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  1. Content type: Research

    Activating mutations in KRAS are prevalent in lung cancer and have been causally linked to the oncogenic process. However, therapies targeted to oncogenic RAS have been ineffective to date and identification o...

    Authors: Edmilson Ozorio dos Santos, Tatiana Correa Carneiro-Lobo, Mateus Nobrega Aoki, Elena Levantini and Daniela Sanchez Bassères

    Citation: Molecular Cancer 2016 15:12

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  2. Content type: Research

    NF-κB signaling pathway plays an important role in gastric carcinogenesis. The basic expression and functional role of NFKB1 and RELA (components of canonical NF-κB pathway) in gastric cancer (GC) have not bee...

    Authors: Tingting Huang, Wei Kang, Bin Zhang, Feng Wu, Yujuan Dong, Joanna H. M. Tong, Weiqin Yang, Yuhang Zhou, Li Zhang, Alfred S. L. Cheng, Jun Yu and Ka Fai To

    Citation: Molecular Cancer 2016 15:9

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  3. Content type: Research

    Detachment of epithelial cells from the extracellular matrix initiates programmed cell death by a process termed anoikis. Malignant cells must acquire anoikis resistance to leave the primary tumour and metasta...

    Authors: Brendan C. Luey and Felicity E. B. May

    Citation: Molecular Cancer 2016 15:8

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  4. Content type: Research

    Cancer associated fibroblasts (CAF) play important roles in tumor growth that involves inflammation and epithelial cell differentiation. Early studies suggested that estrogen receptor alpha (ERα) was expressed...

    Authors: Chiuan-Ren Yeh, Spencer Slavin, Jun Da, Iawen Hsu, Jie Luo, Guang-Qian Xiao, Jie Ding, Fu-Ju Chou and Shuyuan Yeh

    Citation: Molecular Cancer 2016 15:7

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  5. Content type: Review

    PIWI-interacting RNAs (piRNAs) are emerging players in cancer genomics. Originally described in the germline, there are over 20,000 piRNA genes in the human genome. In contrast to microRNAs, piRNAs interact wi...

    Authors: Kevin W. Ng, Christine Anderson, Erin A. Marshall, Brenda C. Minatel, Katey S. S. Enfield, Heather L. Saprunoff, Wan L. Lam and Victor D. Martinez

    Citation: Molecular Cancer 2016 15:5

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  6. Content type: Research

    Circadian disruption and deranged molecular clockworks are involved in carcinogenesis. The cryptochrome genes (CRY1 and CRY2) encode circadian proteins important for the functioning of biological oscillators. The...

    Authors: Gianluigi Mazzoccoli, Tommaso Colangelo, Anna Panza, Rosa Rubino, Angelo De Cata, Cristiana Tiberio, Maria Rosa Valvano, Valerio Pazienza, Giuseppe Merla, Bartolomeo Augello, Domenico Trombetta, Clelia Tiziana Storlazzi, Gemma Macchia, Annamaria Gentile, Francesca Tavano, Manlio Vinciguerra…

    Citation: Molecular Cancer 2016 15:6

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  7. Content type: Review

    As our knowledge of cancer metabolism has increased, it has become apparent that cancer metabolic processes are extremely heterogeneous. The reasons behind this heterogeneity include genetic diversity, the exi...

    Authors: Debanti Sengupta and Guillem Pratx

    Citation: Molecular Cancer 2016 15:4

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  8. Content type: Research

    Initially identified as a molecule that regulates the final step of glycolysis, the M2 isoform of pyruvate kinase (PKM2) was recently reported to have a central role in the metabolic reprogramming of cancer ce...

    Authors: Ninel Azoitei, Alexander Becher, Konrad Steinestel, Arefeh Rouhi, Kristina Diepold, Felicitas Genze, Thomas Simmet and Thomas Seufferlein

    Citation: Molecular Cancer 2016 15:3

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  9. Content type: Research

    Zinc (Zn) hyper-accumulates in breast tumors and malignant cell lines compared to normal mammary epithelium. The mechanisms responsible for Zn accumulation and the consequence of Zn dysregulation are poorly un...

