent truncation mutations of the histone lysine N-methyltransferase KMT2C have been detected by whole exome sequencing studies in various cancers, including malignancies of the prostate. However, the biologic...

    Authors: Tanja Limberger, Michaela Schlederer, Karolina Trachtová, Ines Garces de los Fayos Alonso, Jiaye Yang, Sandra Högler, Christina Sternberg, Vojtech Bystry, Jan Oppelt, Boris Tichý, Margit Schmeidl, Petra Kodajova, Anton Jäger, Heidi A. Neubauer, Monika Oberhuber, Belinda S. Schmalzbauer…
    Citation: Molecular Cancer 2022 21:89
    Content type: Research Published on:

  42. Hypoxia has long been considered as a hallmark of solid tumors and is closely associated with tumor progression. Circular RNAs (circRNAs) have been identified as a critical modulator in various cancers. Howeve...

    Authors: Rui Yang, Hang Chen, Lei Xing, Bin Wang, Mengting Hu, Xiaoqiang Ou, Hong Chen, Yumei Deng, Dawei Liu, Rong Jiang and Junxia Chen
    Citation: Molecular Cancer 2022 21:88
    Content type: Research Published on:

  43. FBXW7 (F-Box and WD Repeat Domain Containing 7) (also referred to as FBW7 or hCDC4) is a component of the Skp1-Cdc53 / Cullin-F-box-protein complex (SCF/β-TrCP). As a member of the F-box protein family, FBXW7 ...

    Authors: Jingyi Fan, Marcia Bellon, Mingyi Ju, Lin Zhao, Minjie Wei, Liwu Fu and Christophe Nicot
    Citation: Molecular Cancer 2022 21:87
    Content type: Review Published on:

  44. Colorectal cancer (CRC) is one of the most common cancers worldwide and a leading cause of carcinogenic death. To date, surgical resection is regarded as the gold standard by the operator for clinical decision...

    Authors: Hui Zhou, Liyong Zhu, Jun Song, Guohui Wang, Pengzhou Li, Weizheng Li, Ping Luo, Xulong Sun, Jin Wu, Yunze Liu, Shaihong Zhu and Yi Zhang
    Citation: Molecular Cancer 2022 21:86
    Content type: Review Published on:

  46. Immune checkpoint inhibitors had a great effect in triple-negative breast cancer (TNBC); however, they benefited only a subset of patients, underscoring the need to co-target alternative pathways and select op...

    Authors: Song-Yang Wu, Ying Xu, Li Chen, Lei Fan, Xiao-Yan Ma, Shen Zhao, Xiao-Qing Song, Xin Hu, Wen-Tao Yang, Wen-Jun Chai, Xiao-Mao Guo, Xi-Zi Chen, Yan-Hui Xu, Xiao-Yu Zhu, Jian-Jun Zou, Zhong-Hua Wang…
    Citation: Molecular Cancer 2022 21:84
    Content type: Research Published on:

  47. Cancer is caused by a combination of genetic and epigenetic abnormalities. Current cancer therapies are limited due to the complexity of their mechanism, underlining the need for alternative therapeutic approa...

    Authors: Sushmaa Chandralekha Selvakumar, K. Auxzilia Preethi, Kehinde Ross, Deusdedit Tusubira, Mohd Wajid Ali Khan, Panagal Mani, Tentu Nageswara Rao and Durairaj Sekar
    Citation: Molecular Cancer 2022 21:83
    Content type: Review Published on:

  48. miR-346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)-linked transcripts in prostate cancer (PC). We sought to delineate the impact of miR-3...

    Authors: C. E. Fletcher, L. Deng, F. Orafidiya, W. Yuan, M. P. G. S. Lorentzen, O. W. Cyran, A. Varela-Carver, T. A. Constantin, D. A. Leach, F. M. Dobbs, I. Figueiredo, B. Gurel, E. Parkes, D. Bogdan, R. R. Pereira, S. G. Zhao…
    Citation: Molecular Cancer 2022 21:82
    Content type: Research Published on:

  50. Previous studies have shown that the N6-methyladenosine (m6A) modification enhances the binding ability of mRNAs/long noncoding RNAs (lncRNAs) to microRNAs (miRNAs), but the impact of this modification on the com...

    Authors: Changwei Lin, Min Ma, Yi Zhang, Liang Li, Fei Long, Canbin Xie, Hua Xiao, Teng Liu, Buning Tian, Kaiyan Yang, Yihang Guo, Miao Chen, Jin Chou, Ni Gong, Xiaorong Li and Gui Hu
    Citation: Molecular Cancer 2022 21:80
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Cancer 2022 21:101

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