    Authors: Paige Chandler, Bose S. Kochupurakkal, Samina Alam, Andrea L. Richardson, David I. Soybel and Shannon L. Kelleher

    Citation: Molecular Cancer 2016 15:2

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  10. Content type: Research

    Neuroblastoma is a malignant embryonal tumor occurring in young children, consisting of undifferentiated neuroectodermal cells derived from the neural crest. Current therapies for high-risk neuroblastoma are i...

    Authors: Constanza L. Cortes, Sonia R. Veiga, Eugènia Almacellas, Javier Hernández-Losa, Joan C. Ferreres, Sara C. Kozma, Santiago Ambrosio, George Thomas and Albert Tauler

    Citation: Molecular Cancer 2016 15:1

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  11. Content type: Research

    A new class of non-coding RNAs, known as long non-coding RNAs (lncRNAs), has been recently described. These lncRNAs are implicated to play pivotal roles in various molecular processes, including development an...

    Authors: Norma I. Rodríguez-Malavé, Thilini R. Fernando, Parth C. Patel, Jorge R. Contreras, Jayanth Kumar Palanichamy, Tiffany M. Tran, Jaime Anguiano, Michael J. Davoren, Michael O. Alberti, Kimanh T. Pioli, Salemiz Sandoval, Gay M. Crooks and Dinesh S. Rao

    Citation: Molecular Cancer 2015 14:214

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  12. Content type: Research

    Abnormal activation of STAT3 and miR-21 plays a vital role in progression and invasion of solid tumors. The cyclin-dependent kinase 5 (CDK5) is reported to contribute to cancer metastasis by regulating epithel...

    Authors: Shan-Shan Sun, Xuan Zhou, Yuan-Yuan Huang, Ling-Ping Kong, Mei Mei, Wen-Yu Guo, Ming-Hui Zhao, Yu Ren, Qiang Shen and Lun Zhang

    Citation: Molecular Cancer 2015 14:213

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  13. Content type: Research

    Pancreatic acinar cell carcinoma (ACC) is a rare tumor entity with an unfavorable prognosis. Recent whole-exome sequencing identified p53 mutations in a subset of human ACC. Activation of the mammalian target ...

    Authors: Bo Kong, Tao Cheng, Chengjia Qian, Weiwei Wu, Katja Steiger, Jing Cao, Anna Melissa Schlitter, Ivonne Regel, Susanne Raulefs, Helmut Friess, Mert Erkan, Irene Esposito, Jörg Kleeff and Christoph W. Michalski

    Citation: Molecular Cancer 2015 14:212

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  14. Content type: Research

    The limited efficacy of current treatments against pancreatic cancer has prompted the search of new alternatives such as virotherapy. Activation of the immune response against cancer cells is emerging as one o...

    Authors: Estanislao Nistal-Villan, Maria Bunuales, Joanna Poutou, Manuela Gonzalez-Aparicio, Carlos Bravo-Perez, Jose I. Quetglas, Beatriz Carte, Gloria Gonzalez-Aseguinolaza, Jesus Prieto, Esther Larrea and Ruben Hernandez-Alcoceba

    Citation: Molecular Cancer 2015 14:210

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  15. Content type: Letter to the Editor

    Through a combined approach integrating RNA-Seq, SNP-array, FISH and PCR techniques, we identified two novel t(15;21) translocations leading to the inactivation of RUNX1 and its partners SIN3A and TCF12. One is a...

    Authors: Alberto L’Abbate, Doron Tolomeo, Francesca De Astis, Angelo Lonoce, Crocifissa Lo Cunsolo, Dominique Mühlematter, Jacqueline Schoumans, Peter Vandenberghe, Achilles Van Hoof, Orazio Palumbo, Massimo Carella, Tommaso Mazza and Clelia Tiziana Storlazzi

    Citation: Molecular Cancer 2015 14:211

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  16. Content type: Research

    Tamoxifen (TAM) and fulvestrant (FUL) are the major drugs for patients with estrogen receptor-positive (ER+) breast cancers. However, the development of endocrine resistance is the impediment for successful treat...

    Authors: Xinfeng Yu, Aiping Luo, Yicong Liu, Shuqing Wang, Ye Li, Wenna Shi, Zhihua Liu and Xianjun Qu

    Citation: Molecular Cancer 2015 14:208

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  17. Content type: Research

    The clinical application of TRAIL receptor agonists as a novel cancer therapy has been tempered by heterogeneity in tumour responses. This is illustrated in breast cancer, where TRAIL is cytotoxic in cell line...

    Authors: Rhiannon French, Olivia Hayward, Samuel Jones, William Yang and Richard Clarkson

    Citation: Molecular Cancer 2015 14:209

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  18. Content type: Review

    Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy and the most common subtype of non-Hodgkin’s lymphoma in adults, with one of the highest mortality rates in most develope...

    Authors: Rosalba Camicia, Hans C. Winkler and Paul O. Hassa

    Citation: Molecular Cancer 2015 14:207

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  19. Content type: Research

    Wnt/β-catenin signaling is often portrayed as a simple pathway that is initiated by Wnt ligand at the cell surface leading, via linear series of interactions between ‘core pathway’ members, to the induction of...

    Authors: Jamie Freeman, David Smith, Branko Latinkic, Ken Ewan, Lee Samuel, Massimo Zollo, Natascia Marino, Lorraine Tyas, Nick Jones and Trevor C. Dale

    Citation: Molecular Cancer 2015 14:206

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  20. Content type: Research

    A promising therapeutic approach for aggressive B-cell Non-Hodgkin lymphoma (NHL), including diffuse large B-cell lymphoma (DLBCL), and Burkitt lymphoma (BL) is to target kinases involved in signal transductio...

    Authors: S. Kreuz, K. B. Holmes, R. M. Tooze and P. F. Lefevre

    Citation: Molecular Cancer 2015 14:205

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  21. Content type: Research

    An inverse correlation between expression of the aldehyde dehydrogenase 1 subfamily A2 (ALDH1A2) and gene promoter methylation has been identified as a common feature of oropharyngeal squamous cell carcinoma (...

    Authors: Katharina Seidensaal, Andre Nollert, Agnes Hiou Feige, Marie Muller, Thomas Fleming, Nikolas Gunkel, Karim Zaoui, Niels Grabe, Wilko Weichert, Klaus-Josef Weber, Peter Plinkert, Christian Simon and Jochen Hess

    Citation: Molecular Cancer 2015 14:204

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  22. Content type: Research

    Pancreatic ductal adenocarcinoma (PDAC) is presently one of the cancers with the worst survival rates and least effective treatments. Moreover, total deaths due to PDAC are predicted to increase in the next 15...

    Authors: Andrea Giannuzzo, Stine Falsig Pedersen and Ivana Novak

    Citation: Molecular Cancer 2015 14:203

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  23. Content type: Research

    Despite the declining incidence of gastric cancer, mortality rate remains high due to late presentation. We aimed to evaluate the sensitivity of miRNA as a diagnostic marker for gastric cancer in the circulation.

    Authors: Vivian Yvonne Shin, Enders K. O. Ng, Vivian W. Chan, Ava Kwong and Kent-Man Chu

    Citation: Molecular Cancer 2015 14:202

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  24. Content type: Research

    One of the challenging problems of current radio-chemotherapy is recurrence and metastasis of cancer cells that survive initial treatment. We propose that one of the unwanted effects of radiochemotherapy is th...

    Authors: Gabriela Schneider, Talita Glaser, Claudiana Lameu, Ahmed Abdelbaset-Ismail, Zachariah Payne Sellers, Marcin Moniuszko, Henning Ulrich and Mariusz Z. Ratajczak

    Citation: Molecular Cancer 2015 14:201

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  25. Content type: Research

    Pancreatic Ductal Adenocarcinoma (PDAC) is a devastating disease hallmarked by limited patient survival. Resistance to chemotherapy, a major cause of treatment failure in PDAC patients, is often attributed to ...

    Authors: Alice Nomura, Olivia McGinn, Vikas Dudeja, Veena Sangwan, Ashok K. Saluja and Sulagna Banerjee

    Citation: Molecular Cancer 2015 14:200

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  26. Content type: Research

    We have previously shown in pancreatic ductal adenocarcinoma (PDAC) cells that the SRC inhibitors PP2 and PP1 effectively inhibited TGF-β1-mediated cellular responses by blocking the kinase function of the TGF...

    Authors: Tobias Bartscht, Benjamin Rosien, Dirk Rades, Roland Kaufmann, Harald Biersack, Hendrik Lehnert, Frank Gieseler and Hendrik Ungefroren

    Citation: Molecular Cancer 2015 14:199

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  27. Content type: Review

    Survivin, a member of the inhibitor of apoptosis family of proteins (IAPs) that controls cell division, apoptosis, metastasis and angiogenesis, is overexpressed in essentially all human cancers. As a consequen...

    Authors: C. Sanhueza, S. Wehinger, J. Castillo Bennett, M. Valenzuela, G. I. Owen and A. F. G. Quest

    Citation: Molecular Cancer 2015 14:198

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  28. Content type: Letter to the Editor

    The ETV6 gene encodes an ETS family transcription factor that is involved in a myriad of chromosomal rearrangements found in hematological malignancies and other neoplasms. A recurrent ETV6 translocation, previou...

    Authors: Paulo Vidal Campregher, Welbert de Oliveira Pereira, Bianca Lisboa, Renato Puga, Ricardo Helman, Mariana Miyagi, Evelyn Helena Ascendino da Mata, Tarcila Santos Datoguia, Elvira Deolinda Rodrigues Pereira Velloso, Nydia Strachman Bacal, Jeffrey S. Ross, Siraj Ali, Vincent Miller, Fernando Ferreira Costa, Nelson Hamerschlak and Fabio Pires de Souza Santos

    Citation: Molecular Cancer 2015 14:197

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  29. Content type: Research

    Drug resistance hampers the efficient treatment of malignancies, including advanced stage ovarian cancer, which has a 5-year survival rate of only 30 %. The molecular processes underlying resistance have been ...

    Authors: Marijn T. M. van Jaarsveld, Patricia F. van Kuijk, Antonius W. M. Boersma, Jozien Helleman, Wilfred F. van IJcken, Ron H. J. Mathijssen, Joris Pothof, Els M. J. J. Berns, Jaap Verweij and Erik A. C. Wiemer

    Citation: Molecular Cancer 2015 14:196

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  30. Content type: Research

    The therapeutic and prognostic value of the glycolytic enzymes hexokinase, phosphofructokinase, and pyruvate kinase (PK) has been implicated in a variety of cancers, while their roles in treatment of and progn...

    Authors: Guanzhen Yu, Wenlong Yu, Guangzhi Jin, Dongyun Xu, Ying Chen, Tian Xia, Allan Yu, Wenzheng Fang, Xiaoli Zhang, Zhaosheng Li and Keping Xie

    Citation: Molecular Cancer 2015 14:193

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  31. Content type: Research

    MicroRNAs have been identified as potential cancer biomarkers due to their presence and stability in many body fluids including urine and plasma, but the relationship of the pattern of expression of these mess...

    Authors: David A. Armstrong, Benjamin B. Green, John D. Seigne, Alan R. Schned and Carmen J. Marsit

    Citation: Molecular Cancer 2015 14:194

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  32. Content type: Research

    High expression of the long non-coding RNA nuclear-enriched abundant transcript 1 (NEAT1) in whole blood has been reported in colorectal cancer patients; however, its’ clinical significance and origin are uncl...

    Authors: Yuchen Wu, Li Yang, Jiang Zhao, Cong Li, Jia Nie, Fangqi Liu, Changhua Zhuo, Yaxin Zheng, Bin Li, Zhimin Wang and Ye Xu

    Citation: Molecular Cancer 2015 14:191

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  33. Content type: Research

    Ovarian cancer is the most lethal gynecologic malignancy, with limited treatment options for chemoresistant disease. An important link between inflammation and peritoneal spread of ovarian cancer is NF-κB sign...

    Authors: Andrew J. Wilson, Jeanette Saskowski, Whitney Barham, Dineo Khabele and Fiona Yull

    Citation: Molecular Cancer 2015 14:192

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  34. Content type: Research

    Temozolomide (TMZ) is an oral DNA-alkylating agent used for treating patients with glioblastoma. However, therapeutic benefits of TMZ can be compromised by the expression of O6-methylguanine methyltransferase ...

    Authors: Jonathan L. Tso, Shuai Yang, Jimmy C. Menjivar, Kazunari Yamada, Yibei Zhang, Irene Hong, Yvonne Bui, Alexandra Stream, William H. McBride, Linda M. Liau, Stanley F. Nelson, Timothy F. Cloughesy, William H. Yong, Albert Lai and Cho-Lea Tso

    Citation: Molecular Cancer 2015 14:189

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  35. Content type: Research

    MicroRNAs (miR, miRNAs) play pivotal roles in numerous physiological and pathophysiological contexts. We investigated whether miR-362-5p act as an oncogene in chronic myeloid leukaemia (CML) and aimed to under...

    Authors: Peng Yang, Fang Ni, Rui-qing Deng, Guo Qiang, Hua Zhao, Ming-zhen Yang, Xin-yi Wang, You-zhi Xu, Li Chen, Dan-lei Chen, Zhi-jun Chen, Li-xin Kan and Si-Ying Wang

    Citation: Molecular Cancer 2015 14:190

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  36. Content type: Research

    Lung cancer is the leading cause of cancer mortality worldwide, mainly due to late diagnosis, poor prognosis and tumor heterogeneity. Thus, the need for biomarkers that will aid classification, treatment and m...

    Authors: Panagiotis Maragozidis, Eirini Papanastasi, Diana Scutelnic, Athina Totomi, Ioanna Kokkori, Sotirios G. Zarogiannis, Theodora Kerenidi, Konstantinos I. Gourgoulianis and Nikolaos A. A. Balatsos

    Citation: Molecular Cancer 2015 14:187

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  37. Content type: Review

    RNA helicases are a large family of proteins with a distinct motif, referred to as the DEAD/H (Asp-Glu-Ala-Asp/His). The exact functions of all the human DEAD/H box proteins are unknown. However, it has been c...

    Authors: Guus Martinus Bol, Min Xie and Venu Raman

    Citation: Molecular Cancer 2015 14:188

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  38. Content type: Research

    Aberrant expression of A20 has been reported in several human malignancies including hepatocellular carcinoma (HCC). However, its clinical relevance and potential role in HCC remain unknown.

    Authors: Haiyang Chen, Liang Hu, Zaili Luo, Jian Zhang, Cunzhen Zhang, Bijun Qiu, Liwei Dong, Yexiong Tan, Jin Ding, Shanhua Tang, Feng Shen, Zhong Li and Hongyang Wang

    Citation: Molecular Cancer 2015 14:186

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  39. Content type: Research

    BCL-xL is an anti-apoptotic BCL-2 family protein that inhibits apoptosis and is overexpressed in many cancers. We have reported that acquired resistance to the BCL-2 inhibitor ABT-199 (venetoclax) is associate...

    Authors: Sayer Al-harbi, Gaurav S. Choudhary, Jey Sabith Ebron, Brian T. Hill, Nagarajavel Vivekanathan, Angela H. Ting, Tomas Radivoyevitch, Mitchell R. Smith, Girish C. Shukla and Alex Almasan

    Citation: Molecular Cancer 2015 14:185

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  40. Content type: Review

    The imprinted oncofetal long non-coding RNA (lncRNA) H19 is expressed in the embryo, down-regulated at birth and then reappears in tumors. Its role in tumor initiation and progression has long been a subject o...

    Authors: Eli Raveh, Imad J. Matouk, Michal Gilon and Abraham Hochberg

    Citation: Molecular Cancer 2015 14:184

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  41. Content type: Research

    The failure to mount an effective DNA damage response to repair UV induced cyclobutane pyrimidine dimers (CPDs) results in an increased propensity to develop cutaneous squamous cell carcinoma (cSCC). High-risk...

    Authors: Martin Hufbauer, James Cooke, Gijsbertus T. J. van der Horst, Herbert Pfister, Alan Storey and Baki Akgül

    Citation: Molecular Cancer 2015 14:183

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  42. Content type: Research

    Understanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics. Here, we dissect the unique involvement of mitogenic...

    Authors: Jessica Bauer, Ozkan Ozden, Naomi Akagi, Timothy Carroll, Daniel R. Principe, Jonas J. Staudacher, Martina E. Spehlmann, Lars Eckmann, Paul J. Grippo and Barbara Jung

    Citation: Molecular Cancer 2015 14:182

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  43. Content type: Research

    Alcohol consumption is a well-established risk factor for head and neck squamous cell carcinoma (HNSCC); however, the molecular mechanisms by which alcohol promotes HNSCC pathogenesis and progression remain po...

    Authors: Maarouf A. Saad, Selena Z. Kuo, Elham Rahimy, Angela E. Zou, Avinaash Korrapati, Mehran Rahimy, Elizabeth Kim, Hao Zheng, Michael Andrew Yu, Jessica Wang-Rodriguez and Weg M. Ongkeko

    Citation: Molecular Cancer 2015 14:181

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  44. Content type: Research

    Compromised colonic butyrate production resulting from low dietary fiber or altered gut microbiota may promote colon neoplasia. Previous reports indicate these actions are mediated in part by altered levels of...

    Authors: Shien Hu, Lan Liu, Eugene B. Chang, Jian-Ying Wang and Jean-Pierre Raufman

    Citation: Molecular Cancer 2015 14:180

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  45. Content type: Research

    Cancer stem cells (CSCs) are considered responsible for the recurrence and chemoresistance of cancer. Dysregulated autophagy is highly prevalent in many types of cancer including pancreatic cancer and has been...

    Authors: Ming-Chen Yang, Hao-Chen Wang, Ya-Chin Hou, Hui-Ling Tung, Tai-Jan Chiu and Yan-Shen Shan

    Citation: Molecular Cancer 2015 14:179

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  46. Content type: Review

    P-cadherin is a classical cell-to-cell adhesion molecule with a homeostatic function in several normal tissues. However, its behaviour in the malignant setting is notably dependent on the cellular context. In ...

    Authors: André Filipe Vieira and Joana Paredes

    Citation: Molecular Cancer 2015 14:178

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  47. Content type: Research

    Apoptosis-stimulating of p53 protein 2 (ASPP2) is one of the ASPP family members and it has been reported to be associated with human cancer. However, the role of it in pancreatic cancer is still not clear.

    Authors: Bin Song, Qi Bian, Yi-Jie Zhang, Cheng-Hao Shao, Gang Li, An-An Liu, Wei Jing, Rui Liu, Ying-Qi Zhou, Gang Jin and Xian-Gui Hu

    Citation: Molecular Cancer 2015 14:177

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